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Entry version 123 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Polycystic kidney disease protein 1-like 2

Gene

Pkd1l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 2
Alternative name(s):
PC1-like 2 protein
Polycystin-1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1l2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2664668, Pkd1l2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1346 – 1366HelicalSequence analysisAdd BLAST21
Transmembranei1554 – 1574HelicalSequence analysisAdd BLAST21
Transmembranei1596 – 1616HelicalSequence analysisAdd BLAST21
Transmembranei1816 – 1836HelicalSequence analysisAdd BLAST21
Transmembranei1863 – 1883HelicalSequence analysisAdd BLAST21
Transmembranei1940 – 1960HelicalSequence analysisAdd BLAST21
Transmembranei2186 – 2206HelicalSequence analysisAdd BLAST21
Transmembranei2222 – 2242HelicalSequence analysisAdd BLAST21
Transmembranei2273 – 2293HelicalSequence analysisAdd BLAST21
Transmembranei2315 – 2335HelicalSequence analysisAdd BLAST21
Transmembranei2380 – 2400HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032257719 – 2461Polycystic kidney disease protein 1-like 2Add BLAST2443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 151By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 143By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1187N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TN88

PRoteomics IDEntifications database

More...
PRIDEi
Q7TN88

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7TN88, 11 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TN88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TN88

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact via its C-terminus with GNAS and GNAI1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TN88, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TN88

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 152C-type lectinPROSITE-ProRule annotationAdd BLAST120
Domaini160 – 251SUEL-type lectinPROSITE-ProRule annotationAdd BLAST92
Domaini255 – 346PKDAdd BLAST92
Domaini424 – 1125REJPROSITE-ProRule annotationAdd BLAST702
Domaini1280 – 1329GPSPROSITE-ProRule annotationAdd BLAST50
Domaini1391 – 1508PLATPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2381 – 2461Interaction with GNAS and GNAI1By similarityAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2103 – 2106Poly-Gly4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TN88

KEGG Orthology (KO)

