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Entry version 118 (29 Sep 2021)
Sequence version 2 (05 Feb 2008)
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Protein

Phospholipid phosphatase-related protein type 4

Gene

Plppr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways (PubMed:19766573).

Binds lysophosphatidic acid (LPA) and mediates its internalization into cells (PubMed:26671989).

Could act as receptor or a transporter of this lipid at the post-synaptic membrane (PubMed:19766573, PubMed:26671989).

Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity).

By similarity2 Publications

Caution

Originally described as a 2-lysophosphatidate/LPA phosphatase (PubMed:12730698). However, other studies suggested it does not have such activity (PubMed:19766573). This is in agreement with the absence of conservation of some residues, including the nucleophile active site, critical for the phosphatase activity of other members of that protein family (PubMed:19766573).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-419408, Lysosphingolipid and LPA receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4By similarity
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 1By similarity
Lipid phosphate phosphatase-related protein type 4By similarity
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plppr4Imported
Synonyms:D3Bwg0562e1 Publication, Kiaa04551 Publication, Lppr4By similarity, Php1By similarity, Prg11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106530, Plppr4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000044667

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice lacking Plppr4 are viable but show a severe alteration of synaptic transmission leading to juvenile epileptic seizures (PubMed:19766573). Excitatory transmission in CA1 pyramidal neurons is significantly increased (PubMed:19766573). It is associated with transiently reduced weight during development, a reduction in brain size and higher mortality 3 to 4 weeks after birth (PubMed:19766573). Heterozygous knockout mice, show loss of somatosensory filter function and altered resilience during stress-related behaviors (PubMed:26671989).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi253H → Q: Loss of function in regulation of glutamatergic synaptic transmission. 1 Publication1
Mutagenesisi346R → T: No effect on localization. Decreased O-glycosylation. Loss of function in LPA internalization into cells. Loss of function in regulation of glutamatergic synaptic transmission. 1 Publication1
Mutagenesisi347S → A or D: Loss of function in LPA import into cell. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174371 – 766Phospholipid phosphatase-related protein type 4Add BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei347PhosphoserineCombined sources1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei386PhosphoserineBy similarity1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei439PhosphoserineCombined sources1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei462PhosphoserineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei608PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated. Probably at Ser-347.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7TME0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TME0

PeptideAtlas

More...
PeptideAtlasi
Q7TME0

PRoteomics IDEntifications database

More...
PRIDEi
Q7TME0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
288264

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7TME0, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TME0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TME0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7TME0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain-specific, it is exclusively expressed in neurons (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044667, Expressed in Ammon's horn and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TME0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230903, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q7TME0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q7TME0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000052306

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TME0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni454 – 494DisorderedSequence analysisAdd BLAST41
Regioni634 – 654DisorderedSequence analysisAdd BLAST21
Regioni672 – 701DisorderedSequence analysisAdd BLAST30
Regioni742 – 766DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi454 – 490Polar residuesSequence analysisAdd BLAST37
Compositional biasi742 – 757Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3030, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021458_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TME0

Identification of Orthologs from Complete Genome Data

More...
OMAi
METEPGQ

Database of Orthologous Groups

More...
OrthoDBi
1621899at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TME0

TreeFam database of animal gene trees

More...
TreeFami
TF316040

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase
IPR043216, PLPP
IPR028684, PLPPR4

The PANTHER Classification System

More...
PANTHERi
PTHR10165, PTHR10165, 1 hit
PTHR10165:SF13, PTHR10165:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01569, PAP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00014, acidPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48317, SSF48317, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TME0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRAGSSGAR GECDISGAGR LRLEQAARLG GRTVHTSPGG GLGARQAAGM
60 70 80 90 100
SAKERPKGKV IKDSVTLLPC FYFVELPILA SSVVSLYFLE LTDVFKPVHS
110 120 130 140 150
GFSCYDRSLS MPYIEPTQEA IPFLMLLSLA FAGPAITIMV GEGILYCCLS
160 170 180 190 200
KRRNGAGLEP NINAGGCNFN SFLRRAVRFV GVHVFGLCST ALITDIIQLS
210 220 230 240 250
TGYQAPYFLT VCKPNYTSLN VSCKENSYIV EDICSGSDLT VINSGRKSFP
260 270 280 290 300
SQHATLAAFA AVYVSMYFNS TLTDSSKLLK PLLVFTFIIC GIICGLTRIT
310 320 330 340 350
QYKNHPVDVY CGFLIGGGIA LYLGLYAVGN FLPSEDSMLQ HRDALRSLTD
360 370 380 390 400
LNQDPSRVLS AKNGSSGDGI AHTEGILNRN HRDASSLTNL KRANADVEII
410 420 430 440 450
TPRSPMGKES MVTFSNTLPR ANTPSVEDPV RRNASIHASM DSARSKQLLT
460 470 480 490 500
QWKSKNESRK MSLQVMDTEP EGQSPPRSIE MRSSSEPSRV GVNGDHHVPG
510 520 530 540 550
NQYLKIQPGT VPGCNNSMPG GPRVSIQSRP GSSQLVHIPE ETQENISTSP
560 570 580 590 600
KSSSARAKWL KAAEKTVACN RSNNQPRIMQ VIAMSKQQGV LQSSPKNAEG
610 620 630 640 650
STVTCTGSIR YKTLTDHEPS GIVRVEAHPE NNRPIIQIPS STEGEGSGSW
660 670 680 690 700
KWKAPEKSSL RQTYELNDLN RDSESCESLK DSFGSGDRKR SNIDSNEHHH
710 720 730 740 750
HGITTIRVTP VEGSEIGSET LSVSSSRDST LRRKGNIILI PERSNSPENT
760
RNIFYKGTSP TRAYKD
Length:766
Mass (Da):83,290
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i371D9FA1A829B5B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGY9A0A0G2JGY9_MOUSE
2-lysophosphatidate phosphatase PLP...
Plppr4 Lppr4
707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC37711 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC97959 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti451Q → R in BAC32865 (PubMed:16141072).Curated1
Sequence conflicti495 – 496DH → ED in AAH24711 (PubMed:15489334).Curated2
Sequence conflicti500G → S in AAH24711 (PubMed:15489334).Curated1
Sequence conflicti543Q → K in BAC32865 (PubMed:16141072).Curated1
Sequence conflicti568A → D in AAP41099 (PubMed:12730698).Curated1
Sequence conflicti568A → D in AAP41100 (PubMed:12730698).Curated1
Sequence conflicti568A → D in AAP57768 (PubMed:12730698).Curated1
Sequence conflicti653K → E in BAC37711 (PubMed:16141072).Curated1
Sequence conflicti654A → V in AAP41099 (PubMed:12730698).Curated1
Sequence conflicti654A → V in AAP41100 (PubMed:12730698).Curated1
Sequence conflicti654A → V in AAP57768 (PubMed:12730698).Curated1
Sequence conflicti737I → V in BAC32865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY266266 mRNA Translation: AAP41099.1
AY266267 mRNA Translation: AAP41100.1
AF541279 mRNA Translation: AAP57768.1
AK129149 mRNA Translation: BAC97959.1 Different initiation.
AK046782 mRNA Translation: BAC32865.1
AK079635 mRNA Translation: BAC37711.1 Different initiation.
BC024711 mRNA Translation: AAH24711.1
BC137701 mRNA Translation: AAI37702.1
BC137702 mRNA Translation: AAI37703.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17795.1

NCBI Reference Sequences

More...
RefSeqi
NP_808332.3, NM_177664.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061071; ENSMUSP00000052306; ENSMUSG00000044667

Database of genes from NCBI RefSeq genomes

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GeneIDi
229791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:229791

UCSC genome browser

More...
UCSCi
uc008rcz.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266266 mRNA Translation: AAP41099.1
AY266267 mRNA Translation: AAP41100.1
AF541279 mRNA Translation: AAP57768.1
AK129149 mRNA Translation: BAC97959.1 Different initiation.
AK046782 mRNA Translation: BAC32865.1
AK079635 mRNA Translation: BAC37711.1 Different initiation.
BC024711 mRNA Translation: AAH24711.1
BC137701 mRNA Translation: AAI37702.1
BC137702 mRNA Translation: AAI37703.1
CCDSiCCDS17795.1
RefSeqiNP_808332.3, NM_177664.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi230903, 3 interactors
IntActiQ7TME0, 2 interactors
MINTiQ7TME0
STRINGi10090.ENSMUSP00000052306

PTM databases

GlyGeniQ7TME0, 9 sites
iPTMnetiQ7TME0
PhosphoSitePlusiQ7TME0
SwissPalmiQ7TME0

Proteomic databases

MaxQBiQ7TME0
PaxDbiQ7TME0
PeptideAtlasiQ7TME0
PRIDEiQ7TME0
ProteomicsDBi288264

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1575, 104 antibodies

The DNASU plasmid repository

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DNASUi
229791

Genome annotation databases

EnsembliENSMUST00000061071; ENSMUSP00000052306; ENSMUSG00000044667
GeneIDi229791
KEGGimmu:229791
UCSCiuc008rcz.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9890
MGIiMGI:106530, Plppr4
VEuPathDBiHostDB:ENSMUSG00000044667

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3030, Eukaryota
GeneTreeiENSGT00940000156181
HOGENOMiCLU_021458_8_0_1
InParanoidiQ7TME0
OMAiMETEPGQ
OrthoDBi1621899at2759
PhylomeDBiQ7TME0
TreeFamiTF316040

Enzyme and pathway databases

ReactomeiR-MMU-419408, Lysosphingolipid and LPA receptors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
229791, 3 hits in 31 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plppr4, mouse

Protein Ontology

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PROi
PR:Q7TME0
RNActiQ7TME0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000044667, Expressed in Ammon's horn and 175 other tissues
GenevisibleiQ7TME0, MM

Family and domain databases

InterProiView protein in InterPro
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase
IPR043216, PLPP
IPR028684, PLPPR4
PANTHERiPTHR10165, PTHR10165, 1 hit
PTHR10165:SF13, PTHR10165:SF13, 1 hit
PfamiView protein in Pfam
PF01569, PAP2, 1 hit
SMARTiView protein in SMART
SM00014, acidPPc, 1 hit
SUPFAMiSSF48317, SSF48317, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPR4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TME0
Secondary accession number(s): B2RQ15
, Q6ZQA8, Q8BV73, Q8BXK2, Q8R3R6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 29, 2021
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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