We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q7SID6 (PA2A_DEIAC)
Protein
Acidic phospholipase A2
Gene
N/A
Organism
Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus)
Status
Functioni
Snake venom phospholipase A2 (PLA2) that inhibits ADP-induced platelet aggregation. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationBy similarityEC:3.1.1.4PROSITE-ProRule annotationBy similarity
Cofactori
Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 27 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 29 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 31 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 | |
Active sitei | 47 | By similarity | 1 | |
Metal bindingi | 48 | Calcium1 Publication | 1 | |
Active sitei | 89 | By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hemostasis impairing toxin, Hydrolase, Platelet aggregation inhibiting toxin, Toxin |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Acidic phospholipase A2 (EC:3.1.1.4)Short name: svPLA2 Alternative name(s): Phosphatidylcholine 2-acylhydrolase |
Organismi | Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) |
Taxonomic identifieri | 36307 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Deinagkistrodon |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235854 | 1 – 123 | Acidic phospholipase A2Add BLAST | 123 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 116 | 1 Publication | ||
Disulfide bondi | 28 ↔ 44 | 1 Publication | ||
Disulfide bondi | 43 ↔ 95 | 1 Publication | ||
Disulfide bondi | 49 ↔ 123 | 1 Publication | ||
Disulfide bondi | 50 ↔ 88 | 1 Publication | ||
Disulfide bondi | 57 ↔ 81 | 1 Publication | ||
Disulfide bondi | 75 ↔ 86 | 1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q7SID6 |
SMRi | Q7SID6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7SID6 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7SID6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SLIQFETLIM KVVKKSGMFW YSAYGCYCGW GGHGRPQDAT DRCCFVHDCC
60 70 80 90 100
YGKVTGCDPK MDSYTYSEEN GDIVCGGDDP CKREICECDR VAAVCFRDNL
110 120
DTYNSDTYWR YPTKNCQEEP DPC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 39 | A → P1 Publication | 1 | |
Natural varianti | 56 | G → S1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77648 mRNA Translation: CAJ85790.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77648 mRNA Translation: CAJ85790.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IJL | X-ray | 2.60 | A/B | 1-123 | [»] | |
AlphaFoldDBi | Q7SID6 | |||||
SMRi | Q7SID6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7SID6 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2A_DEIAC | |
Accessioni | Q7SID6Primary (citable) accession number: Q7SID6 Secondary accession number(s): Q1ZY04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | May 16, 2006 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families