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Protein

Protein FAM57B

Gene

Fam57b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis.1 Publication

GO - Molecular functioni

  • sphingosine N-acyltransferase activity Source: MGI

GO - Biological processi

  • ceramide biosynthetic process Source: MGI
  • negative regulation of fat cell differentiation Source: MGI

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism

Chemistry databases

SwissLipidsiSLP:000001109 [Q7TNV1-1]
SLP:000001110 [Q7TNV1-3]

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM57B
Gene namesi
Name:Fam57b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916202 Fam57b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855431 – 275Protein FAM57BAdd BLAST275

Proteomic databases

PaxDbiQ7TNV1
PRIDEiQ7TNV1

PTM databases

iPTMnetiQ7TNV1
PhosphoSitePlusiQ7TNV1

Expressioni

Tissue specificityi

Each isoform has a distinct expression pattern. Isoform 1 is highly expressed in brain. Isoform 2 is expressed at low levels, if any, in all analyzed tissues, with slightly higher levels in testis. Isoform 3 is expressed at very high levels in testis and, at lower levels, in white adipose tissue. In epididymal fat, isoform 3 is expressed at higher levels in obese mice compared with lean mice. By contrast, isoform 1 and 2 levels are significantly lower in obese mice compared with lean mice.1 Publication

Developmental stagei

Up-regulated during adipogenesis.1 Publication

Inductioni

Isoform 3 is strongly up-regulated by PPARG.

Gene expression databases

BgeeiENSMUSG00000058966 Expressed in 194 organ(s), highest expression level in retina
CleanExiMM_1500016O10RIK
ExpressionAtlasiQ7TNV1 baseline and differential
GenevisibleiQ7TNV1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078392

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261TLCPROSITE-ProRule annotationAdd BLAST228

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4561 Eukaryota
ENOG410XPW0 LUCA
GeneTreeiENSGT00510000046654
HOGENOMiHOG000237329
HOVERGENiHBG051539
InParanoidiQ7TNV1
OMAiASIPFHM
OrthoDBiEOG091G0X5A
PhylomeDBiQ7TNV1
TreeFamiTF350344

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
PfamiView protein in Pfam
PF03798 TRAM_LAG1_CLN8, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TNV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTPMVAGGV VFPGLFLLSK NTLQRLPQLR WEEADAVIVS ARLVSSVQAI
60 70 80 90 100
MASTAGYIVS TSCKHIIDDQ HWLSSAYTQF AVPYFIYDIY AMFLCHWHKH
110 120 130 140 150
QVKGHGGEDG TPRALGSTWA VVRGYLHKEF LMVLHHAAMV LVCFPLSVVW
160 170 180 190 200
RQGKGDFFLG CMLMAEVSTP FVCLGKILIQ YKQQHTLLHK VNGALMLLSF
210 220 230 240 250
LCCRVLLFPY LYWAYGRHAG LPLLSVPMAI PAHVNLGAAL LLAPQLYWFF
260 270
LICRGACRLF RPRGSPPPSP CQTQD
Note: No experimental confirmation available.
Length:275
Mass (Da):30,778
Last modified:November 28, 2006 - v2
Checksum:iF6BABA980959A8AC
GO
Isoform 2 (identifier: Q7TNV1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):25,372
Checksum:i6C81561DC0DEEC32
GO
Isoform 3 (identifier: Q7TNV1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: MLTPMVAGGV...EADAVIVSAR → MALLFLLGCV...RQEAVLVASK

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):31,009
Checksum:i831EAC5382CA5CDC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RP88A0A0U1RP88_MOUSE
Protein FAM57B
Fam57b
91Annotation score:

