Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 106 (26 Feb 2020)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

ATP-binding cassette sub-family A member 7

Gene

Abca7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (By similarity). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (By similarity). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (By similarity).By similarity

Caution

There are conflicting results concerning the role of ABCA7 in lipid transport. ABCA7 was described to play a role in apolipoprotein-mediated phospholipid and cholesterol efflux when expressed in HEK293 cells (By similarity). However, another report shows that ABCA7 deficiency does not influence cholesterol and phospholipid efflux in mouse primary macrophages, but leads to lower serum HDL cholesterol levels and a reduction in fat mass in female mice (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi839 – 846ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1852 – 1859ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPhagocytosis, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1369062 ABC transporters in lipid homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1303134 Abca7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 547ExtracellularBy similarityAdd BLAST505
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Transmembranei653 – 673HelicalSequence analysisAdd BLAST21
Transmembranei679 – 699HelicalSequence analysisAdd BLAST21
Transmembranei733 – 753HelicalSequence analysisAdd BLAST21
Transmembranei847 – 867HelicalSequence analysisAdd BLAST21
Transmembranei1257 – 1277HelicalSequence analysisAdd BLAST21
Topological domaini1278 – 1562ExtracellularBy similarityAdd BLAST285
Transmembranei1563 – 1583HelicalSequence analysisAdd BLAST21
Transmembranei1609 – 1629HelicalSequence analysisAdd BLAST21
Transmembranei1646 – 1666HelicalSequence analysisAdd BLAST21
Transmembranei1674 – 1694HelicalSequence analysisAdd BLAST21
Transmembranei1708 – 1728HelicalSequence analysisAdd BLAST21
Transmembranei1754 – 1774HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002506761 – 2170ATP-binding cassette sub-family A member 7Add BLAST2170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 222By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1370 ↔ 1384By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TNJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TNJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q7TNJ2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TNJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TNJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in blood cells. Also detected in brain and ovary tissues (at protein level). Expressed in platelet.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
256273, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000063805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TNJ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini805 – 1036ABC transporter 1PROSITE-ProRule annotationAdd BLAST232
Domaini1818 – 2050ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TNJ2

KEGG Orthology (KO)

