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Entry version 121 (31 Jul 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Apolipoprotein B-100

Gene

Apob

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-3000471 Scavenging by Class B Receptors
R-RNO-3000480 Scavenging by Class A Receptors
R-RNO-3000497 Scavenging by Class H Receptors
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-432142 Platelet sensitization by LDL
R-RNO-5686938 Regulation of TLR by endogenous ligand
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis
R-RNO-8866423 VLDL assembly
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-8963888 Chylomicron assembly
R-RNO-8963901 Chylomicron remodeling
R-RNO-8964026 Chylomicron clearance
R-RNO-8964038 LDL clearance
R-RNO-8964041 LDL remodeling
R-RNO-8964046 VLDL clearance
R-RNO-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein B-100
Short name:
Apo B-100
Cleaved into the following chain:
Apolipoprotein B-48
Short name:
Apo B-48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Apob
ORF Names:Aa1064, Ac1-060
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Rat genome database

More...
RGDi
2129 Apob

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, Cytoplasm, LDL, Secreted, VLDL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Atherosclerosis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27By similarityAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029353628 – 4743Apolipoprotein B-100Add BLAST4716
ChainiPRO_000029353728 – 2146Apolipoprotein B-48Add BLAST2119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 84PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 199PROSITE-ProRule annotation
Disulfide bondi232 ↔ 248PROSITE-ProRule annotation
Disulfide bondi372 ↔ 377PROSITE-ProRule annotation
Disulfide bondi466 ↔ 501PROSITE-ProRule annotation
Disulfide bondi954 ↔ 964PROSITE-ProRule annotation
Glycosylationi971N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1491N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1973N6-acetyllysineBy similarity1
Modified residuei2006PhosphoserineCombined sources1
Glycosylationi2094N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2791N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2897N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2944N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3063N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3828N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3981PhosphoserineBy similarity1
Modified residuei3985PhosphothreonineBy similarity1
Glycosylationi4203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4232N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TMA5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TMA5

PRoteomics IDEntifications database

More...
PRIDEi
Q7TMA5

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q7TMA5

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TMA5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TMA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in intestine and liver (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000005542 Expressed in 4 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7TMA5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TMA5 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCSK9.

Interacts with MTTP.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Apoa1P046392EBI-15185298,EBI-2925493

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
248449, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-29910N

Protein interaction database and analysis system

More...
IntActi
Q7TMA5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000039779

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TMA5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 660VitellogeninPROSITE-ProRule annotationAdd BLAST628

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 113Heparin-bindingBy similarityAdd BLAST85
Regioni219 – 293Heparin-bindingBy similarityAdd BLAST75
Regioni890 – 947Heparin-bindingBy similarityAdd BLAST58
Regioni2010 – 2145Heparin-bindingBy similarityAdd BLAST136
Regioni3123 – 3198Heparin-bindingBy similarityAdd BLAST76
Regioni3136 – 3146Basic (possible receptor binding region)By similarityAdd BLAST11
Regioni3336 – 3356LDL receptor bindingBy similarityAdd BLAST21
Regioni3346 – 3479Heparin-bindingBy similarityAdd BLAST134
Regioni3349 – 3357Basic (possible receptor binding region)By similarity9

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0654 Eukaryota
KOG4338 Eukaryota
ENOG411104F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00590000083139

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034000

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TMA5

KEGG Orthology (KO)

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KOi
K14462

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALIQCGQ

Database of Orthologous Groups

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OrthoDBi
5350at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7TMA5

