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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Cytoplasmic polyadenylation element-binding protein 3

Gene

Cpeb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (PubMed:17024188, PubMed:26074072). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (PubMed:17024188). Required for the consolidation and maintenance of hippocampal-based long term memory (PubMed:26074003). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA1 and GRIA2 and negatively regulates their translation (PubMed:17024188, PubMed:22153079). Also represses the translation of DLG4, GRIN1 GRIN2A and GRIN2B (PubMed:24155305). When activated, acts as a translational activator of GRIA1 and GRIA2 (PubMed:22153079, PubMed:26074003). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (PubMed:26074071). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (PubMed:26915043). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (PubMed:26074072). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (By similarity). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (By similarity). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (By similarity).By similarity8 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei462Required for RNA-binding activityBy similarity1
Sitei506Required for RNA-binding activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor, RNA-binding
Biological processTranslation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 3
Short name:
CPE-BP3
Short name:
CPE-binding protein 3
Short name:
mCPEB-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cpeb3
Synonyms:Kiaa0940
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443075, Cpeb3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Enhanced thermal sensitivity and increased levels of Trpv1 in lumbar sciatic nerves and spinal cord (PubMed:26915043). Elevated short-term fear response, enhanced long-term spatial memory, dendritic spine enlargement and elevated levels of Dlg4/Psd95, Gria1 and NMDA receptor subunits Grin1, Grin2a and Grin2b (PubMed:26074071). Conditional knockout in the adult forebrain results in viable mice with no gross neurological defects which display normal locomotor, exploratory and anxiety behaviors but have impaired long-term memory, impaired long-term synaptic plasticity and increased levels of Gria1 and Gria2 (PubMed:26074003).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi419S → A: Abolishes phosphorylation by PKA. 1 Publication1
Mutagenesisi420S → A: Reduces phosphorylation by PKA. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002692621 – 716Cytoplasmic polyadenylation element-binding protein 3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei194PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei291Phosphoserine1 Publication1
Modified residuei309Asymmetric dimethylarginineCombined sources1
Modified residuei419Phosphoserine1 Publication1
Modified residuei420Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated by NEURL1-mediated monoubiquitination, resulting in the growth of new dendritic spines and increased levels of GRIA1 and GRIA2. NEURL1-mediated monoubiquitination facilitates synaptic plasticity and hippocampal-dependent memory storage.1 Publication
Under basal unstimulated conditions when CPEB3 is mainly unaggregated, sumoylated and acts as a translational repressor. Following neuronal stimulation, becomes desumoylated and aggregated which is required for the translation of mRNA targets and for dendritic filopodia formation.1 Publication
Following neuronal stimulation, cleaved by CAPN2 which abolishes its translational repressor activity, leading to translation of CPEB3 target mRNAs.1 Publication
Phosphorylation is enhanced by neuronal stimulation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei459 – 460Cleavage; by CAPN21 Publication2

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TN99

PeptideAtlas

More...
PeptideAtlasi
Q7TN99

PRoteomics IDEntifications database

More...
PRIDEi
Q7TN99

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TN99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7TN99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain (at protein level) (PubMed:17024188). In brain, expressed in the hippocampus, granule cells and interneurons of the cerebellum, and mitral cells of the olfactory bulb (at protein level) (PubMed:17024188). Detected in the spinal cord and in peripheral dorsal root ganglia (at protein level) (PubMed:26915043). In the retina, strongly expressed in the retinal ganglion layer and, to a lesser extent, in the inner margin of the inner nuclear layer with expression also detected in the inner and outer plexiform layers (at protein level) (PubMed:20003455). Highly expressed in brain and heart, less in liver, kidney, embryo, skeletal muscle, lung and ovary (PubMed:12871996). Weakly expressed in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus (PubMed:12871996).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the retina, expression increases throughout postnatal development and remains high in the adult (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated following synaptic activity (at protein level) (PubMed:26074003, PubMed:26074072). Up-regulated in granular cells of the dentate gyrus and the pyramidal cells of CA1 and CA3 after kainate-induced seizures (PubMed:12871996).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039652, Expressed in interventricular septum and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7TN99, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7TN99, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Following synaptic activity, aggregates to form amyloid-like oligomers (PubMed:26074003, PubMed:26074072). Aggregation requires an intact actin cytoskeleton (PubMed:26074072).

