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Protein

Mono [ADP-ribose] polymerase PARP16

Gene

Parp16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases.By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152NADBy similarity1
Binding sitei182NADBy similarity1
Sitei193Nicotinamide-stacking aromateBy similarity1
Binding sitei254NAD; may stabilize a reaction intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processUnfolded protein response
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Mono [ADP-ribose] polymerase PARP16Curated (EC:2.4.2.30By similarity)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 15
Poly [ADP-ribose] polymerase 16
Short name:
PARP-16
Gene namesi
Name:Parp16Imported
Synonyms:Artd15Curated
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2446133 Parp16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 287CytoplasmicSequence analysisAdd BLAST287
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 322LumenalSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524381 – 322Mono [ADP-ribose] polymerase PARP16Add BLAST322

Post-translational modificationi

Auto-ADP-ribosylated.By similarity

Keywords - PTMi

ADP-ribosylation

Proteomic databases

MaxQBiQ7TMM8
PaxDbiQ7TMM8
PRIDEiQ7TMM8

PTM databases

PhosphoSitePlusiQ7TMM8

Expressioni

Gene expression databases

BgeeiENSMUSG00000032392 Expressed in 208 organ(s), highest expression level in pancreas
CleanExiMM_PARP16
ExpressionAtlasiQ7TMM8 baseline and differential
GenevisibleiQ7TMM8 MM

Interactioni

Subunit structurei

Interacts with KPNB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7TMM8, 1 interactor
STRINGi10090.ENSMUSP00000070098

Structurei

3D structure databases

ProteinModelPortaliQ7TMM8
SMRiQ7TMM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 91PARP alpha-helicalAdd BLAST87
Domaini94 – 279PARP catalyticPROSITE-ProRule annotationAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi297 – 303Poly-Leu7

Domaini

The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6E Eukaryota
ENOG410ZP73 LUCA
GeneTreeiENSGT00390000014077
HOVERGENiHBG058859
InParanoidiQ7TMM8
KOiK00774
OMAiLHNGLHC
OrthoDBiEOG091G0E9B
PhylomeDBiQ7TMM8
TreeFamiTF323413

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TMM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLSNRAAAR EAASRDVLAA DLRCSLFASA LQSYKRDSVL RPFPASYARH
60 70 80 90 100
DCKDFEALLA DTGRLPNLKE LLQSSRDTDK QAWDLVSWIL SSKILTIHSA
110 120 130 140 150
KKAEFEKIQQ LTGAPHTPVP TPDFLFEIEY FDPANSRFYE TKGERDLIYA
160 170 180 190 200
FHGSRLENFH SIIHNGLHCH LNKTSLFGEG TYLTSDLSLA LIYSPHGHGW
210 220 230 240 250
QHSLLGPILS CVAVCEVIDH PDVKCQIKKK DSKEIDRSRA RIKHSEGGEI
260 270 280 290 300
PPKYFVVTNN QLLRVKYLLV YSQKQPKRAS SQLSWLSSHW FVIMMSLYLL
310 320
LLLIVSVTNS SVFHHFWNRV KR
Length:322
Mass (Da):36,764
Last modified:October 17, 2006 - v2
Checksum:iCA90D8E628AD1874
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SV38A0A1L1SV38_MOUSE
Poly [ADP-ribose] polymerase
Parp16
237Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25S → N in BAC28475 (PubMed:16141072).Curated1
Sequence conflicti168H → Q in BAC28475 (PubMed:16141072).Curated1
Sequence conflicti312V → A in AAH55447 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033791 mRNA Translation: BAC28475.1
AK133475 mRNA Translation: BAE21674.1
BC055447 mRNA Translation: AAH55447.1
CCDSiCCDS23286.1
RefSeqiNP_803411.3, NM_177460.4
UniGeneiMm.31129

Genome annotation databases

EnsembliENSMUST00000069000; ENSMUSP00000070098; ENSMUSG00000032392
ENSMUST00000213396; ENSMUSP00000150318; ENSMUSG00000032392
ENSMUST00000216702; ENSMUSP00000149927; ENSMUSG00000032392
GeneIDi214424
KEGGimmu:214424
UCSCiuc009qcx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033791 mRNA Translation: BAC28475.1
AK133475 mRNA Translation: BAE21674.1
BC055447 mRNA Translation: AAH55447.1
CCDSiCCDS23286.1
RefSeqiNP_803411.3, NM_177460.4
UniGeneiMm.31129

3D structure databases

ProteinModelPortaliQ7TMM8
SMRiQ7TMM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TMM8, 1 interactor
STRINGi10090.ENSMUSP00000070098

PTM databases

PhosphoSitePlusiQ7TMM8

Proteomic databases

MaxQBiQ7TMM8
PaxDbiQ7TMM8
PRIDEiQ7TMM8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069000; ENSMUSP00000070098; ENSMUSG00000032392
ENSMUST00000213396; ENSMUSP00000150318; ENSMUSG00000032392
ENSMUST00000216702; ENSMUSP00000149927; ENSMUSG00000032392
GeneIDi214424
KEGGimmu:214424
UCSCiuc009qcx.2 mouse

Organism-specific databases

CTDi54956
MGIiMGI:2446133 Parp16

Phylogenomic databases

eggNOGiENOG410IF6E Eukaryota
ENOG410ZP73 LUCA
GeneTreeiENSGT00390000014077
HOVERGENiHBG058859
InParanoidiQ7TMM8
KOiK00774
OMAiLHNGLHC
OrthoDBiEOG091G0E9B
PhylomeDBiQ7TMM8
TreeFamiTF323413

Enzyme and pathway databases

ReactomeiR-MMU-197264 Nicotinamide salvaging

Miscellaneous databases

PROiPR:Q7TMM8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032392 Expressed in 208 organ(s), highest expression level in pancreas
CleanExiMM_PARP16
ExpressionAtlasiQ7TMM8 baseline and differential
GenevisibleiQ7TMM8 MM

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAR16_MOUSE
AccessioniPrimary (citable) accession number: Q7TMM8
Secondary accession number(s): Q3V031, Q8CC71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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