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UniProtKB - Q7T373 (Q7T373_DANRE)
Protein
Submitted name:
Paired related homeobox 1
Gene
prrx1a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 96 – 155 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- atrial cardiac muscle cell action potential Source: ZFIN
- cranial skeletal system development Source: ZFIN
- epithelial to mesenchymal transition Source: ZFIN
- heart looping Source: ZFIN
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Paired related homeobox 1ImportedSubmitted name: Paired-related homeobox 1aSubmitted name: Prrx1 proteinImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-020905-5, prrx1a |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000033971, Expressed in caudal fin and 34 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 154 | HomeoboxInterPro annotationAdd BLAST | 61 | |
Domaini | 224 – 237 | OARInterPro annotationAdd BLAST | 14 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 105 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 69 – 83 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the paired homeobox family.ARBA annotation
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000159466 |
HOGENOMi | CLU_087323_0_0_1 |
OMAi | LHAKKNF |
OrthoDBi | 1413050at2759 |
TreeFami | TF351612 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom IPR043378, PRRX1/2 |
PANTHERi | PTHR46385, PTHR46385, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7T373-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSSYAHVMD RQATLPNRLE TAITANQDHL QAKKNFSVSH LLDLEEAREM
60 70 80 90 100
VGAQAEESAG EAGRSMLESP GLTSGSDTTQ QENEQLNAEE KKKRKQRRNR
110 120 130 140 150
TTFNSSQLQA LERVFERTHY PDAFVREDLA RRVNLTEARV QVWFQNRRAK
160 170 180 190 200
FRRNERAMLA SKNASLLKSF SGEVTAVEQP IVPRPAPRPN DYLSWGSSPS
210 220 230 240
YSAMATYSPS CANNTTAQGM NMANSIANLR LKAKEYSLNQ VPTVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX548024 Genomic DNA No translation available. BC053228 mRNA Translation: AAH53228.1 BC165100 mRNA Translation: AAI65100.1 |
RefSeqi | NP_999899.1, NM_214734.1 |
Genome annotation databases
Ensembli | ENSDART00000041365.4; ENSDARP00000041364.3; ENSDARG00000033971.5 |
GeneIDi | 406431 |
KEGGi | dre:406431 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX548024 Genomic DNA No translation available. BC053228 mRNA Translation: AAH53228.1 BC165100 mRNA Translation: AAI65100.1 |
RefSeqi | NP_999899.1, NM_214734.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000041364 |
Genome annotation databases
Ensembli | ENSDART00000041365.4; ENSDARP00000041364.3; ENSDARG00000033971.5 |
GeneIDi | 406431 |
KEGGi | dre:406431 |
Organism-specific databases
CTDi | 406431 |
ZFINi | ZDB-GENE-020905-5, prrx1a |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000159466 |
HOGENOMi | CLU_087323_0_0_1 |
OMAi | LHAKKNF |
OrthoDBi | 1413050at2759 |
TreeFami | TF351612 |
Gene expression databases
Bgeei | ENSDARG00000033971, Expressed in caudal fin and 34 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom IPR043378, PRRX1/2 |
PANTHERi | PTHR46385, PTHR46385, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7T373_DANRE | |
Accessioni | Q7T373Primary (citable) accession number: Q7T373 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2003 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |