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Protein

Transmembrane channel-like protein 8

Gene

Tmc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ion channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ion channel activity Source: GO_Central
  • mechanosensitive ion channel activity Source: GO_Central
  • signaling receptor binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.4.2 the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane channel-like protein 8
Alternative name(s):
Epidermodysplasia verruciformis protein 2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmc8
Synonyms:Ever2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2669037 Tmc8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 118CytoplasmicSequence analysisAdd BLAST118
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 204LumenalSequence analysisAdd BLAST65
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 307CytoplasmicSequence analysisAdd BLAST82
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 375LumenalSequence analysisAdd BLAST47
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 430CytoplasmicSequence analysisAdd BLAST34
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 492LumenalSequence analysisAdd BLAST41
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 536CytoplasmicSequence analysisAdd BLAST23
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 598LumenalSequence analysisAdd BLAST41
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 722CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001853871 – 722Transmembrane channel-like protein 8Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
Modified residuei18PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei658PhosphoserineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TN58

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TN58

PRoteomics IDEntifications database

More...
PRIDEi
Q7TN58

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TN58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TN58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymus, lung, prostate, placenta, testis and spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050106 Expressed in 67 organ(s), highest expression level in thymus

CleanEx database of gene expression profiles

More...
CleanExi
MM_TMC8

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7TN58 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TN58 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101941

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7TN58

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIXB Eukaryota
ENOG410Y7QP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153258

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038033

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TN58

KEGG Orthology (KO)

More...
KOi
K21988

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFHNQLW

TreeFam database of animal gene trees

More...
TreeFami
TF313462

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23302 PTHR23302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07810 TMC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TN58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRQWSVQSG PAPRRPESQA ASEELWEQEV ERLCASRTPV RMLPYAMADK
60 70 80 90 100
RFIRELREPE GVKTTFWQRW HRPRRVARQH LREAEQRLAR GFGLWEGALY
110 120 130 140 150
EIGGLFGTGI QSYFTFLRFL LLLNLLTMLL TACFVLLPLV WLRPPELGPA
160 170 180 190 200
LKLRLQCSSS PLPQSDIPRF HNPLWNILTG RAFNNTYLFY GAYRAGPESS
210 220 230 240 250
SEYSIRLAYL LSPMVCLLLC FCGILQRMAE GLPQQTLLGQ RYRTPLSAKV
260 270 280 290 300
FSSWDFCIRV WEAATIKKHE ISNELKMELE EGRRVELAQQ QTRAQKACRL
310 320 330 340 350
LTYLRTNILI VLLVVGAISA IFWATKYSQD NKEESLFLVL QYLPPGVISL
360 370 380 390 400
VNFLGPQLFT VLIQLENYPP GTEVNLTLIW CVVLKLASLG MFSFSLGQTV
410 420 430 440 450
LCIGRNKTSC ESYGYNACDY QCWENSVGEE LYKLIIFNFL LTVAFAFLVS
460 470 480 490 500
LPRRLLVERF SGWFWTWLDR EEFLVPKNVL DIVAAQTVTW MGLFYCPLLP
510 520 530 540 550
LLNSVFLFLT FYIKKYTLLR NSRASPRRFR ASSSTFFFHL VLLLGLLLAA
560 570 580 590 600
VPLAYVISST HSSWDCGLFT NYSAPWQVVP ELVALQLPLP SQRALRYLSS
610 620 630 640 650
HAFSFPLLIL LSIVLTVCIS QSRANARAIQ GLRKQLVWQV QEKWHLVDDL
660 670 680 690 700
SRLLPELSPE PGSPHSRASR PRSFCPGFPC PGSPGPRTPR LAPSNRLSSS
710 720
SLGAPSASVP ASRFHFPSRT EL
Length:722
Mass (Da):82,329
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33799843E88B6FD9
GO
Isoform 2 (identifier: Q7TN58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-154: R → TG

Note: No experimental confirmation available.
Show »
Length:723
Mass (Da):82,331
Checksum:i373EF46922479C5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QZP7B0QZP7_MOUSE
Transmembrane channel-like protein
Tmc8
722Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ATB9B1ATB9_MOUSE
Transmembrane channel-like protein ...
Tmc8
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179T → A in BAE42658 (PubMed:16141072).Curated1
Sequence conflicti277 – 278ME → VC in AAP69879 (PubMed:12906855).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016451154R → TG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY236501 mRNA Translation: AAP69879.1
AY263160 mRNA Translation: AAP78775.1
AK136329 mRNA Translation: BAE22935.1
AK171772 mRNA Translation: BAE42658.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25689.1 [Q7TN58-1]
CCDS56824.1 [Q7TN58-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001182019.1, NM_001195090.1
NP_862904.1, NM_181856.2 [Q7TN58-1]
XP_006533187.1, XM_006533124.3 [Q7TN58-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.116675

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000050874; ENSMUSP00000051878; ENSMUSG00000050106 [Q7TN58-1]
ENSMUST00000106334; ENSMUSP00000101941; ENSMUSG00000050106 [Q7TN58-2]
ENSMUST00000119455; ENSMUSP00000113628; ENSMUSG00000050106 [Q7TN58-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217356

UCSC genome browser

More...
UCSCi
uc007mns.2 mouse [Q7TN58-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236501 mRNA Translation: AAP69879.1
AY263160 mRNA Translation: AAP78775.1
AK136329 mRNA Translation: BAE22935.1
AK171772 mRNA Translation: BAE42658.1
CCDSiCCDS25689.1 [Q7TN58-1]
CCDS56824.1 [Q7TN58-2]
RefSeqiNP_001182019.1, NM_001195090.1
NP_862904.1, NM_181856.2 [Q7TN58-1]
XP_006533187.1, XM_006533124.3 [Q7TN58-1]
UniGeneiMm.116675

3D structure databases

ProteinModelPortaliQ7TN58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101941

Protein family/group databases

TCDBi1.A.17.4.2 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ7TN58
PhosphoSitePlusiQ7TN58

Proteomic databases

EPDiQ7TN58
PaxDbiQ7TN58
PRIDEiQ7TN58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050874; ENSMUSP00000051878; ENSMUSG00000050106 [Q7TN58-1]
ENSMUST00000106334; ENSMUSP00000101941; ENSMUSG00000050106 [Q7TN58-2]
ENSMUST00000119455; ENSMUSP00000113628; ENSMUSG00000050106 [Q7TN58-2]
GeneIDi217356
KEGGimmu:217356
UCSCiuc007mns.2 mouse [Q7TN58-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
147138
MGIiMGI:2669037 Tmc8

Phylogenomic databases

eggNOGiENOG410IIXB Eukaryota
ENOG410Y7QP LUCA
GeneTreeiENSGT00940000153258
HOGENOMiHOG000038033
HOVERGENiHBG055908
InParanoidiQ7TN58
KOiK21988
OMAiRFHNQLW
TreeFamiTF313462

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tmc8 mouse

Protein Ontology

More...
PROi
PR:Q7TN58

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050106 Expressed in 67 organ(s), highest expression level in thymus
CleanExiMM_TMC8
ExpressionAtlasiQ7TN58 baseline and differential
GenevisibleiQ7TN58 MM

Family and domain databases

InterProiView protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom
PANTHERiPTHR23302 PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810 TMC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMC8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TN58
Secondary accession number(s): Q3TAL0, Q3UWI0, Q7TQ67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: December 5, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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