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Entry version 107 (08 May 2019)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

Ion channel NompC

Gene

trpn1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelSAAS annotation
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.7.1 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ion channel NompCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpn1Imported
Synonyms:nompcImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030728-7 trpn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1198 – 1219HelicalSequence analysisAdd BLAST22
Transmembranei1231 – 1251HelicalSequence analysisAdd BLAST21
Transmembranei1263 – 1285HelicalSequence analysisAdd BLAST23
Transmembranei1297 – 1320HelicalSequence analysisAdd BLAST24
Transmembranei1332 – 1351HelicalSequence analysisAdd BLAST20
Transmembranei1372 – 1395HelicalSequence analysisAdd BLAST24
Transmembranei1447 – 1468HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1293245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q7T1G6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 1055ANK_REP_REGIONInterPro annotationAdd BLAST1009
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 79ANKPROSITE-ProRule annotationAdd BLAST33
Repeati80 – 103ANKPROSITE-ProRule annotationAdd BLAST24
Repeati186 – 218ANKPROSITE-ProRule annotationAdd BLAST33
Repeati219 – 251ANKPROSITE-ProRule annotationAdd BLAST33
Repeati252 – 275ANKPROSITE-ProRule annotationAdd BLAST24
Repeati286 – 318ANKPROSITE-ProRule annotationAdd BLAST33
Repeati319 – 351ANKPROSITE-ProRule annotationAdd BLAST33
Repeati352 – 384ANKPROSITE-ProRule annotationAdd BLAST33
Repeati386 – 419ANKPROSITE-ProRule annotationAdd BLAST34
Repeati420 – 452ANKPROSITE-ProRule annotationAdd BLAST33
Repeati496 – 537ANKPROSITE-ProRule annotationAdd BLAST42
Repeati539 – 562ANKPROSITE-ProRule annotationAdd BLAST24
Repeati578 – 610ANKPROSITE-ProRule annotationAdd BLAST33
Repeati611 – 643ANKPROSITE-ProRule annotationAdd BLAST33
Repeati644 – 667ANKPROSITE-ProRule annotationAdd BLAST24
Repeati678 – 710ANKPROSITE-ProRule annotationAdd BLAST33
Repeati711 – 743ANKPROSITE-ProRule annotationAdd BLAST33
Repeati781 – 813ANKPROSITE-ProRule annotationAdd BLAST33
Repeati814 – 834ANKPROSITE-ProRule annotationAdd BLAST21
Repeati897 – 919ANKPROSITE-ProRule annotationAdd BLAST23
Repeati932 – 964ANKPROSITE-ProRule annotationAdd BLAST33
Repeati966 – 998ANKPROSITE-ProRule annotationAdd BLAST33
Repeati999 – 1031ANKPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1115202at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7T1G6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR002153 TRPC_channel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 7 hits
PF13606 Ank_3, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN
PR01097 TRNSRECEPTRP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 29 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7T1G6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESSCVSGA PQRLVPLALR GEWMALEQKI KTLERGDPDI LQCDEESGMS
60 70 80 90 100
LLMLAVRESR LSVLDRLLEL GANPSDKTKD GRSALHIAAA HSKDEIVKLL
110 120 130 140 150
VRKTDPNSPA GPNDQLPLHY AASRSTGGLA VVQTLLKFSS KDARLTPDKN
160 170 180 190 200
GCLPLLLAAE AGNVGIVREL LSSQSEPQIR AAKTANGDTA LHICCRRRDV
210 220 230 240 250
EMAKILVEFG ANPDSQNDEG QTPLHIAAHE GDENMLKFLY LCKANANISD
260 270 280 290 300
KMDRSPLHIA AERGHTNVVE ILTEKFRSCV LARTKDGNTL LHIASQCGHP
310 320 330 340 350
TTALSFLRKG VPLHMPNKSG AVCLHAAAKR GHTAVVKALL QKGAHVDAAA
360 370 380 390 400
RDGQTALHIA VENCRPQVVQ MLLGFGAHVQ LRGGKAQETP LHISARVKEG
