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Entry version 116 (31 Jul 2019)
Sequence version 2 (18 Mar 2008)
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Protein

Retrotransposon-derived protein PEG10

Gene

Peg10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.By similarity1 Publication

Miscellaneous

The PEG10 locus is imprinted, giving rise to paternally expressed proteins.
The PEG10 gene can be a target for epigenetic repression, either with or without a gain of promoter methylation, in some of the mammary carcinomas of a c-MCY-driven transgenic model.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri344 – 361CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Differentiation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon-derived protein PEG10
Alternative name(s):
Embryonal carcinoma differentiation regulated protein
Mammalian retrotransposon-derived protein 2
Myelin expression factor 3
Short name:
MyEF-3
Myelin expression factor 3-like protein 1
Short name:
MEF3-like protein 1
Paternally expressed gene 10 protein
Retrotransposon gag domain-containing protein 3
Retrotransposon-derived gag-like polyprotein
Ty3/Gypsy-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Peg10
Synonyms:Edr, Mar2, Mart2, Mef3l1, Rgag3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2157785 Peg10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality resulting from placental defects.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003230271 – 958Retrotransposon-derived protein PEG10Add BLAST958

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei753Omega-N-methylarginineCombined sources1
Modified residuei844Omega-N-methylarginineCombined sources1
Modified residuei857Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: Q7TN75-2)
Modified residuei367PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 undergoes proteolytic cleavage.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TN75

PRoteomics IDEntifications database

More...
PRIDEi
Q7TN75

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TN75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TN75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and testis. Expressed during the early process of adipocyte differentiation. Expressed weakly in mammary gland but strongly in breast carcinomas of a c-MCY-driven transgenic model.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo, placenta and amniotic membrane at 10.5 dpc. Expressed in placenta at 9.5 dpc and appeared to increase as gestation progresses peaking around 12.5 and 15.5 dpc (at protein level). Expressed in embryo at 9.5, 12.5 and 16.5 dpc. Expressed in developing musculo-skeletal system, during skeletal myogenesis and also in precartilage primordia and derivative chondrogenic cells of the developing skeleton. Expressed in mesenchymal tissues of developing lung, kidney, gonad, gut and placenta. Not expressed at stages of chondrocyte hypertrophy and ossification of bones. Expressed in all extraembryonic tissues at 9.5 and 12.5 dpc and low-level expression in the embryonic brain and vertebral cartilage at 12.5 dpc.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by MYC and during adipocyte differentiation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000092035 Expressed in 107 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7TN75 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TN75 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ALK1, SIAH1 and SIAH2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228380, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q7TN75, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127306

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TN75

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 326Necessary for interaction with ALK1By similarityAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 34Pro-richAdd BLAST24
Compositional biasi35 – 146Asp-richAdd BLAST112
Compositional biasi545 – 733His-richAdd BLAST189
Compositional biasi926 – 951Pro-richAdd BLAST26

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri344 – 361CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183173

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TN75

Database of Orthologous Groups

More...
OrthoDBi
583605at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032567 LDOC1-rel
IPR021109 Peptidase_aspartic_dom_sf
IPR005162 Retrotrans_gag_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15503 PTHR15503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03732 Retrotrans_gag, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Note: The ribosomal frameshifting efficiency shows an apparent decrease from 68% at 9.5 dpc to 43% by 21.5 dpc during placenta gestation of isoform 1 compared to isoform 2.2 Publications

