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Protein

T-complex protein 1 subunit delta

Gene

Cct4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-390471 Association of TriC/CCT with target proteins during biosynthesis
R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:Cct4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi727937 Cct4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Cct4 are a cause of an early onset sensory neuropathy knowm as mutilated foot (mf). The main clinical features include ataxia, insensitivity to pain and foot ulceration. The pathological features include a severe reduction in the number of sensory ganglia and fibers.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283351 – 539T-complex protein 1 subunit deltaAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Omega-N-methylarginineBy similarity1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei184PhosphoserineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei288N6-acetyllysineBy similarity1
Modified residuei302N6-acetyllysineBy similarity1
Modified residuei319N6-acetyllysineBy similarity1
Modified residuei326N6-acetyllysineBy similarity1
Modified residuei444PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TPB1
PRIDEiQ7TPB1

PTM databases

iPTMnetiQ7TPB1
PhosphoSitePlusiQ7TPB1

Expressioni

Gene expression databases

BgeeiENSRNOG00000009642
GenevisibleiQ7TPB1 RN

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity). Interacts with DNAAF4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248027, 2 interactors
IntActiQ7TPB1, 4 interactors
MINTiQ7TPB1
STRINGi10116.ENSRNOP00000012847

Structurei

3D structure databases

ProteinModelPortaliQ7TPB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
HOVERGENiHBG106507
InParanoidiQ7TPB1
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG091G05G4
PhylomeDBiQ7TPB1
TreeFamiTF106332

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TPB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENVASRSG PPAAGPGNRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT
60 70 80 90 100
SLGPKGMDKM IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI
110 120 130 140 150
EAGDGTTSVV IIAGSLLDSC TKLLQKGIHP TIISESFQKA LEKGLEILTD
160 170 180 190 200
MSRPVQLSDR ETLLNSATTS LNSKVVSQYS SLLSPMSVNA VMKVIDPATA
210 220 230 240 250
TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVANSGITR VEKAKIGLIQ
260 270 280 290 300
FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI
310 320 330 340 350
QKSILRDALS DLALHFLNKM KIMVVKDIER EDIEFICKTI GTKPVAHIDQ
360 370 380 390 400
FTPDMLGSAE LAEEVSLNGS GKLFKITGCT SPGKTVTIVV RGSNKLVIEE
410 420 430 440 450
AERSIHDALC VIRCLVKKRA LIAGGGAPEI ELALRLTEYS RTLSGMESYC
460 470 480 490 500
VRAFADAMEV IPSTLAENAG LNPISTVTEL RNRHAQGEKT TGINVRKGGI
510 520 530
SNILEEMVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR
Length:539
Mass (Da):58,099
Last modified:January 23, 2007 - v3
Checksum:i0BD821D08733CDF8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti450C → Y in mf. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223861 mRNA Translation: AAP46161.1
BC079283 mRNA Translation: AAH79283.1
RefSeqiNP_877966.1, NM_182814.2
UniGeneiRn.97889

Genome annotation databases

EnsembliENSRNOT00000012847; ENSRNOP00000012847; ENSRNOG00000009642
GeneIDi29374
KEGGirno:29374
UCSCiRGD:727937 rat

Similar proteinsi

Entry informationi

Entry nameiTCPD_RAT
AccessioniPrimary (citable) accession number: Q7TPB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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