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Entry version 86 (10 Feb 2021)
Sequence version 1 (15 Dec 2003)
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Protein

Phosphatidylethanolamine N-methyltransferase

Gene

chol-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in the pathway phosphatidylcholine biosynthesis, which is part of Phospholipid metabolism.UniRule annotation2 Publications
View all proteins of this organism that are known to be involved in the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylethanolamine N-methyltransferase1 PublicationUniRule annotation (EC:2.1.1.17UniRule annotation1 Publication)
Short name:
PE methyltransferaseUniRule annotation
Short name:
PEAMTUniRule annotation
Short name:
PEMTUniRule annotation
Alternative name(s):
Cholineless1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chol-11 Publication
Synonyms:cho2
ORF Names:B2E7.130, NCU08045
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Linkage Group IV, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU08045

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 91LumenalUniRule annotationAdd BLAST91
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Topological domaini113 – 115CytoplasmicUniRule annotation3
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Topological domaini137 – 201LumenalUniRule annotationAdd BLAST65
Transmembranei202 – 222HelicalUniRule annotationAdd BLAST21
Topological domaini223 – 229CytoplasmicUniRule annotation7
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21
Topological domaini251 – 279LumenalUniRule annotationAdd BLAST29
Transmembranei280 – 300HelicalUniRule annotationAdd BLAST21
Topological domaini301 – 306CytoplasmicUniRule annotation6
Transmembranei307 – 327HelicalUniRule annotationAdd BLAST21
Topological domaini328 – 389LumenalUniRule annotationAdd BLAST62
Transmembranei390 – 410HelicalUniRule annotationAdd BLAST21
Topological domaini411 – 417CytoplasmicUniRule annotation7
Transmembranei418 – 438HelicalUniRule annotationAdd BLAST21
Topological domaini439 – 467LumenalUniRule annotationAdd BLAST29
Transmembranei468 – 488HelicalUniRule annotationAdd BLAST21
Topological domaini489 – 496CytoplasmicUniRule annotation8
Transmembranei497 – 517HelicalUniRule annotationAdd BLAST21
Topological domaini518 – 573LumenalUniRule annotationAdd BLAST56
Transmembranei574 – 594HelicalUniRule annotationAdd BLAST21
Topological domaini595 – 965CytoplasmicUniRule annotationAdd BLAST371

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004059001 – 965Phosphatidylethanolamine N-methyltransferaseAdd BLAST965

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7SAJ6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005987_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7SAJ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
EAWRQWK

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03217, PEMT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007318, Phopholipid_MeTrfase
IPR016219, Phosphatid-EA_MeTrfase_fun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04191, PEMT, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000383, PEAMT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51598, SAM_CHO2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7SAJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSAADPFA ARLNSDVRQR HPTASATSKN VEGTSQQKQQ QQQQQSEANA
60 70 80 90 100
AASRVKKTYG KTPDGTVFVV PTTHDMVTQL LDPREPKNLS DVAVLAIIAL
110 120 130 140 150
HFLAAYYLPW GVKRPLFAAI FMFWRLAYNV GIGYLLTIQS KYKLLVTWAK
160 170 180 190 200
RWKLFENPAT GKNPRPWLYN LLKKELETKI PQDYKFEEAP IEYNTWLTFR
210 220 230 240 250
RVVDLILMCD FISYCLFAIV CAHKPDGEGL FMCFARWAAG ITLVGFNLWV
260 270 280 290 300
KLDAHRVVKD YAWYWGDFFY LIEQELTFDG VFELAPHPMY SIGYAGYYGI
310 320 330 340 350
SMMAASYDVL FISIIAHAAQ FAFLVIVENP HIEKTYNPPQ PRVRCESEAG
360 370 380 390 400
SQLQEFASEY SVPSTTGRHD NTPLPVHNLI GLKNLDFFRI TDVAIVLLCA
410 420 430 440 450
YLAVVTMVTP NTRFYQALFV LHALAWRLWY SAGLGVILTM QSEEKMFTRH
460 470 480 490 500
FLKYGESVGE AWRQWKGIYH LSNCLCHASF IAASYKMYEF PADWTYGWAL
510 520 530 540 550
LKHVVGLSLI ALQVWTATSI YESLGEFGWF YGDFFFDSKR QLTYTSIYRF
560 570 580 590 600
LNNPERVFGT AGLWGAALIT WSRAIFLMAL AGHFLTLAFL AYVEKPHMQK
610 620 630 640 650
VYGRNLRDDA GVTKFIKRSL PPPVTEWQQS IDKVLDETKH FIDEFVDAAR
660 670 680 690 700
SRLATGSSTI VKDTSALFNK YPARLTLSKI SPDLAGYDPK HYGLSLAGTR
710 720 730 740 750
VVGTNEKATG KESPNARVLK DVKTQAFEYG APIRVKWTAP ANHSKKDWVG
760 770 780 790 800
LYMVTDNRSR EVTEVPSLGR WVPTNPGEYD TTTDQGILVW DQPVEKKSED
810 820 830 840 850
TDLVEGEMVF EGDKLWWTQG VFEFRYHHGG GHHVMSISEP FEIQIPKFDD
860 870 880 890 900
EHMGVDISGE VGERAVEAAL LPVIRNCLDR DPDIAPSNAE ERFGGHVERD
910 920 930 940 950
GKYARRVVYA IRHMFGIDFA PAVVLADGNV RRLAWRICHA KEVLAPFSMS
960
HTNGRTTPVD SKFSE
Length:965
Mass (Da):109,552
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAA3EF9E29E795FE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX897675 Genomic DNA Translation: CAE85544.1
CM002239 Genomic DNA Translation: EAA33479.1

NCBI Reference Sequences

More...
RefSeqi
XP_962715.1, XM_957622.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA33479; EAA33479; NCU08045

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3878822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU08045

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897675 Genomic DNA Translation: CAE85544.1
CM002239 Genomic DNA Translation: EAA33479.1
RefSeqiXP_962715.1, XM_957622.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ7SAJ6

Genome annotation databases

EnsemblFungiiEAA33479; EAA33479; NCU08045
GeneIDi3878822
KEGGincr:NCU08045

Organism-specific databases

VEuPathDBiFungiDB:NCU08045

Phylogenomic databases

HOGENOMiCLU_005987_0_0_1
InParanoidiQ7SAJ6
OMAiEAWRQWK

Enzyme and pathway databases

UniPathwayiUPA00753

Family and domain databases

HAMAPiMF_03217, PEMT, 1 hit
InterProiView protein in InterPro
IPR007318, Phopholipid_MeTrfase
IPR016219, Phosphatid-EA_MeTrfase_fun
PfamiView protein in Pfam
PF04191, PEMT, 2 hits
PIRSFiPIRSF000383, PEAMT, 1 hit
PROSITEiView protein in PROSITE
PS51598, SAM_CHO2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHO2_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7SAJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: December 15, 2003
Last modified: February 10, 2021
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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