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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

cyp11a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.UniRule annotation

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Pathwayi: C21-steroid hormone metabolism

This protein is involved in the pathway C21-steroid hormone metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway C21-steroid hormone metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • C21-steroid hormone biosynthetic process Source: ZFIN
  • cholesterol metabolic process Source: UniProtKB-KW
  • epiboly Source: ZFIN
  • positive regulation of microtubule polymerization Source: ZFIN
  • response to steroid hormone Source: ZFIN

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, SteroidogenesisUniRule annotation, Sterol metabolism
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-196108 Pregnenolone biosynthesis
R-DRE-211976 Endogenous sterols
UniPathwayi
UPA00229

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrialUniRule annotation (EC:1.14.15.6UniRule annotation)
Alternative name(s):
Cholesterol desmolaseUniRule annotation
Gene namesi
Name:cyp11a1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-010306-1 cyp11a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000002347 Expressed in 24 organ(s), highest expression level in mature ovarian follicle

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068056

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOVERGENiHBG051098
KOiK00498
OMAiPLFWGVP
OrthoDBiEOG091G04MV
TreeFamiTF105094

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q7SYJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARWNVTFAR LDQSLSSLKN LLQVKVTRSG RAPQNSTVQP FNKIPGRWRN
60 70 80 90 100
SLLSVLAFTK MGGLRNVHRI MVHNFKTFGP IYREKVGIYD SVYIIKPEDG
110 120 130 140 150
AILFKAEGHH PNRINVDAWT AYRDYRNQKY GVLLKEGKAW KTDRMILNKE
160 170 180 190 200
LLLPKLQGTF VPLLEEVGQD FVARVNKQIE RSGQKQWTTD LTHDLFKFSL
210 220 230 240 250
ESVSAVLYGE RLGLLLDNID PEFQHFIDCV SVMFKTTSPM LYLPPGLLRS
260 270 280 290 300
IGSNIWKNHV EAWDGIFNQA DRYIQNIFKQ WKENPEGNGK YPGVLAILLM
310 320 330 340 350
QDKLSIEDIK ASVTELMAGG VDSVTFTLLW TLYELARQPD LQDELRAEIS
360 370 380 390 400
AARIAFKGDM VQMVKMIPLL KAALKETLRL HPVAMSLPRF ITEDTVIQNY
410 420 430 440 450
HIPAGTLVQL GVYAMGRDHQ FFPKPEQYCP SRWISSKRQY FKSLGFGFGP
460 470 480 490 500
RQCLGRRIAE TEMQIFLIHM LENFRIEKQK QIEVRSKFEL LLMPEKPIML

TIKPLNASR
Length:509
Mass (Da):58,618
Last modified:October 1, 2003 - v1
Checksum:i27F0C349EDA0F903
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8KC03A8KC03_DANRE
Cholesterol side-chain cleavage enz...
cyp11a1
509Annotation score:
X1WFM9X1WFM9_DANRE
Cholesterol side-chain cleavage enz...
cyp11a1
235Annotation score:
X1WBB6X1WBB6_DANRE
Cholesterol side-chain cleavage enz...
cyp11a1
245Annotation score:
X1WH33X1WH33_DANRE
Cholesterol side-chain cleavage enz...
cyp11a1
266Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929050 Genomic DNA No translation available.
BC054701 mRNA Translation: AAH54701.1
RefSeqiNP_694485.2, NM_152953.2
XP_005170754.1, XM_005170697.2
UniGeneiDr.80336

Genome annotation databases

EnsembliENSDART00000024866; ENSDARP00000025030; ENSDARG00000002347
ENSDART00000073566; ENSDARP00000068056; ENSDARG00000002347
GeneIDi80374
KEGGidre:80374

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929050 Genomic DNA No translation available.
BC054701 mRNA Translation: AAH54701.1
RefSeqiNP_694485.2, NM_152953.2
XP_005170754.1, XM_005170697.2
UniGeneiDr.80336

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068056

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000024866; ENSDARP00000025030; ENSDARG00000002347
ENSDART00000073566; ENSDARP00000068056; ENSDARG00000002347
GeneIDi80374
KEGGidre:80374

Organism-specific databases

CTDi1583
ZFINiZDB-GENE-010306-1 cyp11a1

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOVERGENiHBG051098
KOiK00498
OMAiPLFWGVP
OrthoDBiEOG091G04MV
TreeFamiTF105094

Enzyme and pathway databases

UniPathwayi
UPA00229

ReactomeiR-DRE-196108 Pregnenolone biosynthesis
R-DRE-211976 Endogenous sterols

Gene expression databases

BgeeiENSDARG00000002347 Expressed in 24 organ(s), highest expression level in mature ovarian follicle

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7SYJ6_DANRE
AccessioniPrimary (citable) accession number: Q7SYJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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