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Entry version 127 (12 Aug 2020)
Sequence version 3 (27 Jul 2011)
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Protein

Kinesin-like protein KIF26B

Gene

Kif26b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi546 – 553ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Motor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2132295, MHC class II antigen presentation
R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189, Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF26B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kif26b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2447076, Kif26b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice die within 24 hours after birth. Most mice show bilateral kidney agenesis. The development of other organs seems normal. Ureteric bud attraction is impaired after 11.0 dpc. The ureteric buds are attracted close to the mesenchyme but fail to invade and branch into the mesenchyme and the kidney disappears by 14.5 dpc. The mesenchymal cells undergo apoptotic cell death at 12.5 dpc. ITGA8 is reduced at the ureteric bud/mesenchyme junction and does not exhibit basolateral localization. GDNF is not properly maintained in the mesenchyme at 11.5 dpc.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1859T → A: Reduced polyubiquitination when co-expressed with NEDD4; when associated with Ala-1962. 1 Publication1
Mutagenesisi1962S → A: Reduced polyubiquitination when co-expressed with NEDD4; when associated with Ala-1859. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073021 – 2112Kinesin-like protein KIF26BAdd BLAST2112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1859Phosphothreonine1 Publication1
Modified residuei1962Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-1859 and Ser-1962 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules.1 Publication
Polyubiquitinated by NEDD4, resulting in proteasomal degradation.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TNC6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7TNC6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TNC6

PRoteomics IDEntifications database

More...
PRIDEi
Q7TNC6

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q7TNC6

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TNC6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TNC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In newborn kidney, specifically expressed in the mesenchyme.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the developing kidney, only present in the uncommitted mesenchyme and absent from more differentiated structures including renal vesicles and comma-shaped bodies. First detected in the metanephric mesenchyme at 10.5 dpc. After 11.5 dpc, observed in mesenchymal cells surrounding the tips of ureteric buds in the metanephroi. At 11.5 dpc, also detected in limb buds and central nervous system. At 14.5 dpc, strongly expressed in the nephrogenic zone.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by SALL1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026494, Expressed in trigeminal ganglion and 229 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TNC6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYH10.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
234614, 2 interactors

Database of interacting proteins

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DIPi
DIP-59327N

Protein interaction database and analysis system

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IntActi
Q7TNC6, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000124462

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q7TNC6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7TNC6

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini450 – 801Kinesin motorPROSITE-ProRule annotationAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 126Gly-richAdd BLAST69
Compositional biasi1015 – 1119Ser-richAdd BLAST105
Compositional biasi1648 – 1947Ser-richAdd BLAST300

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4280, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156992

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7TNC6

KEGG Orthology (KO)

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KOi
K10404

Database of Orthologous Groups

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OrthoDBi
29955at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7TNC6

