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Protein

ATP-binding cassette sub-family G member 2

Gene

Abcg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain (By similarity). May play a role in early stem cell self-renewal by blocking differentiation.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 86ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 2
Alternative name(s):
Breast cancer resistance protein 1 homolog
Urate exporter
CD_antigen: CD338
Gene namesi
Name:Abcg2
Synonyms:Abcp, Bcrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1347061 Abcg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 393CytoplasmicSequence analysisAdd BLAST393
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Topological domaini415 – 428ExtracellularSequence analysisAdd BLAST14
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 477CytoplasmicSequence analysisAdd BLAST28
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 506ExtracellularSequence analysis8
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 535CytoplasmicSequence analysis8
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 632ExtracellularSequence analysisAdd BLAST76
Transmembranei633 – 653HelicalSequence analysisAdd BLAST21
Topological domaini654 – 657CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073705

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933881 – 657ATP-binding cassette sub-family G member 2Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi592 ↔ 610By similarity
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi603InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ7TMS5
MaxQBiQ7TMS5
PaxDbiQ7TMS5
PeptideAtlasiQ7TMS5
PRIDEiQ7TMS5

PTM databases

iPTMnetiQ7TMS5
PhosphoSitePlusiQ7TMS5
SwissPalmiQ7TMS5

Expressioni

Tissue specificityi

Highly expressed in kidney. Lower expression in liver, colon, heart, spleen, and placenta.1 Publication

Interactioni

Subunit structurei

Monomer under reducing conditions, the minimal functional unit is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ7TMS5
IntActiQ7TMS5, 3 interactors
MINTiQ7TMS5
STRINGi10090.ENSMUSP00000031822

Structurei

3D structure databases

ProteinModelPortaliQ7TMS5
SMRiQ7TMS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 285ABC transporterPROSITE-ProRule annotationAdd BLAST238
Domaini389 – 653ABC transmembrane type-2Add BLAST265

Domaini

The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061 Eukaryota
COG0842 LUCA
COG1131 LUCA
HOGENOMiHOG000046080
HOVERGENiHBG050441
InParanoidiQ7TMS5
KOiK05681
PhylomeDBiQ7TMS5
TreeFamiTF105211

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR030256 ABCG2
IPR027417 P-loop_NTPase
PANTHERiPTHR19241:SF452 PTHR19241:SF452, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q7TMS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSNDHVLV PMSQRNNNGL PRTNSRAVRT LAEGDVLSFH HITYRVKVKS
60 70 80 90 100
GFLVRKTVEK EILSDINGIM KPGLNAILGP TGGGKSSLLD VLAARKDPKG
110 120 130 140 150
LSGDVLINGA PQPAHFKCCS GYVVQDDVVM GTLTVRENLQ FSAALRLPTT
160 170 180 190 200
MKNHEKNERI NTIIKELGLE KVADSKVGTQ FIRGISGGER KRTSIGMELI
210 220 230 240 250
TDPSILFLDE PTTGLDSSTA NAVLLLLKRM SKQGRTIIFS IHQPRYSIFK
260 270 280 290 300
LFDSLTLLAS GKLVFHGPAQ KALEYFASAG YHCEPYNNPA DFFLDVINGD
310 320 330 340 350
SSAVMLNREE QDNEANKTEE PSKGEKPVIE NLSEFYINSA IYGETKAELD
360 370 380 390 400
QLPGAQEKKG TSAFKEPVYV TSFCHQLRWI ARRSFKNLLG NPQASVAQLI
410 420 430 440 450
VTVILGLIIG AIYFDLKYDA AGMQNRAGVL FFLTTNQCFS SVSAVELFVV
460 470 480 490 500
EKKLFIHEYI SGYYRVSSYF FGKVMSDLLP MRFLPSVIFT CVLYFMLGLK
510 520 530 540 550
KTVDAFFIMM FTLIMVAYTA SSMALAIATG QSVVSVATLL MTIAFVFMML
560 570 580 590 600
FSGLLVNLRT IGPWLSWLQY FSIPRYGFTA LQYNEFLGQE FCPGFNVTDN
610 620 630 640 650
STCVNSYAIC TGNEYLINQG IELSPWGLWK NHVALACMII IFLTIAYLKL

