erg-6

Functionⁱ

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).By similarity

Catalytic activityⁱ

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)⁺.

Cofactorⁱ

Mg²⁺By similarity

Pathwayⁱ: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Probable squalene synthase (erg-6)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functionⁱ

farnesyl-diphosphate farnesyltransferase activity Source: GO_Central
oxidoreductase activity Source: UniProtKB-KW
squalene synthase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ergosterol biosynthetic process Source: GO_Central
farnesyl diphosphate metabolic process Source: GO_Central
isoprenoid biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Multifunctional enzyme, Transferase
Biological process	Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
Ligand	Magnesium, NADP

Enzyme and pathway databases

UniPathwayⁱ	UPA00767; UER00751.

UniPathwayⁱ

UPA00767; UER00751.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable squalene synthase (EC:2.5.1.21) Short name: SQS Short name: SS Alternative name(s): FPP:FPP farnesyltransferase Farnesyl-diphosphate farnesyltransferase
Gene namesⁱ	Name:erg-6 Synonyms:erg9 ORF Names:NCU06054
Organismⁱ	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifierⁱ	367110 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa
Proteomesⁱ	UP000001805 Componentⁱ: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBⁱ	FungiDB:NCU06054.

EuPathDBⁱ

FungiDB:NCU06054.

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	294 – 314	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	416 – 436	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000067449	1 – 481	Probable squalene synthaseAdd BLAST		481

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7S4Z6.
SMRⁱ	Q7S4Z6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMⁱ	HOG000186940.
InParanoidⁱ	Q7S4Z6.
KEGG Orthology (KO) More...KOⁱ	K00801.
OMAⁱ	FNFVAIP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2IU6.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00683. Trans_IPPS_HH. 1 hit.
Gene3Dⁱ	1.10.600.10. 1 hit.
InterProⁱ	View protein in InterPro IPR008949. Isoprenoid_synthase_dom_sf. IPR002060. Squ/phyt_synthse. IPR006449. Squal_synth-like. IPR019845. Squalene/phytoene_synthase_CS. IPR033904. Trans_IPPS_HH.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00494. SQS_PSY. 1 hit.
SUPFAMⁱ	SSF48576. SSF48576. 1 hit.
TIGRFAMsⁱ	TIGR01559. squal_synth. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00014. ER_TARGET. 1 hit. PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7S4Z6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGAFTKAAYF LLHPNQLRSI VQWKVWHEPV HRRDPSKETE TEKACFRHLE 
        60         70         80         90        100
LTSRSFSAVI QELNPELLMP ICLFYLVLRG LDTIEDDMTI DLAKKEPLLR 
       110        120        130        140        150
EFADLMEIDG WTFTENGPNE KDRELLVHFD DVIAELKKVK KPYYDIIREI 
       160        170        180        190        200
TVKMGNGMAD YALNAEHNTN GVNTIEEYEL YCHYVAGLVG EGLTRLFVES 
       210        220        230        240        250
NLANPALLER MELTESMGQF LQKTNIIRDI HEDYVDKRRF WPKTIWSKYV 
       260        270        280        290        300
NTWDDMFKPE NREKALQCSS EMVLNALKHT EDCLFYMAGM RDQSVFNFVA 
       310        320        330        340        350
IPQAMAIATL ELVFRNPAIF ERNVKITKGD ACQLMMESTQ NLRVVCEVFR 
       360        370        380        390        400
RYARRIHKKN DPRDPNYLAI SVQCGKIEQF IESIFPTQDP KKIALAQAQN 
       410        420        430        440        450
SNQTAANTTD NGDTTFLVLS MIGVLFVMGG LMIGAAWLMG ARFDMAYEDI 
       460        470        480 
TARVGTLVNG AAAVSSATVS SIPTTVMHQE L

Length:481

Mass (Da):54,942

Last modified:December 15, 2003 - v1

Checksum:ⁱ59ED6533600BF4DC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CM002242 Genomic DNA. Translation: ESA41923.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_011395225.1. XM_011396923.1.

Genome annotation databases

EnsemblFungiⁱ	ESA41923; ESA41923; NCU06054.
GeneIDⁱ	3875964.
KEGGⁱ	ncr:NCU06054.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q7S4Z6	A0A0B0E205 V5ILG1 F7VM49 F8MTW4 G4UVW1	Neurospora crassa Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) Neurospora tetrasperma (strain FGSC 2508 / ATCC MYA-4615 / P0657) Neurospora tetrasperma (strain FGSC 2509 / P0656)	481	UniRef90_Q7S4Z6	Cluster: Probable squalene synthase	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q7S4Z6	A0A0B0E205 V5ILG1 F7VM49 F8MTW4 G4UVW1 A0A0C3DK46 A0A093Z8W2 U4LCI5 F0URX6 A6RE57 +235	Neurospora crassa Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) Neurospora tetrasperma (strain FGSC 2508 / ATCC MYA-4615 / P0657) Neurospora tetrasperma (strain FGSC 2509 / P0656) Oidiodendron maius Zn Pseudogymnoascus sp. VKM F-3775 Pyronema omphalodes (strain CBS 100304) (Pyronema confluens) Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma capsulatum) Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) And more	481	UniRef50_Q7S4Z6	Cluster: Probable squalene synthase	246

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CM002242 Genomic DNA. Translation: ESA41923.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_011395225.1. XM_011396923.1.

3D structure databases

ProteinModelPortalⁱ	Q7S4Z6.
SMRⁱ	Q7S4Z6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	ESA41923; ESA41923; NCU06054.
GeneIDⁱ	3875964.
KEGGⁱ	ncr:NCU06054.

Organism-specific databases

EuPathDBⁱ	FungiDB:NCU06054.

EuPathDBⁱ

FungiDB:NCU06054.

Phylogenomic databases

HOGENOMⁱ	HOG000186940.
InParanoidⁱ	Q7S4Z6.
KEGG Orthology (KO) More...KOⁱ	K00801.
OMAⁱ	FNFVAIP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2IU6.

Enzyme and pathway databases

UniPathwayⁱ	UPA00767; UER00751.

UniPathwayⁱ

UPA00767; UER00751.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00683. Trans_IPPS_HH. 1 hit.
Gene3Dⁱ	1.10.600.10. 1 hit.
InterProⁱ	View protein in InterPro IPR008949. Isoprenoid_synthase_dom_sf. IPR002060. Squ/phyt_synthse. IPR006449. Squal_synth-like. IPR019845. Squalene/phytoene_synthase_CS. IPR033904. Trans_IPPS_HH.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00494. SQS_PSY. 1 hit.
SUPFAMⁱ	SSF48576. SSF48576. 1 hit.
TIGRFAMsⁱ	TIGR01559. squal_synth. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00014. ER_TARGET. 1 hit. PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FDFT_NEUCR
Accessionⁱ	Q7S4Z6Primary (citable) accession number: Q7S4Z6 Secondary accession number(s): V5IKD8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	December 15, 2003
	Last modified:	February 28, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7S4Z6 (FDFT_NEUCR)

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Probable squalene synthase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lanosterol biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: lanosterol biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