TreeFam database of animal gene trees

More...
TreeFami
TF105235

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00225, Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TNC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSVAGNKER LAVSTRGKKY GVNEMCSPTK PSAPCSPESW YRKAYEESRA
60 70 80 90 100
GSRPTPEGAG SALGSSGTPS PGSGTSSPSS FTGSPGPASP GIGTSSPGSL
110 120 130 140 150
GGSPGFGTGS PGSGSGGGSS PGSDRGVWCE NCNARLVELK RQALKLLLPG
160 170 180 190 200
PLPGKDPAFS AVIHDKLQVP NTIRKSWNDR DNRCDICATH LNQLKQEAIQ
210 220 230 240 250
MVLTLEQAAG SEHYDTSLGS PPPISSIPTL VGSRHMGGLQ QPREWAFVPA
260 270 280 290 300
PYATSTYTGL VNKHSGKPNS LGVSNGAEKK SGSPTHQAKV SLQMATSPSN
310 320 330 340 350
GNILNSVAIQ AHQYLDGTWS LSRTNGVTLY PYQISQLMTE TGREGLTESA
360 370 380 390 400
LNRYNADKPA ASSVPAPQGS CVASETSTGT SVAASFFARA AQKLNLSSKK
410 420 430 440 450
KKHRPSTPSV AEAPLFATSF SGILQTSPPP APPCLLRAVN KVKDTPGMGK
460 470 480 490 500
VKVMLRICST SARDTSESSS FLKVDPRKKQ ITLYDPLTCG GQNAFQKRSS
510 520 530 540 550
QVPPKMFAFD AVFPQDASQA EVCAGTVAEV IQSVVNGADG CVFCFGHAKL
560 570 580 590 600
GKSYTMIGRD DSMQNLGIIP CAISWLFKLI NERKEKTGAR FSVRISAVEV
610 620 630 640 650
WGKEENLRDL LSEVATGSLQ DGQSPGVYLC EDPICGTQLQ NQSELRAPTA
660 670 680 690 700
EKAAFFLDAA IASRRSNQQD CDEDDHRNSH MLFTLHIYQY RMEKSGKGGM
710 720 730 740 750
SGGRSRLHLI DLGSCVKALS KNREGGSGLC LSLSALGNVI LALVNGSKHI
760 770 780 790 800
PYKESKLTML LRESLGNVNC RTTMIAHISA AASSYAETLS TIQIASRVLR
810 820 830 840 850
MKKKKTKYTS SSSGGESSCE EGRMRRPTQL RPFHARAPVD PEFPLAPLSS
860 870 880 890 900
DPDYSSSSEQ SCDTVIYIGP NGTALSDKEL TDNEGPPDFV PIVPALQKTR
910 920 930 940 950
GDSRPGEAAE AAASKSERDC LKCNTFAELQ ERLDCIDGSE EPSKFPFEEL
960 970 980 990 1000
PIQFGPEQAG RCAPLSQAVG PDTPSESEKE DNGSDNGQLT EREGTELPAS
1010 1020 1030 1040 1050
KAQRNRSPAP TVTRSSSPSP ASPRSIPGSS SQHSTSQLTQ SPSLQSSRES
1060 1070 1080 1090 1100
LNSCGFVEGK PRPMGSPRLG IASLSKTSEY KPPSSPSQRC KVYTQKGVLP
1110 1120 1130 1140 1150
SSAPPPSLSK DSGMVSSESL LQPDVRTPPV GMSPQVLKKS MSAGSEGFPG
1160 1170 1180 1190 1200
TLVDGEDQEG PPADSKKEIL STTMVTVQQP LELNGEDELV FTLVEELTIS
1210 1220 1230 1240 1250
GVLDSGRPTS IISFNSDCSV QALASGSRPV SIISSISEDL ECYSSMAPVS
1260 1270 1280 1290 1300
EVSITQFLPL PKLGLDEKAR DAGSRRSSIS SWLSEMSAGS DGEQSCHSFI
1310 1320 1330 1340 1350
AQTCFGHGEA MAEPPASEFV SSIQNTAVVC REKPEVGPDN LLILSEMGEE
1360 1370 1380 1390 1400
SGNKAAPIKG CKISTVGKAM VTISNTASLS SCEGYIPMKT NITVYPCIAM
1410 1420 1430 1440 1450
SPRNVQEPES STATPKVSPK ASQAQESKEP STRREMKFED PWLKREEEVK
1460 1470 1480 1490 1500
RENAYSSEEG VKCEPLPSSL KTEGKSEQEL DGRPSSGNRL SSSSSEAAAF
1510 1520 1530 1540 1550
QGTDNVRRVV DGCEMALPGL VAQSPLHVNR NLKSSSLPRA FQKADRHEEL
1560 1570 1580 1590 1600
DSFYHCLADS NGFSAASGIP SSKTTLERKV ASPKHCVLAR PKGTPPLPPV
1610 1620 1630 1640 1650
RKSSLDQKNR ASPQHGGGSS NTSSPLNQPA TFLACFPDES NGKTKDVSSS
1660 1670 1680 1690 1700
SKLFSAKLEQ LASRSNSLGR TTVSHYECLS LERAESLSSV SSRMHAGKDS
1710 1720 1730 1740 1750
TMPRTGRSLG RSTGASPPSC GITQSTGASP KASQSKISAV SKLLLASPKS
1760 1770 1780 1790 1800
RSSLSTSTTK TLSFSTKSLP QSVGQSSNLP PSGKHMSWST QSLSRNRGSG
1810 1820 1830 1840 1850
LASKLPLRAV NGRISELLQG SAGPRSAQLR AEAEERSGAP SEDKPAAAHL
1860 1870 1880 1890 1900
LPSPYSKITP PRKPHRCSSG HGSDNSSVLS GELPPAMGKT ALFYHSGGSS
1910 1920 1930 1940 1950
GYESMMRDSE ATGSASSAQD SMSENSSSVG GRCRSLKNQK KRSNSGSQRR
1960 1970 1980 1990 2000
RLIPALSLDT PSPVRKTASS TGVRWVDGPL RSTQRSLGEP FEIKVYEIDD
2010 2020 2030 2040 2050
VERLQRRRGA TSKEVMCFNA KLKILEHRQQ RIAEVRAKYE WLMKELEATK
2060 2070 2080 2090 2100
QYLMLDPNKW LREFDLEQVL QLDSLEYLEA LEGVTERLES RVNFCKAHLM
2110
MITCFDITSR RR
Length:2,112
Mass (Da):225,511
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACAC968F636DC4D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PX64E9PX64_MOUSE
Kinesin-like protein KIF26B
Kif26b
1,665Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56349 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC36343 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti870P → L in AAH56349 (PubMed:15489334).Curated1
Sequence conflicti1547H → R in BAC36343 (PubMed:16141072).Curated1
Sequence conflicti2050K → R in BAJ06134 (PubMed:20439720).Curated1
Sequence conflicti2050K → R in AAH56349 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB355846 mRNA Translation: BAJ06134.1
AC117695 Genomic DNA No translation available.
AC117756 Genomic DNA No translation available.
AC117766 Genomic DNA No translation available.
AC140776 Genomic DNA No translation available.
BC056349 mRNA Translation: AAH56349.1 Different initiation.
AK076435 mRNA Translation: BAC36343.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS48464.1

