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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Gene

Kctd10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Alternative name(s):
BTB/POZ domain-containing protein KCTD10
Gene namesi
Name:Kctd10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1591979 Kctd10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242 – 244VEF → AEA: Loss of PCNA binding. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474231 – 315BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TPL3
PRIDEiQ7TPL3

PTM databases

PhosphoSitePlusiQ7TPL3

Expressioni

Tissue specificityi

Expressed at highest levels in lung. Also detected in testis and heart. Very low expression, if any, in brain, liver, spleen, kidney and skeletal muscle.1 Publication

Inductioni

By tumor necrosis factor/TNF in cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000047896 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ7TPL3 RN

Interactioni

Subunit structurei

Homotetramer; forms a two-fold symmetric tetramer in solution. Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (By similarity). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (PubMed:15982757). Interacts with PCNA (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi268948, 2 interactors
STRINGi10116.ENSRNOP00000065635

Structurei

3D structure databases

ProteinModelPortaliQ7TPL3
SMRiQ7TPL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 100BTBPROSITE-ProRule annotationAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 245Interaction with PCNA7

Sequence similaritiesi

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGiKOG2716 Eukaryota
ENOG410XQYZ LUCA
GeneTreeiENSGT00920000149007
HOVERGENiHBG052219
InParanoidiQ7TPL3
KOiK15074
OMAiQGLADEC
OrthoDBiEOG091G0L1Y
PhylomeDBiQ7TPL3

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TPL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEMSGESVV TSAVPAAATR TTSFKGASPS SKYVKLNVGG ALYYTTMQTL
60 70 80 90 100
TKQDTMLKAM FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE
110 120 130 140 150
SRREIEELLA EAKYYLVQGL LEECQAALQN KDTYEPFCKV PVITSSKEEQ
160 170 180 190 200
RLIATSDKPA VKLLYNRSNN KYSYTSNSDD NMLKNIELFD KLSLRFNGRV
210 220 230 240 250
LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT KVEFPEARIY
260 270 280 290 300
EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERERIERVR
310
RIHIKRPDDR AHLHQ
Length:315
Mass (Da):35,745
Last modified:October 1, 2003 - v1
Checksum:i469FEA48EE6FA7A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318756 mRNA Translation: AAP79438.1
RefSeqiNP_001009973.1, NM_001009973.1
UniGeneiRn.185282

Genome annotation databases

EnsembliENSRNOT00000073019; ENSRNOP00000065635; ENSRNOG00000047896
GeneIDi494521
KEGGirno:494521

Entry informationi

Entry nameiBACD3_RAT
AccessioniPrimary (citable) accession number: Q7TPL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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