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Entry version 153 (29 Sep 2021)
Sequence version 1 (01 Oct 2003)
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Protein

E3 ubiquitin-protein ligase UHRF2

Gene

Uhrf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair. Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:23434322, PubMed:28402695).

This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (PubMed:28115522).

Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest. Ubiquitinates also PCNP leading to its degradation by the proteasome. Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteosomal degradation. Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation. Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

E3 ligase activity is robustly activated by 5-hydroxy-methylcytosine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri340 – 396PHD-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri734 – 773RING-typePROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Transferase
Biological processCell cycle, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3899300, SUMOylation of transcription cofactors

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UHRF2 (EC:2.3.2.27)
Alternative name(s):
NIRF
Np95-like ring finger protein
Nuclear protein 97
Nuclear zinc finger protein Np97
RING-type E3 ubiquitin transferase UHRF2
Ubiquitin-like PHD and RING finger domain-containing protein 2
Ubiquitin-like-containing PHD and RING finger domains protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Uhrf2
Synonyms:Nirf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923718, Uhrf2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000024817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion mice are viable, fertile, and grossly normal (PubMed:28402695, PubMed:28115522). However, adult mice develop frequent spontaneous seizures and display abnormal electrical activities in brain (PubMed:28402695). In addition, they display reduced 5-hydroxymethylcytosine (5hmC) in genomic DNA in the brain together with impaired spatial memory acquisition and retention (PubMed:28115522).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi214Y → A: Abolishes in vitro binding to H3K9me3. Prevents enrichment at pericentric heterochromatin. 1 Publication1
Mutagenesisi217Y → A: Abolishes in vitro binding to 'Lys-10' methylated H3, H3K9me3. Prevents enrichment at pericentric heterochromatin. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561481 – 803E3 ubiquitin-protein ligase UHRF2Add BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei668PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi705InterchainBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be autoubiquitinated; which may lead to proteasomal degradation.By similarity
Phosphorylated. Phosphorylation may be mediated by CDK2 (By similarity).By similarity
Autosumoylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TMI3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TMI3

PeptideAtlas

More...
PeptideAtlasi
Q7TMI3

PRoteomics IDEntifications database

More...
PRIDEi
Q7TMI3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
298475 [Q7TMI3-1]
298476 [Q7TMI3-2]
298477 [Q7TMI3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TMI3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TMI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly detected in several tissues, including the thymus, spleen, lung, adrenal gland, and ovary. In addition, found in several tissues in the brain (cerebellum, hippocampus, and cerebral cortex).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during cell differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024817, Expressed in superior cervical ganglion and 278 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TMI3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides.

Interacts with H3; the interaction has a preference for the 'Lys-9' trimethylated form of H3 (H3K9me3) (By similarity).

Interacts with PCNP.

Interacts with HDAC1.

Interacts directly with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1 phosphorylation.

Interacts with CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1 phosphorylation.

Interacts with p53/TP53 and RB1.

Interacts with UBE2I.

Interacts with ZNF618.

Interacts with UHRF1.

Interacts with FANCD2.

Interacts with ATR.

Interacts with PCNA (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025739

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TMI3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q7TMI3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TMI3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 78Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78
Domaini449 – 613YDGPROSITE-ProRule annotationAdd BLAST165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 115DisorderedSequence analysisAdd BLAST37
Regioni118 – 312Required for interaction with histone H3Add BLAST195
Regioni154 – 200DisorderedSequence analysisAdd BLAST47
Regioni195 – 289Interaction with PCNPBy similarityAdd BLAST95
Regioni415 – 645Methyl-CpG binding and interaction with HDAC1By similarityAdd BLAST231
Regioni643 – 676DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 93Polar residuesSequence analysisAdd BLAST15
Compositional biasi163 – 200Polar residuesSequence analysisAdd BLAST38
Compositional biasi645 – 676Basic and acidic residuesSequence analysisAdd BLAST32

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 396PHD-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri734 – 773RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRDQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008296

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022357_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TMI3

