UniProtKB - Q7TMK6 (HOOK2_MOUSE)

BLAST

>sp|Q7TMK6|HOOK2_MOUSE Protein Hook homolog 2 OS=Mus musculus OX=10090 GN=Hook2 PE=1 SV=3
MSVDKAELCGSLLTWLQTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISED
SSPSWRLKVRKLEKILQSLVEYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLG
CAISCEKKQEYIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPENYGNFDTQSRRYYFL
SEEVEEGDHLQQHYLDLERQLLLLSEEKQNLAQENAALRERVGRSEVESAPGLTAKKLLL
LQSQLEQLQEENFRLESSREDDRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDEL
RQSSERARQLEATLNSCRRRLGELQELRRQVRQLEERNAGHAERTRQLEEELRRAGSLRA
QLEAQRRQVQELQGQWQEEAMKAEKWLFECRNLEEKCDLVTKEKERLLTERDSLREANEE
LRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAELRETLVRLQLENKRLCQQEAADRE
RQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQKALQEQGGKTEDPTLLKRK
LEDHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQDSLQKKDADLRAMEERYRR
YVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYEKSRRRQEQEEKL
LISAWYSMGMALEHRAGEEHAPAHAQSFLAQQRLATNARRGPLGRQALSLRPTDKH

Align
Format
Add to basket Added to basket
History
Entry version 120 (12 Sep 2018)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Protein Hook homolog 2

Gene

Hook2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.By similarity

GO - Molecular functionⁱ

dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding Source: MGI
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic microtubule organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytoskeleton-dependent intracellular transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
early endosome to late endosome transport Source: UniProtKB
endosome organization Source: UniProtKB
endosome to lysosome transport Source: UniProtKB
lysosome organization Source: UniProtKB
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Hook homolog 2 Short name: mHK2
Gene namesⁱ	Name:Hook2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:2181664 Hook2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219195	1 – 716	Protein Hook homolog 2Add BLAST		716

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	163	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7TMK6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7TMK6
PaxDbⁱ	Q7TMK6
PRIDEⁱ	Q7TMK6

PTM databases

iPTMnetⁱ	Q7TMK6
PhosphoSitePlusⁱ	Q7TMK6

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, cerebellum, kidney, liver and heart, with highest levels in heart and kidney (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000052566 Expressed in 199 organ(s), highest expression level in midgut
CleanExⁱ	MM_HOOK2
ExpressionAtlasⁱ	Q7TMK6 baseline and differential
Genevisibleⁱ	Q7TMK6 MM

Interactionⁱ

Subunit structureⁱ

Self-associates (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3 (By similarity). May interact directly with AKTIP/FTS, HOOK1 and HOOK3 (By similarity). Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect (By similarity). Interacts with CNTRL (By similarity). Interacts with microtubules (By similarity). Interacts with ZC3H14 (By similarity). Interacts with LRGUK (via guanylate kinase-like domain) (PubMed:25781171, PubMed:28003339). Interacts with CCDC181 (PubMed:28283191).By similarity3 Publications

GO - Molecular functionⁱ

dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding Source: MGI
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	228463, 1 interactor
IntActⁱ	Q7TMK6, 3 interactors
STRINGⁱ	10090.ENSMUSP00000067752

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7TMK6
SMRⁱ	Q7TMK6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 122	Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST		117

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 546	Sufficient for interaction with microtubulesBy similarityAdd BLAST	546
Regionⁱ	1 – 161	Required for localization to the centrosome and induction of aggresome formationBy similarityAdd BLAST	161
Regionⁱ	533 – 716	Required for localization to the centrosome and induction of aggresome formationBy similarityAdd BLAST	184
Regionⁱ	582 – 716	Sufficient for interaction with CNTRLBy similarityAdd BLAST	135

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	188 – 427	Sequence analysisAdd BLAST		240
Coiled coilⁱ	455 – 605	Sequence analysisAdd BLAST		151