TreeFam database of animal gene trees

More...
TreeFami
TF331316

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043 CYCLIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.20, 1 hit
2.30.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022176 ApoB100_C
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR009454 Lipid_transpt_open_b-sht
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12491 ApoB100_C, 1 hit
PF00134 Cyclin_N, 1 hit
PF06448 DUF1081, 1 hit
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 1 hit
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TMA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPQRPALRA PLLLLFLLLF LDTSVWAQDA TRFKHLRKYV YSYEAESSSG
60 70 80 90 100
VRGTADSRSA TKINCKVELE VPQVCTLIMR TSQCTLKEVY GFNPEGKALM
110 120 130 140 150
KKTKNSEEFA SAMSRYELKL AFPEGKRVAL YPDLGEPNYI LNIKRGIISA
160 170 180 190 200
LLVPPETEED KQVLFQDTVY GNCSTQVTVN SRKGTVATEM STERNLQHCD
210 220 230 240 250
GFQPISTSVS PLALIKGLVR PLSTLISSSQ SCQYTLEPKR KHVSEAICNE
260 270 280 290 300
QHLFLPFSYK NKYGIMTHVT QKLSLEDTPK INSRFFRGGI NQVGLAFEST
310 320 330 340 350
KSTSPPKQAD AVLKTLQELK KLSISEQNAQ RANLFHKLVT ELRGLSGEAI
360 370 380 390 400
TSLLPQLIEV SSPITLQALI QCGQPECYTH ILQWLKTEKA HPLLIDIVTY
410 420 430 440 450
LMALIPNPSV QRLQEIFNTA KELQSRATLY ALSHAVNSYY AIMDHSRSPV
460 470 480 490 500
LEDIAGYLMK QIDNECMGDE DRTFLILRVI GNMGRTMERV MPALKSSVLN
510 520 530 540 550
CVRSTKPSLQ IQKAALQALR KMEMGDEVRT ILFDTFVNDV APVEKRLAAY
560 570 580 590 600
LLLMRSPSSS DINKIAKLLQ WEQSEQVKNF VASHIANILN SEELYVQDLK
610 620 630 640 650
NLIKNALVNS RLPTIMDFRK FSRNYQISKS VSIPLFDPVS AKIEGNLVFD
660 670 680 690 700
PSSYLPKESM LKTTLTVFGI ASLDLFEIGL EGKGFEPTLE ALFGKQGFFP
710 720 730 740 750
DSVNKALYWV NGQVPDRVSK VLVDHFGYTK DDKHEQDMVN GIMPIVDKLI
760 770 780 790 800
KELKSKEIPE ARAYLRILGK ELGFVRLQDL QVLGKLLLNG AQTFRGVPQM
810 820 830 840 850
IVQAIREGSK DDLFLHYIFM ENAFELPTGV GLQLQVSSSG VFTPGIKAGV
860 870 880 890 900
RLELANIQAE LVAKPSVSLE FVTNMGIIIP DFAKSGVQMN TNFFHESGLE
910 920 930 940 950
ARVALKAGQL KVIIPSPKRP VKLFSGSNTL HLVSTTKTEV IPPLIENRKS
960 970 980 990 1000
WSTCKPFFTG MNYCTTGAYS NASSTESASY YPLTGDTRYE LELKPTGEVE
1010 1020 1030 1040 1050
QYSASATYEL LKEDKSLVDT LKFLVQAEGV QQSEATAMFK YNRRSRTLSS
1060 1070 1080 1090 1100
EVLIPGFDVN FGTILRVNDE SSKDKNTYKL ILDIQNKKIT EVSVVGHVSY
1110 1120 1130 1140 1150
DKKGDGKVKG VVSIPRLQAE ARSEVHTHWS PTKLLFQMDS SATAYGSTIS
1160 1170 1180 1190 1200
KRVAWRYDNE KIEFDWNTGT NVDTKKVASN FPVDLSRYPR MVHEYANGLL
1210 1220 1230 1240 1250
DHRVPQTDMT FRHMGSKLIV DHLNGLSELN LPKVGLPDFH IPDNLFLKTD
1260 1270 1280 1290 1300
GRVKYTLNKN RIEIDIPLPL GGKSSKDLKV PESVRTPALN FKSVGFHLPS
1310 1320 1330 1340 1350
QEVQIPTFTI PKTHQLQVPL LGILDLSTNV YSNLYNWSVS YTGGNTSRDH
1360 1370 1380 1390 1400
FSLQAQYRMK ADSVVDLFSY SVQGSGETTY DSKSTFTLSC DGSLHHKFLD
1410 1420 1430 1440 1450
SKFKVSHVEK FGNNPVSKGL LTFETSSALG PQMSATVQLD SKKKQHLYVK
1460 1470 1480 1490 1500
