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Entry version 152 (16 Oct 2019)
Sequence version 3 (20 Jun 2018)
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Protein

E3 ubiquitin-protein ligase MYCBP2

Gene

Mycbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (By similarity). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (PubMed:14729956, PubMed:17901218, PubMed:18031680). Required for the formation of major central nervous system axon tracts (PubMed:17901218, PubMed:18031680). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (PubMed:18031680). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (PubMed:19371781, PubMed:21324225). Regulates axon guidance in the olfactory system (PubMed:23525682). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (PubMed:23665224). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (By similarity). Regulates the internalization of TRPV1 in peripheral sensory neurons (PubMed:21098484). May mediate ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (By similarity). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (By similarity). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529).By similarity10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4499Zinc 1By similarity1
Metal bindingi4502Zinc 1By similarity1
Metal bindingi4517Zinc 2By similarity1
Metal bindingi4519Zinc 2By similarity1
Metal bindingi4522Zinc 1By similarity1
Metal bindingi4525Zinc 1By similarity1
Metal bindingi4546Zinc 2By similarity1
Metal bindingi4549Zinc 2By similarity1
Metal bindingi4615Zinc 3By similarity1
Metal bindingi4618Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4629By similarity1
Metal bindingi4646Zinc 3By similarity1
Metal bindingi4649Zinc 3By similarity1
Metal bindingi4658Zinc 4By similarity1
Metal bindingi4661Zinc 4By similarity1
Metal bindingi4670Zinc 5By similarity1
Metal bindingi4673Zinc 5By similarity1
Metal bindingi4674Zinc 6By similarity1
Active sitei4681By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4682Important for catalysisBy similarity1
Sitei4687Important for catalysisBy similarity1
Metal bindingi4688Zinc 5By similarity1
Metal bindingi4691Zinc 5By similarity1
Sitei4695Important for catalysisBy similarity1
Metal bindingi4709Zinc 6By similarity1
Metal bindingi4723Zinc 6By similarity1
Metal bindingi4729Zinc 6By similarity1
Metal bindingi4740Zinc 4By similarity1
Metal bindingi4743Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4499 – 4550RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri4653 – 4703B box-typeAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Transferase
Biological processBiological rhythms, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MYCBP2Curated (EC:2.3.2.-By similarity)
Alternative name(s):
Myc-binding protein 2Curated
Pam/highwire/rpm-1 protein1 Publication
Protein Magellan1 Publication
Protein associated with Myc1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mycbp2Imported
Synonyms:Pam1 Publication, Phr11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2179432 Mycbp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethality caused by defects in neuromuscular development (PubMed:17901218). Mice die at birth without taking a breath: phrenic nerves are markedly narrower and contain fewer axons than controls (PubMed:17901218). Mice display incomplete innervation of the diaphragm by the phrenic nerve (PubMed:14729956, PubMed:17901218). Intercostal muscles are completely innervated, but show dysmorphic nerve terminals (PubMed:14729956, PubMed:17901218). Sensory neuron terminals in the diaphragm are abnormal and neuromuscular junctions show excessive sprouting of nerve terminals, consistent with inadequate presynaptic stimulation of the muscle (PubMed:14729956). Embryos display motor axon misprojections and stalling: motor axons are error-prone and wander inefficiently at choice points within embryos (PubMed:18031680). Conditional knockout mice lacking Mycbp2 in the retina, exhibit no gross retinal developmental defects; mutants retain normal retinal lamination, monocular segregation and spontaneous retinal wave activity, but mutant retinal ganglion cells exhibit ipsilateral projection to an improper region of the dorsal lateral geniculate nucleus (dLGN) (PubMed:19371781, PubMed:21324225). Conditional knockout mice lacking Mycbp2 in peripheral sensory neurons display prolonged thermal hyperalgesia: defects are caused by constitutive activation of MAP kinase p38 (Mapk11, Mapk12, Mapk13 and/or Mapk14), leading to inhibit internalization of Trpv1 (PubMed:21098484).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi950 – 951HH → AA: Abolished guanosine exchange factor (GEF) activity for Ran. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559641 – 4749E3 ubiquitin-protein ligase MYCBP2Add BLAST4749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphoserineBy similarity1
Modified residuei178PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei1621PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1745 ↔ 18601 Publication
Modified residuei2841PhosphoserineBy similarity1
Modified residuei2859PhosphoserineBy similarity1
Modified residuei2861PhosphoserineBy similarity1
Modified residuei2905PhosphoserineBy similarity1
Modified residuei2911PhosphoserineBy similarity1
Modified residuei2941PhosphoserineCombined sources1
Modified residuei2943PhosphoserineBy similarity1
Modified residuei2992PhosphoserineCombined sources1
Modified residuei3057PhosphoserineBy similarity1
Modified residuei3162PhosphoserineBy similarity1
Modified residuei3550PhosphoserineCombined sources1
Modified residuei3577PhosphoserineBy similarity1
Modified residuei3992PhosphothreonineCombined sources1
Modified residuei4002PhosphoserineBy similarity1
Modified residuei4003PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TPH6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TPH6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7TPH6

