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Entry version 129 (17 Jun 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Sperm-associated antigen 5

Gene

Spag5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm-associated antigen 5
Alternative name(s):
Mastrin
Mitotic spindle-associated protein p126
Short name:
MAP126
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spag5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927470 Spag5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720941 – 1165Sperm-associated antigen 5Add BLAST1165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei66PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei946Phosphoserine; by GSK3-betaBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TME2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7TME2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TME2

PeptideAtlas

More...
PeptideAtlasi
Q7TME2

PRoteomics IDEntifications database

More...
PRIDEi
Q7TME2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TME2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TME2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, but not in the other tissues tested.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is cell cycle-regulated, with an increase from prophase to cytokinesis and return to basal levels at the next G1 phase.By similarity

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000002055 Expressed in lumbar subsegment of spinal cord and 232 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TME2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, with a globular head domain and a long stalk. Homooligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle.

Interacts with DCLRE1B/Apollo.

Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2.

Interacts with KNSTRN.

Interacts with RPTOR; this interaction competes with RPTOR binding to MTOR, resulting in decreased mTORC1 formation.

Interacts with G3BP1. The complex formed with G3BP1 AND RPTOR is increased by oxidative stress.

Interacts with OSBPL8, PCM1 and CDK5RAP2.

Interacts (via C-terminus) with NUMA1 (via C-terminus); this interaction promotes the recruitment of SPAG5 to the microtubules at spindle poles in a dynein-dynactin-dependent manner.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
207577, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q7TME2, 11 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045286

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TME2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TME2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni453 – 821Interaction with KNSTRNBy similarityAdd BLAST369

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili509 – 856Sequence analysisAdd BLAST348
Coiled coili937 – 1146Sequence analysisAdd BLAST210

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIA9 Eukaryota
ENOG410YG9P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00400000022377

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007803_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TME2

KEGG Orthology (KO)

More...
KOi
K21764

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEDCKGQ

Database of Orthologous Groups

More...
OrthoDBi
257437at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TME2

TreeFam database of animal gene trees

More...
TreeFami
TF336280

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028728 Astrin

The PANTHER Classification System

More...
PANTHERi
PTHR15347 PTHR15347, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7TME2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRVKTLNLG LSPSPQKGKP AMSTPLRELK LQPEALADSG KGPSMISALT
60 70 80 90 100
PYLCRLELKE RCNNSSPVDF INTENNFLSE QFSHPSTHIE ACQRESDPTP
110 120 130 140 150
ESNSLFHTLE EAIETVDDFV VDPRDDSIVE SMVLLPFSLG QQQDLMLQAH
160 170 180 190 200
LDTTAERTKS SLNESLGLED LVGKEVAPCV EDSLTEIVAI RPEQPTFQDP
210 220 230 240 250
PLGPSDTEDA PVDLVPSENV LNFSLARLSP SAVLAQDFSV DHVDPGEETV
260 270 280 290 300
ENRVLQEMET SFPTFPEEAE LGDQAPAANA EAVSPLYLTS SLVEMGPREA
310 320 330 340 350
PGPTVEDASR IPGLESETWM SPLAWLEKGV NTSVMLQNLR QSLSFSSVLQ
360 370 380 390 400
DAAVGNTPLA TCSVGTSFTP PAPLEVGTKD STSETERLLL GCRPPDLATL
410 420 430 440 450
SRHDLEENLL NSLVLLEVLS HQLQAWKSQL TVPHREARDS STQTDSSPCG
460 470 480 490 500
VTKTPKHLQD SKEIRQALLQ ARNVMQSWGL VSGDLLSLLH LSLTHVQEGR
510 520 530 540 550
VTVSQESQRS KTLVSSCSRV LKKLKAKLQS LKTECEEARH SKEMALKGKA
560 570 580 590 600
AAEAVLEAFR AHASQRISQL EQGLTSMQEF RGLLQEAQTQ LIGLHTEQKE
610 620 630 640 650
LAQQTVSLSS ALQQDWTSVQ LNYGIWAALL SWSRELTKKL TAKSRQALQE
660 670 680 690 700
RDAAIEEKKQ VVKEVEQVSA HLEDCKGQIE QLKLENSRLT ADLSAQLQIL
710 720 730 740 750
TSTESQLKEV RSQHSRCVQD LAVKDELLCQ LTQSNKEQAT QWQKEEMELK
760 770 780 790 800
HIQAELLQQQ AVLAKEVQDL RETVEFIDEE SQVAHRELGQ IESQLKVTLE
810 820 830 840 850
LLRERSLQCE TLRDTVDSLR AELASTEAKH EKQALEKTHQ HSQELRLLAE
860 870 880 890 900
QLQSLTLFLQ AKLKENKAES EIILPSTGSA PAQEHPLSND SSISEQTPTA
910 920 930 940 950
AVDEVPEPAP VPLLGSVKSA FTRVASMASF QPTETPDLEK SLAEMSTVLQ
960 970 980 990 1000
ELKSLCSLLQ ESKEEATGVL QREICELHSR LQAQEEEHQE ALKAKEADME
1010 1020 1030 1040 1050
KLNQALCLLR KNEKELLEVI QKQNEKILGQ IDKSGQLINL REEVTQLTQS
1060 1070 1080 1090 1100
LRRAETETKV LQEALEGQLD PSCQLMATNW IQEKVFLSQE VSKLRVMFLE
1110 1120 1130 1140 1150
MKTEKEQLMD KYLSHRHILE ENLRRSDTEL KKLDDTIQHV YETLLSIPET
1160
MKSCKELQGL LEFLS
Length:1,165
Mass (Da):129,993
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0885C71A3AB7A96A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48A → S in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti98P → S in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti225L → P in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti244D → N in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti347S → P in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti441S → G in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti663 – 665KEV → TGM in AAO15441 (PubMed:12893248).Curated3
Sequence conflicti776F → S in AAO15441 (PubMed:12893248).Curated1
Sequence conflicti888 – 889SN → PS in AAO15441 (PubMed:12893248).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF420307 mRNA Translation: AAO15441.1
AY226907 Genomic DNA Translation: AAP46103.1
AL591070 Genomic DNA No translation available.
BC052672 mRNA Translation: AAH52672.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25098.1

NCBI Reference Sequences

More...
RefSeqi
NP_059103.1, NM_017407.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045026; ENSMUSP00000045286; ENSMUSG00000002055

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:54141

UCSC genome browser

More...
UCSCi
uc007kiv.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420307 mRNA Translation: AAO15441.1
AY226907 Genomic DNA Translation: AAP46103.1
AL591070 Genomic DNA No translation available.
BC052672 mRNA Translation: AAH52672.1
CCDSiCCDS25098.1
RefSeqiNP_059103.1, NM_017407.2

3D structure databases

SMRiQ7TME2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207577, 10 interactors
IntActiQ7TME2, 11 interactors
STRINGi10090.ENSMUSP00000045286

PTM databases

iPTMnetiQ7TME2
PhosphoSitePlusiQ7TME2

Proteomic databases

EPDiQ7TME2
MaxQBiQ7TME2
PaxDbiQ7TME2
PeptideAtlasiQ7TME2
PRIDEiQ7TME2

Genome annotation databases

EnsembliENSMUST00000045026; ENSMUSP00000045286; ENSMUSG00000002055
GeneIDi54141
KEGGimmu:54141
UCSCiuc007kiv.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10615
MGIiMGI:1927470 Spag5

Phylogenomic databases

eggNOGiENOG410IIA9 Eukaryota
ENOG410YG9P LUCA
GeneTreeiENSGT00400000022377
HOGENOMiCLU_007803_0_0_1
InParanoidiQ7TME2
KOiK21764
OMAiLEDCKGQ
OrthoDBi257437at2759
PhylomeDBiQ7TME2
TreeFamiTF336280

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54141 6 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Spag5 mouse

Protein Ontology

More...
PROi
PR:Q7TME2
RNActiQ7TME2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002055 Expressed in lumbar subsegment of spinal cord and 232 other tissues
GenevisibleiQ7TME2 MM

Family and domain databases

InterProiView protein in InterPro
IPR028728 Astrin
PANTHERiPTHR15347 PTHR15347, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPAG5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TME2
Secondary accession number(s): B1AQC8, Q8CH61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: June 17, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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