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UniProtKB - Q7TNL4 (STK40_RAT)
Protein
Serine/threonine-protein kinase 40
Gene
Stk40
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 66 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 197 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 41 – 49 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- glycogen metabolic process Source: RGD
- lung alveolus development Source: RGD
- lung development Source: RGD
- lung morphogenesis Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of apoptotic process Source: RGD
- regulation of gene expression Source: RGD
- regulation of MAPK cascade Source: RGD
- respiratory system process Source: RGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase 40 (EC:2.7.11.1)Alternative name(s): Serine/threonine-protein kinase lyk4 |
Gene namesi | Name:Stk40 Synonyms:Lyk4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727884, Stk40 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252264 | 1 – 435 | Serine/threonine-protein kinase 40Add BLAST | 435 |
Proteomic databases
PaxDbi | Q7TNL4 |
PTM databases
PhosphoSitePlusi | Q7TNL4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 332 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 298 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
InParanoidi | Q7TNL4 |
OrthoDBi | 1362510at2759 |
PhylomeDBi | Q7TNL4 |
Family and domain databases
CDDi | cd13974, STKc_SHIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR024236, Ser/Thr_kinase_40 IPR008271, Ser/Thr_kinase_AS IPR024104, Tribbles/Ser_Thr_kinase_40 |
PANTHERi | PTHR22961, PTHR22961, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7TNL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRRASDRGA GETSAKAQAL GTGIAGNNAK RAGPFILGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL
210 220 230 240 250
GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP
410 420 430
KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JST8 | A0A0G2JST8_RAT | Serine/threonine-protein kinase 40 | Stk40 | 435 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 397 | A → T in AAI00063 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY336055 mRNA Translation: AAQ01589.1 BC100062 mRNA Translation: AAI00063.1 |
RefSeqi | NP_898879.2, NM_183056.2 XP_006238943.1, XM_006238881.3 |
Genome annotation databases
GeneIDi | 360230 |
KEGGi | rno:360230 |
UCSCi | RGD:727884, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY336055 mRNA Translation: AAQ01589.1 BC100062 mRNA Translation: AAI00063.1 |
RefSeqi | NP_898879.2, NM_183056.2 XP_006238943.1, XM_006238881.3 |
3D structure databases
AlphaFoldDBi | Q7TNL4 |
SMRi | Q7TNL4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000032827 |
PTM databases
PhosphoSitePlusi | Q7TNL4 |
Proteomic databases
PaxDbi | Q7TNL4 |
Genome annotation databases
GeneIDi | 360230 |
KEGGi | rno:360230 |
UCSCi | RGD:727884, rat |
Organism-specific databases
CTDi | 83931 |
RGDi | 727884, Stk40 |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
InParanoidi | Q7TNL4 |
OrthoDBi | 1362510at2759 |
PhylomeDBi | Q7TNL4 |
Miscellaneous databases
PROi | PR:Q7TNL4 |
Family and domain databases
CDDi | cd13974, STKc_SHIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR024236, Ser/Thr_kinase_40 IPR008271, Ser/Thr_kinase_AS IPR024104, Tribbles/Ser_Thr_kinase_40 |
PANTHERi | PTHR22961, PTHR22961, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STK40_RAT | |
Accessioni | Q7TNL4Primary (citable) accession number: Q7TNL4 Secondary accession number(s): Q498V1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families