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TN75-1) [UniParc]FASTAAdd to basket
Also known as: RF1/RF2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGGSSNC PPPPPPPPPN NNNNNNTPKS PGVPDAEDDD ERRHDELPED
60 70 80 90 100
INNFDEDMNR QFENMNLLDQ VELLAQSYSL LDHLDDFDDD DEDDDFDPEP
110 120 130 140 150
DQDELPEYSD DDDLELQGAA AAPIPNFFSD DDCLEDLPEK FDGNPDMLGP
160 170 180 190 200
FMYQCQLFME KSTRDFSVDR IRVCFVTSML IGRAARWATA KLQRCTYLMH
210 220 230 240 250
NYTAFMMELK HVFEDPQRRE AAKRKIRRLR QGPGPVVDYS NAFQMIAQDL
260 270 280 290 300
DWTEPALMDQ FQEGLNPDIR AELSRQEAPK TLAALITACI HIERRLARDA
310 320 330 340 350
AAKPDPSPRA LVMPPNSQTD PTEPVGGARM RLSKEEKERR RKMNLCLYCG
360 370 380 390 400
NGGHFADTCP AKASKNSPPG KLPGPAVGGP SATGPERIRS PPSEASTQHL
410 420 430 440 450
QVMLQIHMPG RPTLFVRAMI DSGASGNFID QDFVIQNAIP LRIKDWPVMV
460 470 480 490 500
EAIDGHPIAS GPIILETHHL IVDLGDHREI LSFDVTQSPF FPIVLGIRWL
510 520 530 540 550
STHDPHITWS TRSIVFNSDY CRLRCRMFAQ IPSNLLFTVP QPNLHPYLLH
560 570 580 590 600
HVHPHVHPHM HQHLHQHLHQ FLHPDPHQYP HPDPHYHHHQ QADMQHQLQQ
610 620 630 640 650
YLYQYLYYHL YPVMHHHLPP DQHEHLHEYL HQYLHQYLHQ FLHHHLHPDL
660 670 680 690 700
HQYLYQYLHN HMNPDPHHHP HPDPPQDPHH PPHQDPHQHP DPHQDPPHQD
710 720 730 740 750
PHQDAHQDPH MDPHLHQHQH PQPQPHPQQH PNHPQQPPFF YHMAGFRIYH
760 770 780 790 800
PVRYYYIQNV YTPVDEHVYP GHRVVDPNIE MIPGAHSLPS GHLYSMSESE
810 820 830 840 850
MNALRNFVDR NVKDGLMTPT VAPNGAQVLQ VKRGWKLQVT YNCRAPQSGT
860 870 880 890 900
IQNQYLRMSL PNMGDPAHLA SYGEFVQVPG YPYPAYVYYT SPHMMTAWYP
910 920 930 940 950
VGRDVHGRII VVPVVITWSQ NTNRQPPVPQ YPPPQPPPPP PPPPPPPPPP

PASSCSAA
Note: Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-370 and Lys-371.
Length:958
Mass (Da):109,849
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65BA9B1B6714FE14
GO
Isoform 2 (identifier: Q7TN75-2) [UniParc]FASTAAdd to basket
Also known as: RF1

The sequence of this isoform differs from the canonical sequence as follows:
     371-376: KLPGPA → NSPAPL
     377-958: Missing.

Note: Produced by conventional translation.Combined sources
Show »
Length:376
Mass (Da):42,328
Checksum:i901A5E8275AF611E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3F7E9Q3F7_MOUSE
Retrotransposon-derived protein PEG...
Peg10
1,005Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJQ1H3BJQ1_MOUSE
Retrotransposon-derived protein PEG...
Peg10
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132D → G (PubMed:9473521).Curated1
Sequence conflicti185 – 231ARWAT…RRLRQ → PLGYCQAAKMYLPDAQLHCL YDGAEAVLVRPSESVSVQTQ DQTSAP (PubMed:9473521).CuratedAdd BLAST47
Sequence conflicti660 – 661NH → TI (PubMed:11158386).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032009371 – 376KLPGPA → NSPAPL in isoform 2. Curated6
Alternative sequenceiVSP_032010377 – 958Missing in isoform 2. CuratedAdd BLAST582

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB091827 mRNA Translation: BAC77244.1
AC084315 Genomic DNA No translation available.
AF302691 Genomic DNA Translation: AAG39979.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57407.1 [Q7TN75-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035701.1, NM_001040611.1 [Q7TN75-2]
NP_570947.2, NM_130877.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000176204; ENSMUSP00000134963; ENSMUSG00000092035 [Q7TN75-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:170676

UCSC genome browser

More...
UCSCi
uc033iob.1 mouse [Q7TN75-2]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091827 mRNA Translation: BAC77244.1
AC084315 Genomic DNA No translation available.
AF302691 Genomic DNA Translation: AAG39979.1
CCDSiCCDS57407.1 [Q7TN75-2]
RefSeqiNP_001035701.1, NM_001040611.1 [Q7TN75-2]
NP_570947.2, NM_130877.2

3D structure databases

SMRiQ7TN75
ModBaseiSearch...

Protein-protein interaction databases

BioGridi228380, 1 interactor
IntActiQ7TN75, 2 interactors
STRINGi10090.ENSMUSP00000127306

PTM databases

iPTMnetiQ7TN75
PhosphoSitePlusiQ7TN75

Proteomic databases

PaxDbiQ7TN75
PRIDEiQ7TN75

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
170676
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000176204; ENSMUSP00000134963; ENSMUSG00000092035 [Q7TN75-2]
GeneIDi170676
KEGGimmu:170676
UCSCiuc033iob.1 mouse [Q7TN75-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23089
MGIiMGI:2157785 Peg10

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00950000183173
InParanoidiQ7TN75
OrthoDBi583605at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:Q7TN75

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000092035 Expressed in 107 organ(s), highest expression level in heart
ExpressionAtlasiQ7TN75 baseline and differential
GenevisibleiQ7TN75 MM

Family and domain databases

Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR032567 LDOC1-rel
IPR021109 Peptidase_aspartic_dom_sf
IPR005162 Retrotrans_gag_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF03732 Retrotrans_gag, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEG10_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TN75
Secondary accession number(s): Q9EQ11
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 31, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome, Transposable element

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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