DIKVDGQFRV FSLYAQGEYG LSYERDSMTG QMSGESNMKF NSTYFQGTNQ
1510 1520 1530 1540 1550
IVGMYQDGML SVTSTSDLQD GIFKNTASLK YENYELTLKS DSSGQYENFA
1560 1570 1580 1590 1600
ASNKLDMTFS KQSALLRSEH QANYKSLRLV TLLSGSLTSQ GVELNADILG
1610 1620 1630 1640 1650
TDKINTGAHK STLKIAQDGV STSATTNLKY SPLLLENELN AELGLSGASM
1660 1670 1680 1690 1700
KLSTSGRFKE HHAKFSLDGR AALTEVSLGS IYQAMILGAD SKNVFNFKLS
1710 1720 1730 1740 1750
REGLKLSNDM MGSYAEMKLD HTHSLRISGL SLDFFSKMDN IYSGDKFYKQ
1760 1770 1780 1790 1800
NFNLQLQPYS FGITLSNDLK YDALVLTNNG RLRLEPLKLN VGGNFKGTYQ
1810 1820 1830 1840 1850
NNELKHIYTI SYTDLVVASY RADTVATVQG VEFSHRLNAD IEGLASSVDV
1860 1870 1880 1890 1900
TTSYSSDPLH FNNVFRFVLA PFTLGVDTHT SGDGKMSLWG EHTGQMYSKF
1910 1920 1930 1940 1950
LLKAEPLALT FSHDYKGSTS HNLLYKNSVS TALEHTLSAL LTPAEQTSSW
1960 1970 1980 1990 2000
KFKTSLNDKV YSQEFEAYNT KDKIGIELSG RADLSGLYSP IKVPFFYSEP
2010 2020 2030 2040 2050
VNVLNSLEIN DAFDEPREFT IDAVVKYDKN QDVHTISLPF FQSLPDYLER
2060 2070 2080 2090 2100
NRRGIISLLE AMKGELQRLS VDQFVRKYRV ALSRLPQQIH DYLNASDWER
2110 2120 2130 2140 2150
QVAGAKEKLT SFMENYRITD NDVLIALDSA KINLNEKLSQ LETYAIQFDQ
2160 2170 2180 2190 2200
YIRDNYDAQD LKRTIAQIID RIIEKLKMLD EQYHIRVNLA KSIHNLYLFV
2210 2220 2230 2240 2250
ENVDLNQISS SGASWIQNVD TKYQIRIQIQ EKLQHLRTQI HNIDIQQLAA
2260 2270 2280 2290 2300
ELKQQIEALD VPMHLDQLRT AILFQRISVI IERVKYFVMN LIEDFKVTEK
2310 2320 2330 2340 2350
INTFRVIVRE LIEKYEVDRQ IQVLMDKSIE LAHRYSLSEP LQKLSNVLQQ
2360 2370 2380 2390 2400
IEIKDYYDKL VGFIDDTVEW IKAVSFKNII EELNRLIDMS VKKLKAFDYH
2410 2420 2430 2440 2450
QFVDKTNSKI REMTQRINAE IQALELPQKT EALKLWVEDF KTTVSNSLEK
2460 2470 2480 2490 2500
LKDTKVTVVV DWLQDGLAQI KAQFQDALED VRDRIYQMDI QGELERCLSL
2510 2520 2530 2540 2550
VSQVYSTVVT YISDWWTLTA KNITDFAEQY STQKWAESVK ALVEQGFIVP
2560 2570 2580 2590 2600
EIQTFLGTMP AFEVSLHALQ EANFQTPDFI VPLTDLRIPS IWINFKMLKN
2610 2620 2630 2640 2650
VKIPLRFSTP EFTLLNTFRV RSFTIDLLEI KAKIIRTIDQ MLSSELQWPL
2660 2670 2680 2690 2700
PEVYLRDLEM VNISLARLSL PDFHVPEITI PEFTIPNVNL KDLQVPDLHI
2710 2720 2730 2740 2750
PEFQLPHLSC TTEIPAFGKL HSVLKIQSPL FILDASANIQ NITTSENKAE
2760 2770 2780 2790 2800
IVASVTARGE SKFEALNFDF QAQAQFLELN ANPLVLKESV NFSSKHVRME
2810 2820 2830 2840 2850
HEGKILVSGK ALEGKSDTVA RLHTEKNTVE FNNGIVVKIN NQFTLDSQTK
2860 2870 2880 2890 2900
YFHKLSVPRL DFSSKASLNN EIKTLLEAGH MAWTSSGTGS WNWACPNFSD
2910 2920 2930 2940 2950
EGIHSSKISF IVDGPIASFG LSNNINGKHL RVVQKLTSES GFLNYSRFEV
2960 2970 2980 2990 3000
ESKVESQHVG SSILTAEGRA LLGDAKAEMT GEHNANLNGK VIGTLKNSLF
3010 3020 3030 3040 3050
FSAQPFEITA STNNEGNLKV SFPLKLTGKI DFLNNYALFL SPHAQQASWQ
3060 3070 3080 3090 3100
LSTRFNQYKY NQNFSAINNE HNMEASIVMN GDANLDFLNI PLTIPEINLP
3110 3120 3130 3140 3150
YTRFTTPLLK DFSIWEETGL KEFLKTTKQS FDLSIKAQYK KNRDKHSVVI
3160 3170 3180 3190 3200
PLKMFYEFML NNVNSWDRKF EKVRDNALHF LTASYNETKI KFDKYKTENS
3210 3220 3230 3240 3250
LNQPSRTFQN RGHTIPVLNI EVSPFAVETL ASSHVIPKAI RTPSVTIPGP