Sequence cautioni

The sequence BAB23923 differs from that shown. Reason: Frameshift at several positions.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216371 – 50Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_0216361 – 42MLTPM…IVSAR → MALLFLLGCVFFPLCFVVLR WGLQNRTSLRMERQEAVLVA SK in isoform 3. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005271 mRNA Translation: BAB23923.1 Frameshift.
AK131642 mRNA Translation: BAE20735.1
BC055444 mRNA Translation: AAH55444.1
BC093505 mRNA Translation: AAH93505.2
CCDSiCCDS52400.1 [Q7TNV1-3]
CCDS52401.1 [Q7TNV1-1]
CCDS85415.1 [Q7TNV1-2]
RefSeqiNP_001139819.1, NM_001146347.1 [Q7TNV1-2]
NP_081160.1, NM_026884.1 [Q7TNV1-3]
NP_084254.1, NM_029978.1 [Q7TNV1-1]
XP_006508227.1, XM_006508164.2 [Q7TNV1-3]
XP_006508229.1, XM_006508166.1 [Q7TNV1-2]
UniGeneiMm.440393

Genome annotation databases

EnsembliENSMUST00000079423; ENSMUSP00000078392; ENSMUSG00000058966 [Q7TNV1-1]
ENSMUST00000098032; ENSMUSP00000095640; ENSMUSG00000058966 [Q7TNV1-3]
ENSMUST00000205324; ENSMUSP00000145837; ENSMUSG00000058966 [Q7TNV1-3]
ENSMUST00000207020; ENSMUSP00000145721; ENSMUSG00000058966 [Q7TNV1-2]
GeneIDi68952
KEGGimmu:68952
UCSCiuc009jsy.2 mouse [Q7TNV1-1]
uc012ftv.1 mouse [Q7TNV1-3]

Keywords - Coding sequence diversityi

Alternative promoter usage

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005271 mRNA Translation: BAB23923.1 Frameshift.
AK131642 mRNA Translation: BAE20735.1
BC055444 mRNA Translation: AAH55444.1
BC093505 mRNA Translation: AAH93505.2
CCDSiCCDS52400.1 [Q7TNV1-3]
CCDS52401.1 [Q7TNV1-1]
CCDS85415.1 [Q7TNV1-2]
RefSeqiNP_001139819.1, NM_001146347.1 [Q7TNV1-2]
NP_081160.1, NM_026884.1 [Q7TNV1-3]
NP_084254.1, NM_029978.1 [Q7TNV1-1]
XP_006508227.1, XM_006508164.2 [Q7TNV1-3]
XP_006508229.1, XM_006508166.1 [Q7TNV1-2]
UniGeneiMm.440393

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078392

Chemistry databases

SwissLipidsiSLP:000001109 [Q7TNV1-1]
SLP:000001110 [Q7TNV1-3]

PTM databases

iPTMnetiQ7TNV1
PhosphoSitePlusiQ7TNV1

Proteomic databases

PaxDbiQ7TNV1
PRIDEiQ7TNV1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079423; ENSMUSP00000078392; ENSMUSG00000058966 [Q7TNV1-1]
ENSMUST00000098032; ENSMUSP00000095640; ENSMUSG00000058966 [Q7TNV1-3]
ENSMUST00000205324; ENSMUSP00000145837; ENSMUSG00000058966 [Q7TNV1-3]
ENSMUST00000207020; ENSMUSP00000145721; ENSMUSG00000058966 [Q7TNV1-2]
GeneIDi68952
KEGGimmu:68952
UCSCiuc009jsy.2 mouse [Q7TNV1-1]
uc012ftv.1 mouse [Q7TNV1-3]

Organism-specific databases

CTDi83723
MGIiMGI:1916202 Fam57b

Phylogenomic databases

eggNOGiKOG4561 Eukaryota
ENOG410XPW0 LUCA
GeneTreeiENSGT00510000046654
HOGENOMiHOG000237329
HOVERGENiHBG051539
InParanoidiQ7TNV1
OMAiASIPFHM
OrthoDBiEOG091G0X5A
PhylomeDBiQ7TNV1
TreeFamiTF350344

Miscellaneous databases

ChiTaRSiFam57b mouse
PROiPR:Q7TNV1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058966 Expressed in 194 organ(s), highest expression level in retina
CleanExiMM_1500016O10RIK
ExpressionAtlasiQ7TNV1 baseline and differential
GenevisibleiQ7TNV1 MM

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
PfamiView protein in Pfam
PF03798 TRAM_LAG1_CLN8, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA57B_MOUSE
AccessioniPrimary (citable) accession number: Q7TNV1
Secondary accession number(s): Q3V2R2, Q561N3, Q9CW26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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