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Entry version 150 (16 Oct 2019)
Sequence version 2 (01 Mar 2004)
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Protein

Heterogeneous nuclear ribonucleoprotein Q

Gene

Syncrip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein Q
Short name:
hnRNP Q
Alternative name(s):
Glycine- and tyrosine-rich RNA-binding protein
Short name:
GRY-RBP
NS1-associated protein 1
Synaptotagmin-binding, cytoplasmic RNA-interacting protein
pp68
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syncrip
Synonyms:Hnrpq, Nsap1, Nsap1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891690 Syncrip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818682 – 623Heterogeneous nuclear ribonucleoprotein QAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei159PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei221N6-acetyllysineBy similarity1
Modified residuei363N6-acetyllysineBy similarity1
Modified residuei373PhosphotyrosineBy similarity1
Modified residuei444Asymmetric dimethylarginine; by PRMT1; alternateBy similarity1
Modified residuei444Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei496Omega-N-methylarginine; by PRMT1By similarity1
Modified residuei510Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei518Asymmetric dimethylarginine; by PRMT1; alternateBy similarity1
Modified residuei518Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei526Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei526Omega-N-methylarginine; alternateBy similarity1
Modified residuei536Asymmetric dimethylarginine; by PRMT1; alternateBy similarity1
Modified residuei536Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei539Asymmetric dimethylarginine; by PRMT1; alternateBy similarity1
Modified residuei539Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei587PhosphoserineBy similarity1
Cross-linki607Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TMK9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TMK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TMK9

PeptideAtlas

More...
PeptideAtlasi
Q7TMK9

PRoteomics IDEntifications database

More...
PRIDEi
Q7TMK9

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00406117

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TMK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TMK9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7TMK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, adipocytes, kidney and testis.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in spinal cord at 14 dpc and onwards.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032423 Expressed in 318 organ(s), highest expression level in ureter smooth muscle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7TMK9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TMK9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex.

Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1.

Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.

Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs.

Interacts with GTPBP1 (By similarity). Isoform 1 is a component of the APOB mRNA editosome complex.

Isoform 1 interacts with APOBEC1 and A1CF.

Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP.

Isoform 2 interacts with HNRPR.

Interacts with POLR2A hyperphosphorylated C-terminal domain.

Interacts with HABP4 (By similarity).

Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Isoform 1 and isoform 2 interact with SMN. Isoform 2 interacts through its C-terminal domain with SYT7, SYT8 and SYT9. The non-phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes.

By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
207955, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1078 mCRD-poly(A)-bridging complex
CPX-1089 CRD-mediated mRNA stability complex
CPX-1098 C-to-U editosome complex [Q7TMK9-1]

Protein interaction database and analysis system

More...
IntActi
Q7TMK9, 3 interactors

Molecular INTeraction database

More...
MINTi
Q7TMK9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000063744

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7TMK9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini162 – 241RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini243 – 325RRM 2PROSITE-ProRule annotationAdd BLAST83
Domaini338 – 408RRM 3PROSITE-ProRule annotationAdd BLAST71
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati448 – 4501-13
Repeati451 – 4531-23
Repeati460 – 4642-15
Repeati469 – 4722-24
Repeati478 – 4801-33
Repeati485 – 4882-34
Repeati498 – 5001-43
Repeati526 – 5281-53
Repeati539 – 5411-63
Repeati554 – 5561-73
Repeati557 – 5591-83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 561Interaction with APOBEC1By similarityAdd BLAST162
Regioni448 – 5598 X 3 AA repeats of R-G-GAdd BLAST112
Regioni460 – 4883 X 4 AA repeats of Y-Y-G-YAdd BLAST29
Regioni518 – 549Interaction with SMNBy similarityAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi564 – 578Bipartite nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi431 – 434Poly-Tyr4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The domain containing eight Arg-Gly-Gly repeats (RGG/RXR-box) may be involved in RNA-binding and protein-protein interactions. It is methylated by PRMT1, and essential for nuclear localization (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0117 Eukaryota
ENOG410XTJ5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153511

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TMK9

KEGG Orthology (KO)

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KOi
K13160

Database of Orthologous Groups

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OrthoDBi
1384330at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7TMK9

