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Protein

N-acetylneuraminate 9-O-acetyltransferase

Gene

Casd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition.By similarity

Miscellaneous

The Casd1 locus is imprinted. Maternal inherited gene is expressed, while the paternal inherited gene is silenced.1 Publication

Catalytic activityi

Acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Acyl-ester intermediateBy similarity1
Active sitei270By similarity1
Active sitei273By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylneuraminate 9-O-acetyltransferaseBy similarity (EC:2.3.1.45By similarity)
Alternative name(s):
CAS1 domain-containing protein 1
Sialate O-acetyltransferaseBy similarity
Short name:
SOATBy similarity
Gene namesi
Name:Casd1Imported
Synonyms:Cas1, Cast1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2384865 Casd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicCuratedAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 313LumenalBy similarityAdd BLAST274
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 363CytoplasmicCuratedAdd BLAST29
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 395LumenalCuratedAdd BLAST11
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 439CytoplasmicCuratedAdd BLAST23
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461LumenalCurated1
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 486CytoplasmicCurated4
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 513LumenalCurated6
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Topological domaini535 – 546CytoplasmicCuratedAdd BLAST12
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 599LumenalCuratedAdd BLAST32
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 638CytoplasmicCuratedAdd BLAST18
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 671LumenalCuratedAdd BLAST12
Transmembranei672 – 692HelicalSequence analysisAdd BLAST21
Topological domaini693 – 698CytoplasmicCurated6
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21
Topological domaini720 – 725LumenalCurated6
Transmembranei726 – 746HelicalSequence analysisAdd BLAST21
Topological domaini747 – 770CytoplasmicCuratedAdd BLAST24
Transmembranei771 – 791HelicalSequence analysisAdd BLAST21
Topological domaini792 – 797LumenalCurated6

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072311 – 797N-acetylneuraminate 9-O-acetyltransferaseAdd BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ7TN73
MaxQBiQ7TN73
PaxDbiQ7TN73
PRIDEiQ7TN73

PTM databases

iPTMnetiQ7TN73
PhosphoSitePlusiQ7TN73

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Expressed in neonatal brain and in day 10 and 13 embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000015189 Expressed in 274 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_CASD1
ExpressionAtlasiQ7TN73 baseline and differential
GenevisibleiQ7TN73 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015333

Structurei

3D structure databases

ProteinModelPortaliQ7TN73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PC-esterase family. CASD1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1699 Eukaryota
ENOG410XPE6 LUCA
GeneTreeiENSGT00390000004037
HOGENOMiHOG000044770
HOVERGENiHBG062482
InParanoidiQ7TN73
KOiK03377
OMAiWHFGLLL
OrthoDBiEOG091G01RL
PhylomeDBiQ7TN73
TreeFamiTF324898

Family and domain databases

InterProiView protein in InterPro
IPR012419 Cas1_AcylTrans_dom
IPR036915 Cyclin-like_sf
PfamiView protein in Pfam
PF07779 Cas1_AcylT, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q7TN73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALAYNLGK REINHYFSVR SAKVLALVAV LLLAACHLAS RRYRGNDSCE
60 70 80 90 100
YLLSSGRFLG EKVWQPHSCM MHKYKISEAK TCLVDKHIAF IGDSRIRQLF
110 120 130 140 150
YSFVKIINPQ FKEEGNKHEN IPFEDKAASV KVDFLWHPEV NGSMKQCIKV
160 170 180 190 200
WTEDSVLKPH VIVAGAATWS IKIHNGSEEA LAQYKMNITS IAPLLEKLAK
210 220 230 240 250
TSDVYWVLQD PVYEDLLSEN RKMITNEKID AYNEAAVSIL NSSTRTSKSN
260 270 280 290 300
VKMFSVSKLI AQETIMESLD GLHLPESSRE TSAMILMNVY CNKVVKPVDG
310 320 330 340 350
SCCQPRPPLT LIQKLAACFF TLSIIGYFIF YVIHRNAHRK NKPCTDLESG
360 370 380 390 400
EEKKNIINTP VSSLEILLQS FCKLGLIMAY FYMCDRANLF MKENKFYTHS
410 420 430 440 450
SFFIPIIYIL VLGVFYNENT KETKVLNREQ TDEWKGWMQL VILIYHISGA
460 470 480 490 500
STFLPVYMHI RVLVAAYLFQ TGYGHFSYFW IKGDFGIHRV CQVLFRLNFL
510 520 530 540 550
VVVLCIVMDR PYQFYYFVPL VTVWFMVIYV TLALWPQITQ KKANGNFFWY
560 570 580 590 600
LGLLLKLGLL LLCIWFLAYS QGAFEKIFSL WPLSKCFELE GSVYEWWFRW
610 620 630 640 650
RLDRYVVFHG VLFAFIYLAL QRRQILSEGK GEPLFSNKIS NFLLFVSVVS
660 670 680 690 700
FLTYSIWASS CKNKAECNEL HPSVSVVQIV AFILIRNIPG YARSIYSSFF
710 720 730 740 750
AWFGKISLEL FICQYHIWLA ADTRGILVLI PGNPTLNIIV STFIFVCVAH
760 770 780 790
EISQITTDLA QVVIPKDNPS LFRRLACTIA FFGGVLILSS IQDKSRL
Length:797
Mass (Da):91,603
Last modified:October 1, 2003 - v1
Checksum:i9FF23144DDDA8741
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SW49A0A0N4SW49_MOUSE
N-acetylneuraminate 9-O-acetyltrans...
Casd1
132Annotation score:
F6TUA2F6TUA2_MOUSE
N-acetylneuraminate 9-O-acetyltrans...
Casd1
182Annotation score:
M0QWG8M0QWG8_MOUSE
N-acetylneuraminate 9-O-acetyltrans...
Casd1
220Annotation score:
A0A0N4SWB0A0A0N4SWB0_MOUSE
N-acetylneuraminate 9-O-acetyltrans...
Casd1
71Annotation score:

