UniProtKB - Q7TNC4 (LC7L2_MOUSE)
Protein
Putative RNA-binding protein Luc7-like 2
Gene
Luc7l2
Organism
Mus musculus (Mouse)
Status
Functioni
May bind to RNA via its Arg/Ser-rich domain.
GO - Molecular functioni
- enzyme binding Source: MGI
- mRNA binding Source: GO_Central
GO - Biological processi
- mRNA splice site selection Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Putative RNA-binding protein Luc7-like 2Alternative name(s): CGI-74 homolog |
Gene namesi | Name:Luc7l2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2183260, Luc7l2 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
- nucleoplasm 1 Publication
Note: Colocalizes with SCNM1 and SNRNP70 in nuclear speckles.1 Publication
Nucleus
- nuclear speck Source: UniProtKB
- U1 snRNP Source: GO_Central
- U2-type prespliceosome Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187283 | 1 – 392 | Putative RNA-binding protein Luc7-like 2Add BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 266 | 5-hydroxylysine; by JMJD6By similarity | 1 | |
Modified residuei | 269 | 5-hydroxylysine; by JMJD6By similarity | 1 |
Keywords - PTMi
Hydroxylation, PhosphoproteinProteomic databases
PaxDbi | Q7TNC4 |
PeptideAtlasi | Q7TNC4 |
PRIDEi | Q7TNC4 |
PTM databases
iPTMneti | Q7TNC4 |
PhosphoSitePlusi | Q7TNC4 |
Expressioni
Tissue specificityi
All isoforms are expressed in brain, kidney, heart, thymus, stomach, skeletal muscle, testis and spinal cord.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029823, Expressed in stria vascularis of cochlear duct and 296 other tissues |
ExpressionAtlasi | Q7TNC4, baseline and differential |
Genevisiblei | Q7TNC4, MM |
Interactioni
Subunit structurei
Interacts with SCNM1.
1 PublicationGO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 228673, 13 interactors |
IntActi | Q7TNC4, 4 interactors |
MINTi | Q7TNC4 |
STRINGi | 10090.ENSMUSP00000055254 |
Miscellaneous databases
RNActi | Q7TNC4, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 102 – 177 | Sequence analysisAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 239 – 387 | Arg/Ser-richAdd BLAST | 149 |
Sequence similaritiesi
Belongs to the Luc7 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0796, Eukaryota |
GeneTreei | ENSGT00950000183213 |
HOGENOMi | CLU_030397_3_0_1 |
InParanoidi | Q7TNC4 |
OMAi | NHFRDGG |
OrthoDBi | 1499212at2759 |
PhylomeDBi | Q7TNC4 |
TreeFami | TF317607 |
Family and domain databases
InterProi | View protein in InterPro IPR004882, Luc7-rel |
PANTHERi | PTHR12375, PTHR12375, 1 hit |
Pfami | View protein in Pfam PF03194, LUC7, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7TNC4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVSKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASRDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q715 | E9Q715_MOUSE | Putative RNA-binding protein Luc7-l... | Luc7l2 | 272 | Annotation score: | ||
Q05CX5 | Q05CX5_MOUSE | Luc7l2 protein | Luc7l2 | 339 | Annotation score: | ||
E0CZB9 | E0CZB9_MOUSE | Putative RNA-binding protein Luc7-l... | Luc7l2 | 99 | Annotation score: | ||
E0CYQ8 | E0CYQ8_MOUSE | Putative RNA-binding protein Luc7-l... | Luc7l2 | 80 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 147 | G → E in AAH56383 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 245 | K → L in AAK01182 (Ref. 1) Curated | 1 | |
Sequence conflicti | 259 | R → W in AAK01182 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010218 | 260 – 269 | Missing in isoform 2 and isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_010219 | 335 | S → Y in isoform 2 and isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_010220 | 336 – 392 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF318301 mRNA Translation: AAK01182.1 BC002314 mRNA Translation: AAH02314.1 BC056354 mRNA Translation: AAH56354.1 BC056383 mRNA Translation: AAH56383.1 BC056970 mRNA Translation: AAH56970.1 |
CCDSi | CCDS20015.1 [Q7TNC4-1] CCDS51751.1 [Q7TNC4-2] |
RefSeqi | NP_001164320.1, NM_001170849.2 [Q7TNC4-2] NP_619621.2, NM_138680.3 [Q7TNC4-1] |
Genome annotation databases
Ensembli | ENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823 [Q7TNC4-1] ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823 [Q7TNC4-2] |
GeneIDi | 192196 |
KEGGi | mmu:192196 |
UCSCi | uc009bkl.2, mouse [Q7TNC4-2] uc009bkm.2, mouse [Q7TNC4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF318301 mRNA Translation: AAK01182.1 BC002314 mRNA Translation: AAH02314.1 BC056354 mRNA Translation: AAH56354.1 BC056383 mRNA Translation: AAH56383.1 BC056970 mRNA Translation: AAH56970.1 |
CCDSi | CCDS20015.1 [Q7TNC4-1] CCDS51751.1 [Q7TNC4-2] |
RefSeqi | NP_001164320.1, NM_001170849.2 [Q7TNC4-2] NP_619621.2, NM_138680.3 [Q7TNC4-1] |
3D structure databases
SMRi | Q7TNC4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228673, 13 interactors |
IntActi | Q7TNC4, 4 interactors |
MINTi | Q7TNC4 |
STRINGi | 10090.ENSMUSP00000055254 |
PTM databases
iPTMneti | Q7TNC4 |
PhosphoSitePlusi | Q7TNC4 |
Proteomic databases
PaxDbi | Q7TNC4 |
PeptideAtlasi | Q7TNC4 |
PRIDEi | Q7TNC4 |
Genome annotation databases
Ensembli | ENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823 [Q7TNC4-1] ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823 [Q7TNC4-2] |
GeneIDi | 192196 |
KEGGi | mmu:192196 |
UCSCi | uc009bkl.2, mouse [Q7TNC4-2] uc009bkm.2, mouse [Q7TNC4-1] |
Organism-specific databases
CTDi | 51631 |
MGIi | MGI:2183260, Luc7l2 |
Phylogenomic databases
eggNOGi | KOG0796, Eukaryota |
GeneTreei | ENSGT00950000183213 |
HOGENOMi | CLU_030397_3_0_1 |
InParanoidi | Q7TNC4 |
OMAi | NHFRDGG |
OrthoDBi | 1499212at2759 |
PhylomeDBi | Q7TNC4 |
TreeFami | TF317607 |
Miscellaneous databases
BioGRID-ORCSi | 192196, 1 hit in 17 CRISPR screens |
ChiTaRSi | Luc7l2, mouse |
PROi | PR:Q7TNC4 |
RNActi | Q7TNC4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029823, Expressed in stria vascularis of cochlear duct and 296 other tissues |
ExpressionAtlasi | Q7TNC4, baseline and differential |
Genevisiblei | Q7TNC4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004882, Luc7-rel |
PANTHERi | PTHR12375, PTHR12375, 1 hit |
Pfami | View protein in Pfam PF03194, LUC7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LC7L2_MOUSE | |
Accessioni | Q7TNC4Primary (citable) accession number: Q7TNC4 Secondary accession number(s): Q99LM5, Q99PC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families