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Entry version 147 (12 Aug 2020)
Sequence version 3 (16 Oct 2013)
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Protein

F-box only protein 11

Gene

Fbxo11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri836 – 907UBR-typePROSITE-ProRule annotationAdd BLAST72

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8951664, Neddylation
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fbxo11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147134, Fbxo11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi331S → L in Mutt mutant; 13% of heterozygotes show a reduced startle response to a toneburst of 24 kHz and a mild craniofacial abnormality. 17% of homozygotes show perinatal lethality. Surviving homozygotes demonstrate a marked craniofacial abnormality and reduced hearing. 1 Publication1
Mutagenesisi578Q → L in Jeff mutant; heterozygotes are deaf with chronic proliferative otitis media, have a shortened snout and occipital region, and are smaller than wild-type littermates. Homozygotes demonstrate perinatal lethality due to respiratory problems, are born with upper eyelids open and show clefting of the hard or soft palate as well as facial clefting. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198911 – 930F-box only protein 11Add BLAST930

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TPD1

PeptideAtlas

More...
PeptideAtlasi
Q7TPD1

PRoteomics IDEntifications database

More...
PRIDEi
Q7TPD1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TPD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TPD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

At 9.5 dpc and 10.5 dpc, expression is restricted to developing heart tissue. By 11.5 dpc and 12.5 dpc, detected in liver and subsequently in muscle by 13.5 dpc. At 14.5 dpc, still detected in heart, liver and muscle and also in the developing secondary palate including the nasal, medial and oral epithelia of the palatal shelves. At 15.5 dpc and 16.5 dpc, expressed in lung, kidney, heart, liver, muscle and adrenal gland. At this time, fusion of the palate shelves has occurred, with expression confined to the nasal and oral epithelia. At 17.5 dpc, expression in the lung is confined to bronchial epithelial cells and is evident in bone marrow, skin, tissue macrophages, osteoblasts, kidney, liver and spleen. At 18.5 dpc, expressed in bone marrow, liver, kidney and muscle but decreases in heart and lung. At this time, first detected in the middle ear epithelium. At the newborn stage, expression is strong in the middle ear where it is confined to mucin-secreting cells, as well as persisting in bone marrow, kidney and liver. Middle ear expression persists in postnatal head tissue at 4 and 13 days after birth and has declined by 21 days after birth. In the adult, expression is seen in alveolar macrophages of the lung, glomeruli and collecting tubules of the kidney, midbrain, heart and muscle.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Not detected at 8.5 dpc. Expressed from 9.5 dpc throughout development and into adulthood (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005371, Expressed in secondary oocyte and 300 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7TPD1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TPD1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11.

Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated).

Interacts with PRMD1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
230356, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-59433N

Protein interaction database and analysis system

More...
IntActi
Q7TPD1, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000005504

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TPD1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 202F-boxPROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati398 – 420PbH1 1Add BLAST23
Repeati421 – 443PbH1 2Add BLAST23
Repeati444 – 466PbH1 3Add BLAST23
Repeati467 – 489PbH1 4Add BLAST23
Repeati490 – 512PbH1 5Add BLAST23
Repeati513 – 535PbH1 6Add BLAST23
Repeati536 – 558PbH1 7Add BLAST23
Repeati559 – 581PbH1 8Add BLAST23
Repeati582 – 604PbH1 9Add BLAST23
Repeati605 – 627PbH1 10Add BLAST23
Repeati628 – 650PbH1 11Add BLAST23
Repeati651 – 673PbH1 12Add BLAST23
Repeati674 – 696PbH1 13Add BLAST23
Repeati697 – 719PbH1 14Add BLAST23
Repeati720 – 742PbH1 15Add BLAST23
Repeati743 – 765PbH1 16Add BLAST23
Repeati766 – 788PbH1 17Add BLAST23
Repeati789 – 811PbH1 18Add BLAST23
Repeati812 – 833PbH1 19Add BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri836 – 907UBR-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1777, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063425

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TPD1

KEGG Orthology (KO)

More...
KOi
K10297

Database of Orthologous Groups

More...
OrthoDBi
355502at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313602

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448, Beta_helix
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR029799, FBX11/DRE-1
IPR007742, NosD_dom
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
IPR003126, Znf_UBR

