UniProtKB - Q7TNL3 (STK40_MOUSE)
Protein
Serine/threonine-protein kinase 40
Gene
Stk40
Organism
Mus musculus (Mouse)
Status
Functioni
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 66 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 197 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 41 – 49 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- glycogen metabolic process Source: MGI
- lung alveolus development Source: MGI
- lung development Source: MGI
- lung morphogenesis Source: MGI
- multicellular organism growth Source: MGI
- negative regulation of apoptotic process Source: MGI
- regulation of gene expression Source: MGI
- regulation of MAPK cascade Source: MGI
- respiratory system process Source: MGI
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase 40 (EC:2.7.11.1)Alternative name(s): Serine/threonine-protein kinase lyk4 |
Gene namesi | Name:Stk40 Synonyms:Lyk4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921428, Stk40 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252262 | 1 – 435 | Serine/threonine-protein kinase 40Add BLAST | 435 |
Proteomic databases
EPDi | Q7TNL3 |
PaxDbi | Q7TNL3 |
PRIDEi | Q7TNL3 |
PTM databases
iPTMneti | Q7TNL3 |
PhosphoSitePlusi | Q7TNL3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000042608, Expressed in tracheobronchial tree and 262 other tissues |
ExpressionAtlasi | Q7TNL3, baseline and differential |
Genevisiblei | Q7TNL3, MM |
Interactioni
Binary interactionsi
Isoform 1 [Q7TNL3-1]
With | #Exp. | IntAct |
---|---|---|
Rcn2 [Q8BP92] | 3 | EBI-15828080,EBI-642694 |
Protein-protein interaction databases
DIPi | DIP-58526N |
IntActi | Q7TNL3, 1 interactor |
STRINGi | 10090.ENSMUSP00000092354 |
Miscellaneous databases
RNActi | Q7TNL3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 332 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 298 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00950000182986 |
HOGENOMi | CLU_035107_0_0_1 |
InParanoidi | Q7TNL3 |
OMAi | YDSVPQE |
OrthoDBi | 1362510at2759 |
PhylomeDBi | Q7TNL3 |
TreeFami | TF329785 |
Family and domain databases
CDDi | cd13974, STKc_SHIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR024236, Ser/Thr_kinase_40 IPR008271, Ser/Thr_kinase_AS IPR024104, Tribbles/Ser_Thr_kinase_40 |
PANTHERi | PTHR22961, PTHR22961, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7TNL3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRRASDRGA GETSANAKAL GTGIAGNNAK RAGPFVLGPR LGNSPVPSIV
60 70 80 90 100
QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL
110 120 130 140 150
HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS
160 170 180 190 200
DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL
210 220 230 240 250
GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY
260 270 280 290 300
RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
310 320 330 340 350
ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD
360 370 380 390 400
IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP
410 420 430
KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AVZ9 | B1AVZ9_MOUSE | Serine/threonine-protein kinase 40 | Stk40 | 61 | Annotation score: | ||
B1AW00 | B1AW00_MOUSE | Serine/threonine-protein kinase 40 | Stk40 | 164 | Annotation score: |
Sequence cautioni
The sequence AAH46981 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | R → L in BAB26110 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 392 | I → V in BAB26110 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020901 | 1 | M → MKPYLRGASTQELRM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY336057 mRNA Translation: AAQ01591.1 AB102946 mRNA Translation: BAC81568.1 AK009154 mRNA Translation: BAB26110.2 AK050808 mRNA Translation: BAC34419.2 AK154780 mRNA Translation: BAE32823.1 AL731780 Genomic DNA No translation available. BC046981 mRNA Translation: AAH46981.1 Different initiation. |
CCDSi | CCDS51299.1 [Q7TNL3-2] CCDS51300.1 [Q7TNL3-1] |
RefSeqi | NP_001139299.1, NM_001145827.1 [Q7TNL3-2] NP_083076.3, NM_028800.3 [Q7TNL3-1] XP_006503504.1, XM_006503441.3 [Q7TNL3-2] XP_006503505.1, XM_006503442.1 [Q7TNL3-1] XP_017175903.1, XM_017320414.1 [Q7TNL3-1] |
Genome annotation databases
Ensembli | ENSMUST00000094761; ENSMUSP00000092354; ENSMUSG00000042608 [Q7TNL3-1] ENSMUST00000116286; ENSMUSP00000111990; ENSMUSG00000042608 [Q7TNL3-2] |
GeneIDi | 74178 |
KEGGi | mmu:74178 |
UCSCi | uc008usl.2, mouse [Q7TNL3-1] uc008usm.2, mouse [Q7TNL3-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY336057 mRNA Translation: AAQ01591.1 AB102946 mRNA Translation: BAC81568.1 AK009154 mRNA Translation: BAB26110.2 AK050808 mRNA Translation: BAC34419.2 AK154780 mRNA Translation: BAE32823.1 AL731780 Genomic DNA No translation available. BC046981 mRNA Translation: AAH46981.1 Different initiation. |
CCDSi | CCDS51299.1 [Q7TNL3-2] CCDS51300.1 [Q7TNL3-1] |
RefSeqi | NP_001139299.1, NM_001145827.1 [Q7TNL3-2] NP_083076.3, NM_028800.3 [Q7TNL3-1] XP_006503504.1, XM_006503441.3 [Q7TNL3-2] XP_006503505.1, XM_006503442.1 [Q7TNL3-1] XP_017175903.1, XM_017320414.1 [Q7TNL3-1] |
3D structure databases
SMRi | Q7TNL3 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-58526N |
IntActi | Q7TNL3, 1 interactor |
STRINGi | 10090.ENSMUSP00000092354 |
PTM databases
iPTMneti | Q7TNL3 |
PhosphoSitePlusi | Q7TNL3 |
Proteomic databases
EPDi | Q7TNL3 |
PaxDbi | Q7TNL3 |
PRIDEi | Q7TNL3 |
Protocols and materials databases
Antibodypediai | 2156, 159 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000094761; ENSMUSP00000092354; ENSMUSG00000042608 [Q7TNL3-1] ENSMUST00000116286; ENSMUSP00000111990; ENSMUSG00000042608 [Q7TNL3-2] |
GeneIDi | 74178 |
KEGGi | mmu:74178 |
UCSCi | uc008usl.2, mouse [Q7TNL3-1] uc008usm.2, mouse [Q7TNL3-2] |
Organism-specific databases
CTDi | 83931 |
MGIi | MGI:1921428, Stk40 |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00950000182986 |
HOGENOMi | CLU_035107_0_0_1 |
InParanoidi | Q7TNL3 |
OMAi | YDSVPQE |
OrthoDBi | 1362510at2759 |
PhylomeDBi | Q7TNL3 |
TreeFami | TF329785 |
Miscellaneous databases
BioGRID-ORCSi | 74178, 0 hits in 19 CRISPR screens |
ChiTaRSi | Stk40, mouse |
PROi | PR:Q7TNL3 |
RNActi | Q7TNL3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042608, Expressed in tracheobronchial tree and 262 other tissues |
ExpressionAtlasi | Q7TNL3, baseline and differential |
Genevisiblei | Q7TNL3, MM |
Family and domain databases
CDDi | cd13974, STKc_SHIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR024236, Ser/Thr_kinase_40 IPR008271, Ser/Thr_kinase_AS IPR024104, Tribbles/Ser_Thr_kinase_40 |
PANTHERi | PTHR22961, PTHR22961, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STK40_MOUSE | |
Accessioni | Q7TNL3Primary (citable) accession number: Q7TNL3 Secondary accession number(s): B1AW01 Q9D7K3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families