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Entry version 146 (18 Sep 2019)
Sequence version 5 (27 Jul 2011)
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Protein

E3 ubiquitin-protein ligase HUWE1

Gene

Huwe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of PA2G4 (By similarity). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4344Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Transferase
Biological processBiological rhythms, Differentiation, DNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695 Neutrophil degranulation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HUWE1 (EC:2.3.2.26)
Alternative name(s):
E3Histone
HECT, UBA and WWE domain-containing protein 1
HECT-type E3 ubiquitin transferase HUWE1
Upstream regulatory element-binding protein 1
Short name:
URE-B1
Short name:
URE-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Huwe1
Synonyms:Kiaa0312, Ureb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926884 Huwe1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203411 – 4377E3 ubiquitin-protein ligase HUWE1Add BLAST4377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei648PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei740PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1368PhosphoserineCombined sources1
Modified residuei1370PhosphoserineBy similarity1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1907PhosphoserineCombined sources1
Modified residuei2035PhosphothreonineBy similarity1
Modified residuei2266PhosphoserineBy similarity1
Modified residuei2267N6-acetyllysineCombined sources1
Modified residuei2362PhosphoserineCombined sources1
Modified residuei2365PhosphoserineBy similarity1
Modified residuei2391PhosphoserineBy similarity1
Modified residuei2527PhosphoserineBy similarity1
Modified residuei2532PhosphoserineBy similarity1
Modified residuei2535PhosphoserineBy similarity1
Modified residuei2554PhosphothreonineBy similarity1
Modified residuei2584PhosphoserineBy similarity1
Modified residuei2595PhosphoserineBy similarity1
Modified residuei2619PhosphoserineBy similarity1
Modified residuei2751PhosphothreonineBy similarity1
Modified residuei2826PhosphoserineBy similarity1
Modified residuei2833PhosphoserineBy similarity1
Modified residuei2835PhosphoserineBy similarity1
Modified residuei2861PhosphoserineBy similarity1
Modified residuei2887PhosphoserineBy similarity1
Modified residuei2888PhosphoserineBy similarity1
Modified residuei2889PhosphothreonineBy similarity1
Modified residuei2918PhosphoserineBy similarity1
Modified residuei3116PhosphoserineBy similarity1
Modified residuei3117PhosphoserineBy similarity1
Modified residuei3122PhosphoserineBy similarity1
Modified residuei3127PhosphoserineBy similarity1
Modified residuei3135PhosphoserineBy similarity1
Modified residuei3149Omega-N-methylarginineCombined sources1
Modified residuei3557PhosphoserineBy similarity1
Modified residuei3663PhosphoserineBy similarity1
Modified residuei3753PhosphoserineBy similarity1
Modified residuei3758PhosphoserineCombined sources1
Modified residuei3760PhosphoserineBy similarity1
Modified residuei3761PhosphoserineCombined sources1
Modified residuei3810PhosphoserineCombined sources1
Modified residuei3818PhosphoserineCombined sources1
Modified residuei3830PhosphoserineBy similarity1
Modified residuei3833PhosphothreonineBy similarity1
Modified residuei3909PhosphoserineBy similarity1
Modified residuei3922PhosphoserineCombined sources1
Modified residuei3927PhosphothreonineCombined sources1
Modified residuei3930PhosphothreonineCombined sources1
Modified residuei4274PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TMY8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TMY8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7TMY8

PeptideAtlas

More...
PeptideAtlasi
Q7TMY8

PRoteomics IDEntifications database

More...
PRIDEi
Q7TMY8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TMY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TMY8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7TMY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression increases during neuronal differentiation such that the cortical plate contains the highest level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025261 Expressed in 295 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7TMY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TMY8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform p19ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity (By similarity).

Interacts with MYCN, POLB and CDC6 (By similarity).

Interacts with PA2G4 (By similarity).