The PANTHER Classification System

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PANTHERi
PTHR22990:SF20, PTHR22990:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13229, Beta_helix, 2 hits
PF12937, F-box-like, 1 hit
PF05048, NosD, 1 hit
PF02207, zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00722, CASH, 3 hits
SM00256, FBOX, 1 hit
SM00710, PbH1, 19 hits
SM00396, ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51126, SSF51126, 3 hits
SSF81383, SSF81383, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03804, para_beta_helix, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181, FBOX, 1 hit
PS51157, ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TPD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PPQPPQQPPQ
60 70 80 90 100
QQPPPPPQQQ PPPPPPPPPP PPQDRNNAGE RDDVPADMVA EESGPGAQNS
110 120 130 140 150
PYQLRRKTLL PKRTACPTKS SMEGASTSTT ENFGHRAKRA RVSGKSQDLS
160 170 180 190 200
AAPAEQYLQE KLPDEVVLKI FSYLLEQDLC RAACVCKRFS ELANDPILWK
210 220 230 240 250
RLYMEVFEYT RPMMHPEPGK FYQINPEEYE HPNPWKESFQ QLYKGAHVKP
260 270 280 290 300
GFAEHFYSNP ARYKGRENML YYDTIEDALG GVQEAHFDGL IFVHSGIYTD
310 320 330 340 350
EWIYIESPIT MIGAAPGKVA DKVIIENTRD STFVFMEGSE DAYVGYMTIR
360 370 380 390 400
FNPDDKSAQH HNAHHCLEIT VNCSPIIDHC IIRSTCTVGS AVCVSGQGAC
410 420 430 440 450
PTIKHCNISD CENVGLYITD HAQGIYEDNE ISNNALAGIW VKNHGNPIIR
460 470 480 490 500
RNHIHHGRDV GVFTFDHGMG YFESCNIHRN RIAGFEVKAY ANPTVVRCEI
510 520 530 540 550
HHGQTGGIYV HEKGRGQFIE NKIYANNFAG VWITSNSDPT IRGNSIFNGN
560 570 580 590 600
QGGVYIFGDG RGLIEGNDIY GNALAGIQIR TNSCPIVRHN KIHDGQHGGI
610 620 630 640 650
YVHEKGQGVI EENEVYSNTL AGVWVTTGST PVLRRNRIHS GKQVGVYFYD
660 670 680 690 700
NGHGVLEDND IYNHMYSGVQ IRTGSNPKIR RNKIWGGQNG GILVYNSGLG
710 720 730 740 750
CIEDNEIFDN AMAGVWIKTD SNPTLRRNKI HDGRDGGICI FNGGRGLLEE
760 770 780 790 800
NDIFRNAQAG VLISTNSHPV LRKNRIFDGF AAGIEITNHA TATLEGNQIF
810 820 830 840 850
NNRFGGLFLA SGVNVTMKDN KIMNNQDAIE KAVSRGQCLY KISSYTSYPM
860 870 880 890 900
HDFYRCHTCN TTDRNAICVN CIKKCHQGHD VEFIRHDRFF CDCGAGTLSN
910 920 930
PCTLAGEPTH DTDTLYDSAP PIESNTLQHN
Length:930
Mass (Da):103,728
Last modified:October 16, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F644A34F1936393
GO
Isoform 2 (identifier: Q7TPD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Show »
Length:843
Mass (Da):94,015
Checksum:iB177B62DFEA5F524
GO
Isoform 3 (identifier: Q7TPD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     152-152: Missing.

Show »
Length:842
Mass (Da):93,944
Checksum:i7E3BB57A9C0BE237
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2I0S4R2I0_MOUSE
F-box only protein 11
Fbxo11
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EBZ2A0A3Q4EBZ2_MOUSE
F-box only protein 11
Fbxo11
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251G → R in AAI17886 (PubMed:15489334).Curated1
Sequence conflicti694V → F in AAH49946 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0533531 – 87Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_053354152Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC087233 Genomic DNA No translation available.
AC154673 Genomic DNA No translation available.
BC049946 mRNA Translation: AAH49946.1
BC055343 mRNA Translation: AAH55343.1
BC117884 mRNA Translation: AAI17885.1
BC117885 mRNA Translation: AAI17886.1
BC128479 mRNA Translation: AAI28480.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37717.1 [Q7TPD1-1]

NCBI Reference Sequences

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RefSeqi
NP_001074503.1, NM_001081034.2 [Q7TPD1-1]
NP_001335177.1, NM_001348248.1 [Q7TPD1-2]
XP_006524267.1, XM_006524204.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000005504; ENSMUSP00000005504; ENSMUSG00000005371 [Q7TPD1-1]
ENSMUST00000130379; ENSMUSP00000121206; ENSMUSG00000005371 [Q7TPD1-3]
ENSMUST00000235112; ENSMUSP00000157024; ENSMUSG00000005371 [Q7TPD1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
225055

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:225055

UCSC genome browser

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UCSCi
uc008dvf.1, mouse [Q7TPD1-1]
uc008dvg.1, mouse [Q7TPD1-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087233 Genomic DNA No translation available.
AC154673 Genomic DNA No translation available.
BC049946 mRNA Translation: AAH49946.1
BC055343 mRNA Translation: AAH55343.1
BC117884 mRNA Translation: AAI17885.1
BC117885 mRNA Translation: AAI17886.1
BC128479 mRNA Translation: AAI28480.1
CCDSiCCDS37717.1 [Q7TPD1-1]
RefSeqiNP_001074503.1, NM_001081034.2 [Q7TPD1-1]
NP_001335177.1, NM_001348248.1 [Q7TPD1-2]
XP_006524267.1, XM_006524204.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi230356, 6 interactors
DIPiDIP-59433N
IntActiQ7TPD1, 1 interactor
STRINGi10090.ENSMUSP00000005504

PTM databases

iPTMnetiQ7TPD1
PhosphoSitePlusiQ7TPD1

Proteomic databases

PaxDbiQ7TPD1
PeptideAtlasiQ7TPD1
PRIDEiQ7TPD1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
15211, 341 antibodies

Genome annotation databases

EnsembliENSMUST00000005504; ENSMUSP00000005504; ENSMUSG00000005371 [Q7TPD1-1]
ENSMUST00000130379; ENSMUSP00000121206; ENSMUSG00000005371 [Q7TPD1-3]
ENSMUST00000235112; ENSMUSP00000157024; ENSMUSG00000005371 [Q7TPD1-3]
GeneIDi225055
KEGGimmu:225055
UCSCiuc008dvf.1, mouse [Q7TPD1-1]
uc008dvg.1, mouse [Q7TPD1-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80204
MGIiMGI:2147134, Fbxo11

Phylogenomic databases

eggNOGiKOG1777, Eukaryota
GeneTreeiENSGT00530000063425
InParanoidiQ7TPD1
KOiK10297
OrthoDBi355502at2759
TreeFamiTF313602

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-8951664, Neddylation
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
225055, 1 hit in 22 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fbxo11, mouse

Protein Ontology

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PROi
PR:Q7TPD1
RNActiQ7TPD1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005371, Expressed in secondary oocyte and 300 other tissues
ExpressionAtlasiQ7TPD1, baseline and differential
GenevisibleiQ7TPD1, MM

Family and domain databases

Gene3Di2.160.20.10, 3 hits
InterProiView protein in InterPro
IPR039448, Beta_helix
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR029799, FBX11/DRE-1
IPR007742, NosD_dom
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
IPR003126, Znf_UBR
PANTHERiPTHR22990:SF20, PTHR22990:SF20, 1 hit
PfamiView protein in Pfam
PF13229, Beta_helix, 2 hits
PF12937, F-box-like, 1 hit
PF05048, NosD, 1 hit
PF02207, zf-UBR, 1 hit
SMARTiView protein in SMART
SM00722, CASH, 3 hits
SM00256, FBOX, 1 hit
SM00710, PbH1, 19 hits
SM00396, ZnF_UBR1, 1 hit
SUPFAMiSSF51126, SSF51126, 3 hits
SSF81383, SSF81383, 1 hit
TIGRFAMsiTIGR03804, para_beta_helix, 4 hits
PROSITEiView protein in PROSITE
PS50181, FBOX, 1 hit
PS51157, ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX11_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TPD1
Secondary accession number(s): A1A595
, E9QP06, Q08EB9, Q08EC0, Q80UP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 16, 2013
Last modified: August 12, 2020
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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