UniProtKB - Q7T3T5 (PA2AB_DABSI)
Acidic phospholipase A2 daboiatoxin B chain
Functioni
Monomer: Snake venom phospholipase A2 (PLA2) that shows a high PLA2 activity (2110 µmol/min/mg).
Heterodimer (A and B chains): snake venom phospholipase A2 that shows a moderate PLA2 activity (1377 µmol/min/mg). Acts as a presynaptic neurotoxin. In vivo, induces edema and produces neurotoxic symptoms in mice. It exhibits indirect hemolysis and a strong myonecrotic activity and is cytotoxic. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Miscellaneous
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationEC:3.1.1.4PROSITE-ProRule annotation
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 35 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 37 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 39 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 55 | By similarity | 1 | |
Metal bindingi | 56 | CalciumBy similarity | 1 | |
Active sitei | 97 | By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- inflammatory response Source: UniProtKB-KW
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Myotoxin, Neurotoxin, Presynaptic neurotoxin, Toxin |
Biological process | Inflammatory response, Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Acidic phospholipase A2 daboiatoxin B chain (EC:3.1.1.4)Short name: DbTx-B Short name: svPLA2 Alternative name(s): Acidic phospholipase A2-II Phosphatidylcholine 2-acylhydrolase |
Organismi | Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis) |
Taxonomic identifieri | 343250 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Viperinae › Daboia |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | ‹1 – 8 | ›8 | ||
ChainiPRO_0000419223 | 9 – 130 | Acidic phospholipase A2 daboiatoxin B chainAdd BLAST | 122 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 123 | 1 Publication | ||
Disulfide bondi | 36 ↔ 52 | 1 Publication | ||
Disulfide bondi | 51 ↔ 103 | 1 Publication | ||
Disulfide bondi | 57 ↔ 130 | 1 Publication | ||
Disulfide bondi | 58 ↔ 96 | 1 Publication | ||
Disulfide bondi | 65 ↔ 89 | 1 Publication | ||
Disulfide bondi | 83 ↔ 94 | 1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Heterodimer of an acidic protein having phospholipase A2 activity (B chain) and an A chain which weakly inhibits the B chain enzymatic activity but potentiates its lethal potency.
1 PublicationStructurei
Secondary structure
3D structure databases
SMRi | Q7T3T5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7T3T5 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MCLIGVEGNL FQFARLIDAK QEAFSFFKYI SYGCYCGWGG QGTPKDATDR
60 70 80 90 100
CCFVHDCCYA RVKGCNPKLV EYSYSYRTGK IVCGGDDPCL RAVCECDRVA
110 120 130
AICFRENMNT YDKKYMLYSI FDCKEESDQC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY286006 mRNA Translation: AAP37177.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY286006 mRNA Translation: AAP37177.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H4C | X-ray | 2.60 | B/D/F/H | 9-130 | [»] | |
SMRi | Q7T3T5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7T3T5 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2AB_DABSI | |
Accessioni | Q7T3T5Primary (citable) accession number: Q7T3T5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2012 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families