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UniProtKB - Q7RZU4 (SET2_NEUCR)

Entry version 122 (07 Apr 2021)
Sequence version 1 (15 Dec 2003)
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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

set-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.359By similarity)
Alternative name(s):
SET domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:set-2
ORF Names:NCU00269
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Linkage Group III, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:NCU00269

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002697911 – 954Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST954

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7RZU4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 180AWSPROSITE-ProRule annotationAdd BLAST55
Domaini182 – 299SETPROSITE-ProRule annotationAdd BLAST118
Domaini306 – 322Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini569 – 601WWPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili863 – 895Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi849 – 862Pro-richAdd BLAST14

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008492_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7RZU4

Family and domain databases

Conserved Domains Database

More...CDDi		cd19172, SET_SETD2, 1 hit
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1740.100, 1 hit
1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006560, AWS_dom
IPR003616, Post-SET_dom
IPR025788, Set2_fungi
IPR001214, SET_dom
IPR044437, SETD2/Set2_SET
IPR013257, SRI
IPR038190, SRI_sf
IPR035441, TFIIS/LEDGF_dom_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17907, AWS, 1 hit
PF00856, SET, 1 hit
PF08236, SRI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00570, AWS, 1 hit
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47676, SSF47676, 1 hit
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51215, AWS, 1 hit
PS50868, POST_SET, 1 hit
PS51568, SAM_MT43_SET2_1, 1 hit
PS50280, SET, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7RZU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDGHHSPDS TKESKSEEHS KMNGSKLKRD GASNAGNAAT PNGSQTGISR 
        60         70         80         90        100
PPSMSPDEHK AASESTATPS ENVPTQKPSR KASQKNMKRE PVLFNHLPDV 
       110        120        130        140        150
REEACTHFQV IHDCLYGSKN MGASEHDALD CDCAEEWRGD MNHACGEDSD 
       160        170        180        190        200
CINRATKMEC VDGDCNCGSG CQNQRFQRKQ YADVSVIKTE KKGFGLRANT 
       210        220        230        240        250
DLQVNDFIFE YIGEVINEPT FRSRMVKYDK EGIKHFYFMS LTKSEFVDAT 
       260        270        280        290        300
KKGNLGRFCN HSCDPNCYVD KWVVGDKLRM GIFAGRAIKA GEELVFNYNV 
       310        320        330        340        350
DRYGADPQPC YCGEPNCTGF IGGKTQTERA TKLPPATIEA LGIEDGDSWD 
       360        370        380        390        400
TAVAATVKKP RKKKATEDDE EYINRFEPRG LDEEGVTKVM ATLMQCKEKW 
       410        420        430        440        450
IAVKLLGRLQ NADDDHVRNR VVKMHGYQIL KTTLNTFKED TNVVLQILDI 
       460        470        480        490        500
LYQLPRITKN KITDSNIEAA VEPLTHSDHE DVASQSKRLL QEWSKLETAY 
       510        520        530        540        550
RIPRKKLDPS APVTTNSFED DRRNVNHEEH PSRPVNPFEN MVVPTGPRSN 
       560        570        580        590        600
IPQRNMNYFN NQRPRKLPTN LPAGWFVTTD STGKYYFYDK SGHTQWQRPT 
       610        620        630        640        650
TPAVDVPKPS AKVEQNQKAL QDIIDSLTKE PTPRHSANQT PKSNTPVPDN 
       660        670        680        690        700
GKKEKWRSLP VEKQMKIYEN TLFPHVKYVM DKFHRRLPKE DLKRFGREIN 
       710        720        730        740        750
KKLVASDYKN HRVDDPTTIS SNQARKIKKF VKDFFDRAVV KHRENEQRAA 
       760        770        780        790        800
QKAGPSSSGA PSPTNGGSAK SPLGRNGASN ATVKTQQPDA DGDIVLTDVE 
       810        820        830        840        850
DEGENTPATS SSDRKRKRAE EQEVPAPASE AIPSPKRAKE DSTTEDSIPS 
       860        870        880        890        900
PPPPPPPPTD TPLTEEERSM REQEEALMRE NEEAQRLEDE EAERRVSVTV 
       910        920        930        940        950
QGAAVATSKV NGVNGTKAHH TSEASPAVSD ENGMDAGRDE KSHEQMAQQE 

PVSR
Length:954
Mass (Da):106,775
Last modified:December 15, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C0E20C6C7525AFC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CM002238 Genomic DNA Translation: EAA28504.1

NCBI Reference Sequences

More...RefSeqi		XP_957740.1, XM_952647.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		EAA28504; EAA28504; NCU00269

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3873910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ncr:NCU00269

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA Translation: EAA28504.1
RefSeqiXP_957740.1, XM_952647.2

3D structure databases

SMRiQ7RZU4
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiEAA28504; EAA28504; NCU00269
GeneIDi3873910
KEGGincr:NCU00269

Organism-specific databases

VEuPathDBiFungiDB:NCU00269

Phylogenomic databases

HOGENOMiCLU_008492_0_0_1
InParanoidiQ7RZU4

Family and domain databases

CDDicd19172, SET_SETD2, 1 hit
cd00201, WW, 1 hit
Gene3Di1.10.1740.100, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR006560, AWS_dom
IPR003616, Post-SET_dom
IPR025788, Set2_fungi
IPR001214, SET_dom
IPR044437, SETD2/Set2_SET
IPR013257, SRI
IPR038190, SRI_sf
IPR035441, TFIIS/LEDGF_dom_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF17907, AWS, 1 hit
PF00856, SET, 1 hit
PF08236, SRI, 1 hit
SMARTiView protein in SMART
SM00570, AWS, 1 hit
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SM00456, WW, 1 hit
SUPFAMiSSF47676, SSF47676, 1 hit
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215, AWS, 1 hit
PS50868, POST_SET, 1 hit
PS51568, SAM_MT43_SET2_1, 1 hit
PS50280, SET, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET2_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7RZU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 15, 2003
Last modified: April 7, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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