UniProtKB - Q7TN41 (MRGRD_RAT)
Protein
Mas-related G-protein coupled receptor member D
Gene
Mrgprd
Organism
Rattus norvegicus (Rat)
Status
Functioni
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Mas-related G-protein coupled receptor member DAlternative name(s): Beta-alanine receptor G-protein coupled receptor TGR7 |
Gene namesi | Name:Mrgprd Synonyms:Mrgd |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 738040, Mrgprd |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 52 – 64 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 65 – 85 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 92 | ExtracellularSequence analysis | 7 | |
Transmembranei | 93 – 113 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 144 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 145 – 165 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 166 – 184 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 185 – 205 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 220 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 221 – 241 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 242 – 260 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 261 – 281 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 282 – 319 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069759 | 1 – 319 | Mas-related G-protein coupled receptor member DAdd BLAST | 319 |
Proteomic databases
PaxDbi | Q7TN41 |
PRIDEi | Q7TN41 |
PTM databases
PhosphoSitePlusi | Q7TN41 |
Expressioni
Tissue specificityi
Co-expressed in the small diameter neurons with P2X3 and VR1 in dorsal root ganglia.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000013448, Expressed in testis and 4 other tissues |
ExpressionAtlasi | Q7TN41, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SNJC, Eukaryota |
GeneTreei | ENSGT01010000222446 |
HOGENOMi | CLU_009579_4_1_1 |
InParanoidi | Q7TN41 |
OMAi | YWFVLYW |
OrthoDBi | 1015751at2759 |
PhylomeDBi | Q7TN41 |
TreeFami | TF336336 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026232, MRGPCRD IPR026234, MRGPCRFAMILY |
PANTHERi | PTHR11334, PTHR11334, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02110, MRGPCRD PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7TN41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYTPYSSPA PGLTISPTMD PVTWVYFSVT FLAMATCVCG IVGNSMVIWL
60 70 80 90 100
LSFHRVQRSP FCTYVLNLAV ADLLFLLCMA SLLSLETGPL LTASTSARVY
110 120 130 140 150
EGMKRIKYFA YTAGLSLLTA ISTQRCLSVL FPIWYKCHRP QHLSGVVCGV
160 170 180 190 200
LWALALLMNF LASFFCVQFW HPDKYQCFKV DMVFNSLILG IFMPVMVLTS
210 220 230 240 250
AIIFIRMRKN SLLQRRQPRR LYVVILTSVL VFLTCSLPLG INWFLLYWVE
260 270 280 290 300
LPQAVRLLYV CSSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
310
LQDEPEGRET PSTCTNDGV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | R → S in BAD20639 (PubMed:15037633).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF518246 Genomic DNA Translation: AAQ08318.1 AB154411 mRNA Translation: BAD20639.1 |
RefSeqi | NP_001001506.1, NM_001001506.1 XP_006230787.1, XM_006230725.3 |
Genome annotation databases
Ensembli | ENSRNOT00000017958; ENSRNOP00000017958; ENSRNOG00000013448 |
GeneIDi | 293648 |
KEGGi | rno:293648 |
UCSCi | RGD:738040, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF518246 Genomic DNA Translation: AAQ08318.1 AB154411 mRNA Translation: BAD20639.1 |
RefSeqi | NP_001001506.1, NM_001001506.1 XP_006230787.1, XM_006230725.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000017958 |
Chemistry databases
GuidetoPHARMACOLOGYi | 152 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q7TN41 |
Proteomic databases
PaxDbi | Q7TN41 |
PRIDEi | Q7TN41 |
Genome annotation databases
Ensembli | ENSRNOT00000017958; ENSRNOP00000017958; ENSRNOG00000013448 |
GeneIDi | 293648 |
KEGGi | rno:293648 |
UCSCi | RGD:738040, rat |
Organism-specific databases
CTDi | 116512 |
RGDi | 738040, Mrgprd |
Phylogenomic databases
eggNOGi | ENOG502SNJC, Eukaryota |
GeneTreei | ENSGT01010000222446 |
HOGENOMi | CLU_009579_4_1_1 |
InParanoidi | Q7TN41 |
OMAi | YWFVLYW |
OrthoDBi | 1015751at2759 |
PhylomeDBi | Q7TN41 |
TreeFami | TF336336 |
Miscellaneous databases
PROi | PR:Q7TN41 |
Gene expression databases
Bgeei | ENSRNOG00000013448, Expressed in testis and 4 other tissues |
ExpressionAtlasi | Q7TN41, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026232, MRGPCRD IPR026234, MRGPCRFAMILY |
PANTHERi | PTHR11334, PTHR11334, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02110, MRGPCRD PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MRGRD_RAT | |
Accessioni | Q7TN41Primary (citable) accession number: Q7TN41 Secondary accession number(s): Q6L788 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families