UniProtKB - Q7TMD5 (ZC3HE_RAT)
Protein
Zinc finger CCCH domain-containing protein 14
Gene
Zc3h14
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 595 – 620 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 621 – 640 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 20 | |
Zinc fingeri | 641 – 656 | C3H1-type 3PROSITE-ProRule annotationAdd BLAST | 16 | |
Zinc fingeri | 682 – 699 | C3H1-type 4PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 701 – 719 | C3H1-type 5PROSITE-ProRule annotationAdd BLAST | 19 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- poly(A) binding Source: GO_Central
- RNA binding Source: GO_Central
GO - Biological processi
- negative regulation of mRNA polyadenylation Source: GO_Central
- regulation of mRNA stability Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger CCCH domain-containing protein 14Alternative name(s): Nuclear protein UKp83/UKp68 |
Gene namesi | Name:Zc3h14 Synonyms:Npuk68 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621850, Zc3h14 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
Note: Colocalizes with poly(A) RNA in nuclear speckles.1 Publication
Nucleus
- nuclear speck Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- axon cytoplasm Source: RGD
- cytoplasm Source: RGD
- dendrite cytoplasm Source: RGD
- ribonucleoprotein complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331314 | 1 – 736 | Zinc finger CCCH domain-containing protein 14Add BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 85 | PhosphoserineCombined sources | 1 | |
Cross-linki | 99 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 175 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 198 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 240 | PhosphoserineBy similarity | 1 | |
Cross-linki | 245 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 283 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 295 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 309 | PhosphoserineBy similarity | 1 | |
Modified residuei | 327 | PhosphoserineBy similarity | 1 | |
Modified residuei | 343 | PhosphoserineBy similarity | 1 | |
Modified residuei | 357 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 357 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 378 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 390 | PhosphoserineBy similarity | 1 | |
Modified residuei | 409 | PhosphoserineBy similarity | 1 | |
Cross-linki | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 489 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 498 | PhosphoserineBy similarity | 1 | |
Modified residuei | 515 | PhosphoserineCombined sources | 1 | |
Modified residuei | 527 | PhosphoserineBy similarity | 1 | |
Modified residuei | 620 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q7TMD5 |
PRIDEi | Q7TMD5 |
PTM databases
iPTMneti | Q7TMD5 |
PhosphoSitePlusi | Q7TMD5 |
Interactioni
Subunit structurei
Interacts with HOOK2.
Interacts with ZFC3H1 in a RNase-sensitive manner.
By similarityProtein-protein interaction databases
BioGRIDi | 251412, 1 interactor |
STRINGi | 10116.ENSRNOP00000047580 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ZC3H14 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 595 – 620 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 621 – 640 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 20 | |
Zinc fingeri | 641 – 656 | C3H1-type 3PROSITE-ProRule annotationAdd BLAST | 16 | |
Zinc fingeri | 682 – 699 | C3H1-type 4PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 701 – 719 | C3H1-type 5PROSITE-ProRule annotationAdd BLAST | 19 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3702, Eukaryota |
InParanoidi | Q7TMD5 |
OrthoDBi | 893844at2759 |
PhylomeDBi | Q7TMD5 |
Family and domain databases
InterProi | View protein in InterPro IPR040366, Nab2/ZC3H14 IPR000571, Znf_CCCH |
PANTHERi | PTHR14738, PTHR14738, 2 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7TMD5-1) [UniParc]FASTAAdd to basket
Also known as: UKp83
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSPDTSI FDSNVPSNKS
110 120 130 140 150
SFSRGDERRH EAAIPPLAVS SSRPEKRDSR VSTSSQEHKS TNVRHSYDDG
160 170 180 190 200
ASTRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENSLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADTGTHLN RPQLQQQQSS THTAKQLDGQ
260 270 280 290 300
SSQVYEAGRL CEPEVLGSVE DTYSPFFRNN LDKMNIEEEN FRKRKLPVVS
310 320 330 340 350
SVVKVKRFSH DGEEEEEDED YGTRVGSLSS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYPAVPQKQT LPVAPRTRTS QEEVLAEMVQ
410 420 430 440 450
GQNRAPRISP PVKEEEAKGD NAEKIEGTQQ RQLLSRLQID PVTVDTMELS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEIVV TPNQDSGMKT ADALRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEEMC FEGMKPVNQT
560 570 580 590 600
SASNKGLRGL LHPQQLHLLS RQLEDPDGSF SNAEMTDLSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECVYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKA
660 670 680 690 700
DCPFTHMSRR GPVLTPKPAV SSPAPSSNGQ FCRYFPACKK MECPFYHPKH
710 720 730
CRFNTQCTRP DCTFYHPTIT VPPRHALKWI RPQTSE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD4A652 | D4A652_RAT | Zinc finger CCCH domain-containing ... | Zc3h14 | 736 | Annotation score: | ||
D4A7G0 | D4A7G0_RAT | Zinc finger CCCH domain-containing ... | Zc3h14 | 605 | Annotation score: | ||
A0A0G2K596 | A0A0G2K596_RAT | Zinc finger CCCH domain-containing ... | Zc3h14 | 309 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 681 | F → L in BAC76891 (Ref. 1) Curated | 1 | |
Sequence conflicti | 681 | F → L in AAH87712 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033181 | 452 – 582 | Missing in isoform 2. 2 PublicationsAdd BLAST | 131 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032932 mRNA Translation: BAB40453.1 AB097075 mRNA Translation: BAC76890.1 AB097076 mRNA Translation: BAC76891.1 AB097077 mRNA Translation: BAC76892.1 BC087712 mRNA Translation: AAH87712.1 |
RefSeqi | NP_001029123.1, NM_001033951.1 [Q7TMD5-1] NP_620275.1, NM_138920.1 [Q7TMD5-2] |
Genome annotation databases
GeneIDi | 192359 |
KEGGi | rno:192359 |
UCSCi | RGD:621850, rat [Q7TMD5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032932 mRNA Translation: BAB40453.1 AB097075 mRNA Translation: BAC76890.1 AB097076 mRNA Translation: BAC76891.1 AB097077 mRNA Translation: BAC76892.1 BC087712 mRNA Translation: AAH87712.1 |
RefSeqi | NP_001029123.1, NM_001033951.1 [Q7TMD5-1] NP_620275.1, NM_138920.1 [Q7TMD5-2] |
3D structure databases
SMRi | Q7TMD5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251412, 1 interactor |
STRINGi | 10116.ENSRNOP00000047580 |
PTM databases
iPTMneti | Q7TMD5 |
PhosphoSitePlusi | Q7TMD5 |
Proteomic databases
jPOSTi | Q7TMD5 |
PRIDEi | Q7TMD5 |
Genome annotation databases
GeneIDi | 192359 |
KEGGi | rno:192359 |
UCSCi | RGD:621850, rat [Q7TMD5-1] |
Organism-specific databases
CTDi | 79882 |
RGDi | 621850, Zc3h14 |
Phylogenomic databases
eggNOGi | KOG3702, Eukaryota |
InParanoidi | Q7TMD5 |
OrthoDBi | 893844at2759 |
PhylomeDBi | Q7TMD5 |
Miscellaneous databases
PROi | PR:Q7TMD5 |
Family and domain databases
InterProi | View protein in InterPro IPR040366, Nab2/ZC3H14 IPR000571, Znf_CCCH |
PANTHERi | PTHR14738, PTHR14738, 2 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZC3HE_RAT | |
Accessioni | Q7TMD5Primary (citable) accession number: Q7TMD5 Secondary accession number(s): Q7TSK6, Q99NC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families