Sequence similaritiesⁱ

Belongs to the hook family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IG1M Eukaryota ENOG410XQ3G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000101702
HOGENOMⁱ	HOG000294112
HOVERGENⁱ	HBG051920
InParanoidⁱ	Q7TMK6
KEGG Orthology (KO) More...KOⁱ	K16611
OMAⁱ	ERNTVYM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06O9
TreeFamⁱ	TF320231

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR036872 CH_dom_sf IPR008636 Hook-like_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05622 HOOK, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q7TMK6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVDKAELCG SLLTWLQTFQ VSPPCASPQD LSSGLAIAHV LNQIDPSWFN 
        60         70         80         90        100
NEWLQGISED SSPSWRLKVR KLEKILQSLV EYSKNVLGHP VSDQHLPDVS 
       110        120        130        140        150
LIGEFSNPAE LGKLLQLVLG CAISCEKKQE YIQRIMTLEE SVQHVVMEAI 
       160        170        180        190        200
QELMTKDTPD SLSPENYGNF DTQSRRYYFL SEEVEEGDHL QQHYLDLERQ 
       210        220        230        240        250
LLLLSEEKQN LAQENAALRE RVGRSEVESA PGLTAKKLLL LQSQLEQLQE 
       260        270        280        290        300
ENFRLESSRE DDRLRCLELE REVAELQQRN QALTSLSQEA QALKDEMDEL 
       310        320        330        340        350
RQSSERARQL EATLNSCRRR LGELQELRRQ VRQLEERNAG HAERTRQLEE 
       360        370        380        390        400
ELRRAGSLRA QLEAQRRQVQ ELQGQWQEEA MKAEKWLFEC RNLEEKCDLV 
       410        420        430        440        450
TKEKERLLTE RDSLREANEE LRCAQLQPRG LAQADLSLDP TPSGLENLAA 
       460        470        480        490        500
EILPAELRET LVRLQLENKR LCQQEAADRE RQEELQRHLE EANRARHGLE 
       510        520        530        540        550
AQQRLNQQQL SELRAQVEEL QKALQEQGGK TEDPTLLKRK LEDHLQKLHE 
       560        570        580        590        600
ADLELQRKRE YIEELEPPTD SSTARRIEEL QDSLQKKDAD LRAMEERYRR 
       610        620        630        640        650
YVDKARTVIQ TLEPKQRPPT VVSPEFHTLR SQLWERNLRI RQMEMDYEKS 
       660        670        680        690        700
RRRQEQEEKL LISAWYSMGM ALEHRAGEEH APAHAQSFLA QQRLATNARR 
       710 
GPLGRQALSL RPTDKH

Length:716

Mass (Da):83,366

Last modified:July 27, 2011 - v3

Checksum:ⁱF8056FDE58E83DC5

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1B0GSU8	A0A1B0GSU8_MOUSE	Protein Hook homolog 2 Protein Hook homolog 2	Hook2	611	Annotation score:
A0A1B0GT78	A0A1B0GT78_MOUSE	Protein Hook homolog 2 Protein Hook homolog 2	Hook2	692	Annotation score:

Sequence cautionⁱ

The sequence AAH02226 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	51	N → D in AAH19486 (PubMed:15489334).Curated	1
Sequence conflictⁱ	158	T → A in AAH19486 (PubMed:15489334).Curated	1
Sequence conflictⁱ	312	A → T in AAH19486 (PubMed:15489334).Curated	1
Sequence conflictⁱ	312	A → T in AAH26609 (PubMed:15489334).Curated	1
Sequence conflictⁱ	574	Missing in AAH55881 (PubMed:15489334).Curated	1
Sequence conflictⁱ	694	L → M in BAC31143 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK042048 mRNA Translation: BAC31143.1 AK145768 mRNA Translation: BAE26639.1 AK169073 mRNA Translation: BAE40859.1 BC002226 mRNA Translation: AAH02226.1 Different initiation. BC019486 mRNA Translation: AAH19486.1 BC026609 mRNA Translation: AAH26609.1 BC055881 mRNA Translation: AAH55881.1 BC080744 mRNA Translation: AAH80744.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22489.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161463.1, NM_001167991.1 NP_573518.2, NM_133255.2
UniGeneⁱ	Mm.247775