410 420 430 440 450
ERAAEMLLKS GAEVNAEQEN GETALHVAAR HGSLQMIRAL IQEGGDPRWR
460 470 480 490 500
SRVGESPLHV AVRHCHAHVV QEILTFLTNE KSRRDAELCV CEGNQDGETA
510 520 530 540 550
LHLAAELRTD ALHQPEEDIT IIQILMEHQA DITAVTRQTG ETPLHYSARV
560 570 580 590 600
GNTAVLQEML RNVPTNQIQT AINKHSKNGW SPLLLAADQG HTEVVKILLQ
610 620 630 640 650
NNARVDVFDE EGKAAIHLAA QRGHQDIVDV LLSQKAFVNA KTKQGLTPLH
660 670 680 690 700
LSAQNGSARL VRLLVENHQA SVDALSLRKQ TPLHLAAMSG QLDVCSSLLN
710 720 730 740 750
LRADITATDS RGQTPLHLAA ESDHSEVVKL FLRLRPELST LANEDGSTCT
760 770 780 790 800
HIAAAKGSVS VIRELLMFNQ GGVGTLNHKA HGLCPLHLAA AGGHAEVVKV
810 820 830 840 850
LLEAGASVTE EDAEGMTAVH LAAKHGHTHI LEVLRGSVPL KIQSSKTGFT
860 870 880 890 900
ALHVAASFGQ MNFVREILTK VPATIRSEFP TISGKDDIKR QQPLAESGFT
910 920 930 940 950
PLHLASQSGH ESVVRLLLNC PGVQADAETN IQGSSPLHLA AQSGHTAVVG
960 970 980 990 1000
LLLSRSSSLL HQADRRGRSA LHLAAAHGHV DMVRVLLGQG AEINHTDMSG
1010 1020 1030 1040 1050
WTALHYAAEA GCLEVLLFLV ESGASACAEC HGGRTPLQYA AQQNHESAVI
1060 1070 1080 1090 1100
FLLRREKNTL RLLDDKKFIF NLMVCGRMND NLSLEELVLH TSAPLDTAVR
1110 1120 1130 1140 1150
LSRALTLCAL REKERSVDLQ AAAHHCELMA SDLLSLSASA GGQGAGAGPI
1160 1170 1180 1190 1200
LRALDHRGLS VLDCLIEGRQ KGVVSQPAVQ TYLTEVWCGG LQWDSWKILL
1210 1220 1230 1240 1250
LFCCLLLCPP LWLLLALPLT HSFNTIPIVK FMSHLVSHIF LLTLFILTIV
1260 1270 1280 1290 1300
YPPVSPLSQA RLMPSWSECL LLIWLCGMLV SELTFPGERT GLAWIRLLLL
1310 1320 1330 1340 1350
GFSAAALLCH LLAVFTQWWP PTHLHCLFAR NVLLAVAMTL GFIQLLEFLT
1360 1370 1380 1390 1400
FHHLFGPWAI IIRDLIKDLC RFAVILMLFH TAFTLSLTAL CQPLYPQEQH
1410 1420 1430 1440 1450
NTTTEVTVPG PLNMSVLLFF ALFGLTEPDK IPDVDRSPPA TAVLAKMVFG
1460 1470 1480 1490 1500
VYLVVTFIVL INLLIAMMSD TYQRIQAQSD TEWKFGRAVL IRDMSRKSGI
1510 1520 1530 1540 1550
PSPFNLFTNL FYSVKVVCKR AGKMCSSESR DVMNEDEDAE GLSESRSLDL
1560 1570 1580 1590 1600
LSQASVSGIR GNKRTQILPE GGQISLAHSG GHVRVENVAD WPSVVQQFLS
1610
QRRQRDRSTA ERDE
Length:1,614
Mass (Da):175,800
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i773343F37E3CB2DD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY313897 mRNA Translation: AAP86445.1

NCBI Reference Sequences

More...
RefSeqi
NP_899192.1, NM_183349.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
368273

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:368273

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313897 mRNA Translation: AAP86445.1
RefSeqiNP_899192.1, NM_183349.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

BindingDBiQ7T1G6
ChEMBLiCHEMBL1293245

Protein family/group databases

TCDBi1.A.4.7.1 the transient receptor potential ca(2+) channel (trp-cc) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi368273
KEGGidre:368273

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
368273
ZFINiZDB-GENE-030728-7 trpn1

Phylogenomic databases

OrthoDBi1115202at2759
PhylomeDBiQ7T1G6

Family and domain databases

CDDicd00204 ANK, 8 hits
Gene3Di1.25.40.20, 8 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR002153 TRPC_channel
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 7 hits
PF13606 Ank_3, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01415 ANKYRIN
PR01097 TRNSRECEPTRP
SMARTiView protein in SMART
SM00248 ANK, 29 hits
SUPFAMiSSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 23 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7T1G6_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7T1G6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 8, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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