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Protein

Tumor necrosis factor, alpha-induced protein 8-like protein 2 B

Gene

tnfaip8l2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-DRE-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor, alpha-induced protein 8-like protein 2 B
Short name:
TIPE2 B
Short name:
TNF alpha-induced protein 8-like protein 2 B
Short name:
TNFAIP8-like protein 2 B
Gene namesi
Name:tnfaip8l2b
Synonyms:tnfaip8l, tnfaip8l2
ORF Names:zgc:64074
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-040426-1359 tnfaip8l2b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857741 – 186Tumor necrosis factor, alpha-induced protein 8-like protein 2 BAdd BLAST186

Proteomic databases

PaxDbiQ7T364

Expressioni

Gene expression databases

BgeeiENSDARG00000046148 Expressed in 17 organ(s), highest expression level in pharyngeal gill

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067853

Structurei

3D structure databases

SMRiQ7T364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IGTQ Eukaryota
ENOG4111INB LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
InParanoidiQ7T364
OMAiRSGCFGP
OrthoDBiEOG091G0QQ9
PhylomeDBiQ7T364
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequencei

Sequence statusi: Complete.

Q7T364-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METFSSKDMA LKAQKKILSK MATKSMVQMI IDDTSSEILD ELYRVSKEYT
60 70 80 90 100
GNRSEAQKVV KDLIKVVVKI GVLFRHNRFN EEELKLAQNF QKKLRQGAMT
110 120 130 140 150
AISFHEVDFT FDKTVMSDIL TESRDMLLKL VNTHLTTKSH GRINHVFNHY
160 170 180
ADPELLTQLY NSSGPLKPHL NKICNGLNKL LENGTL
Length:186
Mass (Da):21,301
Last modified:October 1, 2003 - v1
Checksum:i3B3E5DEFBC49C3C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053238 mRNA Translation: AAH53238.1
RefSeqiNP_956668.1, NM_200374.1
UniGeneiDr.88310

Genome annotation databases

EnsembliENSDART00000067854; ENSDARP00000067853; ENSDARG00000046148
ENSDART00000150617; ENSDARP00000125388; ENSDARG00000046148
GeneIDi393345
KEGGidre:393345

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053238 mRNA Translation: AAH53238.1
RefSeqiNP_956668.1, NM_200374.1
UniGeneiDr.88310

3D structure databases

SMRiQ7T364
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067853

Proteomic databases

PaxDbiQ7T364

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000067854; ENSDARP00000067853; ENSDARG00000046148
ENSDART00000150617; ENSDARP00000125388; ENSDARG00000046148
GeneIDi393345
KEGGidre:393345

Organism-specific databases

CTDi393345
ZFINiZDB-GENE-040426-1359 tnfaip8l2b

Phylogenomic databases

eggNOGiENOG410IGTQ Eukaryota
ENOG4111INB LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
InParanoidiQ7T364
OMAiRSGCFGP
OrthoDBiEOG091G0QQ9
PhylomeDBiQ7T364
TreeFamiTF323415

Enzyme and pathway databases

ReactomeiR-DRE-1483255 PI Metabolism

Miscellaneous databases

PROiPR:Q7T364

Gene expression databases

BgeeiENSDARG00000046148 Expressed in 17 organ(s), highest expression level in pharyngeal gill

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPL2B_DANRE
AccessioniPrimary (citable) accession number: Q7T364
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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