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Entry version 120 (11 Dec 2019)
Sequence version 2 (20 Apr 2010)
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Protein

Alpha-2-macroglobulin

Gene

A2M

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-114608 Platelet degranulation
R-BTA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-BTA-1474228 Degradation of the extracellular matrix
R-BTA-194840 Rho GTPase cycle
R-BTA-8963896 HDL assembly

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2-macroglobulin
Short name:
Alpha-2-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:A2M
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Add BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000009379024 – 1510Alpha-2-macroglobulinAdd BLAST1487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 86By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 299By similarity
Disulfide bondi269 ↔ 287By similarity
Disulfide bondi278Interchain (with C-431)By similarity
Disulfide bondi431Interchain (with C-278)By similarity
Disulfide bondi470 ↔ 563By similarity
Disulfide bondi595 ↔ 773By similarity
Disulfide bondi644 ↔ 691By similarity
Disulfide bondi823 ↔ 850By similarity
Disulfide bondi848 ↔ 884By similarity
Glycosylationi870N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi922 ↔ 1358By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1009 ↔ 1012Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1116 ↔ 1164By similarity
Disulfide bondi1389 ↔ 15031 Publication
Glycosylationi1440N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1460N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioester bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7SIH1

PeptideAtlas

More...
PeptideAtlasi
Q7SIH1

PRoteomics IDEntifications database

More...
PRIDEi
Q7SIH1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7SIH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000018137 Expressed in 9 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; disulfide-linked.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000006167

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11510
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7SIH1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7SIH1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni692 – 730Bait regionBy similarityAdd BLAST39
Regioni706 – 711InhibitoryBy similarity6
Regioni721 – 725InhibitoryBy similarity5
Regioni732 – 737InhibitoryBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCRI Eukaryota
ENOG410XQIV LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220939

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7SIH1

KEGG Orthology (KO)