3260 3270 3280 3290 3300
NIIVPSYRLV LPSLQLPVFH IPRTLFKFSL PDFKKLSTID NIYIPAMGNF
3310 3320 3330 3340 3350
TYDFSFKSSV ITLNTNAGLY NQSDLVARFL SSSSFVTDAL QYKLEGTSRL
3360 3370 3380 3390 3400
MRKKVLKLAT AVSLTNKFLK GSHDSTISLT KKNMEASVKT TANLHAPIFT
3410 3420 3430 3440 3450
MNFKQELNGN TKSKPTVSSS IELNYDFNSS KLHSAAKGGV DHKFSLESLT
3460 3470 3480 3490 3500
SYLSIESFTK GNIKGSFLSQ EYSGSVANEA NVYLNSKGTR SSVRLQGASN
3510 3520 3530 3540 3550
FAGIWNFEVG ENFAGEATLR RIYGTWEHNM INHLQVFSYF DTKGKQTCRA
3560 3570 3580 3590 3600
TLELSPWTMS TLLQVHVSQP SPLFDLHHFD QEVILKASTK NQKVSWKSEV
3610 3620 3630 3640 3650
QVESQVLQHN AHFSNDQEEV RLDIAGSLEG QLWDLENFFL PAFGKSLREL
3660 3670 3680 3690 3700
LQIDGKRQYL QASTSLHYTK NPNGYLLSLP VQELTDRFII PGLKLNDFSG
3710 3720 3730 3740 3750
IKIYKKLSTS PFALNLTMLP KVKFPGVDLL TQYSKPEGSS VPTFETTIPE
3760 3770 3780 3790 3800
IQLTVSQFTL PKSFPVGNTV FDLNKLTNLI ADVDLPSITL PEQTIEIPSL
3810 3820 3830 3840 3850
EFSVPAGIFI PFFGELTAHV GMASPLYNVT WSTGWKNKAD HVETFLDSTC
3860 3870 3880 3890 3900
SSTLQFLEYA LKVVGTHRIE NDKFIYKIKG TLQHCDFNVK YNEDGIFEGL
3910 3920 3930 3940 3950
WDLEGEAHLD ITSPALTDFH LHYKEDKTSV SASAASPAIG TVSLDASTDD
3960 3970 3980 3990 4000
QSVRLNVYFR PQSPPDNKLS IFKMEWRDKE SDGETYIKIN WEEEAAFRLL
4010 4020 4030 4040 4050
DSLKSNVPKA SEAVYDYVKK YHLGHASSEL RKSLQNDAEH AIRMVDEMNV
4060 4070 4080 4090 4100
NAQRVTRDTY QSLYKKMLAQ ESQSIPEKLK KMVLGSLVRI TQKYHMAVTW
4110 4120 4130 4140 4150
LMDSVIHFLK FNRVQFPGNA GTYTVDELYT IAMRETKKLL SQLFNGLGHL
4160 4170 4180 4190 4200
FSYVQDQVEK SRVINDITFK CPFSPTPCKL KDVLLIFRED LNILSNLGQQ
4210 4220 4230 4240 4250
DINFTTILSD FQSFLERLLD IIEEKIECLK NNESTCVPDH INMFFKTHIP
4260 4270 4280 4290 4300
FAFKSLRENI YSVFSEFNDF VQSILQEGSY KLQQVHQYMK AFREEYFDPS
4310 4320 4330 4340 4350
VVGWTVKYYE IEEKMVDLIK TLLAPLRDFY SEYSVTAADF ASKMSTQVEQ
4360 4370 4380 4390 4400
FVSRDIREYL SMLADINGKG REKVAELSIV VKERIKSWST AVAEITSDYL
4410 4420 4430 4440 4450
RQLHSKLQDF SDQLSGYYEK FVAESTRLID LSIQNYHMFL RYIAELLKKL
4460 4470 4480 4490 4500
QVATANNGLL KRGDFEAAVK LGIACLYNEG LSVSDEAYAE VNGLKASRFF
4510 4520 4530 4540 4550
SMDERLNMGS DPFIWLSICP PCFRKLRDFA GKGCWEAQPA LAKDCAGGSQ
4560 4570 4580 4590 4600
LGLEGKAFSE SVCQLFQASQ AVNKQQIFSV QKGLSDTVRY ILIGWLVEVA
4610 4620 4630 4640 4650
PMKDFTSLCL HLTVECVGRY LQRKLVPRYK LQLLGIACMV ICTWFISKEI
4660 4670 4680 4690 4700
LTIREAVRLT DNTYKYKDLV RVKREIISAL EGKIRIPTVV DYKEVLLTLV
4710 4720 4730 4740
PVTPRTQYLC SFLCELTLSV YTPAHLASAA LLLARLMHGQ TQP
Length:4,743
Mass (Da):536,024
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01AD103F8EC5320
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M6Z1F1M6Z1_RAT
Apolipoprotein B-100
Apob
4,506Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at position 2147.1 Publication
The stop codon (UAA) at position 2147 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY318958 mRNA Translation: AAP85369.1
AY321317 mRNA Translation: AAP86249.1