NCBI Reference Sequences

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RefSeqi
NP_001155137.1, NM_001161665.1
XP_011237124.1, XM_011238822.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000161017; ENSMUSP00000124462; ENSMUSG00000026494

Database of genes from NCBI RefSeq genomes

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GeneIDi
269152

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:269152

UCSC genome browser

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UCSCi
uc007dvh.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB355846 mRNA Translation: BAJ06134.1
AC117695 Genomic DNA No translation available.
AC117756 Genomic DNA No translation available.
AC117766 Genomic DNA No translation available.
AC140776 Genomic DNA No translation available.
BC056349 mRNA Translation: AAH56349.1 Different initiation.
AK076435 mRNA Translation: BAC36343.1 Different initiation.
CCDSiCCDS48464.1
RefSeqiNP_001155137.1, NM_001161665.1
XP_011237124.1, XM_011238822.2

3D structure databases

SMRiQ7TNC6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234614, 2 interactors
DIPiDIP-59327N
IntActiQ7TNC6, 2 interactors
STRINGi10090.ENSMUSP00000124462

PTM databases

CarbonylDBiQ7TNC6
iPTMnetiQ7TNC6
PhosphoSitePlusiQ7TNC6

Proteomic databases

jPOSTiQ7TNC6
MaxQBiQ7TNC6
PaxDbiQ7TNC6
PRIDEiQ7TNC6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34719, 86 antibodies

Genome annotation databases

EnsembliENSMUST00000161017; ENSMUSP00000124462; ENSMUSG00000026494
GeneIDi269152
KEGGimmu:269152
UCSCiuc007dvh.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55083
MGIiMGI:2447076, Kif26b

Phylogenomic databases

eggNOGiKOG4280, Eukaryota
GeneTreeiENSGT00940000156992
InParanoidiQ7TNC6
KOiK10404
OrthoDBi29955at2759
PhylomeDBiQ7TNC6
TreeFamiTF105235

Enzyme and pathway databases

ReactomeiR-MMU-2132295, MHC class II antigen presentation
R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189, Kinesins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
269152, 2 hits in 16 CRISPR screens

Protein Ontology

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PROi
PR:Q7TNC6
RNActiQ7TNC6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026494, Expressed in trigeminal ganglion and 229 other tissues
GenevisibleiQ7TNC6, MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00225, Kinesin, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067, KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI26B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TNC6
Secondary accession number(s): D5MP63
, E9PXV6, Q0VB48, Q8BHX2, Q8BKH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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