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Protein

Synaptotagmin-14

Gene

Syt14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

GO - Molecular functioni

  • phospholipid binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-14
Alternative name(s):
Synaptotagmin XIV
Short name:
SytXIV
Gene namesi
Name:Syt14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444490 Syt14

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 47Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST23
Topological domaini48 – 555CytoplasmicSequence analysisAdd BLAST508

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839791 – 555Synaptotagmin-14Add BLAST555

Proteomic databases

PaxDbiQ7TN84
PRIDEiQ7TN84

PTM databases

iPTMnetiQ7TN84
PhosphoSitePlusiQ7TN84

Expressioni

Tissue specificityi

Expressed in heart and testis. Expressed in brain (especially in the cerebellum).2 Publications

Gene expression databases

BgeeiENSMUSG00000016200 Expressed in 163 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_SYT14
ExpressionAtlasiQ7TN84 baseline and differential
GenevisibleiQ7TN84 MM

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016344

Structurei

3D structure databases

ProteinModelPortaliQ7TN84
SMRiQ7TN84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 378C2 1PROSITE-ProRule annotationAdd BLAST103
Domaini417 – 521C2 2PROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3J Eukaryota
ENOG41117JG LUCA
GeneTreeiENSGT00920000148994
HOVERGENiHBG062897
InParanoidiQ7TN84
KOiK19328
PhylomeDBiQ7TN84
TreeFamiTF351132

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028696 SYT14
PANTHERiPTHR10024:SF209 PTHR10024:SF209, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q7TN84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIVLML LLFLYINKKF
60 70 80 90 100
CFENVGGFPD LGSGYNTRTN SQDKMYNSYM DRDEPGSSSE SEDEALGKYH
110 120 130 140 150
EALSRTHNSR WPLVDSRQKS YAWETRQKYS PLSAEYDGYS TEASMEDGNC
160 170 180 190 200
IQRMRRTPPL DELQPPPYQD DSGSPHLSCT PSEIGDAKCE ISHCSNSPRC
210 220 230 240 250
SFNKCPSEGS TGHEAESYHN KGYEDDVPSD STAVLSPEDM SAQGSSSQLP
260 270 280 290 300
KPFDPEPEAK YGTLDVTFDY DSERQKLLVT VTAVTDIPTY NRTGGNSWQV
310 320 330 340 350
HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV
360 370 380 390 400
HRMKKEKIVG EKIFYLTKLN LQGKMSLPVI LEPSYNPSGC DSQVSLSEAS
410 420 430 440 450
CGDSTSSCQS LQHGSVPEIL IGLLYNATTG RLSAEVIKGS HFKNLAANRP
460 470 480 490 500
PNTYVKLTLL NSMGQEMSKC KTSTRRGQPN PVYKETFVFQ VALFQLSDVT
510 520 530 540 550
LILSVYNRRS MKRKEMIGWI SLGLNSSGEE ELRHWTAMKE SKGQQVCRWH

ALLES
Length:555
Mass (Da):62,044
Last modified:October 1, 2003 - v1
Checksum:i7728CA866BFBA84E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZP31B7ZP31_MOUSE
Synaptotagmin-14
Syt14
574Annotation score:
A0A0A6YWI3A0A0A6YWI3_MOUSE
Synaptotagmin-14
Syt14
77Annotation score:
A0A1L1SVE7A0A1L1SVE7_MOUSE
Synaptotagmin-14
Syt14
838Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102947 mRNA Translation: BAC76808.1
CCDSiCCDS48489.1
RefSeqiNP_853524.1, NM_181546.3
UniGeneiMm.170401
Mm.76710

Genome annotation databases

EnsembliENSMUST00000195354; ENSMUSP00000142190; ENSMUSG00000016200
GeneIDi329324
KEGGimmu:329324
UCSCiuc007edu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102947 mRNA Translation: BAC76808.1
CCDSiCCDS48489.1
RefSeqiNP_853524.1, NM_181546.3
UniGeneiMm.170401
Mm.76710

3D structure databases

ProteinModelPortaliQ7TN84
SMRiQ7TN84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016344

PTM databases

iPTMnetiQ7TN84
PhosphoSitePlusiQ7TN84

Proteomic databases

PaxDbiQ7TN84
PRIDEiQ7TN84

Protocols and materials databases

DNASUi329324
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000195354; ENSMUSP00000142190; ENSMUSG00000016200
GeneIDi329324
KEGGimmu:329324
UCSCiuc007edu.2 mouse

Organism-specific databases

CTDi255928
MGIiMGI:2444490 Syt14

Phylogenomic databases

eggNOGiENOG410IT3J Eukaryota
ENOG41117JG LUCA
GeneTreeiENSGT00920000148994
HOVERGENiHBG062897
InParanoidiQ7TN84
KOiK19328
PhylomeDBiQ7TN84
TreeFamiTF351132

Miscellaneous databases

PROiPR:Q7TN84
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016200 Expressed in 163 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_SYT14
ExpressionAtlasiQ7TN84 baseline and differential
GenevisibleiQ7TN84 MM

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028696 SYT14
PANTHERiPTHR10024:SF209 PTHR10024:SF209, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYT14_MOUSE
AccessioniPrimary (citable) accession number: Q7TN84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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