More...
KOi
K03910

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPSNCFG

Database of Orthologous Groups

More...
OrthoDBi
354230at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897 A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR010916 TonB_box_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF07678 TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7SIH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKNKLLYPS LTLLLLLLLP TDASVSGKPQ YMVLVPSLLH TETPEKGCLL
60 70 80 90 100
LSHLNETVTV SASLESVREN RSLFTDVVAE KDLFHCVSFT LPRSPTSQEV
110 120 130 140 150
MFLTIQVKGP TQEFKKRTTV LVKNEESLVF VQTDKPIYKP EQTVKFRIVL
160 170 180 190 200
LDESFHPLNE LVPLVYVEDP KGNRIAQWQN LEVENGLQQL TFPLSSEPFQ
210 220 230 240 250
GSYKVVVQKG SGGTAEHPFT VEEFVLPKFE VQVRMPKIIT ILEEEVQVSV
260 270 280 290 300
CGLYTYGKPV PGRVTMNMCR KYRNPSNCYG EESNAVCEKF SGELNNEGCF
310 320 330 340 350
SQQVNTKIFQ LKRQEFEMKI EVEAKIQEEG TEVELTGKGA TEITTTITKL
360 370 380 390 400
SFVTVDSNLR RGIPFTGKVL LVDGKGVPMP NKVIFITANE ANHNSNTTTD
410 420 430 440 450
EHGLAQFSIT TTKIKGTSLS IRVKYKDHSP CYGYQWLSEE HQDAYHSANL
460 470 480 490 500
VFSRSNSFVY LEPLPRELPC GKTQTVQAHY VLKGQVLKDL KELVFYYLIM
510 520 530 540 550
AKGGIVRSGT HTLPVEQGDM QGHFSMSVPV ESDIAPVARL LIYAILPDGE
560 570 580 590 600
VVGDSARYEI EHCLANKVGL NFSPGQSFPA SQAHLRVTAS PQSLCALRAV
610 620 630 640 650
DQSVLLMRPE AELSAATVYN LLPVKDLSSF PSSVNQQEED NEDCISHDNV
660 670 680 690 700
YINGIMYFPV SNTNEKDMYS FLQDMGLKAF TNSKIHKPKI CPQPEEHRIQ
710 720 730 740 750
HHTLLASPVR AEMGRNRDFV HFDDTSEPPT ETVRKYFPET WIWDLVVVSS
760 770 780 790 800
SGVHEVEVTV PDTITEWKAG ALCLSRDTGL GLSPTASLRV FQPFFVELTM
810 820 830 840 850
PYSVIRGEAF TLKATVLNYL PKCIRVSVQL EASPAFLAVP EKEQETYCIC
860 870 880 890 900
GNGRQTVSWA VTPKSLGNVN FTVSAEAVES QELCGSEVPV VPEHGRKDTI
910 920 930 940 950
IKPLLVEPEG LEKEVIFNSL LCPSVDFVFL GAEDGGQVLR HFPPAAATDT
960 970 980 990 1000
AADAHDPARP GAKVSESLSL KLPPNVVEES ARASFSVLGD ILGSAMRNTQ
1010 1020 1030 1040 1050
NLLQMPYGCG EQNMARFAPN IYVLDYLNET QQLTAELKSK AILYLNTGYQ
1060 1070 1080 1090 1100
RQLLYKHFDG SYSTFGEHRG NSEGNTWLTA FVLKSFAQAR GYIFIDEAHI
1110 1120 1130 1140 1150
TEALTWLAQK QKSNGCFRST GTLLNNAIKG GVDDEVTLSA YITIALLEMP
1160 1170 1180 1190 1200
LPVTHPVVRN ALFCLDSAWK SAKEGSQGSH VYTKALLAYA FALAGNQERR
1210 1220 1230 1240 1250
TEVLTSLYEE AVKEDNTIHW TRPQKPRLLT EDIYQPRAPS AEVEMTAYVI
1260 1270 1280 1290 1300
LAHVTAQPAP NPEDLKRATS IVKWISKQQN CQGGFSSTQD TVVALHALSR
1310 1320 1330 1340 1350
YGAATFTSAR KAAQVTIQSS GTFSTKFQVE NSNRLLLQQV SLPEVPGEYS
1360 1370 1380 1390 1400
MSVTGEGCVY LQTSLKYNIL PKKDEFPFAL EVQTLPQTCD GPKAHTSFQI
1410 1420 1430 1440 1450
SLSVSYIGSR PASNMAIVDV KMVSGFIPLK PTVKMLERSN VSRTEVSNNH
1460 1470 1480 1490 1500
VLIYLDKVTN ETLTLTFTVL QDIPVRDLKP AIVKVYDYYE TDEFAVAEYS
1510
APCSKDIGNA
Length:1,510
Mass (Da):167,576
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93928C5436E0E20F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC153840 mRNA Translation: AAI53841.1

NCBI Reference Sequences

More...
RefSeqi
NP_001103265.1, NM_001109795.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
513856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:513856

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153840 mRNA Translation: AAI53841.1
RefSeqiNP_001103265.1, NM_001109795.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AYOX-ray1.90A/B1375-1504[»]
SMRiQ7SIH1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006167

Protein family/group databases

MEROPSiI39.001

PTM databases

iPTMnetiQ7SIH1

Proteomic databases

PaxDbiQ7SIH1
PeptideAtlasiQ7SIH1
PRIDEiQ7SIH1

Genome annotation databases

GeneIDi513856
KEGGibta:513856

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2

Phylogenomic databases

eggNOGiENOG410KCRI Eukaryota
ENOG410XQIV LUCA
HOGENOMiHOG000220939
InParanoidiQ7SIH1
KOiK03910
OMAiNPSNCFG
OrthoDBi354230at2759
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation
R-BTA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-BTA-1474228 Degradation of the extracellular matrix
R-BTA-194840 Rho GTPase cycle
R-BTA-8963896 HDL assembly

Miscellaneous databases

EvolutionaryTraceiQ7SIH1

Gene expression databases

BgeeiENSBTAG00000018137 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

CDDicd02897 A2M_2, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR010916 TonB_box_CS
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF07678 TED_complement, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2MG_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7SIH1
Secondary accession number(s): A8E647
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: April 20, 2010
Last modified: December 11, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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