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Protein
Submitted name:

Potassium voltage-gated channel subfamily A member 2

Gene

KCNA2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-GGA-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily A member 2Imported
Submitted name:
Shaker subfamily potassium channel Kv1.2 alpha subunitImported
Gene namesi
Name:KCNA2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei164 – 188HelicalSequence analysisAdd BLAST25
Transmembranei222 – 243HelicalSequence analysisAdd BLAST22
Transmembranei250 – 268HelicalSequence analysisAdd BLAST19
Transmembranei328 – 349HelicalSequence analysisAdd BLAST22
Transmembranei389 – 410HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSGALG00000000442 Expressed in 7 organ(s), highest expression level in cerebellum

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039829

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 133BTBInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
KOiK04875
OMAiGMTFHTY
OrthoDBiEOG091G10NU
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004049 K_chnl_volt-dep_Kv1.2
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF23 PTHR11537:SF23, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01509 KV12CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q7T1A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVATGDPAD EAAALPGHPQ DTYNPETDHE CCERVVINIS GLRFETQLKT
60 70 80 90 100
LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR
110 120 130 140 150
PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW
160 170 180 190 200
LLFEYPESSG PARIIAIVSV MVILISIVSF CLETLPIFRD ENEDMHGSGL
210 220 230 240 250
SHPPYSNSSM GYQQSTSFTD PFFIVETLCI IWFSFEFLVR FFACPSKAGF
260 270 280 290 300
FTNIMNIIDI VAIIPYFITL GTELAEKPED GQQGQQAMSL AILRVIRLVR
310 320 330 340 350
VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE
360 370 380 390 400
ADESESQFPS IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL
410 420 430 440 450
TIALPVPVIV SNFNYFYHRE TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA
460 470 480 490
STISKSDYME IQEGVNNSNE DFREENLKTA NCTLANTNYV NITKMLTDV
Length:499
Mass (Da):56,613
Last modified:October 1, 2003 - v1
Checksum:i796F10C4BD83C4B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000216 Genomic DNA No translation available.
AY329361 mRNA Translation: AAP94023.1
RefSeqiNP_989794.1, NM_204463.1
UniGeneiGga.9083

Genome annotation databases

EnsembliENSGALT00000000599; ENSGALP00000039829; ENSGALG00000000442
GeneIDi395117
KEGGigga:395117

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000216 Genomic DNA No translation available.
AY329361 mRNA Translation: AAP94023.1
RefSeqiNP_989794.1, NM_204463.1
UniGeneiGga.9083

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039829

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000599; ENSGALP00000039829; ENSGALG00000000442
GeneIDi395117
KEGGigga:395117

Organism-specific databases

CTDi3737

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
KOiK04875
OMAiGMTFHTY
OrthoDBiEOG091G10NU
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-GGA-1296072 Voltage gated Potassium channels

Gene expression databases

BgeeiENSGALG00000000442 Expressed in 7 organ(s), highest expression level in cerebellum

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004049 K_chnl_volt-dep_Kv1.2
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF23 PTHR11537:SF23, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01509 KV12CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7T1A0_CHICK
AccessioniPrimary (citable) accession number: Q7T1A0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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