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UniProtKB - Q7S133 (SWR1_NEUCR)

Protein

Helicase swr-1

Gene

crf1-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi970 – 977ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • histone binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase swr-1 (EC:3.6.4.12)
Alternative name(s):
Chromatin remodeling factor 1-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crf1-1
Synonyms:swr1
ORF Names:NCU09993
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:NCU09993

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743711 – 1845Helicase swr-1Add BLAST1845

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q7S133

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7S133

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini418 – 493HSAPROSITE-ProRule annotationAdd BLAST76
Domaini957 – 1122Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1510 – 1660Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1073 – 1076DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 51Thr-richAdd BLAST50
Compositional biasi246 – 292Pro-richAdd BLAST47

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000186095

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7S133

KEGG Orthology (KO)

More...KOi		K11681

Identification of Orthologs from Complete Genome Data

More...OMAi		RQGWNND

Family and domain databases

Conserved Domains Database

More...CDDi		cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7S133-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTMMTDSGT ASDSGAGLVD STRNDTTTTT TTTTTPGDND ADDDNTNGTT 
        60         70         80         90        100
TGHHDNNETD NNSKSYSSTH HVPAIDNTST TNANDNEDAA GFLDRDQSPL 
       110        120        130        140        150
SSISSPLSEP DNFEFDTEPI PSILSPKSTT SDNHARDGET PELDEDGQPP 
       160        170        180        190        200
AKRRRVRETT PHNHSRKPKP ESPPWKKFEA EGPTTIITED GRRKSGRVNP 
       210        220        230        240        250
VLLGMKPSDK KVTRKAIQTS PVSNKSSAST SRKPAPASSS NSKHAPAKMP 
       260        270        280        290        300
PPPPPPKAPA RKSATTHETR PSASRSRRRS PSPRRPATPP KPAAVGTRRS 
       310        320        330        340        350
TRQALAHSRA SYDDGQLSPG ASRATPRIKL KVRPPLTVIP LVHPNQANVR 
       360        370        380        390        400
PKLGPTFEEY FARAHEIPVE EGGQHIPDEE PKYTDEMALQ DAKVILRVEK 
       410        420        430        440        450
EVEPGGLLAP DRCSAFEPEA EEEPPRQWAH LDHLTKAMTN FRKLMYREQQ 
       460        470        480        490        500
LHMQAAKRIA IACEAEWRRR NPQPKTAEEI ELEEMEASKA KWRQVIRAFA 
       510        520        530        540        550
GTWENVRVEV NRRRLVEWEA EEQRRVKAAL NQAVNLSEQK LQQRQAQVDG 
       560        570        580        590        600
DEITDEDEDE DDEDLASGMP SVMGDEKESD EHSDQGSDEM SDENDEDEDE 
       610        620        630        640        650
DNMSSSEDDD KKSTASDEGL TQEELRAKYA NLPTLGTTDE TEETTKDVEM 
       660        670        680        690        700
ADAPAAMDGS VANDDDTSDE SVDMDDDLGS SEESDDDEEE EEDDEEEEES 
       710        720        730        740        750
DDEPAGLLGL FFGKSELKKL KEEAVTEEPS VEPAGDVEMT DASAALRPEL 
       760        770        780        790        800
QVNGHAHEAP ITNGTHTNEQ LASSQTEGAD DEVSLLVIPN DEIAAENTQT 
       810        820        830        840        850
AAEPGSGVVE KDFLTNDSSL KYPNEIVQSE NQTLPAKESV EAGGDLPMVD 
       860        870        880        890        900
APSTDDLQRE TAAAPSLEAP PNTRHDSQET VAATDMQSQS QTQSPKTTDT 
       910        920        930        940        950
KPTDVDTPHS ELAVSVQKPD SRQSSPQPTT PTVKTEIPFL LRGTLREYQH 
       960        970        980        990       1000
HGLDWLAGLY ANNTNGILAD EMGLGKTIQT IALLAHLACH HEVWGPHLVI 
      1010       1020       1030       1040       1050
VPTSVMLNWE MEFKKWCPGF KILTYYGNQE ERKRKRQGWN NDDVWNVCIT 
      1060       1070       1080       1090       1100
SYQMVLQDQQ VFRRRRWHYM ILDEAHNIKN FKSQRWQTLL GFNTQARLLL 
      1110       1120       1130       1140       1150
TGTPLQNNLT ELWSLLYFLA PPENGEGGFV DLTEFHNWFA RPESQILESG 
      1160       1170       1180       1190       1200
REQLDDEARA IIAKLHKVLR PYLLRRLKAD VEKQMPAKYE HVEFCRLSKR 
      1210       1220       1230       1240       1250
QRELYDGFLS RADTRETLQS GNYMSIINCL MQLRKVCNHP DLFVDRPIMT 
      1260       1270       1280       1290       1300
SFRMSRSVPA DYEWKEKFIR NRLLATKPMT TVNLSFLNMI PTEYEDLSKT 
      1310       1320       1330       1340       1350
HTDRIAQLSS HRILLDLREA QKVRANNAYT ALDPSSVKSN LVYLESAARW 
      1360       1370       1380       1390       1400
GRFEELQHCV YINALRRQQR PIYGKRLTEF LTLDTHLRPY KPRPRVPAKI 
      1410       1420       1430       1440       1450
MSWFEEDSFL LHNAIPTLQQ RAESMEMTIT KFACVTPAVV TGPEMNRFLL 
      1460       1470       1480       1490       1500
GERGIQLFED LDLKLSAPVK YAPYMPPQPP PDPWHEARMR LTIQFPDKRL 
      1510       1520       1530       1540       1550
LQYDCGKLQA LDKLLRKLQA GGHRALIFTQ MTKVLDILEQ FLNIHGHKYL 
      1560       1570       1580       1590       1600
RLDGATKVEQ RQILTDRFNH DPRILCFILS TRSGGLGINL TGADTVIFYD 
      1610       1620       1630       1640       1650
QDWNPAMDKQ CQDRCHRIGQ TRDVHIYRLV SEHTIEANIL RKASQKQMLD 
      1660       1670       1680       1690       1700
DVVIQEGEFT TDYFNRLSVR DVLGSNGEVI ASNEDDVAAN LAMDRVLGGP 
      1710       1720       1730       1740       1750
STTGAGGYDG TADGGGGASQ PPVRNVGRVL EMAEDREDVD AAKAAEKEIM 
      1760       1770       1780       1790       1800
QDEADFGEAG STRPGTPGDG LADLDGQLLG GEENKEVEDE VIEYNAWGER 
      1810       1820       1830       1840 
MHTIDEYMLG FMAKALEGTP LELPRDRKKG RDRNRNRKGK DSRKR
Length:1,845
Mass (Da):206,953
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E19DC989ACFEE39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CM002242 Genomic DNA Translation: EAA29066.1

NCBI Reference Sequences

More...RefSeqi		XP_958302.1, XM_953209.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		EAA29066; EAA29066; NCU09993

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3874449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ncr:NCU09993

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002242 Genomic DNA Translation: EAA29066.1
RefSeqiXP_958302.1, XM_953209.2

3D structure databases

ProteinModelPortaliQ7S133
SMRiQ7S133
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA29066; EAA29066; NCU09993
GeneIDi3874449
KEGGincr:NCU09993

Organism-specific databases

EuPathDBiFungiDB:NCU09993

Phylogenomic databases

HOGENOMiHOG000186095
InParanoidiQ7S133
KOiK11681
OMAiRQGWNND

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWR1_NEUCR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7S133
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 15, 2003
Last modified: January 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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