More...
KOi
K04988

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TN88

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752, PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000203, GPS
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR003915, PKD_2
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF00059, Lectin_C, 1 hit
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01433, POLYCYSTIN2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 1 hit
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 1 hit
SSF49723, SSF49723, 1 hit
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS50221, GPS, 1 hit
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit
PS50228, SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7TN88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLVFLGLA LSSGATVAKS EGGSLCSRSQ VFFRDACYEF VPLEHTFPGA
60 70 80 90 100
QGWCEGHGGH LAFIPDEDTQ QFLQRHITQD REWWIGLTGG SGHNGTVGGS
110 120 130 140 150
GTWLDTSNVN YSNWQEGQAT PAPGSCGYIG SGPSSQWAAL EDCTQTFAFV
160 170 180 190 200
CEFGVGRSLA CEGHNATMHC DSGEVILVQD AFYGHQTPYL CTRGIWPPSD
210 220 230 240 250
LEGECGWVSV KDEVAGQCQG LQACQVAVDG TYFGDPCPTR GSYLWVQYQC
260 270 280 290 300
LEGLRLVVPN GSFIFDNVTI SLMWLLSPYT GNLSCVLSMG DGYTFDPYNP
310 320 330 340 350
PSVSSNVTHQ FSSPGEFTVF AECTTSEWHV TAQKQVILCE KVETPRITGC
360 370 380 390 400
TGLAGAGVGL LCQAVFGEPL WVQVDLDGGA GATYAVLSHN RTLAEFTAQR
410 420 430 440 450
GSQLYNLTLD RDIQEMLGPG RHHLKIQAVS NEGTGTASAP SGNFTVYFVE
460 470 480 490 500
PLSGLRASWA SDRVELGWDL VVNVSVARGT LEELTFEVAG LNANFSQEEE
510 520 530 540 550
SVGQSSGNYH VAVPAEGTFL VTVHVRNAFS ELSLDIGNIT VTASSSLQEL
560 570 580 590 600
SGINAEAKSG HKQDMKVFTE PELYVDPFTE VTLGWPDDDP GLNFHWSCGR
610 620 630 640 650
CWAQWNACVG RQLLHTDQRL LVLHTFCLPP LNSAVTLHLA ILRGQELEKE
660 670 680 690 700
TEQCLYVSAP LNLGPQISCE KNCRPVKADQ DVLLTVTVGD ETSVAVFSWY
710 720 730 740 750
LDDTVPEEVE PLPAACRLRG FWPRSLTLLH SNSSVLLLNS SFLQTWGPVI
760 770 780 790 800
PIRVTALTSH AYGEDTYMIS MLPRPEVPAC TIDPEEGSVL TSFTVSCSTP
810 820 830 840 850
ATLGPVEYCF CLPSGFCLHC GPEPALPAVY LPLGEEKDGF VLPVVISVTN
860 870 880 890 900
RAGDIEQTQV AVKVGHSYTG VEDVTFQEMV SERIATALHQ ESGREQLLLF
910 920 930 940 950
AKAVSSELNS EVQSPGSGQL GMDIKRKVRE LMLRSLSVVT TGLQNMQRVQ
960 970 980 990 1000
ALAEVLREVT QRAEELTPAA QWEASCALQR ATEALLVAST KVRPEDQRRQ
1010 1020 1030 1040 1050
EATRAMFEAV GSVLEASLSH RSEEPMEANS SQVAYIVAQL LRVIDHFQSA
1060 1070 1080 1090 1100
LLLGTLPGGL PAILVTPSIS VYTDRIQPRS WQGSSVHTAA ADSVTFTLPA
1110 1120 1130 1140 1150
ATFLCPMEDS QEPVDIRMMS FSQNPFPSRS QFDVSGTVGG LRLTSSSGHP
1160 1170 1180 1190 1200
IPVKNLSQNI EILLPRISAH IEPKMLSLAS REALSVNVTA GDTALGIQLH
1210 1220 1230 1240 1250
WGPGVPLILS LGYGYHPNET SYDAQTHLPP VAATGDLPTW ILHPEDLPFG
1260 1270 1280 1290 1300
EGVYYLRVVP EADLESSSGR NLTVGITTFL AHCVFWDETQ ETWDDSGCQV
1310 1320 1330 1340 1350
GPRTTPSQTH CLCNHLTFFG SSFLVMPNAI DVRQTAELFA TFEDNPVVVT
1360 1370 1380 1390 1400
TVGCLCMLYV LVLIWARRKD IQDQAKVKVV VLEDNDPFAQ YHYLVTVYTG
1410 1420 1430 1440 1450
HRRGAATSSK VTLTLYGSDG ESEPHHLSDP DAAVFERGGV DVFLLSTLFP
1460 1470 1480 1490 1500
LGELQSLRLW HDNSGDRPSW YVSRVLVYDS VVDRKWYFLC NSWLSVDVGD
1510 1520 1530 1540 1550
CVLDKVFPVA TEQDRKQFSH LFFTKTSTGF QDGHIWYSVF CSATRSSFTR
1560 1570 1580 1590 1600
VQRVSCCFSM LLCTMLTSIM FWGVPKDPAE QKMDLGKIEF TWQEVMIGLE
1610 1620 1630 1640 1650
SSILMFPINL LIVQIFRNTR PRLPMGKDGR QKQGPPNLTP SAQPTEEGLL
1660 1670 1680 1690 1700
TPETGIQSLI SSLFKALKVQ PPASGWDSMN PVDINYLLTL MEDIICPEST
1710 1720 1730 1740 1750
EGPGFWEEAK GREDPITSTR GSVKPKENTW HPKPELAVRG LWKDSVYRRC
1760 1770 1780 1790 1800
LYLQLEHVER ELQLLGPQGF LHHHSHAQAL RQLHVLKGHL WGQPGTPALA
1810 1820 1830 1840 1850
YPSTSRVSKS PRGLPWWCVL VGWLLVATTS GVAAFFTMLY GLHYGRVSSL
1860 1870 1880 1890 1900
KWLISMAVSF VESVFITQPL KVLGFAAFFA LVLKREDDEE TLPLFPGHLS
1910 1920 1930 1940 1950
SPGPGVLFRS RRHSSERAYQ PPPMAAIEKM KTTRLKEQKA FALIREILAY
1960 1970 1980 1990 2000
LAFLWMLLLV AYGQRDPNAY HFHRHLERSF SQGFSPVLGF RGFFEWANTT
2010 2020 2030 2040 2050
LVKNLYGHHP GFVTDGNSKL VGSAHIRQVR VRESSCAVAQ QLQDSLDGCH
2060 2070 2080 2090 2100
GPYSLGIEDL VDYGEGWNAS AYNNSNGFPQ AWRYQSQSQR RGYPMWGKLT
2110 2120 2130 2140 2150
LYGGGGYVVP LGTDHQSASR ILQYLFDNSW LDALTRAVFV EFTVYNANVN
2160 2170 2180 2190 2200
LFCTVTLTLE TSGLGTFFSH VTLQSLRLYP FTDGWHPFVV AAELTYFLFL
2210 2220 2230 2240 2250
FYYMVVQGKL MRKQKWGYFC SKWNLLEVAI ILASWSALVV FVKRTILADR
2260 2270 2280 2290 2300
DLQRYREHRE GISFSETAAA DAALGYIIAF LVLLSTVKLW HLLRLNPKMN
2310 2320 2330 2340 2350
MITSALRRAW GDISGFVAVI LIMLLAYSFA SNLVFGWKLR SYKTLFDAAE
2360 2370 2380 2390 2400
TMVSLQLGIF NYEEVLDYSP ILGSLLIGSC IVFMTFVVLN LFISVILVAF
2410 2420 2430 2440 2450
SEEQKSDQLS EEGEIADLLL VKILSFLGIR CKREETWSSS EQPELPPQAL
2460
APQPAQALSR V
Length:2,461
Mass (Da):271,977
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F837EBA57D54BF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4D4E9Q4D4_MOUSE
Polycystic kidney disease protein 1...
Pkd1l2
2,461Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QPG2E9QPG2_MOUSE
Polycystic kidney disease protein 1...
Pkd1l2
2,462Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY164484 mRNA Translation: AAO32797.1