Interacts with STAT5B; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532).

Interacts with E3 ubiquitin-protein ligase NEURL1; this leads to monoubiquitination and activation of CPEB3 (PubMed:22153079).

Interacts with CAPN2; this leads to cleavage of CPEB3 (PubMed:22711986).

Interacts (via C-terminal RNA-binding region) with TOB1; TOB1 also binds CNOT7/CAF1 and recruits it to CPEB3 to form a ternary complex (By similarity).

Interacts with SUMO-conjugating enzyme UBC9 (PubMed:26074071).

Interacts with IPO5; the interaction is enhanced in a RAN-regulated manner following neuronal stimulation and mediates CPEB3 nuclear import (By similarity).

Interacts with exportin XPO1/CRM1 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
229024, 2 interactors

Protein interaction database and analysis system

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IntActi
Q7TN99, 3 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000118723

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q7TN99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7TN99

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini459 – 550RRM 1PROSITE-ProRule annotationAdd BLAST92
Domaini567 – 649RRM 2PROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 31Gln-richAdd BLAST19
Compositional biasi32 – 202Pro-richAdd BLAST171
Compositional biasi226 – 236Poly-AlaAdd BLAST11

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal Gln-rich region is required for the formation of amyloid-like oligomers and for the stability of long-term potentiation and spatial memory.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM CPEB family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0129, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158949

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7TN99

KEGG Orthology (KO)

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KOi
K02602

Database of Orthologous Groups

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OrthoDBi
1075356at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7TN99

TreeFam database of animal gene trees

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TreeFami
TF317658

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.130, 1 hit
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032296, CEBP_ZZ
IPR038446, CEBP_ZZ_sf
IPR034819, CPEB
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR12566, PTHR12566, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16366, CEBP_ZZ, 1 hit
PF16367, RRM_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TN99-1) [UniParc]FASTAAdd to basket
Also known as: mCPEB-3a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQDDLLMDKS KTQPQSQQQQ RQQQQQQQQL QPEPGAAEAP STPLSSEIPK
60 70 80 90 100
PEDSSAVPAL SPASAPPAPN GPDKMQMESP LLPGLSFHQP PQQPPPPQEP
110 120 130 140 150
TAPGASLSPS FGSTWSTGTT NAVEDSFFQG ITPVNGTMLF QNFPHHVNPV
160 170 180 190 200
FGGTFSPQIG LAQTQHHQQP PPPAPQPPQP AQPPQAQPSQ QRRSPASPSQ
210 220 230 240 250
APYAQRSAAA YGHQPIMTSK PSSSSAVAAA AAAAAASSAS SSWNTHQSVN
260 270 280 290 300
AAWSAPSNPW GGLQAGRDPR RAVGVGVGVG VGVPSPLNPI SPLKKPFSSN
310 320 330 340 350
VIAPPKFPRA APLTSKSWME DNAFRTDNGN NLLPFQDRSR PYDTFNLHSL
360 370 380 390 400
ENSLMDMIRT DHEPLKGKHY PNSGPPMSFA DIMWRNHFAG RMGINFHHPG
410 420 430 440 450
TDNIMALNTR SYGRRRGRSS LFPFEDAFLD DSHGDQALSS GLSSPTRCQN
460 470 480 490 500
GERVERYSRK VFVGGLPPDI DEDEITASFR RFGPLVVDWP HKAESKSYFP
510 520 530 540 550
PKGYAFLLFQ EESSVQALID ACLEEDGKLY LCVSSPTIKD KPVQIRPWNL
560 570 580 590 600
SDSDFVMDGS QPLDPRKTIF VGGVPRPLRA VELAMIMDRL YGGVCYAGID
610 620 630 640 650
TDPELKYPKG AGRVAFSNQQ SYIAAISARF VQLQHNDIDK RVEVKPYVLD
660 670 680 690 700
DQMCDECQGT RCGGKFAPFF CANVTCLQYY CEYCWASIHS RAGREFHKPL
710
VKEGGDRPRH VPFRWS
Length:716
Mass (Da):78,335
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FA1D8125FD69819
GO
Isoform 2 (identifier: Q7TN99-2) [UniParc]FASTAAdd to basket
Also known as: mCPEB-3b