PRoteomics IDEntifications database

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PRIDEi
Q7TPH6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TPH6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TPH6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7TPH6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is mostly restricted to the nervous system, including expression in motor and sensory axons (PubMed:18031680). During postnatal development, expression is particularly strong in the cerebellum, hippocampus and retina (PubMed:14729956). Lower levels of expression are observed throughout the cerebral cortex (PubMed:14729956).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Dynamically expressed in embryonic nervous system from 8.5 dpc through 18.5 dpc (PubMed:14729956, PubMed:18031680). At 10.5 dpc, shortly after the birth of the first motor neurons, highly expressed in the developing motor columns, dorsal root ganglion and newly formed neurons within the dorsal neural tube (PubMed:18031680). As embryos develop to 11.5 dpc, expression levels increase in the dorsal root ganglion and expression in the spinal cord expandes as the number of postmitotic neurons increase (PubMed:18031680). By 12.5 dpc expression is widespread within the spinal cord (PubMed:18031680).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033004 Expressed in 306 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7TPH6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYC (By similarity).

Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin) (By similarity).

Interacts with FBXO45 (PubMed:19398581).

Interacts with RAE1 (By similarity).

Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145).

Interacts with (sumoylated) RANGAP1; interaction with sumoylated RANGAP1 inhibits E3 ubiquitin-protein ligase activity and promotes MYCBP2 translocation to the nucleus (PubMed:26304119).

Interacts with RAN (PubMed:26304119).

Interacts with ATP13A2; the interaction inhibits the ubiquitination of TSC2 by MYCBP2 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Slc12a5Q636334EBI-1811542,EBI-1811510From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
222897, 146 interactors

Protein interaction database and analysis system

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IntActi
Q7TPH6, 142 interactors

Molecular INTeraction database

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MINTi
Q7TPH6

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000124710

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14749
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7TPH6

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7TPH6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati600 – 655RCC1 1Sequence analysisAdd BLAST56
Repeati699 – 755RCC1 2Sequence analysisAdd BLAST57
Repeati907 – 957RCC1 3Sequence analysisAdd BLAST51
Repeati958 – 1009RCC1 4Sequence analysisAdd BLAST52
Repeati1011 – 1066RCC1 5Sequence analysisAdd BLAST56
Repeati2331 – 2438FilaminSequence analysisAdd BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3789 – 3967DOCPROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1235 – 1386PHR domain 1Add BLAST152
Regioni1723 – 1881PHR domain 2Add BLAST159
Regioni2018 – 2544RAE1 bindingBy similarityAdd BLAST527
Regioni4610 – 4747Tandem cysteine domainBy similarityAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi103 – 126Lys-richSequence analysisAdd BLAST24
Compositional biasi766 – 814Cys-richSequence analysisAdd BLAST49
Compositional biasi2792 – 2916Ser-richSequence analysisAdd BLAST125
Compositional biasi2885 – 2993Pro-richSequence analysisAdd BLAST109
Compositional biasi3266 – 3286Lys-richSequence analysisAdd BLAST21
Compositional biasi3334 – 3365Gly-richSequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners.1 Publication
The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RING-Cys relay (RCR) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4499 – 4550RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri4653 – 4703B box-typeAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1428 Eukaryota
ENOG410XP1T LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155756

