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Protein

Putative RNA-binding protein Luc7-like 2

Gene

Luc7l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.

GO - Molecular functioni

  • enzyme binding Source: MGI
  • mRNA binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 2
Alternative name(s):
CGI-74 homolog
Gene namesi
Name:Luc7l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2183260 Luc7l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872831 – 392Putative RNA-binding protein Luc7-like 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei2665-hydroxylysine; by JMJD6By similarity1
Modified residuei2695-hydroxylysine; by JMJD6By similarity1

Keywords - PTMi

Hydroxylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TNC4
PeptideAtlasiQ7TNC4
PRIDEiQ7TNC4

PTM databases

iPTMnetiQ7TNC4
PhosphoSitePlusiQ7TNC4

Expressioni

Tissue specificityi

All isoforms are expressed in brain, kidney, heart, thymus, stomach, skeletal muscle, testis and spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000029823 Expressed in 280 organ(s), highest expression level in stria vascularis of cochlear duct
CleanExiMM_LUC7L2
ExpressionAtlasiQ7TNC4 baseline and differential
GenevisibleiQ7TNC4 MM

Interactioni

Subunit structurei

Interacts with SCNM1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228673, 2 interactors
IntActiQ7TNC4, 4 interactors
MINTiQ7TNC4
STRINGi10090.ENSMUSP00000055254

Structurei

3D structure databases

ProteinModelPortaliQ7TNC4
SMRiQ7TNC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili102 – 177Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi239 – 387Arg/Ser-richAdd BLAST149

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiQ7TNC4
KOiK13212
OMAiNHFRDGG
OrthoDBiEOG091G0PSO
PhylomeDBiQ7TNC4
TreeFamiTF317607

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TNC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVSKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASRDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Length:392
Mass (Da):46,583
Last modified:October 1, 2003 - v1
Checksum:i1A5202B1F537A7CC
GO
Isoform 2 (identifier: Q7TNC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-269: Missing.
     335-335: S → Y
     336-392: Missing.

Show »
Length:325
Mass (Da):38,611
Checksum:i5C8AC61980E5D16D
GO
Isoform 3 (identifier: Q7TNC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: S → Y
     336-392: Missing.

Show »
Length:335
Mass (Da):39,790
Checksum:i6184B722DCEDA297
GO
Isoform 4 (identifier: Q7TNC4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-269: Missing.

Show »
Length:382
Mass (Da):45,405
Checksum:i34D02E7A1679AB98
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q715E9Q715_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l2
272Annotation score:
Q05CX5Q05CX5_MOUSE
Luc7l2 protein
Luc7l2
339Annotation score:
E0CZB9E0CZB9_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l2
99Annotation score:
E0CYQ8E0CYQ8_MOUSE
Putative RNA-binding protein Luc7-l...
Luc7l2
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147G → E in AAH56383 (PubMed:15489334).Curated1
Sequence conflicti245K → L in AAK01182 (Ref. 1) Curated1
Sequence conflicti259R → W in AAK01182 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010218260 – 269Missing in isoform 2 and isoform 4. 1 Publication10
Alternative sequenceiVSP_010219335S → Y in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_010220336 – 392Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318301 mRNA Translation: AAK01182.1
BC002314 mRNA Translation: AAH02314.1
BC056354 mRNA Translation: AAH56354.1
BC056383 mRNA Translation: AAH56383.1
BC056970 mRNA Translation: AAH56970.1
CCDSiCCDS20015.1 [Q7TNC4-1]
CCDS51751.1 [Q7TNC4-2]
RefSeqiNP_001164320.1, NM_001170849.2 [Q7TNC4-2]
NP_619621.2, NM_138680.3 [Q7TNC4-1]
UniGeneiMm.276133
Mm.479854
Mm.482221

Genome annotation databases

EnsembliENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823 [Q7TNC4-1]
ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823 [Q7TNC4-2]
GeneIDi192196
KEGGimmu:192196
UCSCiuc009bkl.2 mouse [Q7TNC4-2]
uc009bkm.2 mouse [Q7TNC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318301 mRNA Translation: AAK01182.1
BC002314 mRNA Translation: AAH02314.1
BC056354 mRNA Translation: AAH56354.1
BC056383 mRNA Translation: AAH56383.1
BC056970 mRNA Translation: AAH56970.1
CCDSiCCDS20015.1 [Q7TNC4-1]
CCDS51751.1 [Q7TNC4-2]
RefSeqiNP_001164320.1, NM_001170849.2 [Q7TNC4-2]
NP_619621.2, NM_138680.3 [Q7TNC4-1]
UniGeneiMm.276133
Mm.479854
Mm.482221

3D structure databases

ProteinModelPortaliQ7TNC4
SMRiQ7TNC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228673, 2 interactors
IntActiQ7TNC4, 4 interactors
MINTiQ7TNC4
STRINGi10090.ENSMUSP00000055254

PTM databases

iPTMnetiQ7TNC4
PhosphoSitePlusiQ7TNC4

Proteomic databases

PaxDbiQ7TNC4
PeptideAtlasiQ7TNC4
PRIDEiQ7TNC4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057692; ENSMUSP00000055254; ENSMUSG00000029823 [Q7TNC4-1]
ENSMUST00000161538; ENSMUSP00000124010; ENSMUSG00000029823 [Q7TNC4-2]
GeneIDi192196
KEGGimmu:192196
UCSCiuc009bkl.2 mouse [Q7TNC4-2]
uc009bkm.2 mouse [Q7TNC4-1]

Organism-specific databases

CTDi51631
MGIiMGI:2183260 Luc7l2

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiQ7TNC4
KOiK13212
OMAiNHFRDGG
OrthoDBiEOG091G0PSO
PhylomeDBiQ7TNC4
TreeFamiTF317607

Miscellaneous databases

ChiTaRSiLuc7l2 mouse
PROiPR:Q7TNC4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029823 Expressed in 280 organ(s), highest expression level in stria vascularis of cochlear duct
CleanExiMM_LUC7L2
ExpressionAtlasiQ7TNC4 baseline and differential
GenevisibleiQ7TNC4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLC7L2_MOUSE
AccessioniPrimary (citable) accession number: Q7TNC4
Secondary accession number(s): Q99LM5, Q99PC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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