NCBI Reference Sequences

More...
RefSeqi
NP_083962.4, NM_029686.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76645

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76645

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164484 mRNA Translation: AAO32797.1
RefSeqiNP_083962.4, NM_029686.4

3D structure databases

SMRiQ7TN88
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104721

PTM databases

GlyGeniQ7TN88, 11 sites
iPTMnetiQ7TN88
PhosphoSitePlusiQ7TN88

Proteomic databases

PaxDbiQ7TN88
PRIDEiQ7TN88

Genome annotation databases

GeneIDi76645
KEGGimmu:76645

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114780
MGIiMGI:2664668, Pkd1l2

Phylogenomic databases

eggNOGiKOG3599, Eukaryota
InParanoidiQ7TN88
KOiK04988
OrthoDBi1276906at2759
PhylomeDBiQ7TN88

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
76645, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pkd1l2, mouse

Protein Ontology

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PROi
PR:Q7TN88
RNActiQ7TN88, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

CDDicd01752, PLAT_polycystin, 1 hit
Gene3Di2.60.120.740, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000203, GPS
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR003915, PKD_2
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom
PfamiView protein in Pfam
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF00059, Lectin_C, 1 hit
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
PRINTSiPR01433, POLYCYSTIN2
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SUPFAMiSSF49299, SSF49299, 1 hit
SSF49723, SSF49723, 1 hit
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS50221, GPS, 1 hit
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit
PS50228, SUEL_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK1L2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TN88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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