UniProtKB - Q7RZU4 (SET2_NEUCR)
Protein
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene
set-2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.By similarity
Catalytic activityi
- L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteinePROSITE-ProRule annotationBy similarityEC:2.1.1.359PROSITE-ProRule annotationBy similarity
GO - Molecular functioni
- histone methyltransferase activity (H3-K36 specific) Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Repressor, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.359By similarity)Alternative name(s): SET domain-containing protein 2 |
Gene namesi | Name:set-2 ORF Names:NCU00269 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:NCU00269 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269791 | 1 – 954 | Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST | 954 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 180 | AWSPROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 182 – 299 | SETPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 306 – 322 | Post-SETPROSITE-ProRule annotationAdd BLAST | 17 | |
Domaini | 569 – 601 | WWPROSITE-ProRule annotationAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 863 – 895 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 849 – 862 | Pro-richAdd BLAST | 14 |
Domaini
The AWS and SET domains are necessary for transcription repression.By similarity
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
HOGENOMi | CLU_008492_0_0_1 |
InParanoidi | Q7RZU4 |
Family and domain databases
CDDi | cd19172, SET_SETD2, 1 hit cd00201, WW, 1 hit |
Gene3Di | 1.10.1740.100, 1 hit 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR003616, Post-SET_dom IPR025788, Set2_fungi IPR001214, SET_dom IPR044437, SETD2/Set2_SET IPR013257, SRI IPR038190, SRI_sf IPR035441, TFIIS/LEDGF_dom_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF00856, SET, 1 hit PF08236, SRI, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00508, PostSET, 1 hit SM00317, SET, 1 hit SM00456, WW, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS51568, SAM_MT43_SET2_1, 1 hit PS50280, SET, 1 hit PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7RZU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDGHHSPDS TKESKSEEHS KMNGSKLKRD GASNAGNAAT PNGSQTGISR
60 70 80 90 100
PPSMSPDEHK AASESTATPS ENVPTQKPSR KASQKNMKRE PVLFNHLPDV
110 120 130 140 150
REEACTHFQV IHDCLYGSKN MGASEHDALD CDCAEEWRGD MNHACGEDSD
160 170 180 190 200
CINRATKMEC VDGDCNCGSG CQNQRFQRKQ YADVSVIKTE KKGFGLRANT
210 220 230 240 250
DLQVNDFIFE YIGEVINEPT FRSRMVKYDK EGIKHFYFMS LTKSEFVDAT
260 270 280 290 300
KKGNLGRFCN HSCDPNCYVD KWVVGDKLRM GIFAGRAIKA GEELVFNYNV
310 320 330 340 350
DRYGADPQPC YCGEPNCTGF IGGKTQTERA TKLPPATIEA LGIEDGDSWD
360 370 380 390 400
TAVAATVKKP RKKKATEDDE EYINRFEPRG LDEEGVTKVM ATLMQCKEKW
410 420 430 440 450
IAVKLLGRLQ NADDDHVRNR VVKMHGYQIL KTTLNTFKED TNVVLQILDI
460 470 480 490 500
LYQLPRITKN KITDSNIEAA VEPLTHSDHE DVASQSKRLL QEWSKLETAY
510 520 530 540 550
RIPRKKLDPS APVTTNSFED DRRNVNHEEH PSRPVNPFEN MVVPTGPRSN
560 570 580 590 600
IPQRNMNYFN NQRPRKLPTN LPAGWFVTTD STGKYYFYDK SGHTQWQRPT
610 620 630 640 650
TPAVDVPKPS AKVEQNQKAL QDIIDSLTKE PTPRHSANQT PKSNTPVPDN
660 670 680 690 700
GKKEKWRSLP VEKQMKIYEN TLFPHVKYVM DKFHRRLPKE DLKRFGREIN
710 720 730 740 750
KKLVASDYKN HRVDDPTTIS SNQARKIKKF VKDFFDRAVV KHRENEQRAA
760 770 780 790 800
QKAGPSSSGA PSPTNGGSAK SPLGRNGASN ATVKTQQPDA DGDIVLTDVE
810 820 830 840 850
DEGENTPATS SSDRKRKRAE EQEVPAPASE AIPSPKRAKE DSTTEDSIPS
860 870 880 890 900
PPPPPPPPTD TPLTEEERSM REQEEALMRE NEEAQRLEDE EAERRVSVTV
910 920 930 940 950
QGAAVATSKV NGVNGTKAHH TSEASPAVSD ENGMDAGRDE KSHEQMAQQE
PVSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM002238 Genomic DNA Translation: EAA28504.1 |
RefSeqi | XP_957740.1, XM_952647.2 |
Genome annotation databases
EnsemblFungii | EAA28504; EAA28504; NCU00269 |
GeneIDi | 3873910 |
KEGGi | ncr:NCU00269 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM002238 Genomic DNA Translation: EAA28504.1 |
RefSeqi | XP_957740.1, XM_952647.2 |
3D structure databases
SMRi | Q7RZU4 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | EAA28504; EAA28504; NCU00269 |
GeneIDi | 3873910 |
KEGGi | ncr:NCU00269 |
Organism-specific databases
VEuPathDBi | FungiDB:NCU00269 |
Phylogenomic databases
HOGENOMi | CLU_008492_0_0_1 |
InParanoidi | Q7RZU4 |
Family and domain databases
CDDi | cd19172, SET_SETD2, 1 hit cd00201, WW, 1 hit |
Gene3Di | 1.10.1740.100, 1 hit 1.20.930.10, 1 hit |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR003616, Post-SET_dom IPR025788, Set2_fungi IPR001214, SET_dom IPR044437, SETD2/Set2_SET IPR013257, SRI IPR038190, SRI_sf IPR035441, TFIIS/LEDGF_dom_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF00856, SET, 1 hit PF08236, SRI, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00508, PostSET, 1 hit SM00317, SET, 1 hit SM00456, WW, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS51568, SAM_MT43_SET2_1, 1 hit PS50280, SET, 1 hit PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SET2_NEUCR | |
Accessioni | Q7RZU4Primary (citable) accession number: Q7RZU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 15, 2003 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families