Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase RhebL1

Gene

Rhebl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38MagnesiumBy similarity1
Binding sitei63GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 21GTPBy similarity6
Nucleotide bindingi32 – 38GTPBy similarity7
Nucleotide bindingi119 – 122GTPBy similarity4
Nucleotide bindingi149 – 150GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase RhebL1
Alternative name(s):
Ras homolog enriched in brain-like protein 1
Short name:
Rheb-like protein 1
Gene namesi
Name:Rhebl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi727778 Rhebl1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003242961 – 180GTPase RhebL1Add BLAST180
PropeptideiPRO_0000324297181 – 183Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180Cysteine methyl esterBy similarity1
Lipidationi180S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ7TNZ5
PRIDEiQ7TNZ5

PTM databases

PhosphoSitePlusiQ7TNZ5

Expressioni

Gene expression databases

BgeeiENSRNOG00000054385
GenevisibleiQ7TNZ5 RN

Interactioni

Subunit structurei

Interacts with MTOR.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036452

Structurei

3D structure databases

ProteinModelPortaliQ7TNZ5
SMRiQ7TNZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00920000149101
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ7TNZ5
KOiK07849
OMAiGKTRMPV
OrthoDBiEOG091G0ONO
PhylomeDBiQ7TNZ5
TreeFamiTF314986

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVRYRKVA ILGYRSVGKT SLAHQFVEGE FLKGYDPTVE NTYSKTVTLG
60 70 80 90 100
KDEFHLHLVD TAGQDKYSIL PYSFIIGVHG YVLVYNVTSL RSFQIVKNLY
110 120 130 140 150
QKLQEGHGKT RLPVLLVGNK ADLSADREVQ AVEGKKLAES WGATFMESSA
160 170 180
RDNQLIQDIF IRVIQEIARV ENSYGQDRRC CLM
Length:183
Mass (Da):20,749
Last modified:October 1, 2003 - v1
Checksum:i9C051CABDBA8A6D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327411 mRNA Translation: AAP92803.1
RefSeqiNP_877977.1, NM_182825.1
UniGeneiRn.43211

Genome annotation databases

EnsembliENSRNOT00000089523; ENSRNOP00000074953; ENSRNOG00000054385
GeneIDi359959
KEGGirno:359959
UCSCiRGD:727778 rat

Similar proteinsi

Entry informationi

Entry nameiREBL1_RAT
AccessioniPrimary (citable) accession number: Q7TNZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health