Interacts with NR1D1 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
208493, 61 interactors

Protein interaction database and analysis system

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IntActi
Q7TMY8, 52 interactors

Molecular INTeraction database

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MINTi
Q7TMY8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026292

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TMY8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1316 – 1355UBAPROSITE-ProRule annotationAdd BLAST40
Domaini1370 – 1389UIMCuratedAdd BLAST20
Domaini1603 – 1680WWEPROSITE-ProRule annotationAdd BLAST78
Domaini4041 – 4377HECTPROSITE-ProRule annotationAdd BLAST337

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2295 – 2469Glu-richAdd BLAST175
Compositional biasi2427 – 2490Asp-richAdd BLAST64
Compositional biasi3484 – 3552Thr-richAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HECT domain mediates inhibition of the transcriptional activity of p53.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0939 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156319

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7TMY8

KEGG Orthology (KO)

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KOi
K10592

Database of Orthologous Groups

More...
OrthoDBi
25515at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit
cd14288 UBA_HUWE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR010309 E3_Ub_ligase_DUF908
IPR010314 E3_Ub_ligase_DUF913
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR025527 HUWE1/Rev1_UBM
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041918 UBA_HUWE1
IPR004170 WWE-dom
IPR037197 WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012 DUF908, 1 hit
PF06025 DUF913, 1 hit
PF00632 HECT, 1 hit
PF00627 UBA, 1 hit
PF14377 UBM, 3 hits
PF02825 WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00165 UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839 SSF117839, 1 hit
SSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS50030 UBA, 1 hit
PS50918 WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TMY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE
60 70 80 90 100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT
110 120 130 140 150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR
160 170 180 190 200
LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLQMLK YPPSATTLHF
210 220 230 240 250
EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP
260 270 280 290 300
KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI
310 320 330 340 350
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT
360 370 380 390 400
GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG
410 420 430 440 450
EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH
460 470 480 490 500
SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPSTTQEGEE METDMDGVQC
510 520 530 540 550
IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY
560 570 580 590 600
GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV
610 620 630 640 650
LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD
660 670 680 690 700
PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ
710 720 730 740 750
KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSAQQNETE
760 770 780 790 800
PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL
810 820 830 840 850
PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDL
860 870 880 890 900
ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH
910 920 930 940 950
AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV
960 970 980 990 1000
LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS
1010 1020 1030 1040 1050
MDASAQGLLE GIELDGDTLA PMETDEPSSS DSKGKSKITP AMAARIKQIK
1060 1070 1080 1090 1100
PLLSASSRLG RALAELFGLL VKLCVGSPVR QRRSHHAAST TTAPTPAARS
1110 1120 1130 1140 1150
TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP MLFDERKYPY
1160 1170 1180 1190 1200
HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD
1210 1220 1230 1240 1250
AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF
1260 1270 1280 1290 1300
TCIKNLWNRK PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG
1310 1320 1330 1340 1350
EEEAGQEEGG SRREPQVNQQ QLQQLMDMGF TREHAMEALL NTSTMEQATE
1360 1370 1380 1390 1400
YLLTHPPPII GGVVRDLSMS EEDQMMRAIA MSLGQDIPMD QRAESPEEVA
1410 1420 1430 1440 1450
CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT DTMLPGCFHL
1460 1470 1480 1490 1500
LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL
1510 1520 1530 1540 1550
PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES
1560 1570 1580 1590 1600
SGILNVLIKL LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS
1610 1620 1630 1640 1650
KRRAQMTKYL QSNSNNWRWF DDRSGRWCSY SASNNSTIDS AWKSGETSVR
