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Protein

Zinc metalloproteinase/disintegrin

Gene
N/A
Organism
Gloydius saxatilis (Rock mamushi) (Gloydius intermedius saxatilis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Snake venom metalloproteinase saxin: impairs hemostasis in the envenomed animal.By similarity
Disintegrin: binds and inhibits integrins.By similarity

Miscellaneous

The disintegrin belongs to the dimeric disintegrin subfamily.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi201CalciumBy similarity1
Metal bindingi285CalciumBy similarity1
Metal bindingi334Zinc; catalyticBy similarity1
Active sitei335PROSITE-ProRule annotation1
Metal bindingi338Zinc; catalyticBy similarity1
Metal bindingi344Zinc; catalyticBy similarity1
Metal bindingi389Calcium; via carbonyl oxygenBy similarity1
Metal bindingi392CalciumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Protease, Toxin
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase/disintegrin
Cleaved into the following 2 chains:
OrganismiGloydius saxatilis (Rock mamushi) (Gloydius intermedius saxatilis)
Taxonomic identifieri92067 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeGloydius

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000032263221 – 190By similarityAdd BLAST170
ChainiPRO_0000322633191 – 394Snake venom metalloproteinase saxinAdd BLAST204
PropeptideiPRO_0000322634395 – 418By similarityAdd BLAST24
ChainiPRO_0000322635419 – 483DisintegrinAdd BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi309 ↔ 389By similarity
Disulfide bondi349 ↔ 373By similarity
Disulfide bondi351 ↔ 356By similarity
Disulfide bondi425 ↔ 448By similarity
Disulfide bondi439 ↔ 445By similarity
Disulfide bondi444 ↔ 469By similarity
Disulfide bondi457 ↔ 476By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (disintegrin).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7SZE0
SMRiQ7SZE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 394Peptidase M12BPROSITE-ProRule annotationAdd BLAST197
Domaini402 – 483DisintegrinPROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi461 – 463Cell attachment site3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006978

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7SZE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVLLVTIC LVIFPYQGSS IILESGNVND YEVVYPQKVT ALPKGAVQPK
60 70 80 90 100
YEDAMQYEFK VNGEPVVLHL EKNKGLFSED YSETHYSPDG RKITTNPPVE
110 120 130 140 150
DHCYYHGRIQ NDADSTASIS ACNGLKGHFK HQGEMYLIEP LKLSDSEAHA
160 170 180 190 200
VYKYENVEKE DEAPKMCGVT QTNWKSDEPI KKASQLVVTP EQQRFPQRYI
210 220 230 240 250
ELVVVADQGM FTKYNSNLDT IRTWVHELVD TINEFYRSLN VRVSLTELEI
260 270 280 290 300
WSNEDLINVQ PAAPHTLDSF GEWRQRDLLH RISHDNAMLL TSTDFDGDTI
310 320 330 340 350
GFAHVGTMCD PKRSVGIVQD HSAINLLVAV TMAHELGHNL GTDHDGNQCH
360 370 380 390 400
CSANSCIMGD VLREGLSYEF SDCSQNQYQT YLTDHNPQCI LNEPLRTDTV
410 420 430 440 450
STPVSGNELL ETGEECDCGT PANPCCDAAT CKLRPGAQCA EGLCCDQCKF
460 470 480
TRAGKICRRA RGDNPDDRCT GQSSDCPRNP FHA
Length:483
Mass (Da):54,011
Last modified:October 1, 2003 - v1
Checksum:i9F144352C32F5567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204244 mRNA Translation: AAP20639.1
AY204247 mRNA Translation: AAP20642.1
AY204248 mRNA Translation: AAP20643.1

Similar proteinsi

Entry informationi

Entry nameiVM2SA_GLOSA
AccessioniPrimary (citable) accession number: Q7SZE0
Secondary accession number(s): Q7SZD6, Q7SZD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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