NCBI Reference Sequences

More...
RefSeqi
NP_062160.2, NM_019287.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000046811; ENSRNOP00000039779; ENSRNOG00000005542

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:54225

Keywords - Coding sequence diversityi

RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318958 mRNA Translation: AAP85369.1
AY321317 mRNA Translation: AAP86249.1
RefSeqiNP_062160.2, NM_019287.2

3D structure databases

SMRiQ7TMA5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi248449, 1 interactor
DIPiDIP-29910N
IntActiQ7TMA5, 1 interactor
STRINGi10116.ENSRNOP00000039779

PTM databases

CarbonylDBiQ7TMA5
iPTMnetiQ7TMA5
PhosphoSitePlusiQ7TMA5

Proteomic databases

jPOSTiQ7TMA5
PaxDbiQ7TMA5
PRIDEiQ7TMA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046811; ENSRNOP00000039779; ENSRNOG00000005542
GeneIDi54225
KEGGirno:54225

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
338
RGDi2129 Apob

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
KOG4338 Eukaryota
ENOG411104F LUCA
GeneTreeiENSGT00590000083139
HOGENOMiHOG000034000
InParanoidiQ7TMA5
KOiK14462
OMAiALIQCGQ
OrthoDBi5350at2759
PhylomeDBiQ7TMA5
TreeFamiTF331316

Enzyme and pathway databases

ReactomeiR-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-3000471 Scavenging by Class B Receptors
R-RNO-3000480 Scavenging by Class A Receptors
R-RNO-3000497 Scavenging by Class H Receptors
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-432142 Platelet sensitization by LDL
R-RNO-5686938 Regulation of TLR by endogenous ligand
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis
R-RNO-8866423 VLDL assembly
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-8963888 Chylomicron assembly
R-RNO-8963901 Chylomicron remodeling
R-RNO-8964026 Chylomicron clearance
R-RNO-8964038 LDL clearance
R-RNO-8964041 LDL remodeling
R-RNO-8964046 VLDL clearance
R-RNO-975634 Retinoid metabolism and transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7TMA5

Gene expression databases

BgeeiENSRNOG00000005542 Expressed in 4 organ(s), highest expression level in liver
ExpressionAtlasiQ7TMA5 baseline and differential
GenevisibleiQ7TMA5 RN

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR022176 ApoB100_C
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR009454 Lipid_transpt_open_b-sht
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
PfamiView protein in Pfam
PF12491 ApoB100_C, 1 hit
PF00134 Cyclin_N, 1 hit
PF06448 DUF1081, 1 hit
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOB_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TMA5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2003
Last modified: July 31, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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