Sp5 transcription factor-like

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior pattern specification Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Sp5l is a mediator of Fgf signals in anteroposterior patterning of the neuroectoderm in zebrafish embryo."
    Sun Z., Zhao J., Zhang Y., Meng A.
    Dev Dyn 235:2999-3006(2006) [PubMed] [Europe PMC] [Abstract]
• hindbrain development Source: ZFINInferred from mutant phenotypeⁱ
  • "The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning."
    Weidinger G., Thorpe C.J., Wuennenberg-Stapleton K., Ngai J., Moon R.T.
    Curr. Biol. 15:489-500(2005) [PubMed] [Europe PMC] [Abstract]
• mesoderm development Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish."
    Thorpe C.J., Weidinger G., Moon R.T.
    Development 132:1763-1772(2005) [PubMed] [Europe PMC] [Abstract]
• mesoderm formation Source: ZFINInferred from mutant phenotypeⁱ
  • Ref.2

    "An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction."
    Zhao J., Cao Y., Zhao C., Postlethwait J., Meng A.
    EMBO J. 22:6078-6088(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• mesoderm morphogenesis Source: ZFINInferred from genetic interactionⁱ
  • "The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning."
    Weidinger G., Thorpe C.J., Wuennenberg-Stapleton K., Ngai J., Moon R.T.
    Curr. Biol. 15:489-500(2005) [PubMed] [Europe PMC] [Abstract]
• notochord development Source: ZFINInferred from genetic interactionⁱ
  • "Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish."
    Thorpe C.J., Weidinger G., Moon R.T.
    Development 132:1763-1772(2005) [PubMed] [Europe PMC] [Abstract]
• post-anal tail morphogenesis Source: ZFINInferred from genetic interactionⁱ
  • "Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish."
    Thorpe C.J., Weidinger G., Moon R.T.
    Development 132:1763-1772(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: ZFINInferred from mutant phenotypeⁱ
  • Ref.2

    "An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction."
    Zhao J., Cao Y., Zhao C., Postlethwait J., Meng A.
    EMBO J. 22:6078-6088(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway Source: ZFINInferred from genetic interactionⁱ
  • "The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning."
    Weidinger G., Thorpe C.J., Wuennenberg-Stapleton K., Ngai J., Moon R.T.
    Curr. Biol. 15:489-500(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAALTLSRAD NFLHNFLQDR TPSSSPESGP NTLSFLATTC SQAWQEGSQL 
        60         70         80         90        100
PYEGPVGSAS SMFQLWSNDV APNSSLSAHQ MTFTVPKMQF PSHMQPTLGS 
       110        120        130        140        150
HSHHHHHHHH HHHELPLTPP AEPPSAYSFE LSPVKMQGNA PYYTQHNAVS 
       160        170        180        190        200
QNFPSFLQNP SGRAHLPGGH VEDGQQWWSL PQGNSAPSGH PFSLGRQLVL 
       210        220        230        240        250
GHQPQIAALL QGTSKGLLSS TRRCRRCKCP NCQSTGNGGA ALEFGKKRLH 
       260        270        280        290        300
ICHIPDCGKV YKKTSHLKAH LRWHAGERPF ICNWLFCGKS FTRSDELQRH 
       310        320        330        340        350
LRTHTGEKRF GCQQCGKRFM RSDHLSKHVK THQSRKSRSS QPPHSGTDAL 

LSNIKRE                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