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Protein

Retrotransposon-derived protein PEG10

Gene

Peg10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.By similarity1 Publication

Miscellaneous

The PEG10 locus is imprinted, giving rise to paternally expressed proteins.
The PEG10 gene can be a target for epigenetic repression, either with or without a gain of promoter methylation, in some of the mammary carcinomas of a c-MCY-driven transgenic model.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri344 – 361CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Differentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon-derived protein PEG10
Alternative name(s):
Embryonal carcinoma differentiation regulated protein
Mammalian retrotransposon-derived protein 2
Myelin expression factor 3
Short name:
MyEF-3
Myelin expression factor 3-like protein 1
Short name:
MEF3-like protein 1
Paternally expressed gene 10 protein
Retrotransposon gag domain-containing protein 3
Retrotransposon-derived gag-like polyprotein
Ty3/Gypsy-like protein
Gene namesi
Name:Peg10
Synonyms:Edr, Mar2, Mart2, Mef3l1, Rgag3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2157785 Peg10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality resulting from placental defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230271 – 958Retrotransposon-derived protein PEG10Add BLAST958

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei753Omega-N-methylarginineCombined sources1
Modified residuei844Omega-N-methylarginineCombined sources1
Modified residuei857Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: Q7TN75-2)
Modified residuei367PhosphoserineCombined sources1

Post-translational modificationi

Isoform 1 undergoes proteolytic cleavage.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TN75
PRIDEiQ7TN75

PTM databases

iPTMnetiQ7TN75
PhosphoSitePlusiQ7TN75

Expressioni

Tissue specificityi

Expressed in brain and testis. Expressed during the early process of adipocyte differentiation. Expressed weakly in mammary gland but strongly in breast carcinomas of a c-MCY-driven transgenic model.3 Publications

Developmental stagei

Expressed in embryo, placenta and amniotic membrane at 10.5 dpc. Expressed in placenta at 9.5 dpc and appeared to increase as gestation progresses peaking around 12.5 and 15.5 dpc (at protein level). Expressed in embryo at 9.5, 12.5 and 16.5 dpc. Expressed in developing musculo-skeletal system, during skeletal myogenesis and also in precartilage primordia and derivative chondrogenic cells of the developing skeleton. Expressed in mesenchymal tissues of developing lung, kidney, gonad, gut and placenta. Not expressed at stages of chondrocyte hypertrophy and ossification of bones. Expressed in all extraembryonic tissues at 9.5 and 12.5 dpc and low-level expression in the embryonic brain and vertebral cartilage at 12.5 dpc.3 Publications

Inductioni

Up-regulated by MYC and during adipocyte differentiation.2 Publications

Gene expression databases

BgeeiENSMUSG00000092035 Expressed in 107 organ(s), highest expression level in heart
CleanExiMM_PEG10
ExpressionAtlasiQ7TN75 baseline and differential
GenevisibleiQ7TN75 MM

Interactioni

Subunit structurei

Interacts with ALK1, SIAH1 and SIAH2.By similarity

Protein-protein interaction databases

BioGridi228380, 1 interactor
IntActiQ7TN75, 2 interactors
STRINGi10090.ENSMUSP00000134963

Structurei

3D structure databases

ProteinModelPortaliQ7TN75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 326Necessary for interaction with ALK1By similarityAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 34Pro-richAdd BLAST24
Compositional biasi35 – 146Asp-richAdd BLAST112
Compositional biasi545 – 733His-richAdd BLAST189
Compositional biasi926 – 951Pro-richAdd BLAST26

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri344 – 361CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00880000138027
HOVERGENiHBG108242
InParanoidiQ7TN75

Family and domain databases

Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR032567 LDOC1-rel
IPR021109 Peptidase_aspartic_dom_sf
IPR005162 Retrotrans_gag_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF03732 Retrotrans_gag, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Note: The ribosomal frameshifting efficiency shows an apparent decrease from 68% at 9.5 dpc to 43% by 21.5 dpc during placenta gestation of isoform 1 compared to isoform 2.2 Publications

