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Protein

Desmoglein-4

Gene

Dsg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • cell-cell adhesion Source: MGI
  • hair follicle development Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • keratinocyte differentiation Source: MGI

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-4
Gene namesi
Name:Dsg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2661061 Dsg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 634ExtracellularSequence analysisAdd BLAST585
Transmembranei635 – 655HelicalSequence analysisAdd BLAST21
Topological domaini656 – 1041CytoplasmicSequence analysisAdd BLAST386

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah). Lah mice pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within a few month. They have thickened skin and do not exhibit any growth retardation.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000385724 – 49Sequence analysisAdd BLAST26
ChainiPRO_000000385850 – 1041Desmoglein-4Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiQ7TMD7
PaxDbiQ7TMD7
PRIDEiQ7TMD7

PTM databases

iPTMnetiQ7TMD7
PhosphoSitePlusiQ7TMD7

Expressioni

Tissue specificityi

Strongly expressed in the skin; during the anagen stage of hair follicles in the matrix, precortex and inner rooth sheath.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000001804 Expressed in 7 organ(s), highest expression level in zone of skin
CleanExiMM_DSG4

Interactioni

Protein-protein interaction databases

BioGridi201094, 1 interactor
IntActiQ7TMD7, 1 interactor
STRINGi10090.ENSMUSP00000019426

Structurei

3D structure databases

ProteinModelPortaliQ7TMD7
SMRiQ7TMD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini158 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini270 – 385Cadherin 3PROSITE-ProRule annotationAdd BLAST116
Domaini389 – 497Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Repeati884 – 910Desmoglein repeat 1Add BLAST27
Repeati911 – 941Desmoglein repeat 2Add BLAST31

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiQ7TMD7
KOiK07599
OMAiRMHSTPV
OrthoDBiEOG091G011Q
TreeFamiTF331809

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TMD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWLLFRNIC LLILFMVVLG VNSEFIVEVK ELDIENGTTT WQTVRRQKRE
60 70 80 90 100
WIKFAAACRE GEDNSKRNPI ARIRSDCEVS QRITYRISGA GIDRPPYGVF
110 120 130 140 150
TINPRTGEIN ITSVVDREIT PLFLIHCRAL NSRGEDLERP LELRVKVMDV
160 170 180 190 200
NDNPPVFTQN VYTANIEENS DANALVVKLS ATDADEDNHL NSKIAYKIIS
210 220 230 240 250
QEPAGAPMFM VNRYTGEVRT MSNFLDREQH SMYNLLVRGS DRDGATDGLS
260 270 280 290 300
SECDCRIKIL DVNDNFPILE KTSYSASIEE NCLSSELIRL QAIDLDEEGT
310 320 330 340 350
DNWLAQYSIL SGNDGNWFEI QTDPKTNEGI LKVVKMLDYE QEPNIYLSIG
360 370 380 390 400
VRNQAEFHHS VASQFQMHST PVRIQVVNVR EGPTFSPSSM TFSLRGGMRG
410 420 430 440 450
ASLMNYVLGT YTAIDMDTGN PATNVRYVIG HDAGSWLKVD SRTGEIQFSR
460 470 480 490 500
EFDMKSKYIT DGIYAAQILA IDDGSGRTAT GTICIEIPDA NDYCPVIYAE
510 520 530 540 550
SRSVCTHASS VRIYVNDHSF GSPFTFCVVD ESPDIANIWD IRSINGTSAI
560 570 580 590 600
LMTEQTLSPG PYQIPILVKD SHNRACELPQ TVLLDACFCD DHHVCLHSST
610 620 630 640 650
TGIYTGDITW VTDDMYGTVT DDGVRQSNVG LGPAGIGMII LGLLLLLLSP
660 670 680 690 700
LLLLMCCCKR RQPEGLGTRF APVPEGGEGV MQPWRIEGAH PEDRDVSNIC
710 720 730 740 750
VPMTASNTQD RIDSSEIYTN TYAGGGTVEG GVSGVELNTG VGTATGMVAA
760 770 780 790 800
GATGTLRKRS STIGTLREYQ DTGMNMAFLD SYFSEKAYAY ADEDEGRPAN
810 820 830 840 850
DCLLIYDHEG AGSPVGSIGC CSWIVDDLDE SYIETLDPKF RTLAEICLDT
860 870 880 890 900
EIEPFPSHQA CIPISTDLPL LGPNYFVNES SGMTLSEAEF QAEMAAASEP
910 920 930 940 950
MIHGDIIVTE TYTTSDPCVQ PTTIVFDSQI PPNVVVTETV MAPVYDVQGN
960 970 980 990 1000
ICVPAEIANT HNVYYAERVV ASPGIPDMGN SNISDACIGP VMSGGILVGP
1010 1020 1030 1040
EIQVTQMMSP DIHISQTTGS TSPMTSQHRV TRYSNMHYSR Q
Length:1,041
Mass (Da):114,449
Last modified:October 1, 2003 - v1
Checksum:i230ECC0553048B2B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti196Y → S in lah. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227349 mRNA Translation: AAP44999.1
AY191584 mRNA Translation: AAO91793.1
CCDSiCCDS29082.1
RefSeqiNP_853543.1, NM_181564.2
UniGeneiMm.358619

Genome annotation databases

EnsembliENSMUST00000019426; ENSMUSP00000019426; ENSMUSG00000001804
GeneIDi16769
KEGGimmu:16769
UCSCiuc008een.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227349 mRNA Translation: AAP44999.1
AY191584 mRNA Translation: AAO91793.1
CCDSiCCDS29082.1
RefSeqiNP_853543.1, NM_181564.2
UniGeneiMm.358619

3D structure databases

ProteinModelPortaliQ7TMD7
SMRiQ7TMD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201094, 1 interactor
IntActiQ7TMD7, 1 interactor
STRINGi10090.ENSMUSP00000019426

PTM databases

iPTMnetiQ7TMD7
PhosphoSitePlusiQ7TMD7

Proteomic databases

MaxQBiQ7TMD7
PaxDbiQ7TMD7
PRIDEiQ7TMD7

Protocols and materials databases

DNASUi16769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019426; ENSMUSP00000019426; ENSMUSG00000001804
GeneIDi16769
KEGGimmu:16769
UCSCiuc008een.1 mouse

Organism-specific databases

CTDi147409
MGIiMGI:2661061 Dsg4

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiQ7TMD7
KOiK07599
OMAiRMHSTPV
OrthoDBiEOG091G011Q
TreeFamiTF331809

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:Q7TMD7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001804 Expressed in 7 organ(s), highest expression level in zone of skin
CleanExiMM_DSG4

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDSG4_MOUSE
AccessioniPrimary (citable) accession number: Q7TMD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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