1660 1670 1680 1690 1700
FTAGRRRYTV QFTTMVQVNE ETGNRRPVML TLLRVPRLSK NSKSSNGQEL
1710 1720 1730 1740 1750
EKTLEESKET DIKHKENKGN DIPLALESTN TEKEASLDET KIGEILIQGL
1760 1770 1780 1790 1800
TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS
1810 1820 1830 1840 1850
TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA
1860 1870 1880 1890 1900
GSTTSGVVSG SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP
1910 1920 1930 1940 1950
RGSGTASDDE FENLRIKGPN AVQLVKTTPL KPSSLPVIPD TIKEVIYDML
1960 1970 1980 1990 2000
NALAAYHAPE EADKSDPKPG GTTQEVGQLL QDMGDDVYQQ YRSLTRQSSD
2010 2020 2030 2040 2050
FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEASTPEETR EGKKDKEGDR
2060 2070 2080 2090 2100
TSEEGKQKSK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE
2110 2120 2130 2140 2150
LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV
2160 2170 2180 2190 2200
ALVNEVKAAL GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA
2210 2220 2230 2240 2250
TAKTQHNGMN NIIRLFLKKG LVNDLARVPH SLDLSSPNMA NTVNAALKPL
2260 2270 2280 2290 2300
ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ GASQDSSSHQ QDPGEPGEAE
2310 2320 2330 2340 2350
VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ EMQVENELED
2360 2370 2380 2390 2400
LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR
2410 2420 2430 2440 2450
EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE
2460 2470 2480 2490 2500
GEEGDEDDDD DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS
2510 2520 2530 2540 2550
SATDIPPSPG NIPTTHPLMV RHADHSSLTL GSGSSTTRLT QGIGRSQRTL
2560 2570 2580 2590 2600
RQLTANTGHT IHVHYPGNRQ PNPPLILQRL LGPSAAADIL QLSSSLPLQS
2610 2620 2630 2640 2650
RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT LSSIPTALTR
2660 2670 2680 2690 2700
WTEECKVLDA ESMHDCVSVV KVPIVNHLEF LRDEELEERR EKRRKQLAEE
2710 2720 2730 2740 2750
ETKIIDKGKE DKENRDQSAQ CTVTKTNDST EQNVSDGTPM PDSYPTTPSS
2760 2770 2780 2790 2800
TDAPTSESKE TLGTLQPSQQ QPALPPPPSL GEIPQELQSP AEEVANSTQL
2810 2820 2830 2840 2850
LMPIELEELG PTRPSGEAET TQMELSPAPT ITSLSPERAE DSDALTAVSS
2860 2870 2880 2890 2900
QLEGSPMDTS SLASCTLEEA VGDTPAAGSS EQPTAGSSTP GDAPSVVAEV
2910 2920 2930 2940 2950
QGRPDVSRES NQPPEDSSPP ASSESSSTRD SAVAISGADS RGILEEPLPS
2960 2970 2980 2990 3000
TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRSAPS
3010 3020 3030 3040 3050
SNSSAPAVVG NPGVTEVSPE FLAALPPAIQ EEVLAQQRAE QQRRELAQNA
3060 3070 3080 3090 3100
SSDTPMDPVT FIQTLPSDLR RSVLEDMEDS VLAVMPPDIA AEAQALRREQ
3110 3120 3130 3140 3150
EARQRQLMHE RLFGHSSTSA LSAILRSPAF TSRLSGNRGV QYTRLAVQRG
3160 3170 3180 3190 3200
GTFQMGGSSS HNRPSGSNVD TLLRLRGRLL LDHEALSCLL VLLFVDEPKL
3210 3220 3230 3240 3250
NTSRLHRVLR NLCYHAQTRH WVIRSLLSIL QRSSESELCI ETPKLSTSEE
3260 3270 3280 3290 3300
RGKKSSKSCA SSSHENRPLD LLHKMESKSS NQLSWLSVSM DAALGCRTNI
3310 3320 3330 3340 3350
FQIQRSGGRK HTEKHASSGS TVHIHPQAAP VVCRHVLDTL IQLAKVFPSH
3360 3370 3380 3390 3400
FTQQRTKETN CESDRERGSK QACSPCSSQS SSSGICTDFW DLLVKLDNMN
3410 3420 3430 3440 3450
VSRKGKNSVK SVPVSSGGEG ETSPHSLEAS PLGQLMNMLS HPVIRRSSLL
3460 3470 3480 3490 3500
TEKLLRLLSL ISIALPENKV SEVQTNSSNS GSSTAATSNT STTTTTTTTA
3510 3520 3530 3540 3550
TAPTPTPPAA TTPVTSAPAL VAATAISTIT VAASTTVTTP TTATTTVSTS
3560 3570 3580 3590 3600
TTKGSKSPAK VGEGGSGIDF KMVSSGLTEN QLQLSVEVLT SHSCSEEGLE
3610 3620 3630 3640 3650
DAANVLLQLS RGDSGTRDTV LKLLLNGARH LGYTLCKQIG TLLAELREYN
3660 3670 3680 3690 3700
LEQQRRAQCE TLSPDGLPEE QPQTTKLKGK MQSRFDMAEN VVIVASQKRP
3710 3720 3730 3740 3750
LGGRELQLPS MSMLTSKTST QKFFLRVLQV IIQLRDDTRR ANKKAKQTGR
3760 3770 3780 3790 3800
LGSSGLGSAS SIQAAVRQLE AEADAIIQMV REGQRARRQQ QAATSESSNQ
3810 3820 3830 3840 3850
SETSVRREES PMDVDQPSPS AQDTQSIVIS DGTPQGEKEK EEKPPELPLL
3860 3870 3880 3890 3900
SEQLSLDELW DMLGECLKEL EESHDQHAVL VLQPAVEAFF LVHATERESK
3910 3920 3930 3940 3950
PPVRDTRESQ LAHIKDEPPP LSPAPLTPAT PSSLDPFFSR EPSSMHISSS
3960 3970 3980 3990 4000
LPPDTQKFLR FAETHRTVLN QILRQSTTHL ADGPFAVLVD YIRVLDFDVK
4010 4020 4030 4040 4050
RKYFRQELER LDEGLRKEDM AVHVRRDHVF EDSYRELHRK SPEEMKNRLY
4060 4070 4080 4090 4100
IVFEGEEGQD AGGLLREWYM IISREMFNPM YALFRTSPGD RVTYTINPSS
4110 4120 4130 4140 4150
HCNPNHLSYF KFVGRIVAKA VYDNRLLECY FTRSFYKHIL GKSVRYTDME
4160 4170 4180 4190 4200
SEDYHFYQGL VYLLENDVST LGYDLTFSTE VQEFGVCEVR DLKPNGANIL
4210 4220 4230 4240 4250
VTEENKKEYV HLVCQMRMTG AIRKQLAAFL EGFYEIIPKR LISIFTEQEL
4260 4270 4280 4290 4300
ELLISGLPTI DIDDLKSNTE YHKYQSNSIQ IQWFWRALRS FDQADRAKFL
4310 4320 4330 4340 4350
QFVTGTSKVP LQGFAALEGM NGIQKFQIHR DDRSTDRLPS AHTCFNQLDL
4360 4370
PAYESFEKLR HMLLLAIQEC SEGFGLA
Length:4,377
Mass (Da):482,635
Last modified:July 27, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22700C859CD9AF83
GO
Isoform 2 (identifier: Q7TMY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3347-3364: FPSHFTQQRTKETNCESD → RSLKESLTPGFFGHQHLG
     3365-4377: Missing.

