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Protein

Innate immunity activator protein

Gene

Inava

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Innate immunity activator proteinBy similarity
Gene namesi
Name:InavaBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921579 5730559C18Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

After infection with Citrobacter rodentium, mutants show significantly increased bacterial loads at day 5 compared to wild types. They are able to control the infection by day 12 post-infection, they exhibit significantly shortened colon length. They don't have impaired cytokine reponse (PubMed:29420262). Mutants also exhibit impaired recovery from dextran sodium sulfate-induces colitis, they show increased body weight loss and reduced colon length (PubMed:29420262).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517301 – 663Innate immunity activator proteinAdd BLAST663

Proteomic databases

MaxQBiQ7TN12
PaxDbiQ7TN12
PRIDEiQ7TN12

PTM databases

iPTMnetiQ7TN12
PhosphoSitePlusiQ7TN12

Expressioni

Gene expression databases

CleanExiMM_5730559C18RIK

Interactioni

Subunit structurei

Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation. Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion. Interacts (via N-terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin-protein ligase complexes (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113785

Structurei

3D structure databases

ProteinModelPortaliQ7TN12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili117 – 147Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 170Nuclear localization signal (NLS) 1By similarity7
Motifi332 – 338Nuclear localization signal (NLS) 2By similarity7
Motifi422 – 428Nuclear localization signal (NLS) 3By similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi282 – 309Pro-richAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3529 Eukaryota
ENOG410XQFP LUCA
HOGENOMiHOG000233699
HOVERGENiHBG080963
InParanoidiQ7TN12
PhylomeDBiQ7TN12

Family and domain databases

InterProiView protein in InterPro
IPR021774 DUF3338
IPR039106 INAVA
PANTHERiPTHR16093:SF4 PTHR16093:SF4, 1 hit
PfamiView protein in Pfam
PF11819 DUF3338, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TN12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQMPKLNEI PPGRGGPGEP WGEGRWAGPT GPEAARPARG ARGQARGARA
60 70 80 90 100
RWDSWEHSRL PTHPGPGWDQ CSPSFLCAPS SQKLIMESKD EVSDSDSGII
110 120 130 140 150
LQSGPDSPVS PMKELTNAVR KQQRALEARL EACLEELRRL CLREAELTGT
160 170 180 190 200
LPAEYPLKPG EKAPKVRRRI GAAYKLDEWA LHREDPLSSL ERQLALQLQI
210 220 230 240 250
TEAARRLCAE ENLSRQARRQ RKHAALQEEK KLRDLQRCLG DRRRNSEPPP
260 270 280 290 300
TTVPSLGREL SASDDSSLSD GLLLEEEDSQ APKPPPESPA PPSRPLPPQS
310 320 330 340 350
LEGLQPTGPE SGGQERAPIQ NSPWKETSLD HPYEKPRKSS ELSSESSSPA
360 370 380 390 400
TTPQDQPNPS SLWVLDAASY HVVPIRNVPG QRQGRTSAPA TPEMQGRRGQ
410 420 430 440 450
SQSLRVDSFR AGAEGRGRSA FPRRRPTHYT VTVPDSCFTP GKPPLPHPAC
460 470 480 490 500
HSCSEDSGSD VSSISHPTSP GSSSPDISFL RPLCLPEPPR HRGAWGPACG
510 520 530 540 550
RELAPHYSKL LLPAGYFPTG RYVMVAEGHL PPGEWELCRA AVGAAYDEEG
560 570 580 590 600
APLRYQRLVP SHSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS
610 620 630 640 650
SRPHSLDRQG AFRVRSLPPG RESFGRASGP RTQVPPVYVL RRSTDGAPVQ
660
VFVPENGEII SQV
Length:663
Mass (Da):72,693
Last modified:October 1, 2003 - v1
Checksum:i3B1BEB1A8D6298E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti564R → G in BAC25149 (PubMed:16141072).Curated1
Sequence conflicti564R → G in BAC25571 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052416 mRNA Translation: AAH52416.2
BC053100 mRNA Translation: AAH53100.1
AK006603 mRNA Translation: BAC25149.1
AK018917 mRNA Translation: BAC25571.1
RefSeqiNP_083148.3, NM_028872.3
UniGeneiMm.36763

Genome annotation databases

GeneIDi67313
KEGGimmu:67313

Similar proteinsi

Entry informationi

Entry nameiINAVA_MOUSE
AccessioniPrimary (citable) accession number: Q7TN12
Secondary accession number(s): Q7TN27, Q8BGK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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