UniProtKB - Q7S133 (SWR1_NEUCR)
Protein
Helicase swr-1
Gene
crf1-1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 970 – 977 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
- histone binding Source: GO_Central
GO - Biological processi
- ATP-dependent chromatin remodeling Source: GO_Central
- chromatin remodeling Source: GO_Central
- gene silencing Source: GO_Central
- histone exchange Source: GO_Central
Keywordsi
Molecular function | Activator, Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:crf1-1 Synonyms:swr1 ORF Names:NCU09993 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:NCU09993 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- Swr1 complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074371 | 1 – 1845 | Helicase swr-1Add BLAST | 1845 |
Interactioni
Subunit structurei
Component of the SWR1 chromatin-remodeling complex.
By similarityGO - Molecular functioni
- histone binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 418 – 493 | HSAPROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 957 – 1122 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 1510 – 1660 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 151 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1073 – 1076 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2 – 51 | Thr-richAdd BLAST | 50 | |
Compositional biasi | 246 – 292 | Pro-richAdd BLAST | 47 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | HOG000186095 |
InParanoidi | Q7S133 |
KOi | K11681 |
OMAi | RQGWNND |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR002464 DNA/RNA_helicase_DEAH_CS IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR014012 HSA_dom IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N |
Pfami | View protein in Pfam PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit |
SUPFAMi | SSF52540 SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51204 HSA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7S133-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTMMTDSGT ASDSGAGLVD STRNDTTTTT TTTTTPGDND ADDDNTNGTT
60 70 80 90 100
TGHHDNNETD NNSKSYSSTH HVPAIDNTST TNANDNEDAA GFLDRDQSPL
110 120 130 140 150
SSISSPLSEP DNFEFDTEPI PSILSPKSTT SDNHARDGET PELDEDGQPP
160 170 180 190 200
AKRRRVRETT PHNHSRKPKP ESPPWKKFEA EGPTTIITED GRRKSGRVNP
210 220 230 240 250
VLLGMKPSDK KVTRKAIQTS PVSNKSSAST SRKPAPASSS NSKHAPAKMP
260 270 280 290 300
PPPPPPKAPA RKSATTHETR PSASRSRRRS PSPRRPATPP KPAAVGTRRS
310 320 330 340 350
TRQALAHSRA SYDDGQLSPG ASRATPRIKL KVRPPLTVIP LVHPNQANVR
360 370 380 390 400
PKLGPTFEEY FARAHEIPVE EGGQHIPDEE PKYTDEMALQ DAKVILRVEK
410 420 430 440 450
EVEPGGLLAP DRCSAFEPEA EEEPPRQWAH LDHLTKAMTN FRKLMYREQQ
460 470 480 490 500
LHMQAAKRIA IACEAEWRRR NPQPKTAEEI ELEEMEASKA KWRQVIRAFA
510 520 530 540 550
GTWENVRVEV NRRRLVEWEA EEQRRVKAAL NQAVNLSEQK LQQRQAQVDG
560 570 580 590 600
DEITDEDEDE DDEDLASGMP SVMGDEKESD EHSDQGSDEM SDENDEDEDE
610 620 630 640 650
DNMSSSEDDD KKSTASDEGL TQEELRAKYA NLPTLGTTDE TEETTKDVEM
660 670 680 690 700
ADAPAAMDGS VANDDDTSDE SVDMDDDLGS SEESDDDEEE EEDDEEEEES
710 720 730 740 750
DDEPAGLLGL FFGKSELKKL KEEAVTEEPS VEPAGDVEMT DASAALRPEL