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHMCSCH

Database of Orthologous Groups

More...
OrthoDBi
705927at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TMI3

TreeFam database of animal gene trees

More...
TreeFami
TF106434

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.280.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015947, PUA-like_sf
IPR036987, SRA-YDG_sf
IPR003105, SRA_YDG
IPR021991, TTD_dom
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628, PHD, 1 hit
PF02182, SAD_SRA, 1 hit
PF12148, TTD, 1 hit
PF00240, ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249, PHD, 1 hit
SM00184, RING, 2 hits
SM00466, SRA, 1 hit
SM00213, UBQ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54236, SSF54236, 1 hit
SSF57903, SSF57903, 1 hit
SSF88697, SSF88697, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50053, UBIQUITIN_2, 1 hit
PS51015, YDG, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7TMI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWIQVRTIDG SQTRTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK
60 70 80 90 100
QLENGYTLFD YDVGLNDIIQ LLVRPDSSLP STSKQNDAQV KPSSHNPPKV
110 120 130 140 150
KKTARGGSSS QPSTSARTCL IDPGFGLYKV NELVDARDVG LGAWFEAHIH
160 170 180 190 200
SVTRASDGHS RGKTPLKNGS SYKRTNGNVN HNSKENTNKL DNVPSTSNSD
210 220 230 240 250
SVAADEDVIY HIEYDEYPES GILEMNVKDL RPRARTILKW NELNVGDVVM
260 270 280 290 300
VNYNVENPGK RGFWYDAEIT TLKTISRTKK EVRVKVFLGG SEGTLNDCRV
310 320 330 340 350
MSVDEIFKIE KPGAHPISFA DGKFLRKNDP ECDLCGGDPD KTCHMCSCHK
360 370 380 390 400
CGEKRDPNMQ LLCDECNMAY HIYCLSPPLD KVPEEEYWYC PSCKTDSSEV
410 420 430 440 450
VKAGERLKLS KKKAKMPSAS TESRRDWGRG MACVGRTKEC TIVPSNHYGP
460 470 480 490 500
IPGIPVGSTW RFRVQVSEAG VHRPHVGGIH GRSNDGAYSL VLAGGFEDEV
510 520 530 540 550
DRGDEFTYTG SGGKNLAGNK RIGAPSADQT LTNMNRALAL NCDAPLDDKI
560 570 580 590 600
GAESRNWRAG KPVRVIRSFK GRKISKYAPE EGNRYDGIYK VVKYWPEISS
610 620 630 640 650
SHGFLVWRYL LRRDDVEPAP WTSEGIERSR RLCLRLQYPA GYPSEKEGKK
660 670 680 690 700
TKGQSKKQGS EATKRPASDD ECPGDSKVLK ASDSTDAVEA FQLTPQQQRL
710 720 730 740 750
IREDCQNQKL WDEVLASLVE GPNFLKKLEQ SFMCVCCQEL VYQPVTTECF
760 770 780 790 800
HNVCKDCLQR SFKAQVFSCP ACRHDLGQNY VMVLNETLQT LLDLFFPGYS

KGR
Length:803
Mass (Da):90,106
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD799B0205E0E036E
GO
Isoform 2 (identifier: Q7TMI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     501-516: DRGDEFTYTGSGGKNL → VSNDVTLFFRTNLDHF
     517-803: Missing.

Show »
Length:516
Mass (Da):57,761
Checksum:i3D6862E9D1E1DEDD
GO
Isoform 3 (identifier: Q7TMI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-803: Missing.