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.

Show »
Length:708
Mass (Da):77,302
Checksum:i44921082F8A1AEAC
GO
Isoform 3 (identifier: Q7TN99-3) [UniParc]FASTAAdd to basket
Also known as: mCPEB-3c

The sequence of this isoform differs from the canonical sequence as follows:
     367-389: Missing.

Show »
Length:693
Mass (Da):75,692
Checksum:i8DF1697A5BAEF6AF
GO
Isoform 4 (identifier: Q7TN99-4) [UniParc]FASTAAdd to basket
Also known as: mCPEB-3d

The sequence of this isoform differs from the canonical sequence as follows:
     367-389: Missing.
     409-416: Missing.

Show »
Length:685
Mass (Da):74,659
Checksum:i088EA7D992502AFD
GO
Isoform 5 (identifier: Q7TN99-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-389: Missing.
     581-584: VELA → GEWK
     585-716: Missing.

Show »
Length:561
Mass (Da):60,702
Checksum:iDB0FAD814A67D91E
GO
Isoform 6 (identifier: Q7TN99-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     367-389: Missing.

Show »
Length:477
Mass (Da):52,690
Checksum:i3B60E9638C701797
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J102A0A0R4J102_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
716Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z1R6D3Z1R6_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5R9D3Z5R9_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
699Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3Z5D3Z3Z5_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5F3D3Z5F3_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUL6D3YUL6_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXB8D3YXB8_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T0J8F6T0J8_MOUSE
Cytoplasmic polyadenylation element...
Cpeb3
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC41458 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti372N → P in BAE27791 (PubMed:16141072).Curated1
Sequence conflicti372N → P in BAC41458 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0585651 – 216Missing in isoform 6. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_022036367 – 389Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_022037409 – 416Missing in isoform 2 and isoform 4. 1 Publication8
Alternative sequenceiVSP_022038581 – 584VELA → GEWK in isoform 5. 1 Publication4
Alternative sequenceiVSP_022039585 – 716Missing in isoform 5. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY313774 mRNA Translation: AAQ20843.1
AK147243 mRNA Translation: BAE27791.1
AK161513 mRNA Translation: BAE36436.1
AB093274 mRNA Translation: BAC41458.1 Different initiation.
BC128377 mRNA Translation: AAI28378.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29775.1 [Q7TN99-1]
CCDS70946.1 [Q7TN99-4]
CCDS70947.1 [Q7TN99-3]

NCBI Reference Sequences

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RefSeqi
NP_001277755.1, NM_001290826.1
NP_001277756.1, NM_001290827.1
NP_001277757.1, NM_001290828.1 [Q7TN99-3]
NP_001277758.1, NM_001290829.1
NP_938042.2, NM_198300.3
XP_006526892.1, XM_006526829.3
XP_006526893.1, XM_006526830.3
XP_006526894.1, XM_006526831.3
XP_006526895.1, XM_006526832.3
XP_006526896.1, XM_006526833.3
XP_006526897.1, XM_006526834.2
XP_006526902.1, XM_006526839.3
XP_011245510.1, XM_011247208.1 [Q7TN99-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000126188; ENSMUSP00000120416; ENSMUSG00000039652 [Q7TN99-3]
ENSMUST00000126781; ENSMUSP00000122442; ENSMUSG00000039652 [Q7TN99-5]
ENSMUST00000213231; ENSMUSP00000151042; ENSMUSG00000111861 [Q7TN99-3]
ENSMUST00000214706; ENSMUSP00000150033; ENSMUSG00000111861 [Q7TN99-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
208922

