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UniProtKB - Q7T2A5 (EIF3L_DANRE)

Entry version 107 (02 Dec 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Eukaryotic translation initiation factor 3 subunit L

Gene

eif3l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DRE-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DRE-72702, Ribosomal scanning and start codon recognition

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit LUniRule annotation
Short name:
eIF3lUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6-interacting proteinUniRule annotation
Eukaryotic translation initiation factor 3 subunit E-interacting proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eif3l
Synonyms:eif3eip, eif3s6ip
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-040426-2138, eif3s6ip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002974951 – 576Eukaryotic translation initiation factor 3 subunit LAdd BLAST576

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7T2A5

PRoteomics IDEntifications database

More...PRIDEi		Q7T2A5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000101082, Expressed in presomitic mesoderm and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000090402

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini330 – 536PCIPROSITE-ProRule annotationAdd BLAST207

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-3 subunit L family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3677, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000411

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029210_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7T2A5

Identification of Orthologs from Complete Genome Data

More...OMAi		YEIQDVY

Database of Orthologous Groups

More...OrthoDBi		393910at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7T2A5

TreeFam database of animal gene trees

More...TreeFami		TF101523

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_03011, eIF3l, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019382, eIF3l
IPR000717, PCI_dom
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13242, PTHR13242, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10255, Paf67, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50250, PCI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7T2A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYPAEEEDV NYDPYSYPND YDYHTGDPKA DLAYERQYEH QQTYHVIPEV 
        60         70         80         90        100
IKNFLQYFHK TISDLIDQKV YELQANRVSS ESIEQKIYEI QDVYENSWNK 
       110        120        130        140        150
LTDRFFKTSP WPEAEAIASL VGNDAVFLIL YKELYYRHIY AKVSGGPTLD 
       160        170        180        190        200
QRFESYYNYC NLFNYILNAD GPAPLELPNQ WLWDIIDEFI YQFQSFSQYR 
       210        220        230        240        250
CKTAKKSEEE IEFLRNNPKI WNVHSVLNVL HSLVDKSNIN RQLEVYTSGG 
       260        270        280        290        300
DPESVAGEYG RHSLYKMLGY FSLVGLLRLH SLLGDYYQAI KVLENIELNK 
       310        320        330        340        350
KSMYSRVPEC QITTYYYVGF AYLMMRRYQD AIRVFANILL YIQRTRNMFQ 
       360        370        380        390        400
RTTYKYEMIN KQNEQMHGLL AIALTMYPMR IDESIHTQLR EKYGDKMLRM 
       410        420        430        440        450
QKGDLQVFEE LFSFACPKFL SPVVPNYENV HPNYHKEPFQ QQLKVFAEEV 
       460        470        480        490        500
QQQAQLSTIR SFLKLYTTMP VAKLAGFLDM SEQEFRIQLL VFKHKMKNLV 
       510        520        530        540        550
WTSGISALDG EFQSASEVDF YIDKDMIHIA DTKVARRYGD FFIRQIHKFE 
       560        570 
ELNRTLKKMP LNTGASISSS STSRAT
Length:576
Mass (Da):67,993
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC393326B16E9690
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC054626 mRNA Translation: AAH54626.1

NCBI Reference Sequences

More...RefSeqi		NP_998293.1, NM_213128.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000161017; ENSDARP00000134724; ENSDARG00000101082

Database of genes from NCBI RefSeq genomes

More...GeneIDi		406402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:406402

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054626 mRNA Translation: AAH54626.1
RefSeqiNP_998293.1, NM_213128.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090402

Proteomic databases

PaxDbiQ7T2A5
PRIDEiQ7T2A5

Genome annotation databases

EnsembliENSDART00000161017; ENSDARP00000134724; ENSDARG00000101082
GeneIDi406402
KEGGidre:406402

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		406402
ZFINiZDB-GENE-040426-2138, eif3s6ip

Phylogenomic databases

eggNOGiKOG3677, Eukaryota
GeneTreeiENSGT00390000000411
HOGENOMiCLU_029210_0_1_1
InParanoidiQ7T2A5
OMAiYEIQDVY
OrthoDBi393910at2759
PhylomeDBiQ7T2A5
TreeFamiTF101523

Enzyme and pathway databases

ReactomeiR-DRE-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DRE-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DRE-72702, Ribosomal scanning and start codon recognition

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q7T2A5

Gene expression databases

BgeeiENSDARG00000101082, Expressed in presomitic mesoderm and 32 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
HAMAPiMF_03011, eIF3l, 1 hit
InterProiView protein in InterPro
IPR019382, eIF3l
IPR000717, PCI_dom
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR13242, PTHR13242, 1 hit
PfamiView protein in Pfam
PF10255, Paf67, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50250, PCI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIF3L_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7T2A5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2003
Last modified: December 2, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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