Show »
Length:216
Mass (Da):24,138
Checksum:iC2C868076470EBCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti274T → S in AAM33798 (Ref. 1) Curated1
Sequence conflicti278T → S in AAM33798 (Ref. 1) Curated1
Sequence conflicti793D → E in AAM33798 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013876217 – 803Missing in isoform 3. 1 PublicationAdd BLAST587
Alternative sequenceiVSP_013877501 – 516DRGDE…GGKNL → VSNDVTLFFRTNLDHF in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_013878517 – 803Missing in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB116653 mRNA Translation: BAC81739.1
AF274047 mRNA Translation: AAM33798.1
AK031036 mRNA Translation: BAC27224.1
AK041564 mRNA Translation: BAC30987.1
AK042321 mRNA Translation: BAC31223.1
AK051743 mRNA Translation: BAC34750.1
AK080925 mRNA Translation: BAC38081.1
BC060241 mRNA Translation: AAH60241.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37955.1 [Q7TMI3-1]

NCBI Reference Sequences

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RefSeqi
NP_659122.2, NM_144873.2 [Q7TMI3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000025739; ENSMUSP00000025739; ENSMUSG00000024817 [Q7TMI3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
109113

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:109113

UCSC genome browser

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UCSCi
uc008hef.1, mouse [Q7TMI3-3]
uc008heh.1, mouse [Q7TMI3-2]
uc008hei.1, mouse [Q7TMI3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116653 mRNA Translation: BAC81739.1
AF274047 mRNA Translation: AAM33798.1
AK031036 mRNA Translation: BAC27224.1
AK041564 mRNA Translation: BAC30987.1
AK042321 mRNA Translation: BAC31223.1
AK051743 mRNA Translation: BAC34750.1
AK080925 mRNA Translation: BAC38081.1
BC060241 mRNA Translation: AAH60241.1
CCDSiCCDS37955.1 [Q7TMI3-1]
RefSeqiNP_659122.2, NM_144873.2 [Q7TMI3-1]

3D structure databases

BMRBiQ7TMI3
SMRiQ7TMI3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025739

PTM databases

iPTMnetiQ7TMI3
PhosphoSitePlusiQ7TMI3

Proteomic databases

EPDiQ7TMI3
PaxDbiQ7TMI3
PeptideAtlasiQ7TMI3
PRIDEiQ7TMI3
ProteomicsDBi298475 [Q7TMI3-1]
298476 [Q7TMI3-2]
298477 [Q7TMI3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9697, 299 antibodies

The DNASU plasmid repository

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DNASUi
109113

Genome annotation databases

EnsembliENSMUST00000025739; ENSMUSP00000025739; ENSMUSG00000024817 [Q7TMI3-1]
GeneIDi109113
KEGGimmu:109113
UCSCiuc008hef.1, mouse [Q7TMI3-3]
uc008heh.1, mouse [Q7TMI3-2]
uc008hei.1, mouse [Q7TMI3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115426
MGIiMGI:1923718, Uhrf2
VEuPathDBiHostDB:ENSMUSG00000024817

Phylogenomic databases

eggNOGiENOG502QRDQ, Eukaryota
GeneTreeiENSGT00390000008296
HOGENOMiCLU_022357_0_0_1
InParanoidiQ7TMI3
OMAiCHMCSCH
OrthoDBi705927at2759
PhylomeDBiQ7TMI3
TreeFamiTF106434

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-3899300, SUMOylation of transcription cofactors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
109113, 2 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Uhrf2, mouse

Protein Ontology

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PROi
PR:Q7TMI3
RNActiQ7TMI3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024817, Expressed in superior cervical ganglion and 278 other tissues
GenevisibleiQ7TMI3, MM

Family and domain databases

Gene3Di2.30.280.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015947, PUA-like_sf
IPR036987, SRA-YDG_sf
IPR003105, SRA_YDG
IPR021991, TTD_dom
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF00628, PHD, 1 hit
PF02182, SAD_SRA, 1 hit
PF12148, TTD, 1 hit
PF00240, ubiquitin, 1 hit
SMARTiView protein in SMART
SM00249, PHD, 1 hit
SM00184, RING, 2 hits
SM00466, SRA, 1 hit
SM00213, UBQ, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit
SSF57903, SSF57903, 1 hit
SSF88697, SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50053, UBIQUITIN_2, 1 hit
PS51015, YDG, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUHRF2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TMI3
Secondary accession number(s): Q8BG56
, Q8BJP6, Q8BY30, Q8K1I5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2003
Last modified: September 29, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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