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TN75-1) [UniParc]FASTAAdd to basket
Also known as: RF1/RF2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGGSSNC PPPPPPPPPN NNNNNNTPKS PGVPDAEDDD ERRHDELPED
60 70 80 90 100
INNFDEDMNR QFENMNLLDQ VELLAQSYSL LDHLDDFDDD DEDDDFDPEP
110 120 130 140 150
DQDELPEYSD DDDLELQGAA AAPIPNFFSD DDCLEDLPEK FDGNPDMLGP
160 170 180 190 200
FMYQCQLFME KSTRDFSVDR IRVCFVTSML IGRAARWATA KLQRCTYLMH
210 220 230 240 250
NYTAFMMELK HVFEDPQRRE AAKRKIRRLR QGPGPVVDYS NAFQMIAQDL
260 270 280 290 300
DWTEPALMDQ FQEGLNPDIR AELSRQEAPK TLAALITACI HIERRLARDA
310 320 330 340 350
AAKPDPSPRA LVMPPNSQTD PTEPVGGARM RLSKEEKERR RKMNLCLYCG
360 370 380 390 400
NGGHFADTCP AKASKNSPPG KLPGPAVGGP SATGPERIRS PPSEASTQHL
410 420 430 440 450
QVMLQIHMPG RPTLFVRAMI DSGASGNFID QDFVIQNAIP LRIKDWPVMV
460 470 480 490 500
EAIDGHPIAS GPIILETHHL IVDLGDHREI LSFDVTQSPF FPIVLGIRWL
510 520 530 540 550
STHDPHITWS TRSIVFNSDY CRLRCRMFAQ IPSNLLFTVP QPNLHPYLLH
560 570 580 590 600
HVHPHVHPHM HQHLHQHLHQ FLHPDPHQYP HPDPHYHHHQ QADMQHQLQQ
610 620 630 640 650
YLYQYLYYHL YPVMHHHLPP DQHEHLHEYL HQYLHQYLHQ FLHHHLHPDL
660 670 680 690 700
HQYLYQYLHN HMNPDPHHHP HPDPPQDPHH PPHQDPHQHP DPHQDPPHQD
710 720 730 740 750
PHQDAHQDPH MDPHLHQHQH PQPQPHPQQH PNHPQQPPFF YHMAGFRIYH
760 770 780 790 800
PVRYYYIQNV YTPVDEHVYP GHRVVDPNIE MIPGAHSLPS GHLYSMSESE
810 820 830 840 850
MNALRNFVDR NVKDGLMTPT VAPNGAQVLQ VKRGWKLQVT YNCRAPQSGT
860 870 880 890 900
IQNQYLRMSL PNMGDPAHLA SYGEFVQVPG YPYPAYVYYT SPHMMTAWYP
910 920 930 940 950
VGRDVHGRII VVPVVITWSQ NTNRQPPVPQ YPPPQPPPPP PPPPPPPPPP

PASSCSAA
Note: Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-370 and Lys-371.
Length:958
Mass (Da):109,849
Last modified:March 18, 2008 - v2
Checksum:i65BA9B1B6714FE14
GO
Isoform 2 (identifier: Q7TN75-2) [UniParc]FASTAAdd to basket
Also known as: RF1

The sequence of this isoform differs from the canonical sequence as follows:
     371-376: KLPGPA → NSPAPL
     377-958: Missing.

Note: Produced by conventional translation.Combined sources
Show »
Length:376
Mass (Da):42,328
Checksum:i901A5E8275AF611E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3F7E9Q3F7_MOUSE
Retrotransposon-derived protein PEG...
Peg10
1,005Annotation score:
H3BJQ1H3BJQ1_MOUSE
Retrotransposon-derived protein PEG...
Peg10
604Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132D → G (PubMed:9473521).Curated1
Sequence conflicti185 – 231ARWAT…RRLRQ → PLGYCQAAKMYLPDAQLHCL YDGAEAVLVRPSESVSVQTQ DQTSAP (PubMed:9473521).CuratedAdd BLAST47
Sequence conflicti660 – 661NH → TI (PubMed:11158386).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032009371 – 376KLPGPA → NSPAPL in isoform 2. Curated6
Alternative sequenceiVSP_032010377 – 958Missing in isoform 2. CuratedAdd BLAST582

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091827 mRNA Translation: BAC77244.1
AC084315 Genomic DNA No translation available.
AF302691 Genomic DNA Translation: AAG39979.1
CCDSiCCDS57407.1 [Q7TN75-2]
RefSeqiNP_001035701.1, NM_001040611.1 [Q7TN75-2]
NP_570947.2, NM_130877.2
UniGeneiMm.320575

Genome annotation databases

EnsembliENSMUST00000176204; ENSMUSP00000134963; ENSMUSG00000092035 [Q7TN75-2]
GeneIDi170676
KEGGimmu:170676
UCSCiuc033iob.1 mouse [Q7TN75-2]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091827 mRNA Translation: BAC77244.1
AC084315 Genomic DNA No translation available.
AF302691 Genomic DNA Translation: AAG39979.1
CCDSiCCDS57407.1 [Q7TN75-2]
RefSeqiNP_001035701.1, NM_001040611.1 [Q7TN75-2]
NP_570947.2, NM_130877.2
UniGeneiMm.320575

3D structure databases

ProteinModelPortaliQ7TN75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228380, 1 interactor
IntActiQ7TN75, 2 interactors
STRINGi10090.ENSMUSP00000134963

PTM databases

iPTMnetiQ7TN75
PhosphoSitePlusiQ7TN75

Proteomic databases

PaxDbiQ7TN75
PRIDEiQ7TN75

Protocols and materials databases

DNASUi170676
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000176204; ENSMUSP00000134963; ENSMUSG00000092035 [Q7TN75-2]
GeneIDi170676
KEGGimmu:170676
UCSCiuc033iob.1 mouse [Q7TN75-2]

Organism-specific databases

CTDi23089
MGIiMGI:2157785 Peg10

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00880000138027
HOVERGENiHBG108242
InParanoidiQ7TN75

Miscellaneous databases

PROiPR:Q7TN75
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000092035 Expressed in 107 organ(s), highest expression level in heart
CleanExiMM_PEG10
ExpressionAtlasiQ7TN75 baseline and differential
GenevisibleiQ7TN75 MM

Family and domain databases

Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR032567 LDOC1-rel
IPR021109 Peptidase_aspartic_dom_sf
IPR005162 Retrotrans_gag_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF03732 Retrotrans_gag, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEG10_MOUSE
AccessioniPrimary (citable) accession number: Q7TN75
Secondary accession number(s): Q9EQ11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 10, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome, Transposable element

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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