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Protein

Hedgehog-interacting protein

Gene

Hhip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi383Zinc; shared with SHHBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5632681 Ligand-receptor interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Hedgehog-interacting protein
Short name:
HHIP
Short name:
HIP
Gene namesi
Name:Hhip
Synonyms:Hip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1341847 Hhip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000762418 – 700Hedgehog-interacting proteinAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 536PROSITE-ProRule annotation
Disulfide bondi218 ↔ 543PROSITE-ProRule annotation
Disulfide bondi402 ↔ 624PROSITE-ProRule annotation
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi435 ↔ 452PROSITE-ProRule annotation
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 594PROSITE-ProRule annotation
Disulfide bondi612 ↔ 623PROSITE-ProRule annotation
Disulfide bondi625 ↔ 634PROSITE-ProRule annotation
Disulfide bondi639 ↔ 649PROSITE-ProRule annotation
Disulfide bondi643 ↔ 655PROSITE-ProRule annotation
Disulfide bondi657 ↔ 666PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TN16
PaxDbiQ7TN16
PRIDEiQ7TN16

PTM databases

PhosphoSitePlusiQ7TN16

Expressioni

Tissue specificityi

In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the surerior colliculus.1 Publication

Developmental stagei

First detected at 8.75 dpc, in the ventral midline of the neural tube and in the ventral medial somites. At 10.5 dpc, expression in the notochord is maintained in the caudal region. Expression is lost in the floor plate, but is retained in the ventral half of the neural tube and in the sclerotome of the adjacent somites. In the midbrain, expression confined to two lateral stripes adjacent to the floor plate. Also expressed in the gut mesenchyme along the length of the gastro-intestinal tract and in the mesenchyme of the posterior half of the limb. Expressed in the underlying mesenchyme of the epithelium of a number of tissues including lung, gut and whisker. Also expressed in the perichondrium and in the androgen-producing interstitial somatic cells of the developing testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000064325 Expressed in 173 organ(s), highest expression level in left lung lobe
CleanExiMM_HHIP
GenevisibleiQ7TN16 MM

Interactioni

Subunit structurei

Interacts with all three hedgehog family members, SHH, IHH and DHH.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200300, 1 interactor
STRINGi10090.ENSMUSP00000078047

Structurei

3D structure databases

ProteinModelPortaliQ7TN16
SMRiQ7TN16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini607 – 634EGF-like 1PROSITE-ProRule annotationAdd BLAST28
Domaini635 – 667EGF-like 2PROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni376 – 388Interaction with SHH zinc binding siteBy similarityAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 54Arg-richAdd BLAST20

Domaini

A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.By similarity

Sequence similaritiesi

Belongs to the HHIP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEIH Eukaryota
ENOG410ZT1I LUCA
GeneTreeiENSGT00530000063250
HOGENOMiHOG000008644
HOVERGENiHBG051901
InParanoidiQ7TN16
KOiK06231
OMAiFYYTCRG
OrthoDBiEOG091G01D0
PhylomeDBiQ7TN16
TreeFamiTF329059