TreeFam database of animal gene trees

More...
TreeFami
TF314932

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12483 RRM1_hnRNPQ, 1 hit
cd12489 RRM2_hnRNPQ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041337 hnRNP_Q_AcD
IPR006535 HnRNP_R/Q_splicing_fac
IPR034544 hnRNPQ_RRM1
IPR034548 hnRNPQ_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18360 hnRNP_Q_AcD, 1 hit
PF00076 RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928 SSF54928, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01648 hnRNP-R-Q, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TMK9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG
60 70 80 90 100
LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK
110 120 130 140 150
TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD
160 170 180 190 200
SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG
210 220 230 240 250
LNRGYAFVTF CTKEAAQEAV KLYNNHEIRS GKHIGVCISV ANNRLFVGSI
260 270 280 290 300
PKSKTKEQIL EEFSKVTEGL TDVILYHQPD DKKKNRGFCF LEYEDHKTAA
310 320 330 340 350
QARRRLMSGK VKVWGNVGTV EWADPIEDPD PEVMAKVKVL FVRNLANTVT
360 370 380 390 400
EEILEKSFSQ FGKLERVKKL KDYAFIHFDE RDGAVKAMEE MNGKDLEGEN
410 420 430 440 450
IEIVFAKPPD QKRKERKAQR QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG
460 470 480 490 500
RGGYGYPPDY YGYEDYYDYY GYDYHNYRGG YEDPYYGYED FQVGARGRGG
510 520 530 540 550
RGARGAAPSR GRGAAPPRGR AGYSQRGGPG SARGVRGARG GAQQQRGRGV
560 570 580 590 600
RGARGGRGGN VGGKRKADGY NQPDTKRRQT NNQNWGSQPI AQQPLQGGDH
610 620
SGNYGYKSEN QEFYQDTFGQ QWK
Length:623
Mass (Da):69,633
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8139FF9E2C8FB304
GO
Isoform 2 (identifier: Q7TMK9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-562: VRGARGGRGGNVG → QGKGVEAGPDLLQ
     563-623: Missing.

Note: May be due to a competing donor splice site and to an exon inclusion.Curated
Show »
Length:562
Mass (Da):62,672
Checksum:i810BCFA286105377
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V018G3V018_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
588Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZ48G3UZ48_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J259A0A0R4J259_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
561Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZI2G3UZI2_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UXJ6G3UXJ6_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWM1G3UWM1_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UXU5G3UXU5_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XA76G3XA76_MOUSE
Heterogeneous nuclear ribonucleopro...
Syncrip
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH55863 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58807 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143K → E in AAH58807 (PubMed:15489334).Curated1
Sequence conflicti194M → T in AAH50079 (PubMed:15489334).Curated1
Sequence conflicti201L → LTGL in AAC62511 (Ref. 1) Curated1
Sequence conflicti220V → A in AAC62511 (Ref. 1) Curated1
Sequence conflicti291L → Q in AAC62511 (Ref. 1) Curated1
Sequence conflicti298T → A in AAC62511 (Ref. 1) Curated1
Sequence conflicti407K → N in BAC37152 (PubMed:16141072).Curated1
Sequence conflicti411Q → K in BAC37152 (PubMed:16141072).Curated1
Sequence conflicti421Q → H in BAC37152 (PubMed:16141072).Curated1
Sequence conflicti528G → A in AAC62511 (Ref. 1) Curated1
Sequence conflicti543Missing in AAC62511 (Ref. 1) Curated1
Sequence conflicti582N → H in AAC62511 (Ref. 1) Curated1
Isoform 2 (identifier: Q7TMK9-2)
Sequence conflicti549 – 550GQ → G in BAA88342 (PubMed:10734137).Curated2
Sequence conflicti549 – 550GQ → G in AAH41148 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009585550 – 562VRGAR…GGNVG → QGKGVEAGPDLLQ in isoform 2. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_009586563 – 623Missing in isoform 2. 4 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF093821 mRNA Translation: AAC62511.1
AB035725 mRNA Translation: BAA88342.1
AK034845 mRNA Translation: BAC28852.1
AK077588 mRNA Translation: BAC36880.1
AK078158 mRNA Translation: BAC37152.1
BC004001 mRNA Translation: AAH04001.1 Sequence problems.
BC041148 mRNA Translation: AAH41148.2
BC050079 mRNA Translation: AAH50079.2
BC055863 mRNA Translation: AAH55863.1 Different initiation.
BC058807 mRNA Translation: AAH58807.1 Different initiation.
BC080309 mRNA Translation: AAH80309.1
BC108363 mRNA Translation: AAI08364.2
AF408434 mRNA Translation: AAL11726.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23388.1 [Q7TMK9-2]
CCDS57686.1 [Q7TMK9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001271257.1, NM_001284328.1
NP_001298042.1, NM_001311113.1
NP_062640.2, NM_019666.2 [Q7TMK9-1]
NP_062770.1, NM_019796.5 [Q7TMK9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000069221; ENSMUSP00000063744; ENSMUSG00000032423 [Q7TMK9-2]
ENSMUST00000173801; ENSMUSP00000133649; ENSMUSG00000032423 [Q7TMK9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56403