LFLKKYS
Length:657
Mass (Da):72,978
Last modified:October 1, 2003 - v1
Checksum:iDCD70C5D9FA2BA5F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0B6A0A0R4J0B6_MOUSE
ATP-binding cassette sub-family G m...
Abcg2 mCG_124607
657Annotation score:
S4R2E1S4R2E1_MOUSE
ATP-binding cassette sub-family G m...
Abcg2
576Annotation score:
S4R2M4S4R2M4_MOUSE
ATP-binding cassette sub-family G m...
Abcg2
130Annotation score:
D3YZX5D3YZX5_MOUSE
ATP-binding cassette sub-family G m...
Abcg2
115Annotation score:
D3YVG8D3YVG8_MOUSE
ATP-binding cassette sub-family G m...
Abcg2
50Annotation score:
D3Z150D3Z150_MOUSE
ATP-binding cassette sub-family G m...
Abcg2
172Annotation score:
A0A0N4SWA2A0A0N4SWA2_MOUSE
ATP-binding cassette sub-family G m...
Abcg2
159Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → M in AAD54216 (PubMed:10485464).Curated1
Sequence conflicti492V → I in AAD54216 (PubMed:10485464).Curated1
Sequence conflicti512 – 516TLIMV → GLGAE in AAD09189 (PubMed:9850061).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140218 mRNA Translation: AAD54216.1
BC053730 mRNA Translation: AAH53730.1
AF103875 mRNA Translation: AAD09189.1
CCDSiCCDS20195.1
RefSeqiNP_036050.1, NM_011920.3
XP_006506211.1, XM_006506148.3
XP_006506212.1, XM_006506149.3
XP_006506213.1, XM_006506150.3
XP_006506214.1, XM_006506151.3
XP_011239664.1, XM_011241362.1
UniGeneiMm.333096

Genome annotation databases

GeneIDi26357
KEGGimmu:26357

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140218 mRNA Translation: AAD54216.1
BC053730 mRNA Translation: AAH53730.1
AF103875 mRNA Translation: AAD09189.1
CCDSiCCDS20195.1
RefSeqiNP_036050.1, NM_011920.3
XP_006506211.1, XM_006506148.3
XP_006506212.1, XM_006506149.3
XP_006506213.1, XM_006506150.3
XP_006506214.1, XM_006506151.3
XP_011239664.1, XM_011241362.1
UniGeneiMm.333096

3D structure databases

ProteinModelPortaliQ7TMS5
SMRiQ7TMS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ7TMS5
IntActiQ7TMS5, 3 interactors
MINTiQ7TMS5
STRINGi10090.ENSMUSP00000031822

Chemistry databases

ChEMBLiCHEMBL2073705

PTM databases

iPTMnetiQ7TMS5
PhosphoSitePlusiQ7TMS5
SwissPalmiQ7TMS5

Proteomic databases

EPDiQ7TMS5
MaxQBiQ7TMS5
PaxDbiQ7TMS5
PeptideAtlasiQ7TMS5
PRIDEiQ7TMS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26357
KEGGimmu:26357

Organism-specific databases

CTDi9429
MGIiMGI:1347061 Abcg2

Phylogenomic databases

eggNOGiKOG0061 Eukaryota
COG0842 LUCA
COG1131 LUCA
HOGENOMiHOG000046080
HOVERGENiHBG050441
InParanoidiQ7TMS5
KOiK05681
PhylomeDBiQ7TMS5
TreeFamiTF105211

Miscellaneous databases

PROiPR:Q7TMS5
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR030256 ABCG2
IPR027417 P-loop_NTPase
PANTHERiPTHR19241:SF452 PTHR19241:SF452, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABCG2_MOUSE
AccessioniPrimary (citable) accession number: Q7TMS5
Secondary accession number(s): Q9R004, Q9Z1T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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