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018143 Folate_rcpt-like
IPR012938 Glc/Sorbosone_DH
IPR011041 Quinoprot_gluc/sorb_DH
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit
PF07995 GSDH, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SUPFAMiSSF50952 SSF50952, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TN16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKMLSFKLL LLAVALGFFE GDAKFGERNE GSGARRRRCL NGNPPKRLKR
60 70 80 90 100
RDRRVMSQLE LLSGGEILCG GFYPRVSCCL QSDSPGLGRL ENKIFSATNN
110 120 130 140 150
SECSRLLEEI QCAPCSPHSQ SLFYTPERDV LDGDLALPLL CKDYCKEFFY
160 170 180 190 200
TCRGHIPGLL QTTADEFCFY YARKDAGLCF PDFPRKQVRG PASNYLGQME
210 220 230 240 250
DYEKVGGISR KHKHNCLCVQ EVMSGLRQPV SAVHSGDGSH RLFILEKEGY
260 270 280 290 300
VKILTPEGEL FKEPYLDIHK LVQSGIKGGD ERGLLSLAFH PNYKKNGKLY
310 320 330 340 350
VSYTTNQERW AIGPHDHILR VVEYTVSRKN PHQVDVRTAR VFLEVAELHR
360 370 380 390 400
KHLGGQLLFG PDGFLYIILG DGMITLDDME EMDGLSDFTG SVLRLDVDTD
410 420 430 440 450
MCNVPYSIPR SNPHFNSTNQ PPEVFAHGLH DPGRCAVDRH PTDININLTI
460 470 480 490 500
LCSDSNGKNR SSARILQIIK GRDYESEPSL LEFKPFSNGP LVGGFVYRGC
510 520 530 540 550
QSERLYGSYV FGDRNGNFLT LQQSPVTKQW QEKPLCLGAS SSCRGYFSGH
560 570 580 590 600
ILGFGEDELG EVYILSSSKS MTQTHNGKLY KIVDPKRPLM PEECRVTVQP
610 620 630 640 650
AQPLTSDCSR LCRNGYYTPT GKCCCSPGWE GDFCRIAKCE PACRHGGVCV
660 670 680 690 700
RPNKCLCKKG YLGPQCEQVD RNVRRVTRAG ILDQIIDMTS YLLDLTSYIV
Length:700
Mass (Da):78,513
Last modified:March 29, 2005 - v2
Checksum:i91007C5AF6070B80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29N → S in AAD31172 (PubMed:10050855).Curated1
Sequence conflicti473D → G in AAH53012 (PubMed:15489334).Curated1
Sequence conflicti607D → V in BAC27575 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116865 mRNA Translation: AAD31172.1
AK031841 mRNA Translation: BAC27575.1
BC053012 mRNA Translation: AAH53012.1
CCDSiCCDS22440.1
RefSeqiNP_064655.4, NM_020259.4
UniGeneiMm.254493

Genome annotation databases

EnsembliENSMUST00000079038; ENSMUSP00000078047; ENSMUSG00000064325
GeneIDi15245
KEGGimmu:15245
UCSCiuc009mix.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116865 mRNA Translation: AAD31172.1
AK031841 mRNA Translation: BAC27575.1
BC053012 mRNA Translation: AAH53012.1
CCDSiCCDS22440.1
RefSeqiNP_064655.4, NM_020259.4
UniGeneiMm.254493

3D structure databases

ProteinModelPortaliQ7TN16
SMRiQ7TN16
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200300, 1 interactor
STRINGi10090.ENSMUSP00000078047

PTM databases

PhosphoSitePlusiQ7TN16

Proteomic databases

MaxQBiQ7TN16
PaxDbiQ7TN16
PRIDEiQ7TN16

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079038; ENSMUSP00000078047; ENSMUSG00000064325
GeneIDi15245
KEGGimmu:15245
UCSCiuc009mix.2 mouse

Organism-specific databases

CTDi64399
MGIiMGI:1341847 Hhip

Phylogenomic databases

eggNOGiENOG410IEIH Eukaryota
ENOG410ZT1I LUCA
GeneTreeiENSGT00530000063250
HOGENOMiHOG000008644
HOVERGENiHBG051901
InParanoidiQ7TN16
KOiK06231
OMAiFYYTCRG
OrthoDBiEOG091G01D0
PhylomeDBiQ7TN16
TreeFamiTF329059

Enzyme and pathway databases

ReactomeiR-MMU-5632681 Ligand-receptor interactions

Miscellaneous databases

ChiTaRSiHhip mouse
PROiPR:Q7TN16
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064325 Expressed in 173 organ(s), highest expression level in left lung lobe
CleanExiMM_HHIP
GenevisibleiQ7TN16 MM

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018143 Folate_rcpt-like
IPR012938 Glc/Sorbosone_DH
IPR011041 Quinoprot_gluc/sorb_DH
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit
PF07995 GSDH, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SUPFAMiSSF50952 SSF50952, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHHIP_MOUSE
AccessioniPrimary (citable) accession number: Q7TN16
Secondary accession number(s): Q8C0B0, Q9WU59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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