Note: No experimental confirmation available.
Show »
Length:3,364
Mass (Da):369,701
Checksum:iBD5116429BF0E509
GO
Isoform 3 (identifier: Q7TMY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3780-3794: Missing.

Note: No experimental confirmation available.
Show »
Length:4,362
Mass (Da):480,898
Checksum:i0D640BFE13725964
GO
Isoform 4 (identifier: Q7TMY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3795-3832: SESSNQSETS...DTQSIVISDG → VSMMPVAPHS...LVCFCITFAK
     3833-4377: Missing.

Note: No experimental confirmation available.
Show »
Length:3,832
Mass (Da):419,496
Checksum:iC8B75208FD6CB0EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AFQ0A2AFQ0_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
4,378Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XP90F6XP90_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
1,176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UYC1F6UYC1_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JD97A0A0G2JD97_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDF2D6RDF2_MOUSE
E3 ubiquitin-protein ligase HUWE1
Huwe1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti253K → R in AAX24124 (PubMed:15767685).Curated1
Sequence conflicti253K → R in AAV90839 (PubMed:15989956).Curated1
Sequence conflicti1728S → I in AAV90839 (PubMed:15989956).Curated1
Sequence conflicti1728S → I in BAC41411 (PubMed:12465718).Curated1
Sequence conflicti2032E → EG in AAV90839 (PubMed:15989956).Curated1
Sequence conflicti2032E → EG in BAC41411 (PubMed:12465718).Curated1
Sequence conflicti2032E → EG in AAH70444 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0111473347 – 3364FPSHF…NCESD → RSLKESLTPGFFGHQHLG in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0111483365 – 4377Missing in isoform 2. 1 PublicationAdd BLAST1013
Alternative sequenceiVSP_0111493780 – 3794Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0111503795 – 3832SESSN…VISDG → VSMMPVAPHSFLYPPSCTMS SVGVHCPYLVCFCITFAK in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0111513833 – 4377Missing in isoform 4. 1 PublicationAdd BLAST545

