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Protein

SEC14 domain and spectrin repeat-containing protein 1

Gene

sestd1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels trpc4 and trpc5. Binds phospholipids (By similarity).By similarity

GO - Biological processi

  • blood vessel morphogenesis Source: ZFIN

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 domain and spectrin repeat-containing protein 1
Alternative name(s):
Protein Solo
Gene namesi
Name:sestd1
Synonyms:sol, solo
ORF Names:si:dz106a20.1, si:dz42h5.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030801-1 sestd1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094971 – 714SEC14 domain and spectrin repeat-containing protein 1Add BLAST714

Proteomic databases

PaxDbiQ7SX85
PRIDEiQ7SX85

Expressioni

Gene expression databases

BgeeiENSDARG00000040614 Expressed in 34 organ(s), highest expression level in tail
ExpressionAtlasiQ7SX85 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116017

Structurei

3D structure databases

SMRiQ7SX85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 153CRAL-TRIOPROSITE-ProRule annotationAdd BLAST153
Repeati275 – 381Spectrin 1Add BLAST107
Repeati384 – 497Spectrin 2Add BLAST114
Repeati503 – 605Spectrin 3Add BLAST103

Sequence similaritiesi

Belongs to the SOLO family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPZN LUCA
GeneTreeiENSGT00730000111148
HOGENOMiHOG000072717
HOVERGENiHBG104429
InParanoidiQ7SX85
OMAiCTTRSSG
OrthoDBiEOG091G03F6
PhylomeDBiQ7SX85
TreeFamiTF332003

Family and domain databases

CDDicd00170 SEC14, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR018159 Spectrin/alpha-actinin
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
SMARTiView protein in SMART
SM00150 SPEC, 2 hits
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q7SX85-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASCILPVL KKKLAFLSGG KDRRSGLILT IPLCTEQTSM EELSTTLDYL
60 70 80 90 100
LGIPSEKCKA RGFTVIVDGR KSQWNIVKTV VLMLQNVIPA EVSLVCVVKP
110 120 130 140 150
DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTDEFGGSLL
160 170 180 190 200
YDHLDWVNKR LVFEKFTKES TSLLDELIVI NENEKGSQAE KDRSSESNIL
210 220 230 240 250
PSFDPETVLQ TGHELLSELQ QRRFNGSEGG GGGGTAWSPM DDELLAQPQV
260 270 280 290 300
MKLLDSLREQ YTKYQEVCRQ RSKRSQLEEI QTKVMQVVNW LEGPGTDQLR
310 320 330 340 350
TQWGIGDSIR ASQALQQKHE EIESQHSEWF AVYVELNQQI AALLSAGDEE
360 370 380 390 400
DLMELKGLQQ QLSDVCYRQA SQLEFRQNVL QSAYEFHMTA QDLSQQLDGL
410 420 430 440 450
LGMLCADVAP ADGAAIQQTL KHLEEKLKSV ESALQTLREK GQALLDQMSN
460 470 480 490 500
QTSFSYGKEV GVENKENIDH IHSVMEDMQL RKQRCEDMVD VRRLKMLQMV
510 520 530 540 550
QLFKCEEDAS QAVEWLGELL DALLKTHIRL GDDSQETKVL LEKHKKFVDV
560 570 580 590 600
AQSTYDYGRQ LLQATVVLCQ SLRCTTRSSG DTLPRLNRVW KQFTVTSDER
610 620 630 640 650
QHRLEMASAF HTAAEKIVRE SPELAELLVD VEAYEEVETL GKGLLDRLTV
660 670 680 690 700
PVIFPDGSEQ FFGSPGDMAS SAESIRERMK LVEEKRFLQE EAEQRLEEEE
710
EEEEAALEVE PRES
Length:714
Mass (Da):81,274
Last modified:October 14, 2008 - v3
Checksum:i5008FFC9832405B5
GO
Isoform 2 (identifier: Q7SX85-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     211-234: Missing.

Note: No experimental confirmation available.
Show »
Length:651
Mass (Da):74,647
Checksum:i7B00A72253B39532
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QGU8E9QGU8_DANRE
SEC14 domain and spectrin repeat-co...
sestd1
232Annotation score:

Sequence cautioni

The sequence CAD58743 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230G → K in BAC78395 (PubMed:12837271).Curated1
Sequence conflicti627L → V in BAC78395 (PubMed:12837271).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355591 – 39Missing in isoform 2. CuratedAdd BLAST39
Alternative sequenceiVSP_035560211 – 234Missing in isoform 2. CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096104 mRNA Translation: BAC78395.1
AL732415 Genomic DNA Translation: CAD58743.1 Sequence problems.
AL732458 Genomic DNA Translation: CAD61241.1
CR848760 Genomic DNA No translation available.
BC134893 mRNA Translation: AAI34894.1
RefSeqiNP_878301.2, NM_182881.2 [Q7SX85-1]
XP_005167932.1, XM_005167875.3 [Q7SX85-1]
UniGeneiDr.79572

Genome annotation databases

EnsembliENSDART00000059448; ENSDARP00000059447; ENSDARG00000040614 [Q7SX85-1]
ENSDART00000139775; ENSDARP00000116017; ENSDARG00000040614 [Q7SX85-1]
ENSDART00000192523; ENSDARP00000152076; ENSDARG00000040614 [Q7SX85-1]
GeneIDi360133
KEGGidre:360133

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSESD1_DANRE
AccessioniPrimary (citable) accession number: Q7SX85
Secondary accession number(s): A4IG23, Q7ZZ43, Q8AW09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 14, 2008
Last modified: September 12, 2018
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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