Genome annotation databases

Ensemblⁱ	ENSMUST00000064495; ENSMUSP00000067752; ENSMUSG00000052566
GeneIDⁱ	170833
KEGGⁱ	mmu:170833
UCSC genome browser More...UCSCⁱ	uc009moq.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7TMK6	Hook microtubule-tethering protein 2		RAT		719	UniRef90_Q7TMK6
Uncharacterized protein		MOUSE		715
UPI00067D4878		MICOH		719
UPI00077DD122		PERMB		719
UPI000A32708F		MESAU		718
+18

Protein	Similar proteins		Species	Score	Length	Source
Q7TMK6	Protein Hook homolog 1		DANRE		715	UniRef50_Q7TMK6
Protein Hook homolog 2		XENLA		721
Hook microtubule-tethering protein 2		RAT		719
Uncharacterized protein		MOUSE		715
Protein Hook 2		ICTPU		711
+451

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK042048 mRNA Translation: BAC31143.1 AK145768 mRNA Translation: BAE26639.1 AK169073 mRNA Translation: BAE40859.1 BC002226 mRNA Translation: AAH02226.1 Different initiation. BC019486 mRNA Translation: AAH19486.1 BC026609 mRNA Translation: AAH26609.1 BC055881 mRNA Translation: AAH55881.1 BC080744 mRNA Translation: AAH80744.1
CCDSⁱ	CCDS22489.1
RefSeqⁱ	NP_001161463.1, NM_001167991.1 NP_573518.2, NM_133255.2
UniGeneⁱ	Mm.247775

3D structure databases

ProteinModelPortalⁱ	Q7TMK6
SMRⁱ	Q7TMK6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	228463, 1 interactor
IntActⁱ	Q7TMK6, 3 interactors
STRINGⁱ	10090.ENSMUSP00000067752

PTM databases

iPTMnetⁱ	Q7TMK6
PhosphoSitePlusⁱ	Q7TMK6

Proteomic databases

EPDⁱ	Q7TMK6
MaxQBⁱ	Q7TMK6
PaxDbⁱ	Q7TMK6
PRIDEⁱ	Q7TMK6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000064495; ENSMUSP00000067752; ENSMUSG00000052566
GeneIDⁱ	170833
KEGGⁱ	mmu:170833
UCSCⁱ	uc009moq.2 mouse

Organism-specific databases

CTDⁱ	29911
MGIⁱ	MGI:2181664 Hook2

Phylogenomic databases

eggNOGⁱ	ENOG410IG1M Eukaryota ENOG410XQ3G LUCA
GeneTreeⁱ	ENSGT00690000101702
HOGENOMⁱ	HOG000294112
HOVERGENⁱ	HBG051920
InParanoidⁱ	Q7TMK6
KOⁱ	K16611
OMAⁱ	ERNTVYM
OrthoDBⁱ	EOG091G06O9
TreeFamⁱ	TF320231

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q7TMK6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000052566 Expressed in 199 organ(s), highest expression level in midgut
CleanExⁱ	MM_HOOK2
ExpressionAtlasⁱ	Q7TMK6 baseline and differential
Genevisibleⁱ	Q7TMK6 MM

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR036872 CH_dom_sf IPR008636 Hook-like_fam
Pfamⁱ	View protein in Pfam PF05622 HOOK, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HOOK2_MOUSE
Accessionⁱ	Q7TMK6Primary (citable) accession number: Q7TMK6 Secondary accession number(s): Q66JV2 , Q8BY47, Q8R347, Q8VCN4, Q99LU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7TMK6 (HOOK2_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein Hook homolog 2

Hook2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