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY772010 mRNA Translation: AAV90839.3
AY929611 mRNA Translation: AAX24124.1
AL672180 Genomic DNA No translation available.
AL954855 Genomic DNA No translation available.
BX571795 Genomic DNA No translation available.
AB093227 mRNA Translation: BAC41411.2
BC011391 mRNA Translation: AAH11391.1
BC017642 mRNA Translation: AAH17642.2
BC054372 mRNA Translation: AAH54372.1
BC070444 mRNA Translation: AAH70444.1
AK083499 mRNA Translation: BAC38936.1
AB025966 mRNA Translation: BAA84697.1

NCBI Reference Sequences

More...
RefSeqi
NP_067498.4, NM_021523.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000112622; ENSMUSP00000108241; ENSMUSG00000025261 [Q7TMY8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:59026

UCSC genome browser

More...
UCSCi
uc009upq.2 mouse [Q7TMY8-1]
uc009upr.1 mouse [Q7TMY8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY772010 mRNA Translation: AAV90839.3
AY929611 mRNA Translation: AAX24124.1
AL672180 Genomic DNA No translation available.
AL954855 Genomic DNA No translation available.
BX571795 Genomic DNA No translation available.
AB093227 mRNA Translation: BAC41411.2
BC011391 mRNA Translation: AAH11391.1
BC017642 mRNA Translation: AAH17642.2
BC054372 mRNA Translation: AAH54372.1
BC070444 mRNA Translation: AAH70444.1
AK083499 mRNA Translation: BAC38936.1
AB025966 mRNA Translation: BAA84697.1
RefSeqiNP_067498.4, NM_021523.4

3D structure databases

SMRiQ7TMY8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi208493, 61 interactors
IntActiQ7TMY8, 52 interactors
MINTiQ7TMY8
STRINGi10090.ENSMUSP00000026292

PTM databases

iPTMnetiQ7TMY8
PhosphoSitePlusiQ7TMY8
SwissPalmiQ7TMY8

Proteomic databases

EPDiQ7TMY8
jPOSTiQ7TMY8
PaxDbiQ7TMY8
PeptideAtlasiQ7TMY8
PRIDEiQ7TMY8

Genome annotation databases

EnsembliENSMUST00000112622; ENSMUSP00000108241; ENSMUSG00000025261 [Q7TMY8-1]
GeneIDi59026
KEGGimmu:59026
UCSCiuc009upq.2 mouse [Q7TMY8-1]
uc009upr.1 mouse [Q7TMY8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10075
MGIiMGI:1926884 Huwe1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0939 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000156319
InParanoidiQ7TMY8
KOiK10592
OrthoDBi25515at2759

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Huwe1 mouse

Protein Ontology

More...
PROi
PR:Q7TMY8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025261 Expressed in 295 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ7TMY8 baseline and differential
GenevisibleiQ7TMY8 MM

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd14288 UBA_HUWE1, 1 hit
Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR010309 E3_Ub_ligase_DUF908
IPR010314 E3_Ub_ligase_DUF913
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR025527 HUWE1/Rev1_UBM
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041918 UBA_HUWE1
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF06012 DUF908, 1 hit
PF06025 DUF913, 1 hit
PF00632 HECT, 1 hit
PF00627 UBA, 1 hit
PF14377 UBM, 3 hits
PF02825 WWE, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
SSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS50030 UBA, 1 hit
PS50918 WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHUWE1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TMY8
Secondary accession number(s): A2AFQ1
, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 146 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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