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112908

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7TPH6

KEGG Orthology (KO)

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KOi
K10693

Database of Orthologous Groups

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OrthoDBi
215263at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7TPH6

TreeFam database of animal gene trees

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TreeFami
TF313151

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR017868 Filamin/ABP280_repeat-like
IPR008979 Galactose-bd-like_sf
IPR014756 Ig_E-set
IPR012983 PHR
IPR038648 PHR_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003646 SH3-like_bac-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF03256 ANAPC10, 1 hit
PF00630 Filamin, 1 hit
PF08005 PHR, 2 hits
PF00415 RCC1, 1 hit
PF08239 SH3_3, 1 hit
PF13639 zf-RING_2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51284 DOC, 1 hit
PS50194 FILAMIN_REPEAT, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 3 hits
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q7TPH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMMCAATASP AAASSGPGGD GFFAAATISS SPAPGALFMP VPDGSVAAAG
60 70 80 90 100
LGLGLPTTDS RGHYQLLLSG RALADRYRRI YTTALSDRDQ AGSSTGHPAS
110 120 130 140 150
RNKKILNKKK LKRKQKSKSK VKTRSKSENV ENTVIIPDIK LHSNPSAFNI
160 170 180 190 200
YCNVRHCVLE WQKKETSLAA ASKNSVQSGE SDSDEEEESR EPPIKLPKII
210 220 230 240 250
EVGLCEVFEL IKETRFSHPS LCLRSLQALL NVLQGQQPEG LQSEPPEVLE
260 270 280 290 300
SLFQLLLEIT VRSTGMNDST GQSLTALSCA CLFSLVASWG ETGRTLQAIS
310 320 330 340 350
AILTNNGSHA CQTIQVPTIL NSLQRSVQAV LVGKIQVQDW FSNGIKKAAL
360 370 380 390 400
MHKWPLKEVS VDEDDQCLLQ NDGFFLYLLC KDGLYKIGSG YSGTVRGHIY
410 420 430 440 450
NSTSRIRNRK EKKSWLGYAQ GYLLYRDLNN HSMTAIRISP ETLEQDGTVL
460 470 480 490 500
LPDCHTEGQN ILFTDGEYIN QIAASRDDGF VVRIFATSTE PVLQQELQLK
510 520 530 540 550
LARKCLHACG ISLFDLEKDL HIISTGFDEE SAILGAGREF ALMKTANGKI
560 570 580 590 600
YYTGKYQSLG IKQGGPSAGK WVELPITKSP KIVHFSVGHD GSHALLVAED
610 620 630 640 650
GSVFFTGSAS KGEDGESTKS RRQSKPYKPK KIIKMEGKIV VYTACNNGSS
660 670 680 690 700
SVISKDGELY MFGKDAIYSD SSSLVSDLKG HFVTQVAMGK AHTCVLMKNG
710 720 730 740 750
EVWTFGVNNK GQCGRDTGAM NQGGKGFGVE NMATAMDEDL EEELDEKDEK
760 770 780 790 800
SMMCPPGMHK WKLEQCMVCT VCGDCTGYGA SCVSSGRPDR VPGGICGCGS
810 820 830 840 850
GESGCAVCGC CKACARELDG QEARQRGILD AVKEMIPLDL LLAVPVPGVN
860 870 880 890 900
IEEHLQLRQE EKRQRVIRRH RLEDGRGPLV FAGPIFMNHR EQALARLRSH
910 920 930 940 950
PAQLKHKRDK HKDGSGDRGE KDASKITTYP PGSVRFDCEL RAVQVSCGFH
960 970 980 990 1000
HSVVLMENGD VYTFGYGQHG QLGHGDVNSR GCPTLVQALP GPSTQVTAGS
1010 1020 1030 1040 1050
NHTAVLLMDG QVFTFGSFSK GQLGRPILDI PYWNAKPAPM PNIGSKYGRK
1060 1070 1080 1090 1100
ATWIGASGDQ TFLRIDEALI NSHVLATSEI FASKHIIGLV PASISEPPPF
1110 1120 1130 1140 1150
KCLLINKVDG SCKTFNDSEQ EDLQGFGVCL DPVYDVLWRF RPSTRELWCY
1160 1170 1180 1190 1200
NAVVADARLP SATDMQSRCS ILSPELALPT GSRALTTRSH AALHILGCLD
