Znf24

Functionⁱ

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	251 – 273	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	279 – 301	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	307 – 329	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	335 – 357	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
metal ion binding Source: UniProtKB-KW
sequence-specific DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

myelination Source: UniProtKB
negative regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 24 Alternative name(s): Zinc finger protein 191 Short name: Zfp-191
Gene namesⁱ	Name:Znf24 Synonyms:Zfp191, Znf191
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 18

Organism-specific databases

Rat genome database More...RGDⁱ	727963 Zfp191

RGDⁱ

727963 Zfp191

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000366922	1 – 368	Zinc finger protein 24Add BLAST		368

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	132	PhosphoserineBy similarity	1
Modified residueⁱ	142	PhosphoserineBy similarity	1
Cross-linkⁱ	147	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	177	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	236	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	274	PhosphoserineBy similarity	1
Cross-linkⁱ	277	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	286	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	292	PhosphoserineBy similarity	1
Modified residueⁱ	335	PhosphotyrosineBy similarity	1
Cross-linkⁱ	361	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	367	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Sumoylated.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q7TNK3
PRIDEⁱ	Q7TNK3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000016562 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000016562 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000022304

STRINGⁱ

10116.ENSRNOP00000022304

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7TNK3
SMRⁱ	Q7TNK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	52 – 134	SCAN boxPROSITE-ProRule annotationAdd BLAST		83

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	251 – 301	Necessary and sufficient for nuclear localizationBy similarityAdd BLAST		51

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	251 – 273	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	279 – 301	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	307 – 329	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	335 – 357	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q7TNK3
KEGG Orthology (KO) More...KOⁱ	K09230
OMAⁱ	TWNHLPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09O3
PhylomeDBⁱ	Q7TNK3
TreeFamⁱ	TF338304

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7TNK3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPNPDEE EKILRVKLEE DPDGEEGSSI SWNHLPDPEI 
        60         70         80         90        100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF 
       110        120        130        140        150
VAILPRELQT LVREHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV 
       160        170        180        190        200
LVEEIASQED AQGLPSSELD AVENQLKWAS WELHSLRHCD DDATAENGAL 
       210        220        230        240        250
APKQEIASAG ESHEVPGTLN IGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ 
       260        270        280        290        300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV 
       310        320        330        340        350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL 
       360 
FRHQRRHNAE KLLNVVKV

Length:368

Mass (Da):41,910

Last modified:October 1, 2003 - v1

Checksum:ⁱD0E1A13347CB875F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY336973 mRNA Translation: AAQ16149.1
NCBI Reference Sequences More...RefSeqⁱ	NP_892000.1, NM_182955.1 XP_006254526.1, XM_006254464.3 XP_006254527.1, XM_006254465.3
UniGeneⁱ	Rn.162286 Rn.6583

Genome annotation databases

Ensemblⁱ	ENSRNOT00000022304; ENSRNOP00000022304; ENSRNOG00000016562
GeneIDⁱ	360204
KEGGⁱ	rno:360204
UCSC genome browser More...UCSCⁱ	RGD:727963 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7TNK3	Zinc finger protein 24	)	HUMAN		368	UniRef90_P17028
Zinc finger protein 24		MOUSE		368
Zinc finger protein 24		PANPA		368
Zinc finger protein 24		PANTR		368
Zinc finger protein 24		PONAB		368
+111

Protein	Similar proteins		Species	Score	Length	Source
Q7TNK3	Zinc finger protein 24	)	HUMAN		368	UniRef50_P17028
Zinc finger protein 24		MOUSE		368
Zinc finger protein 24		PONAB		368
Zinc finger protein 24		PANPA		368
Zinc finger protein 24		PANTR		368
+113

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY336973 mRNA Translation: AAQ16149.1
RefSeqⁱ	NP_892000.1, NM_182955.1 XP_006254526.1, XM_006254464.3 XP_006254527.1, XM_006254465.3
UniGeneⁱ	Rn.162286 Rn.6583

3D structure databases

ProteinModelPortalⁱ	Q7TNK3
SMRⁱ	Q7TNK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000022304

STRINGⁱ

10116.ENSRNOP00000022304

Proteomic databases

PaxDbⁱ	Q7TNK3
PRIDEⁱ	Q7TNK3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000022304; ENSRNOP00000022304; ENSRNOG00000016562
GeneIDⁱ	360204
KEGGⁱ	rno:360204
UCSCⁱ	RGD:727963 rat

Organism-specific databases

CTDⁱ	59057
RGDⁱ	727963 Zfp191

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q7TNK3
KOⁱ	K09230
OMAⁱ	TWNHLPD
OrthoDBⁱ	EOG091G09O3
PhylomeDBⁱ	Q7TNK3
TreeFamⁱ	TF338304

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q7TNK3

PROⁱ

PR:Q7TNK3

Gene expression databases

Bgeeⁱ	ENSRNOG00000016562 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000016562 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNF24_RAT
Accessionⁱ	Q7TNK3Primary (citable) accession number: Q7TNK3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
	Last sequence update:	October 1, 2003
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniProtKB - Q7TNK3 (ZNF24_RAT)

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Zinc finger protein 24

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