Sequence cautioni

The sequence AAH18542 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH38009 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091829 mRNA Translation: BAC77246.1
BC018542 mRNA Translation: AAH18542.1 Different initiation.
BC038009 mRNA Translation: AAH38009.1 Different initiation.
BC058953 mRNA Translation: AAH58953.1
BC125377 mRNA Translation: AAI25378.1
BC125379 mRNA Translation: AAI25380.1
CCDSiCCDS19896.1
RefSeqiNP_663373.2, NM_145398.2
UniGeneiMm.270703

Genome annotation databases

EnsembliENSMUST00000015333; ENSMUSP00000015333; ENSMUSG00000015189
GeneIDi213819
KEGGimmu:213819
UCSCiuc009avo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091829 mRNA Translation: BAC77246.1
BC018542 mRNA Translation: AAH18542.1 Different initiation.
BC038009 mRNA Translation: AAH38009.1 Different initiation.
BC058953 mRNA Translation: AAH58953.1
BC125377 mRNA Translation: AAI25378.1
BC125379 mRNA Translation: AAI25380.1
CCDSiCCDS19896.1
RefSeqiNP_663373.2, NM_145398.2
UniGeneiMm.270703

3D structure databases

ProteinModelPortaliQ7TN73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015333

PTM databases

iPTMnetiQ7TN73
PhosphoSitePlusiQ7TN73

Proteomic databases

EPDiQ7TN73
MaxQBiQ7TN73
PaxDbiQ7TN73
PRIDEiQ7TN73

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015333; ENSMUSP00000015333; ENSMUSG00000015189
GeneIDi213819
KEGGimmu:213819
UCSCiuc009avo.1 mouse

Organism-specific databases

CTDi64921
MGIiMGI:2384865 Casd1

Phylogenomic databases

eggNOGiKOG1699 Eukaryota
ENOG410XPE6 LUCA
GeneTreeiENSGT00390000004037
HOGENOMiHOG000044770
HOVERGENiHBG062482
InParanoidiQ7TN73
KOiK03377
OMAiWHFGLLL
OrthoDBiEOG091G01RL
PhylomeDBiQ7TN73
TreeFamiTF324898

Miscellaneous databases

ChiTaRSiCasd1 mouse
PROiPR:Q7TN73
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015189 Expressed in 274 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_CASD1
ExpressionAtlasiQ7TN73 baseline and differential
GenevisibleiQ7TN73 MM

Family and domain databases

InterProiView protein in InterPro
IPR012419 Cas1_AcylTrans_dom
IPR036915 Cyclin-like_sf
PfamiView protein in Pfam
PF07779 Cas1_AcylT, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASD1_MOUSE
AccessioniPrimary (citable) accession number: Q7TN73
Secondary accession number(s): Q1RN01, Q6PD39, Q8VEF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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