760 770 780 790 800
QVNGHAHEAP ITNGTHTNEQ LASSQTEGAD DEVSLLVIPN DEIAAENTQT
810 820 830 840 850
AAEPGSGVVE KDFLTNDSSL KYPNEIVQSE NQTLPAKESV EAGGDLPMVD
860 870 880 890 900
APSTDDLQRE TAAAPSLEAP PNTRHDSQET VAATDMQSQS QTQSPKTTDT
910 920 930 940 950
KPTDVDTPHS ELAVSVQKPD SRQSSPQPTT PTVKTEIPFL LRGTLREYQH
960 970 980 990 1000
HGLDWLAGLY ANNTNGILAD EMGLGKTIQT IALLAHLACH HEVWGPHLVI
1010 1020 1030 1040 1050
VPTSVMLNWE MEFKKWCPGF KILTYYGNQE ERKRKRQGWN NDDVWNVCIT
1060 1070 1080 1090 1100
SYQMVLQDQQ VFRRRRWHYM ILDEAHNIKN FKSQRWQTLL GFNTQARLLL
1110 1120 1130 1140 1150
TGTPLQNNLT ELWSLLYFLA PPENGEGGFV DLTEFHNWFA RPESQILESG
1160 1170 1180 1190 1200
REQLDDEARA IIAKLHKVLR PYLLRRLKAD VEKQMPAKYE HVEFCRLSKR
1210 1220 1230 1240 1250
QRELYDGFLS RADTRETLQS GNYMSIINCL MQLRKVCNHP DLFVDRPIMT
1260 1270 1280 1290 1300
SFRMSRSVPA DYEWKEKFIR NRLLATKPMT TVNLSFLNMI PTEYEDLSKT
1310 1320 1330 1340 1350
HTDRIAQLSS HRILLDLREA QKVRANNAYT ALDPSSVKSN LVYLESAARW
1360 1370 1380 1390 1400
GRFEELQHCV YINALRRQQR PIYGKRLTEF LTLDTHLRPY KPRPRVPAKI
1410 1420 1430 1440 1450
MSWFEEDSFL LHNAIPTLQQ RAESMEMTIT KFACVTPAVV TGPEMNRFLL
1460 1470 1480 1490 1500
GERGIQLFED LDLKLSAPVK YAPYMPPQPP PDPWHEARMR LTIQFPDKRL
1510 1520 1530 1540 1550
LQYDCGKLQA LDKLLRKLQA GGHRALIFTQ MTKVLDILEQ FLNIHGHKYL
1560 1570 1580 1590 1600
RLDGATKVEQ RQILTDRFNH DPRILCFILS TRSGGLGINL TGADTVIFYD
1610 1620 1630 1640 1650
QDWNPAMDKQ CQDRCHRIGQ TRDVHIYRLV SEHTIEANIL RKASQKQMLD
1660 1670 1680 1690 1700
DVVIQEGEFT TDYFNRLSVR DVLGSNGEVI ASNEDDVAAN LAMDRVLGGP
1710 1720 1730 1740 1750
STTGAGGYDG TADGGGGASQ PPVRNVGRVL EMAEDREDVD AAKAAEKEIM
1760 1770 1780 1790 1800
QDEADFGEAG STRPGTPGDG LADLDGQLLG GEENKEVEDE VIEYNAWGER
1810 1820 1830 1840
MHTIDEYMLG FMAKALEGTP LELPRDRKKG RDRNRNRKGK DSRKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM002242 Genomic DNA Translation: EAA29066.1 |
RefSeqi | XP_958302.1, XM_953209.2 |
Genome annotation databases
EnsemblFungii | EAA29066; EAA29066; NCU09993 |
GeneIDi | 3874449 |
KEGGi | ncr:NCU09993 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM002242 Genomic DNA Translation: EAA29066.1 |
RefSeqi | XP_958302.1, XM_953209.2 |
3D structure databases
SMRi | Q7S133 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | EAA29066; EAA29066; NCU09993 |
GeneIDi | 3874449 |
KEGGi | ncr:NCU09993 |
Organism-specific databases
EuPathDBi | FungiDB:NCU09993 |
Phylogenomic databases
HOGENOMi | HOG000186095 |
InParanoidi | Q7S133 |
KOi | K11681 |
OMAi | RQGWNND |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR002464 DNA/RNA_helicase_DEAH_CS IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR014012 HSA_dom IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N |
Pfami | View protein in Pfam PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit |
SUPFAMi | SSF52540 SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51204 HSA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SWR1_NEUCR | |
Accessioni | Q7S133Primary (citable) accession number: Q7S133 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 15, 2003 | |
Last modified: | July 31, 2019 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families