More...
KOi
K05645

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TNJ2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030369 ABCA7
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit
PTHR19229:SF49 PTHR19229:SF49, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TNJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFCTQLMLL LWKNYTYRRR QPIQLVVELL WPLFLFFILV AVRHSHPPLE
60 70 80 90 100
HHECHFPNKP LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS
110 120 130 140 150
LISRLLADAH TVLGGHSTQD MLAALGKLIP VLRAVGSGAW PQESNQPAKQ
160 170 180 190 200
GSVTELLEKI LQRASLETVL GQAQDSMRKF SDATRTVAQE LLTLPSLVEL
210 220 230 240 250
RALLRRPRGS AGSLELISEA LCSTKGPSSP GGLSLNWYEA NQINEFMGPE
260 270 280 290 300
LAPTLPDSSL SPACSEFVGA LDDHPVSRLL WRRLKPLILG KILFAPDTNF
310 320 330 340 350
TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQKLLD
360 370 380 390 400
VEGTGWQQQT PKGQKQLEAI RDFLDPSRGR YNWQEAHADM GRLAEILGQI
410 420 430 440 450
LECVSLDKLE AVPSEEALVS RALELLGERR LWAGIVFLSP EHPLDSSEPP
460 470 480 490 500
SPTTTGPGHL RVKIRMDIDD VTRTNKIRDK FWDPGPSADP LMDLRYVWGG
510 520 530 540 550
FVYLQDLLEQ AAVRVLSGRD SRAGLYLQQM PHPCYVDDVF LRVLSRSLPL
560 570 580 590 600
FLTLAWIYSV ALTVKAVVRE KETRLRETMR AMGLSRAVLW LGWFLSCLGP
610 620 630 640 650
FLVSAALLVL VLKLGNILPY SHPVVVFLFL AAFAVATVAQ SFLLSAFFSR
660 670 680 690 700
ANLAAACGGL AYFALYLPYV LCVAWRERLP LGGLLAVSLL SPVAFGFGCE
710 720 730 740 750
SLALLEEQGD GAQWHNLGTG PAEDVFSLAQ VSAFLLLDAV IYGLALWYLE
760 770 780 790 800
AVCPGQYGIP EPWNFPFRRS YWCGPGPPKS SVLAPAPQDP KVLVEEPPPG
810 820 830 840 850
LVPGVSIRGL KKHFRGSPQP ALRGLNLDFY EGHITAFLGH NGAGKTTTLS
860 870 880 890 900
ILSGLFPPSS GSASILGHDV QTNMAAIRPH LGICPQYNVL FDMLTVEEHV
910 920 930 940 950
WFYGRLKGVS AAAIDSEQEH LIRDVGLIPK RDTQTRHLSG GMQRKLSVAI
960 970 980 990 1000
AFVGGSRVVI MDEPTAGVDP ASRRGIWELL LKYREGRTLI LSTHHLDEAE
1010 1020 1030 1040 1050
LLGDRVAMVA SGSLCCCGSP LFLRRHLGCG YYLTLVKSSQ SLVTHDLKGD
1060 1070 1080 1090 1100
TEDPRREKKS GSEGKTADTV LTRDGPHRSS QVPAPDAVPV TPSAALILEL
1110 1120 1130 1140 1150
VQRHVPGAQL VEELPHELVL ALPYAGALDG SFATVFQELD QQLERLGLTG
1160 1170 1180 1190 1200
YGISDTNLEE IFLKVVEEAH AHGEGGDPRQ QQHLLTATPQ PHTGPEASVL
1210 1220 1230 1240 1250
ENGELAKLVL DPQAPKGSAP TTAQVQGWTL TCQQLRALLH KRFLLARRSR
1260 1270 1280 1290 1300
RGLFAQIVLP ALFVGLALFF TLIVPPFGQY PPLQLSPAMY GPQVSFFSED
1310 1320 1330 1340 1350
APADPNRMKL LEALLGEAGL QDPSVQGKGS RGSECTHSLA CYFTVPEVPP
1360 1370 1380 1390 1400
DVASILASGN WTPDSPSPAC QCSQPGARRL LPDCPAGAGG PPPPQAMAGF
1410 1420 1430 1440 1450
GEVVQNLTGR NVSDFLVKTY PSLVRRGLKT KKWVDEVRYG GFSLGGRDPD
1460 1470 1480 1490 1500
LPSGREVVRT VAEMRALLSP QPGNTLDRIL NNLTQWALGL DARNSLKIWF
1510 1520 1530 1540 1550
NNKGWHAMVA FVNRANNGLL RAFLPSGSVR HAHSITTLNH PLNLTKEQLS
1560 1570 1580 1590 1600
EATLIASSVD VLVSICVVFA MSFVPASFTL VLIEERITRA KHLQLVSGLP
1610 1620 1630 1640 1650
QTLYWLGNFL WDMCNYLVAV CIVVLIFLAF QQKAYVAPEN LPALLLLLLL
1660 1670 1680 1690 1700
YGWSITPLMY PASFFFSVPS TAYVVLTCIN LFIGINSSMA TFVLELLSDQ
1710 1720 1730 1740 1750
NLQEVSRILK QVFLIFPHFC LGRGLIDMVR NQAMADAFER LGDKQFQSPL
1760 1770 1780 1790 1800
RWDIIGKNLL AMVAQGPLFL LITLLLQHRN RLLPQPKSRL PPPLGEEDED
1810 1820 1830 1840 1850
VVRERERVTK GATQGDVLVL RDLTKVYRGQ RSPAVDHLCL GIPPGECFGL
1860 1870 1880 1890 1900
LGVNGAGKTS TFRMVTGDTL PSSGEAVLAG HNVAQEPSAA HRSMGYCPQS
1910 1920 1930 1940 1950
DAIFDLLTGR EHLELFARLR GVPEAQVAQT ALSGLVRLGL PSYADRPAGT
1960 1970 1980 1990 2000
YSGGNKRKLA TALALVGDPA VVFLDEPTTG MDPSARRFLW NNLLSVVREG
2010 2020 2030 2040 2050
RSVVLTSHSM EECEALCTRL AIMVNGRFRC LGSAQHLKSR FGAGHTLTLR
2060 2070 2080 2090 2100
VPPDQPEPAI AFIVTTFPDA ELREVHGSRL RFQLPPGGGC TLARVFRELA
2110 2120 2130 2140 2150
AQGKAHGVED FSVSQTTLEE VFLYFSKDQG EEEEGSGQET ETREVSTPGL
2160 2170
QHPKRVSRFL EDPSSVETVI
Length:2,170
Mass (Da):237,720
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i003C8DF70B8744CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LR67F1LR67_RAT
ATP-binding cassette sub-family A m...
Abca7
2,170Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB097814 mRNA Translation: BAC81426.1

NCBI Reference Sequences

More...
RefSeqi
NP_997481.1, NM_207598.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
299609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:299609

UCSC genome browser

More...
UCSCi
RGD:1303134 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097814 mRNA Translation: BAC81426.1
RefSeqiNP_997481.1, NM_207598.1

3D structure databases

SMRiQ7TNJ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi256273, 1 interactor
STRINGi10116.ENSRNOP00000063805

PTM databases

iPTMnetiQ7TNJ2
PhosphoSitePlusiQ7TNJ2

Proteomic databases

jPOSTiQ7TNJ2
PaxDbiQ7TNJ2
PRIDEiQ7TNJ2

Genome annotation databases

GeneIDi299609
KEGGirno:299609
UCSCiRGD:1303134 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10347
RGDi1303134 Abca7

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
InParanoidiQ7TNJ2
KOiK05645
OrthoDBi131191at2759
PhylomeDBiQ7TNJ2

Enzyme and pathway databases

ReactomeiR-RNO-1369062 ABC transporters in lipid homeostasis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7TNJ2

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030369 ABCA7
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF49 PTHR19229:SF49, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCA7_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TNJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: February 26, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again