UniProtKB - Q7S4Z6 (FDFT_NEUCR)
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Protein
Probable squalene synthase
Gene
erg-6
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).By similarity
Catalytic activityi
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.
Cofactori
Mg2+By similarity
: lanosterol biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Probable squalene synthase (erg-6)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.
GO - Molecular functioni
- farnesyl-diphosphate farnesyltransferase activity Source: GO_Central
- oxidoreductase activity Source: UniProtKB-KW
- squalene synthase activity Source: GO_Central
GO - Biological processi
- ergosterol biosynthetic process Source: GO_Central
- farnesyl diphosphate metabolic process Source: GO_Central
- isoprenoid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Multifunctional enzyme, Transferase |
Biological process | Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Ligand | Magnesium, NADP |
Enzyme and pathway databases
UniPathwayi | UPA00767; UER00751. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable squalene synthase (EC:2.5.1.21)Short name: SQS Short name: SS Alternative name(s): FPP:FPP farnesyltransferase Farnesyl-diphosphate farnesyltransferase |
Gene namesi | Name:erg-6 Synonyms:erg9 ORF Names:NCU06054 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:NCU06054. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 416 – 436 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067449 | 1 – 481 | Probable squalene synthaseAdd BLAST | 481 |
Structurei
3D structure databases
ProteinModelPortali | Q7S4Z6. |
SMRi | Q7S4Z6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the phytoene/squalene synthase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000186940. |
InParanoidi | Q7S4Z6. |
KOi | K00801. |
OMAi | FNFVAIP. |
OrthoDBi | EOG092C2IU6. |
Family and domain databases
CDDi | cd00683. Trans_IPPS_HH. 1 hit. |
Gene3Di | 1.10.600.10. 1 hit. |
InterProi | View protein in InterPro IPR008949. Isoprenoid_synthase_dom_sf. IPR002060. Squ/phyt_synthse. IPR006449. Squal_synth-like. IPR019845. Squalene/phytoene_synthase_CS. IPR033904. Trans_IPPS_HH. |
Pfami | View protein in Pfam PF00494. SQS_PSY. 1 hit. |
SUPFAMi | SSF48576. SSF48576. 1 hit. |
TIGRFAMsi | TIGR01559. squal_synth. 1 hit. |
PROSITEi | View protein in PROSITE PS00014. ER_TARGET. 1 hit. PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q7S4Z6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAFTKAAYF LLHPNQLRSI VQWKVWHEPV HRRDPSKETE TEKACFRHLE
60 70 80 90 100
LTSRSFSAVI QELNPELLMP ICLFYLVLRG LDTIEDDMTI DLAKKEPLLR
110 120 130 140 150
EFADLMEIDG WTFTENGPNE KDRELLVHFD DVIAELKKVK KPYYDIIREI
160 170 180 190 200
TVKMGNGMAD YALNAEHNTN GVNTIEEYEL YCHYVAGLVG EGLTRLFVES
210 220 230 240 250
NLANPALLER MELTESMGQF LQKTNIIRDI HEDYVDKRRF WPKTIWSKYV
260 270 280 290 300
NTWDDMFKPE NREKALQCSS EMVLNALKHT EDCLFYMAGM RDQSVFNFVA
310 320 330 340 350
IPQAMAIATL ELVFRNPAIF ERNVKITKGD ACQLMMESTQ NLRVVCEVFR
360 370 380 390 400
RYARRIHKKN DPRDPNYLAI SVQCGKIEQF IESIFPTQDP KKIALAQAQN
410 420 430 440 450
SNQTAANTTD NGDTTFLVLS MIGVLFVMGG LMIGAAWLMG ARFDMAYEDI
460 470 480
TARVGTLVNG AAAVSSATVS SIPTTVMHQE L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM002242 Genomic DNA. Translation: ESA41923.1. |
RefSeqi | XP_011395225.1. XM_011396923.1. |
Genome annotation databases
EnsemblFungii | ESA41923; ESA41923; NCU06054. |
GeneIDi | 3875964. |
KEGGi | ncr:NCU06054. |
Similar proteinsi
Entry informationi
Entry namei | FDFT_NEUCR | |
Accessioni | Q7S4Z6Primary (citable) accession number: Q7S4Z6 Secondary accession number(s): V5IKD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | December 15, 2003 | |
Last modified: | February 28, 2018 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |