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Protein

F-box only protein 11

Gene

Fbxo11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri836 – 907UBR-typePROSITE-ProRule annotationAdd BLAST72

GO - Molecular functioni

  • protein-arginine N-methyltransferase activity Source: MGI
  • ubiquitin-protein transferase activity Source: CACAO
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 11
Gene namesi
Name:Fbxo11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2147134 Fbxo11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi331S → L in Mutt mutant; 13% of heterozygotes show a reduced startle response to a toneburst of 24 kHz and a mild craniofacial abnormality. 17% of homozygotes show perinatal lethality. Surviving homozygotes demonstrate a marked craniofacial abnormality and reduced hearing. 1 Publication1
Mutagenesisi578Q → L in Jeff mutant; heterozygotes are deaf with chronic proliferative otitis media, have a shortened snout and occipital region, and are smaller than wild-type littermates. Homozygotes demonstrate perinatal lethality due to respiratory problems, are born with upper eyelids open and show clefting of the hard or soft palate as well as facial clefting. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198911 – 930F-box only protein 11Add BLAST930

Proteomic databases

PaxDbiQ7TPD1
PeptideAtlasiQ7TPD1
PRIDEiQ7TPD1

PTM databases

iPTMnetiQ7TPD1
PhosphoSitePlusiQ7TPD1

Expressioni

Tissue specificityi

At E9.5 and E10.5, expression is restricted to developing heart tissue. By E11.5 and E12.5, detected in liver and subsequently in muscle by E13.5. At E14.5, still detected in heart, liver and muscle and also in the developing secondary palate including the nasal, medial and oral epithelia of the palatal shelves. At E15.5 and E16.5, expressed in lung, kidney, heart, liver, muscle and adrenal gland. At this time, fusion of the palate shelves has occurred, with expression confined to the nasal and oral epithelia. At E17.5, expression in the lung is confined to bronchial epithelial cells and is evident in bone marrow, skin, tissue macrophages, osteoblasts, kidney, liver and spleen. At E18.5, expressed in bone marrow, liver, kidney and muscle but decreases in heart and lung. At this time, first detected in the middle ear epithelium. At the newborn stage, expression is strong in the middle ear where it is confined to mucin-secreting cells, as well as persisting in bone marrow, kidney and liver. Middle ear expression persists in postnatal head tissue at 4 and 13 days after birth and has declined by 21 days after birth. In the adult, expression is seen in alveolar macrophages of the lung, glomeruli and collecting tubules of the kidney, midbrain, heart and muscle.1 Publication

Developmental stagei

Not detected at E8.5. Expressed from E9.5 throughout development and into adulthood (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000005371 Expressed in 286 organ(s), highest expression level in pineal body
CleanExiMM_FBXO11
ExpressionAtlasiQ7TPD1 baseline and differential
GenevisibleiQ7TPD1 MM

Interactioni

Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Bcl6P411832EBI-15955324,EBI-6253762

Protein-protein interaction databases

BioGridi230356, 2 interactors
DIPiDIP-59433N
IntActiQ7TPD1, 1 interactor
STRINGi10090.ENSMUSP00000005504

Structurei

3D structure databases

ProteinModelPortaliQ7TPD1
SMRiQ7TPD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 202F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati398 – 420PbH1 1Add BLAST23
Repeati421 – 443PbH1 2Add BLAST23
Repeati444 – 466PbH1 3Add BLAST23
Repeati467 – 489PbH1 4Add BLAST23
Repeati490 – 512PbH1 5Add BLAST23
Repeati513 – 535PbH1 6Add BLAST23
Repeati536 – 558PbH1 7Add BLAST23
Repeati559 – 581PbH1 8Add BLAST23
Repeati582 – 604PbH1 9Add BLAST23
Repeati605 – 627PbH1 10Add BLAST23
Repeati628 – 650PbH1 11Add BLAST23
Repeati651 – 673PbH1 12Add BLAST23
Repeati674 – 696PbH1 13Add BLAST23
Repeati697 – 719PbH1 14Add BLAST23
Repeati720 – 742PbH1 15Add BLAST23
Repeati743 – 765PbH1 16Add BLAST23
Repeati766 – 788PbH1 17Add BLAST23
Repeati789 – 811PbH1 18Add BLAST23
Repeati812 – 833PbH1 19Add BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri836 – 907UBR-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1777 Eukaryota
ENOG410YP8C LUCA
GeneTreeiENSGT00530000063425
HOGENOMiHOG000020584
HOVERGENiHBG051565
InParanoidiQ7TPD1
KOiK10297
OrthoDBiEOG091G01YS
TreeFamiTF313602

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR029799 FBX11/DRE-1
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR003126 Znf_UBR
PANTHERiPTHR22990:SF20 PTHR22990:SF20, 1 hit
PfamiView protein in Pfam
PF13229 Beta_helix, 2 hits
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 19 hits
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF51126 SSF51126, 3 hits
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR03804 para_beta_helix, 4 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS51157 ZF_UBR, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TPD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PPQPPQQPPQ
60 70 80 90 100
QQPPPPPQQQ PPPPPPPPPP PPQDRNNAGE RDDVPADMVA EESGPGAQNS
110 120 130 140 150
PYQLRRKTLL PKRTACPTKS SMEGASTSTT ENFGHRAKRA RVSGKSQDLS
160 170 180 190 200
AAPAEQYLQE KLPDEVVLKI FSYLLEQDLC RAACVCKRFS ELANDPILWK
210 220 230 240 250
RLYMEVFEYT RPMMHPEPGK FYQINPEEYE HPNPWKESFQ QLYKGAHVKP
260 270 280 290 300
GFAEHFYSNP ARYKGRENML YYDTIEDALG GVQEAHFDGL IFVHSGIYTD
310 320 330 340 350
EWIYIESPIT MIGAAPGKVA DKVIIENTRD STFVFMEGSE DAYVGYMTIR
360 370 380 390 400
FNPDDKSAQH HNAHHCLEIT VNCSPIIDHC IIRSTCTVGS AVCVSGQGAC
410 420 430 440 450
PTIKHCNISD CENVGLYITD HAQGIYEDNE ISNNALAGIW VKNHGNPIIR
460 470 480 490 500
RNHIHHGRDV GVFTFDHGMG YFESCNIHRN RIAGFEVKAY ANPTVVRCEI
510 520 530 540 550
HHGQTGGIYV HEKGRGQFIE NKIYANNFAG VWITSNSDPT IRGNSIFNGN
560 570 580 590 600
QGGVYIFGDG RGLIEGNDIY GNALAGIQIR TNSCPIVRHN KIHDGQHGGI
610 620 630 640 650
YVHEKGQGVI EENEVYSNTL AGVWVTTGST PVLRRNRIHS GKQVGVYFYD
660 670 680 690 700
NGHGVLEDND IYNHMYSGVQ IRTGSNPKIR RNKIWGGQNG GILVYNSGLG
710 720 730 740 750
CIEDNEIFDN AMAGVWIKTD SNPTLRRNKI HDGRDGGICI FNGGRGLLEE
760 770 780 790 800
NDIFRNAQAG VLISTNSHPV LRKNRIFDGF AAGIEITNHA TATLEGNQIF
810 820 830 840 850
NNRFGGLFLA SGVNVTMKDN KIMNNQDAIE KAVSRGQCLY KISSYTSYPM
860 870 880 890 900
HDFYRCHTCN TTDRNAICVN CIKKCHQGHD VEFIRHDRFF CDCGAGTLSN
910 920 930
PCTLAGEPTH DTDTLYDSAP PIESNTLQHN
Length:930
Mass (Da):103,728
Last modified:October 16, 2013 - v3
Checksum:i0F644A34F1936393
GO
Isoform 2 (identifier: Q7TPD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Show »
Length:843
Mass (Da):94,015
Checksum:iB177B62DFEA5F524
GO
Isoform 3 (identifier: Q7TPD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     152-152: Missing.

Show »
Length:842
Mass (Da):93,944
Checksum:i7E3BB57A9C0BE237
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6T356F6T356_MOUSE
F-box only protein 11
Fbxo11
855Annotation score:
S4R2I0S4R2I0_MOUSE
F-box only protein 11
Fbxo11
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251G → R in AAI17886 (PubMed:15489334).Curated1
Sequence conflicti694V → F in AAH49946 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0533531 – 87Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_053354152Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087233 Genomic DNA No translation available.
AC154673 Genomic DNA No translation available.
BC049946 mRNA Translation: AAH49946.1
BC055343 mRNA Translation: AAH55343.1
BC117884 mRNA Translation: AAI17885.1
BC117885 mRNA Translation: AAI17886.1
BC128479 mRNA Translation: AAI28480.1
CCDSiCCDS37717.1 [Q7TPD1-1]
RefSeqiNP_001074503.1, NM_001081034.2 [Q7TPD1-1]
NP_001335177.1, NM_001348248.1 [Q7TPD1-2]
XP_006524267.1, XM_006524204.3 [Q7TPD1-2]
UniGeneiMm.386857

Genome annotation databases

EnsembliENSMUST00000005504; ENSMUSP00000005504; ENSMUSG00000005371 [Q7TPD1-1]
GeneIDi225055
KEGGimmu:225055
UCSCiuc008dvf.1 mouse [Q7TPD1-1]
uc008dvg.1 mouse [Q7TPD1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087233 Genomic DNA No translation available.
AC154673 Genomic DNA No translation available.
BC049946 mRNA Translation: AAH49946.1
BC055343 mRNA Translation: AAH55343.1
BC117884 mRNA Translation: AAI17885.1
BC117885 mRNA Translation: AAI17886.1
BC128479 mRNA Translation: AAI28480.1
CCDSiCCDS37717.1 [Q7TPD1-1]
RefSeqiNP_001074503.1, NM_001081034.2 [Q7TPD1-1]
NP_001335177.1, NM_001348248.1 [Q7TPD1-2]
XP_006524267.1, XM_006524204.3 [Q7TPD1-2]
UniGeneiMm.386857

3D structure databases

ProteinModelPortaliQ7TPD1
SMRiQ7TPD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230356, 2 interactors
DIPiDIP-59433N
IntActiQ7TPD1, 1 interactor
STRINGi10090.ENSMUSP00000005504

PTM databases

iPTMnetiQ7TPD1
PhosphoSitePlusiQ7TPD1

Proteomic databases

PaxDbiQ7TPD1
PeptideAtlasiQ7TPD1
PRIDEiQ7TPD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005504; ENSMUSP00000005504; ENSMUSG00000005371 [Q7TPD1-1]
GeneIDi225055
KEGGimmu:225055
UCSCiuc008dvf.1 mouse [Q7TPD1-1]
uc008dvg.1 mouse [Q7TPD1-3]

Organism-specific databases

CTDi80204
MGIiMGI:2147134 Fbxo11

Phylogenomic databases

eggNOGiKOG1777 Eukaryota
ENOG410YP8C LUCA
GeneTreeiENSGT00530000063425
HOGENOMiHOG000020584
HOVERGENiHBG051565
InParanoidiQ7TPD1
KOiK10297
OrthoDBiEOG091G01YS
TreeFamiTF313602

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFbxo11 mouse
PROiPR:Q7TPD1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005371 Expressed in 286 organ(s), highest expression level in pineal body
CleanExiMM_FBXO11
ExpressionAtlasiQ7TPD1 baseline and differential
GenevisibleiQ7TPD1 MM

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR039448 Beta_helix
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR029799 FBX11/DRE-1
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR003126 Znf_UBR
PANTHERiPTHR22990:SF20 PTHR22990:SF20, 1 hit
PfamiView protein in Pfam
PF13229 Beta_helix, 2 hits
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 19 hits
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF51126 SSF51126, 3 hits
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR03804 para_beta_helix, 4 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS51157 ZF_UBR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX11_MOUSE
AccessioniPrimary (citable) accession number: Q7TPD1
Secondary accession number(s): A1A595
, E9QP06, Q08EB9, Q08EC0, Q80UP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 16, 2013
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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