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Protein

Beta-defensin 38

Gene

Defb38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Synthetic Defb38 kills both Gram-negative (E.coli and P.aeruginosa) and Gram-positive (E.faecium) bacteria.1 Publication

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 38
Short name:
BD-38
Short name:
mBD-38
Alternative name(s):
Defensin, beta 38
Gene namesi
Name:Defb38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2672972 Defb38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000695022 – 63Beta-defensin 38Add BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 58By similarity
Disulfide bondi36 ↔ 51By similarity
Disulfide bondi41 ↔ 59By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7TNV7
PRIDEiQ7TNV7

Expressioni

Tissue specificityi

Only expressed in epididymis (caput, corpus and cauda).1 Publication

Gene expression databases

BgeeiENSMUSG00000053790 Expressed in 5 organ(s), highest expression level in liver
CleanExiMM_DEFB38
ExpressionAtlasiQ7TNV7 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067553

Structurei

3D structure databases

ProteinModelPortaliQ7TNV7
SMRiQ7TNV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00900000141571
HOGENOMiHOG000112188
HOVERGENiHBG080892
InParanoidiQ7TNV7
OMAiYFECPWL
OrthoDBiEOG091G18L0
PhylomeDBiQ7TNV7

Family and domain databases

InterProiView protein in InterPro
IPR001855 Defensin_beta-typ
PfamiView protein in Pfam
PF00711 Defensin_beta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TNV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKISCFLLLI LSLYFFQINQ AIGPDTKKCV QRKNACHYFE CPWLYYSVGT
60
CYKGKGKCCQ KRY
Length:63
Mass (Da):7,443
Last modified:October 1, 2003 - v1
Checksum:i56C7FCF84834B282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ575424 mRNA Translation: CAE01397.1
AJ578471 mRNA Translation: CAE17668.1
CCDSiCCDS40248.1
RefSeqiNP_898857.1, NM_183036.1
UniGeneiMm.271558

Genome annotation databases

EnsembliENSMUST00000066416; ENSMUSP00000067553; ENSMUSG00000053790
GeneIDi360212
KEGGimmu:360212
UCSCiuc009laa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDFB38_MOUSE
AccessioniPrimary (citable) accession number: Q7TNV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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