1210 1220 1230 1240 1250
TLAAMQDLKM GIASTEEETQ AVMKVYSKED YSVVNRFESH GGGWGYSAHS
1260 1270 1280 1290 1300
VEAIRFSADT DILLGGLGLF GGRGEYTAKI KLFELGPDGG DHETDGDLLA
1310 1320 1330 1340 1350
ETDVLAYDCA AREKYAMMFD EPVLLQAGWW YVAWARVSGP SSDCGSHGQA
1360 1370 1380 1390 1400
SITTDDGVIF QFKSSKKSNN GTDVNAGQIP QLLYRLPTSD GSTSKGKQQT
1410 1420 1430 1440 1450
SEPVHILKRS FARTVSVECF ESLLSILHWS WTTLVLGVEE LRGLKGFQFT
1460 1470 1480 1490 1500
ATLLDLERLR FVGTCCLRLL RVYTCEIYPV SATGKAVVEE TSKLAECIGK
1510 1520 1530 1540 1550
TRTLLRKILS EGVDHCMVKL DNDPQGYLSQ PLRLLEAVLQ ECHNTFTACF
1560 1570 1580 1590 1600
HSFYPTPALQ WACLCDLLNC LDQEANFKTS SSRLLAAVMS ALCHTSVKLT
1610 1620 1630 1640 1650
SLFPIAYDGE VLLRSIVKQV STENDSTLVH RFPLLVGHME KLSQSEENIS
1660 1670 1680 1690 1700
GMTSFREVLE KMLVIVVLPV RNSLRRESEL FSSHLVSNTC GLLASIVSEL
1710 1720 1730 1740 1750
TASALGSEVD GLNSLHSVKA SANRFTKTSQ GRSWNTGNGS PDAICFAVDK
1760 1770 1780 1790 1800
PGIVVVGFAV YGGGGIHEYE LEVLVDDSEH AGDSTHSHRW TSLELVKGTY
1810 1820 1830 1840 1850
TTDDSPSDIA EIRLDKVVPL KENVKYAVRL RNYGSRTANG DGGMTTVQCP
1860 1870 1880 1890 1900
DGVTFTFSTC SLSSNGTNQT RGQIPQILYY RSEFDGDLQS QLLSKANEED
1910 1920 1930 1940 1950
KNCSRALSVV STVVRAAKDL LHRALAVDAD DIPELLSSSS LFSMLLPLII
1960 1970 1980 1990 2000
AYIGPVAAAI PKVAVEVFGL VQQLLPSVAI LNQKYAPPAF NPNQSTDSTT
2010 2020 2030 2040 2050
GNQPEQGLSA CTTSNHYAVI ESEHPYKPAC VMHYKVTFPE CVRWMTIEFD
2060 2070 2080 2090 2100
PQCGTAQSED VIRLLIPVRT IQNSGYGAKL TSVHENLNSW VELKKYSGSS
2110 2120 2130 2140 2150
GWPTMVLVLP GNEALFSLET ASDYVKDDKA SFYGFKCFAI GYEFSPGPDE
2160 2170 2180 2190 2200
GVIQLEKELA NLGGVCAAAL MKKDLALPVG NELEEDLEIL EEAALQVCKT
2210 2220 2230 2240 2250
HSGILGKGLA LSHSPTILEA LEGNLPLQIQ SNEQSFLDDF IACVPGSSGG
2260 2270 2280 2290 2300
RLARWLQPDS YADPQKTSLI LNKDDIRCGW PTTITVQTKD QYGDVVHVPN
2310 2320 2330 2340 2350
MKVEVKAVPV SQKKTSLQQD QGKKCQRIPG SPSAAASSAD MTFGGLASPK
2360 2370 2380 2390 2400
LDVSYEPMIV KEARYIAITM MKVYENYSFE ELRFASPTPK RPSENMLIRV
2410 2420 2430 2440 2450
NNDGTYCANW TPGAIGLYTV HVTIDGIEID AGLEVKVKDP PKGMIPPGTQ
2460 2470 2480 2490 2500
LVKPKADPQP NKIRKFVAKD SAGLRIRSHP SLQSEQIGIV RVNGTITFID
2510 2520 2530 2540 2550
EIHNDDGVWL RLNEETIKKY VPNMNGYTEA WCLSFNQHLG KSLLVPVDNI
2560 2570 2580 2590 2600
FNASQGVRDL DVFSWTSKAF FPQEPKTNTD DFFKDMNSCG PQEATMQERD
2610 2620 2630 2640 2650
HPFLRGGPGM YKVVKTGPSG HNIRSCPNLR GIPIGMLVLG NKVKAVGEVT
2660 2670 2680 2690 2700
NSEGAWVQLD KNSMVEFCES DEGEAWSLAR DRGGNQYLRH EDEQVLLDQN
2710 2720 2730 2740 2750
SQPPPPSPFS VQAFNKGASC SAQGFDYGLG NNKGDQLSAI LNSIQSRPNL
2760 2770 2780 2790 2800
PAPSIFDQAA KPPSSLVHSP FVFGQPLSFQ QRQLQSDRGT ISTSSRPVST
2810 2820 2830 2840 2850
SGKSELPSKH SRSVKPDGHV SRTPADQKKP RGTEGLSASE SLMLKSDAAK
2860 2870 2880 2890 2900
LRSDSHSRSL SPNHNTLQTL KSDGRTSSGF RAESPGPGSR SSSPKPKPLP
2910 2920 2930 2940 2950
TPRSSPSGAS SPRSSSPQDK NLPQKSTAPA KTKLDPPRER SKSDSYTLDP
2960 2970 2980 2990 3000
DTLRKKKMPL TEPLRGRSTS PKPKPVPKDP KDSPGSENRA PSPHVVQENL
3010 3020 3030 3040 3050
HSEVVEVCTS STLKTNGVTD STCDDSGDLK SVDEGSNKVH FSIGKAPLKD