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:208922

UCSC genome browser

More...
UCSCi
uc008hhz.2, mouse [Q7TN99-1]
uc008hia.2, mouse [Q7TN99-3]
uc008hic.2, mouse [Q7TN99-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313774 mRNA Translation: AAQ20843.1
AK147243 mRNA Translation: BAE27791.1
AK161513 mRNA Translation: BAE36436.1
AB093274 mRNA Translation: BAC41458.1 Different initiation.
BC128377 mRNA Translation: AAI28378.1
CCDSiCCDS29775.1 [Q7TN99-1]
CCDS70946.1 [Q7TN99-4]
CCDS70947.1 [Q7TN99-3]
RefSeqiNP_001277755.1, NM_001290826.1
NP_001277756.1, NM_001290827.1
NP_001277757.1, NM_001290828.1 [Q7TN99-3]
NP_001277758.1, NM_001290829.1
NP_938042.2, NM_198300.3
XP_006526892.1, XM_006526829.3
XP_006526893.1, XM_006526830.3
XP_006526894.1, XM_006526831.3
XP_006526895.1, XM_006526832.3
XP_006526896.1, XM_006526833.3
XP_006526897.1, XM_006526834.2
XP_006526902.1, XM_006526839.3
XP_011245510.1, XM_011247208.1 [Q7TN99-3]

3D structure databases

SMRiQ7TN99
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229024, 2 interactors
IntActiQ7TN99, 3 interactors
STRINGi10090.ENSMUSP00000118723

PTM databases

iPTMnetiQ7TN99
PhosphoSitePlusiQ7TN99

Proteomic databases

PaxDbiQ7TN99
PeptideAtlasiQ7TN99
PRIDEiQ7TN99

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30391, 115 antibodies

Genome annotation databases

EnsembliENSMUST00000126188; ENSMUSP00000120416; ENSMUSG00000039652 [Q7TN99-3]
ENSMUST00000126781; ENSMUSP00000122442; ENSMUSG00000039652 [Q7TN99-5]
ENSMUST00000213231; ENSMUSP00000151042; ENSMUSG00000111861 [Q7TN99-3]
ENSMUST00000214706; ENSMUSP00000150033; ENSMUSG00000111861 [Q7TN99-5]
GeneIDi208922
KEGGimmu:208922
UCSCiuc008hhz.2, mouse [Q7TN99-1]
uc008hia.2, mouse [Q7TN99-3]
uc008hic.2, mouse [Q7TN99-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22849
MGIiMGI:2443075, Cpeb3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0129, Eukaryota
GeneTreeiENSGT00940000158949
InParanoidiQ7TN99
KOiK02602
OrthoDBi1075356at2759
PhylomeDBiQ7TN99
TreeFamiTF317658

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
208922, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cpeb3, mouse

Protein Ontology

More...
PROi
PR:Q7TN99
RNActiQ7TN99, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039652, Expressed in interventricular septum and 257 other tissues
ExpressionAtlasiQ7TN99, baseline and differential
GenevisibleiQ7TN99, MM

Family and domain databases

Gene3Di3.30.40.130, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR032296, CEBP_ZZ
IPR038446, CEBP_ZZ_sf
IPR034819, CPEB
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PANTHERiPTHR12566, PTHR12566, 1 hit
PfamiView protein in Pfam
PF16366, CEBP_ZZ, 1 hit
PF16367, RRM_7, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPEB3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TN99
Secondary accession number(s): A1A562
, Q3TT89, Q3UHR6, Q8CHC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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