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Entry version 100 (11 Dec 2019)
Sequence version 1 (15 Dec 2003)
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Protein

GPI inositol-deacylase

Gene

bst-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei397By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
neucr-q6mfs7 PGAP1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GPI inositol-deacylase (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bst-1
ORF Names:B2N18.110, NCU08021
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:NCU08021

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei882 – 902HelicalSequence analysisAdd BLAST21
Transmembranei929 – 949HelicalSequence analysisAdd BLAST21
Transmembranei980 – 1000HelicalSequence analysisAdd BLAST21
Transmembranei1005 – 1025HelicalSequence analysisAdd BLAST21
Transmembranei1053 – 1073HelicalSequence analysisAdd BLAST21
Transmembranei1103 – 1123HelicalSequence analysisAdd BLAST21
Transmembranei1130 – 1150HelicalSequence analysisAdd BLAST21
Transmembranei1172 – 1192HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776401 – 1256GPI inositol-deacylaseAdd BLAST1256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1242N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7SAM0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 134Poly-GlnAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GPI inositol-deacylase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000180936

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7SAM0

KEGG Orthology (KO)

More...
KOi
K05294

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRFASKY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR012908 PGAP1-like
IPR039529 PGAP1/BST1

The PANTHER Classification System

More...
PANTHERi
PTHR15495 PTHR15495, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07819 PGAP1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00120 LIPASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7SAM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTRLAGTSE DGHLCPVEAP FPNVDFLLHQ QLQQEQDVYA NSTTNATASP
60 70 80 90 100
PIAPTSVLPR PSRPSQSSAA ERTSPESPSV RQSPTKRDRN PGPSSISGAG
110 120 130 140 150
PLNLEHQSPS QQSQNQQQQQ QQQQQQQQQQ QQQQSFYARS RRSGNFNWKL
160 170 180 190 200
SHSRNGSIEK PPPSFFSSSF SHSPSTPPLS LGAPANGAAH SKEMEKEEEQ
210 220 230 240 250
KFVGKRPRIR SPWAITFVTL LISILGIGFL ALVLNSSFTR HIDPKGCRMS
260 270 280 290 300
YMRPGYAKFD DFDTEHTRFA SKYSLYLYRE LGIENDAKVR GVPVLFIPGN
310 320 330 340 350
AGSYKQVRPI AAEAANYFHD VLQQDESAVK AGARSLDFFT VDFNEDITAF
360 370 380 390 400
HGQTLLDQAE YLNEAIRYIL SLYLDRTRSD RDPNLPDPTS VIVLGHSMGG
410 420 430 440 450
VVARTMLIMP NYQANSINTI ITMSAPHARP PVSFDSEIVK TYKDINDYWR
460 470 480 490 500
RAYSQQWANN NPLWHVTLVS IAGGGLDTVV PSDYASVESL VPDTHGFTVF
510 520 530 540 550
TTSIPNVWTS MDHAAILWCD QFRKALVKAI FDVVDVNRAA QTKPRADRMR
560 570 580 590 600
VFKRWFLTGM EEVAEKTVPS KDPSTLLTLE DNLSSVIAQG ERLVLRSLGA
610 620 630 640 650
SGAVRAHLLP IPPSGSPEAK RFTLLTDHKL DVSSESGRLE VLFCSVFPMQ
660 670 680 690 700
PGQAVAGFAA QINLAGDSSA STRLACNNAA SDVVTLPASL RSSQYPFSKE
710 720 730 740 750
GEPPKTHFSY LQYDVEDIAE HQYVAVIEKT HTPTPGFVIA EFSDVSQSHR
760 770 780 790 800
TRHISLRRLL AFGMKFRLPS SRPMVSELKV PTMQSSLLAY NLEISEQNCG
810 820 830 840 850
KQQELFAPLI RQYLTEPYES KFFVNAREAA VSIHGVAPYV PPPLKSRSTE
860 870 880 890 900
DGLSFQFWTD PTCASNINIK MSIDVMGSLG KLYMRYRTVF AAFPLLVVTL
910 920 930 940 950
VLRKQFRIYD TTGVFISFSE SLDLCLRQSI PLVLAFLTFL SLFIWNSSSS
960 970 980 990 1000
ATANIWNWAN VTSGAIDFHQ NDLLIGTQDP FFWFLVPVIG LICVGICTVF
1010 1020 1030 1040 1050
NYMTLTLVHI LSTAVSLLSF RPGWIRNDER RKALPLPAFY PTSPRRRMVT
1060 1070 1080 1090 1100
TAILLVLVST LIPYQFAYLV CCLVQLTTTV RAQRLASDLR SAANSNFYNY
1110 1120 1130 1140 1150
VHSILLLMLW ILPINLPILV VWIHNLAVHW LTPFSSHHNV LSIMPFIILV
1160 1170 1180 1190 1200
ETLTTGKMVP RVNSRFKHFT SVLLFGIALY AAIYGVSYAY MLHYLVNLVA
1210 1220 1230 1240 1250
AWLAIVHSTS DNWSVLSGIK HISCTLFDAG NTNNVGGVNG TNNTMLAEDC

KMRKEP
Length:1,256
Mass (Da):140,123
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41B003D0E5EBFFD4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAE85512 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX897674 Genomic DNA Translation: CAE85512.1 Sequence problems.
CM002239 Genomic DNA Translation: EAA33455.1

NCBI Reference Sequences

More...
RefSeqi
XP_962691.1, XM_957598.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA33455; EAA33455; NCU08021

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3878857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU08021

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897674 Genomic DNA Translation: CAE85512.1 Sequence problems.
CM002239 Genomic DNA Translation: EAA33455.1
RefSeqiXP_962691.1, XM_957598.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

ESTHERineucr-q6mfs7 PGAP1

Proteomic databases

PRIDEiQ7SAM0

Genome annotation databases

EnsemblFungiiEAA33455; EAA33455; NCU08021
GeneIDi3878857
KEGGincr:NCU08021

Organism-specific databases

EuPathDBiFungiDB:NCU08021

Phylogenomic databases

HOGENOMiHOG000180936
InParanoidiQ7SAM0
KOiK05294
OMAiTRFASKY

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR012908 PGAP1-like
IPR039529 PGAP1/BST1
PANTHERiPTHR15495 PTHR15495, 1 hit
PfamiView protein in Pfam
PF07819 PGAP1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBST1_NEUCR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7SAM0
Secondary accession number(s): Q6MFS7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 15, 2003
Last modified: December 11, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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