3060 3070 3080 3090 3100
EQEMRASPKI SRKCANRHTR PKKEKSNFLF KGDGTKSLEP AKQAMSPSVA
3110 3120 3130 3140 3150
ECARAVFASF LWHEGIVHDA MACSSFLKFN PDLSKEHAPI RSSLNSQPPT
3160 3170 3180 3190 3200
EEKEIKLKNR HSLEISSALN MFNIAPHGPD ISKMGSINKN KVLSMLKEPP
3210 3220 3230 3240 3250
LHEKCEDGKS EATFEMSMHH TMKSKSPLPL TLQHLVAFWE DISLATIKAA
3260 3270 3280 3290 3300
SQNMIFPSPG SCAVLKKKEC EKENKKTKKE KKKKEKTEIR PRGNLFGEMA
3310 3320 3330 3340 3350
QLAVGGPEKD TICELCGESH PYPVTYHMRQ AHPGCGRYAG GQGYNSIGHF
3360 3370 3380 3390 3400
CGGWAGNCGD GGMGGSTWYL VCDRCREKYL REKQAAAREK VKQSRRKPMQ
3410 3420 3430 3440 3450
VKTPRALPTM EAHQVIKANA LFLLSLSSAA EPSILCYHPA KPFQSQLPIV
3460 3470 3480 3490 3500
KEGVSEDLPV KMPCLYLQTL ARHHHENFVG YQDDNLFQDE MRYLRSTSVP
3510 3520 3530 3540 3550
APYISVTPDA SPNVFEEPES NMKSMPPSLE TSPITDTDLA KRTVFQRSYS
3560 3570 3580 3590 3600
VVASEYDKQH SILPARVKAI PRRRVNSGDT VGSSLLRHPS PELSRLISAH
3610 3620 3630 3640 3650
SSLSKGERNF QWPVLAFVIQ HHDLEGLEIA MKQALRKSAC RVFAMEAFNW
3660 3670 3680 3690 3700
LLCNVIQTTS LHDILWHFVA ALTPSPVEAE EDEDEDNKSN KENAEQEKDT
3710 3720 3730 3740 3750
RVCEHPLSDI VIAGEAAHPL PHTFHRLLQT ISDLMMSLPS GSSLQQMALR
3760 3770 3780 3790 3800
CWSLKFKQSD HQFLHQSNVF HHINNILSKS DDGDSEESFS ISVQSGFEAM
3810 3820 3830 3840 3850
SQELCIVMCL KDLTSIVDIK TSSRPAMIGS LTDGSTETFW ESGDEDKNKT
3860 3870 3880 3890 3900
KNITINCVKG INARYVSVHV DNSRDLGNKV TSMTFLTGKA VEELCRIKQV
3910 3920 3930 3940 3950
DLDSRHIGWV TSELPGGDNQ IIKIELKGPE NTLRVRQVKV LGWKDGESTK
3960 3970 3980 3990 4000
IAGQISASVA QQRSCEAETL RVFRLITSQV FGKLISGDAE PTPEQEEKAL
4010 4020 4030 4040 4050
LSSPEGEEKV YNATSDADLK EHMVGIIFSR SKLTNLQKQV CAHIVQAIRM
4060 4070 4080 4090 4100
EATRVREEWE HAISSKENAN SQPSDEDASS DAYCFELLSM VLALSGSNVG
4110 4120 4130 4140 4150
RQYLAQQLTL LQDLFSLLHT ASPRVQRQVT SLLRRVLPEV TPNRLASIIG
4160 4170 4180 4190 4200
VKSLPPADIS DIIHSTEKGD WNKLGILDMF LGCIAKALTV QLKAKGTTIT
4210 4220 4230 4240 4250
GTAGTTVGKG VTTVTLPMIF NSSYLRRGES HWWMKGSTPT QISEIIIRLI
4260 4270 4280 4290 4300
KDMAAGHLSE AWSRVTKNAI AETIIALTKM EEEFRSPVRC IATTRLWLAL
4310 4320 4330 4340 4350
ASLCVLDQDH VDRLSSGRWM GKDGQQKQMP MCDNHDDGET AAIILCNICG
4360 4370 4380 4390 4400
NLCTDCDRFL HLHRRTKTHQ RQVFKEEEEA IKVDLHEGCG RTKLFWLMAL
4410 4420 4430 4440 4450
ADSKTMKAMV EFREHTGKPT TSSSEACRFC GSRSGTELSA VGSVCSDADC
4460 4470 4480 4490 4500
QEYAKIACSK THPCGHPCGG VRNEEHCLPC LHGCDKSATT LKQDADDMCM
4510 4520 4530 4540 4550
ICFTEALSAA PAIQLDCSHV FHLQCCRRVL ENRWLGPRIT FGFISCPICK
4560 4570 4580 4590 4600
NKINHIVLKD LLDPIKELYE DVRRKALMRL EYEGLHKSEA ITTPGVRFYN
4610 4620 4630 4640 4650
DAAGYAMNRY AYYVCYKCRK AYFGGEARCD AEAGQGDDYD PRELICGACS
4660 4670 4680 4690 4700
DVSRAQMCPK HGTDFLEYKC RYCCSVAVFF CFGTTHFCNA CHDDFQRMTS
4710 4720 4730 4740
IPKEELPHCP AGPKGKQLEG TECPLHVVHP PTGEEFALGC GVCRNAHTF
Length:4,749
Mass (Da):521,232
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD225D8DCA55961E7
GO
Isoform 2Curated (identifier: Q7TPH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4010-4012: Missing.