UCSC genome browser

More...
UCSCi
uc009qyo.2 mouse [Q7TMK9-2]
uc009qyq.2 mouse [Q7TMK9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093821 mRNA Translation: AAC62511.1
AB035725 mRNA Translation: BAA88342.1
AK034845 mRNA Translation: BAC28852.1
AK077588 mRNA Translation: BAC36880.1
AK078158 mRNA Translation: BAC37152.1
BC004001 mRNA Translation: AAH04001.1 Sequence problems.
BC041148 mRNA Translation: AAH41148.2
BC050079 mRNA Translation: AAH50079.2
BC055863 mRNA Translation: AAH55863.1 Different initiation.
BC058807 mRNA Translation: AAH58807.1 Different initiation.
BC080309 mRNA Translation: AAH80309.1
BC108363 mRNA Translation: AAI08364.2
AF408434 mRNA Translation: AAL11726.1
CCDSiCCDS23388.1 [Q7TMK9-2]
CCDS57686.1 [Q7TMK9-1]
RefSeqiNP_001271257.1, NM_001284328.1
NP_001298042.1, NM_001311113.1
NP_062640.2, NM_019666.2 [Q7TMK9-1]
NP_062770.1, NM_019796.5 [Q7TMK9-2]

3D structure databases

SMRiQ7TMK9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi207955, 7 interactors
ComplexPortaliCPX-1078 mCRD-poly(A)-bridging complex
CPX-1089 CRD-mediated mRNA stability complex
CPX-1098 C-to-U editosome complex [Q7TMK9-1]
IntActiQ7TMK9, 3 interactors
MINTiQ7TMK9
STRINGi10090.ENSMUSP00000063744

PTM databases

iPTMnetiQ7TMK9
PhosphoSitePlusiQ7TMK9
SwissPalmiQ7TMK9

2D gel databases

REPRODUCTION-2DPAGEiIPI00406117

Proteomic databases

EPDiQ7TMK9
jPOSTiQ7TMK9
PaxDbiQ7TMK9
PeptideAtlasiQ7TMK9
PRIDEiQ7TMK9

Genome annotation databases

EnsembliENSMUST00000069221; ENSMUSP00000063744; ENSMUSG00000032423 [Q7TMK9-2]
ENSMUST00000173801; ENSMUSP00000133649; ENSMUSG00000032423 [Q7TMK9-1]
GeneIDi56403
KEGGimmu:56403
UCSCiuc009qyo.2 mouse [Q7TMK9-2]
uc009qyq.2 mouse [Q7TMK9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10492
MGIiMGI:1891690 Syncrip

Phylogenomic databases

eggNOGiKOG0117 Eukaryota
ENOG410XTJ5 LUCA
GeneTreeiENSGT00940000153511
InParanoidiQ7TMK9
KOiK13160
OrthoDBi1384330at2759
PhylomeDBiQ7TMK9
TreeFamiTF314932

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Syncrip mouse

Protein Ontology

More...
PROi
PR:Q7TMK9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032423 Expressed in 318 organ(s), highest expression level in ureter smooth muscle
ExpressionAtlasiQ7TMK9 baseline and differential
GenevisibleiQ7TMK9 MM

Family and domain databases

CDDicd12483 RRM1_hnRNPQ, 1 hit
cd12489 RRM2_hnRNPQ, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR041337 hnRNP_Q_AcD
IPR006535 HnRNP_R/Q_splicing_fac
IPR034544 hnRNPQ_RRM1
IPR034548 hnRNPQ_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF18360 hnRNP_Q_AcD, 1 hit
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01648 hnRNP-R-Q, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPQ_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TMK9
Secondary accession number(s): O88991
, Q2YDV8, Q68ED6, Q80YV6, Q8BGP1, Q8C5K6, Q8CGC2, Q91ZR0, Q99KU9, Q9QYF4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: October 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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