Show »
Length:4,746
Mass (Da):520,855
Checksum:i697FFD8B37DEB01E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SMY7F6SMY7_MOUSE
E3 ubiquitin-protein ligase MYCBP2
Mycbp2
4,636Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CZG3F7CZG3_MOUSE
E3 ubiquitin-protein ligase MYCBP2
Mycbp2
871Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T4V9F6T4V9_MOUSE
E3 ubiquitin-protein ligase MYCBP2
Mycbp2
1,463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti860E → K in AAP88591 (PubMed:14729956).1
Sequence conflicti999G → C in AAP88591 (PubMed:14729956).1
Sequence conflicti1831R → S in AAP88591 (PubMed:14729956).1
Sequence conflicti1987P → S in AAP88591 (PubMed:14729956).1
Sequence conflicti3685E → G in AAP88591 (PubMed:14729956).1
Sequence conflicti4636G → E in AAP88591 (PubMed:14729956).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0141844010 – 4012Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC114410 Genomic DNA No translation available.
AC114585 Genomic DNA No translation available.
CT025554 Genomic DNA No translation available.
AY325887 mRNA Translation: AAP88591.1
BC059257 mRNA Translation: AAH59257.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49559.1 [Q7TPH6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_997098.2, NM_207215.2 [Q7TPH6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000159855; ENSMUSP00000124710; ENSMUSG00000033004 [Q7TPH6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:105689

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114410 Genomic DNA No translation available.
AC114585 Genomic DNA No translation available.
CT025554 Genomic DNA No translation available.
AY325887 mRNA Translation: AAP88591.1
BC059257 mRNA Translation: AAH59257.1
CCDSiCCDS49559.1 [Q7TPH6-2]
RefSeqiNP_997098.2, NM_207215.2 [Q7TPH6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GBWX-ray1.32A1229-1390[»]
3HWJX-ray2.25A/B1723-1883[»]
SMRiQ7TPH6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi222897, 146 interactors
IntActiQ7TPH6, 142 interactors
MINTiQ7TPH6
STRINGi10090.ENSMUSP00000124710

PTM databases

iPTMnetiQ7TPH6
PhosphoSitePlusiQ7TPH6
SwissPalmiQ7TPH6

Proteomic databases

EPDiQ7TPH6
jPOSTiQ7TPH6
PaxDbiQ7TPH6
PRIDEiQ7TPH6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
105689

Genome annotation databases

EnsembliENSMUST00000159855; ENSMUSP00000124710; ENSMUSG00000033004 [Q7TPH6-2]
GeneIDi105689
KEGGimmu:105689

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23077
MGIiMGI:2179432 Mycbp2

Phylogenomic databases

eggNOGiKOG1428 Eukaryota
ENOG410XP1T LUCA
GeneTreeiENSGT00940000155756
HOGENOMiHOG000112908
InParanoidiQ7TPH6
KOiK10693
OrthoDBi215263at2759
PhylomeDBiQ7TPH6
TreeFamiTF313151

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mycbp2 mouse
EvolutionaryTraceiQ7TPH6

Protein Ontology

More...
PROi
PR:Q7TPH6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033004 Expressed in 306 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ7TPH6 baseline and differential

Family and domain databases

Gene3Di2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR017868 Filamin/ABP280_repeat-like
IPR008979 Galactose-bd-like_sf
IPR014756 Ig_E-set
IPR012983 PHR
IPR038648 PHR_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003646 SH3-like_bac-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF00630 Filamin, 1 hit
PF08005 PHR, 2 hits
PF00415 RCC1, 1 hit
PF08239 SH3_3, 1 hit
PF13639 zf-RING_2, 1 hit
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS50194 FILAMIN_REPEAT, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 3 hits
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYCB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TPH6
Secondary accession number(s): E9PUJ6, Q6PCM8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 20, 2018
Last modified: October 16, 2019
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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